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Organic Chemistry 51B. Lecture 22. Conjugation, Resonance, Diels-Alder Reactions, Part 2.

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UCI Chem 51B Organic Chemistry (Winter 2013) Lec 22. Organic Chemistry -- Conjugation, Resonance, Diels-Alder Reactions -- Part 2 View the complete course: http://ocw.uci.edu/courses/chem_51b_organic_chemistry.html Instructor: David Van Vranken, Ph.D. License: Creative Commons BY-NC-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: This is the second quarter of the organic chemistry series. Topics covered include: Fundamental concepts relating to carbon compounds with emphasis on structural theory and the nature of chemical bonding, stereochemistry, reaction mechanisms, and spectroscopic, physical, and chemical properties of the principal classes of carbon compounds. This video is part of a 26-lecture undergraduate-level course titled "Organic Chemistry" taught at UC Irvine by Professor David Van Vranken. Organic Chemistry (Chem 51B) is part of OpenChem. http://ocw.uci.edu/collections/open_chemistry.html Recorded March 6, 2013. Index of Topics: 00:13- A molecule today, a barrel tomorrow 00:42- Fracking 04:57- 16.12: The Diels-Alder Reaction 10:42- 16.13: Diene Requires an s-cis conformation 14:53- 16.13: Stereospecificity in the Diels-Alder Reaction 21:08- 16.13: Drawing Bridged Bicyclic Products of Diels-Alder Reactions 29:41- 16.13: The Endo Rule for Cyclic Dienes CHAPTER 17-Benzene and Aromatic Compounds 34:05- 17.1: The C=C pi bonds in benzene exhibit low reactivity 39:19- 17.3: Disubstituted benzene rings: ortho, meta, and para relationships 45:06- 17.4: C NMR Spectroscopy 47:14- 17.4: H NMR Spectroscopy Required attribution: Vranken, David Van. Organic Chemistry 51B (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_51b_organic_chemistry.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).

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Kwillt Learning Resource - Keeping warm in later life project

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This resource explores factors and barriers influencing older people keeping warm in winter. The research has been funded by a National Institute for Health Research, Research for Patient Benefit grant. The key partners involved include: NHS Rotherham, Sheffield Hallam University, National Energy Action, Rotherham Metropolitan Borough Council and Rotherham Older Peoples Experiences of Services.

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Kwillt | Keeping warm in later life project | learning resource | older | cold | cold home | reflection | pen portraits | Rotherham | Sheffield | Sheffield Hallam University | Yorkshire | National Institute for Health Research | Research for Patient Benefit grant | NHS Rotherham | National Energy Action | Rotherham Metropolitan Borough Council | Rotherham Older Peoples Experiences of Services | HEALTH CARE / MEDICINE / HEALTH and SAFETY | P

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Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales Attribution-NonCommercial-NoDerivs 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-nd/2.0/uk/ http://creativecommons.org/licenses/by-nc-nd/2.0/uk/

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Molecular Structure & Statistical Mechanics 131B. Lecture 20. NMR Applications/ Review

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UCI Chem 131B Molecular Structure & Statistical Mechanics (Winter 2013) Lec 20. Molecular Structure & Statistical Mechanics -- NMR Applications/Review. View the complete course: http://ocw.uci.edu/courses/chem_131b_molecular_structure_and_elementary_statistical_mechanics.html Instructor: Rachel Martin, Ph.D. License: Creative Commons BY-NC-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: Principles of quantum mechanics with application to the elements of atomic structure and energy levels, diatomic molecular spectroscopy and structure determination, and chemical bonding in simple molecules. Molecular Structure & Statistical Mechanics (Chem 131B) is part of OpenChem: http://ocw.uci.edu/collections/open_chemistry.html This video is part of a 26-lecture undergraduate-level course titled "Molecular Structure & Statistical Mechanics" taught at UC Irvine by Rachel Martin, Ph.D. Recorded on February 27, 2013. Index of Topics: 0:06:48 NMR Applications/Review 0:10:26 Going Through the Process 0:15:59 Sidechain Correlations - TOCSY 0:17:54 Mistic Structure 0:18:59 Relative Sizes of Interactions 0:19:40 Quadrupolar Nuclei 0:25:19 Spin 1 0:27:34 Bicelles: Membrane Mimetics 0:29:39 ^(2)H Spectra 0:31:59 Multiple Lipid Phases 0:35:56 NMR Spectroscopy Worksheet Required attribution: Martin, Rachel. Molecular Structure & Statistical Mechanics 131B (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_131b_molecular_structure_and_elementary_statistical_mechanics.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).

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Anne Bohm and Professor Alan Day, 1988

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Exhibition of Richard Robbins pictures at St Johns Smith Square prior to the Lionel Robbins memorial concert Information from LSE Magazine November 1984 No68 p.24 (Retirements) Alan Day came to the School as an Assistant Lecturer ion economics in 1949, after service in the RAF followed by three years at Cambridge. He soon became a leading member of the group of academics gathered round Richard Sayers, from which emerged some of the best contemporary work on monetary institutions both domestic and international. From an early stage the breadth of his interests was evident, and for many years what he wrote in The Observer on Sunday was a major topic for discussion on Monday. These interests took him to the Treasury for two years; to a period as editor of the National Institute Economic Review, and to membership of official committees on the London Taxicab Trade and Local Government Finance, while for many years he has been a member of the Council of the Consumers Association. But perhaps his most abiding interest outside the School was in civil aviation; for three years he was a member of the board of the British Airports Authority and later he became Economic Adviser to the Civil Aviation Authority. In 1979 he was appointed Pro-Director, quite exceptionally he was reappointed for a second term; but to the regret of all his friends and colleagues sudden ill health led to his untimely retirement from the School late in 1983. Since then, his remarkable recovery has enabled him to resume many of his activities; in particular, he is pursuing a life-long interest in restoring old buildings by devoting much of his time to an eighteenth century manor house in Kent. IMAGELIBRARY/297 Persistent URL: archives.lse.ac.uk/dserve.exe?dsqServer=lib-4.lse.ac.uk&a...

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General Chemistry 1C. Lecture 23. Chemical Kinetics Pt. 2.

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UCI Chem 1C General Chemistry (Spring 2013) Lec 23. General Chemistry -- Chemical Kinetics -- Part 2 View the complete course: http://ocw.uci.edu/courses/chem_1c_general_chemistry.html Instructor: Ramesh D. Arasasingham, Ph.D. License: Creative Commons BY-NC-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: UCI Chem 1C is the third and final quarter of General Chemistry series and covers the following topics: equilibria, aqueous acid-base equilibria, solubility equilibria, oxidation reduction reactions, electrochemistry; kinetics; special topics. General Chemistry (Chem 1C) is part of OpenChem: http://ocw.uci.edu/collections/open_chemistry.html This video is part of a 26-lecture undergraduate-level course titled "General Chemistry" taught at UC Irvine by Ramesh D. Arasasingham, Ph.D. Recorded on May 31, 2013. Index of Topics: 0:00:00 Review on Rates 0:04:02 Kinetic Rate Laws 0:08:57 Example Using N2O5 0:15:53 Determining Rate Law and Order for Reaction 0:28:16 Determing Rate Expression and Value of the Constant 0:42:56 Measuring Rate of Chemical Reaction with Graphs Required attribution: Arasasingham, Ramesh D. Ph.D. General Chemistry 1C (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_1c_general_chemistry.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US)

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Professor James Meade, 1993

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With restored Phillips Machine Extracts from ?The Phillips Machine Project? by Nicholas Bar, LSE Magazine, June 1988, No75, p.3 A.W. H. ?Bill? Phillips is known worldwide as the originator of the Phillips Curve. Less well known is the remarkable man he was personally, and his extraordinary route to academic prominence via what came to be called the Phillips Machine. Trained as an electrical engineer in his native New Zealand in the 1930s, he caught the travel bug and took up an engineering job in the Australian outback, where he also earned money by running a cinema and hunting crocodiles. He reached London in 1938 via the Trans-Siberian railway and joined the RAF at the outbreak of war. He was captured in Java and spent most of the war in a Japanese POW camp, where he learned Chinese and some Russian from fellow prisoners. Back in Britain he took the BSc (Econ) 1946-49, special subject sociology. He developed a great interest in economics?and like many of his generation, became very caught up with Keynesian theory. Though fascinated he found the Keynesian model hard going. With Walter Newlyn (an undergraduate contemporary, later Professor of Economics at Leeds University) to help with the economic theory, he fell back on his engineering training. He saw that money stocks could be represented as tanks of water, and monetary flows by water circulating round plastic tubes. With a grant of 100 (obtained with Newlyn?s help) he spent the summer of 1949 in a garage in Croydon ?living on air? as James Meade was later to put it, working on a hydraulic representation of the Keynesian model. In the machine he constructed, the circular flow of income was represented by water being pumped round a series of clear plastic tubes, with outflows representing savings, taxes and imports, and inflows representing investment, government spending and exports. The model had three tanks representing the stock of money, one for transaction balances and one for foreign-held sterling balances. The whole system determined the level of income, the rate of interest, imports, exports and the exchange to an accuracy (astonishing at the time) of +two per cent. The time path of income and the other variables was traced out by plotter pens making it possible to analyse the quantitative effects of economic policy. The machine, in the jargon, was a hydraulic representation of an open economy IS-LM model with an explicit underlying dynamic structure. It was this very Heath Robinson prototype which, with the enthusiastic support of James Meade (then Professor of Commerce at the School), Phillips demonstrated to Lionel Robbins? seminar in November 1949. Those attending gazed in wonder at this large (7ft high x 5ft wide x 3ft deep) ?thing? in the middle of the room. Phillips, chain smoking, paced back and forth explaining it in a heavy New Zealand drawl, in the process giving one of the best lectures on Keynes that anyone in the audience had ever heard. Then he switched the machine on. And it worked! According to Lord Robbins? recollections, ?there was income dividing itself into consumption and saving?Keynes and Robertson need never have quarrelled if they had had the Phillips Machine before them??Phillips was made an Assistant Lecturer in Economics in 1950, Lecturer 1951, Reader 1954, and Tooke Professor of Economic Science and Statistics in 1958 (the year his Phillips Curve paper was published). He took up a Chair at the Australian National University in 1967 and, having suffered a major stroke, retired to Auckland in 1970, where he died five years later aged 60, mourned by many friends for personal as much for professional reasons.? IMAGELIBRARY/282 Persistent URL: archives.lse.ac.uk/dserve.exe?dsqServer=lib-4.lse.ac.uk&a...

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Schwimmer, Rosika Bc.1910

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TWL.2000.161Postcard, printed, cardboard, monochrome photographic studio portrait of 'ROSIKA B SCHWIMMER', standing next to a table with three books on it, upper body, front-profile, white border along bottom front edge, black text, printed inscription front: 'MATE OLGA FELVETELE ATELIER OLGA MATE BEDY-SCHWIMMER ROZSA ROSIKA B SCHWIMMER', printed inscription reverse (in four languages): 'INTERNATIONAL WOMAN SUFFRAGE CONGRESS BUDAPEST - HUNGARY', manuscript inscription reverse: 'Rosika Schwimmer Ambassador to USA [United States of America] [Switzerland?] during?'.

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Professor A.W.H (Bill) Phillips

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Extracts from ?The Phillips Machine Project? by Nicholas Bar, LSE Magazine, June 1988, No75, p.3 A.W. H. ?Bill? Phillips is known worldwide as the originator of the Phillips Curve. Less well known is the remarkable man he was personally, and his extraordinary route to academic prominence via what came to be called the Phillips Machine. Trained as an electrical engineer in his native New Zealand in the 1930s, he caught the travel bug and took up an engineering job in the Australian outback, where he also earned money by running a cinema and hunting crocodiles. He reached London in 1938 via the Trans-Siberian railway and joined the RAF at the outbreak of war. He was captured in Java and spent most of the war in a Japanese POW camp, where he learned Chinese and some Russian from fellow prisoners. Back in Britain he took the BSc (Econ) 1946-49, special subject sociology. He developed a great interest in economics?and like many of his generation, became very caught up with Keynesian theory. Though fascinated he found the Keynesian model hard going. With Walter Newlyn (an undergraduate contemporary, later Professor of Economics at Leeds University) to help with the economic theory, he fell back on his engineering training. He saw that money stocks could be represented as tanks of water, and monetary flows by water circulating round plastic tubes. With a grant of 100 (obtained with Newlyn?s help) he spent the summer of 1949 in a garage in Croydon ?living on air? as James Meade was later to put it, working on a hydraulic representation of the Keynesian model. In the machine he constructed, the circular flow of income was represented by water being pumped round a series of clear plastic tubes, with outflows representing savings, taxes and imports, and inflows representing investment, government spending and exports. The model had three tanks representing the stock of money, one for transaction balances and one for foreign-held sterling balances. The whole system determined the level of income, the rate of interest, imports, exports and the exchange to an accuracy (astonishing at the time) of +two per cent. The time path of income and the other variables was traced out by plotter pens making it possible to analyse the quantitative effects of economic policy. The machine, in the jargon, was a hydraulic representation of an open economy IS-LM model with an explicit underlying dynamic structure. It was this very Heath Robinson prototype which, with the enthusiastic support of James Meade (then Professor of Commerce at the School), Phillips demonstrated to Lionel Robbins? seminar in November 1949. Those attending gazed in wonder at this large (7ft high x 5ft wide x 3ft deep) ?thing? in the middle of the room. Phillips, chain smoking, paced back and forth explaining it in a heavy New Zealand drawl, in the process giving one of the best lectures on Keynes that anyone in the audience had ever heard. Then he switched the machine on. And it worked! According to Lord Robbins? recollections, ?there was income dividing itself into consumption and saving?Keynes and Robertson need never have quarrelled if they had had the Phillips Machine before them??Phillips was made an Assistant Lecturer in Economics in 1950, Lecturer 1951, Reader 1954, and Tooke Professor of Economic Science and Statistics in 1958 (the year his Phillips Curve paper was published). He took up a Chair at the Australian National University in 1967 and, having suffered a major stroke, retired to Auckland in 1970, where he died five years later aged 60, mourned by many friends for personal as much for professional reasons.? IMAGELIBRARY/244 Persistent URL: archives.lse.ac.uk/dserve.exe?dsqServer=lib-4.lse.ac.uk&a...

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Department of Social Science and Administration, 1971

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Seated left to right: Muriel Brown, Howard Glennerster, Kit Russell, Roger Hadley, Kay McDougall, Brian Abel-Smith, Richard Titmuss, Garth Plowman, Zofia Butrym, Peter Levin, George Goetschius, Angela Vivian, Don Gregory. Standing left to right: Andrew Howell, Tessa Blackstone, Joan Edmonds, Beata Blair, Ruth Griffiths, Sally Sainsbury, Mike Reddin, Doreen Wilson, Christine Stander, Leone Kellaher, David Piachaud, Vivienne Gilby, Rosalind Brooke, Jackie Shreeve, Anne Edwards, Helen Burns, Judith Benjamin, Maureen Mulvany, Dianna Wories, Charlotte Sutton, Kathleen Hill, Janie Thomas, Roberta Gillingwater, Irmi Elkan, Geoffrey Sage IMAGELIBRARY/234 Persistent URL: archives.lse.ac.uk/dserve.exe?dsqServer=lib-4.lse.ac.uk&a...

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Fairmount Avenue Methodist Church, Richmond, Va

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Description: Fairmount Avenue Methodist Church, Fairmount Avenue and 20ths St., Richmond, Va. Organized April 1889 in a chapel at Stewart and Redd Sts., with 23 members, then known as Howard's Grove Methodist Church. In 1892 a new church was erected at the present location and name changed to Fairmount Avenue. The first preacher in charge was Rev. LeRoy J. Phaup who was appointed by the Va. M.E. Conference in November 1899. 14th appointment in 1912 Rev. E.V Carson. Present building erected 1913-14. Manufacturer: Southern Bargain House, Richmond, Va. Date Postmarked: 1920 Rights: This item is in the public domain. Acknowledgement of the Virginia Commonwealth University Libraries as a source is requested. Reference URL: dig.library.vcu.edu/u?/postcard,118 Collection: Rarely Seen Richmond: Early twentieth century Richmond as seen through vintage postcards

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Professor James Meade with Phillips Machine, 1996

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Professor of Commerce at LSE 1947-1957, received the Nobel Prize in Economic Sciences (jointly) in 1977 Extracts from ?The Phillips Machine Project? by Nicholas Bar, LSE Magazine, June 1988, No75, p.3 A.W. H. ?Bill? Phillips is known worldwide as the originator of the Phillips Curve. Less well known is the remarkable man he was personally, and his extraordinary route to academic prominence via what came to be called the Phillips Machine. Trained as an electrical engineer in his native New Zealand in the 1930s, he caught the travel bug and took up an engineering job in the Australian outback, where he also earned money by running a cinema and hunting crocodiles. He reached London in 1938 via the Trans-Siberian railway and joined the RAF at the outbreak of war. He was captured in Java and spent most of the war in a Japanese POW camp, where he learned Chinese and some Russian from fellow prisoners. Back in Britain he took the BSc (Econ) 1946-49, special subject sociology. He developed a great interest in economics?and like many of his generation, became very caught up with Keynesian theory. Though fascinated he found the Keynesian model hard going. With Walter Newlyn (an undergraduate contemporary, later Professor of Economics at Leeds University) to help with the economic theory, he fell back on his engineering training. He saw that money stocks could be represented as tanks of water, and monetary flows by water circulating round plastic tubes. With a grant of 100 (obtained with Newlyn?s help) he spent the summer of 1949 in a garage in Croydon ?living on air? as James Meade was later to put it, working on a hydraulic representation of the Keynesian model. In the machine he constructed, the circular flow of income was represented by water being pumped round a series of clear plastic tubes, with outflows representing savings, taxes and imports, and inflows representing investment, government spending and exports. The model had three tanks representing the stock of money, one for transaction balances and one for foreign-held sterling balances. The whole system determined the level of income, the rate of interest, imports, exports and the exchange to an accuracy (astonishing at the time) of +two per cent. The time path of income and the other variables was traced out by plotter pens making it possible to analyse the quantitative effects of economic policy. The machine, in the jargon, was a hydraulic representation of an open economy IS-LM model with an explicit underlying dynamic structure. It was this very Heath Robinson prototype which, with the enthusiastic support of James Meade (then Professor of Commerce at the School), Phillips demonstrated to Lionel Robbins? seminar in November 1949. Those attending gazed in wonder at this large (7ft high x 5ft wide x 3ft deep) ?thing? in the middle of the room. Phillips, chain smoking, paced back and forth explaining it in a heavy New Zealand drawl, in the process giving one of the best lectures on Keynes that anyone in the audience had ever heard. Then he switched the machine on. And it worked! According to Lord Robbins? recollections, ?there was income dividing itself into consumption and saving?Keynes and Robertson need never have quarrelled if they had had the Phillips Machine before them??Phillips was made an Assistant Lecturer in Economics in 1950, Lecturer 1951, Reader 1954, and Tooke Professor of Economic Science and Statistics in 1958 (the year his Phillips Curve paper was published). He took up a Chair at the Australian National University in 1967 and, having suffered a major stroke, retired to Auckland in 1970, where he died five years later aged 60, mourned by many friends for personal as much for professional reasons.? IMAGELIBRARY/724 Persistent URL: archives.lse.ac.uk/dserve.exe?dsqServer=lib-4.lse.ac.uk&a...

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Anthony Russell

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Name: Anthony Russell Arrested for: Larceny Arrested at: North Shields Police Station Arrested on: 27 May 1904 Tyne and Wear Archives ref: DX1388-1-29-Anthony Russell For an image of Russell's accomplice, Robert Lightly see www.flickr.com/photos/twm_news/19140868465/in/dateposted/. The Shields Daily Gazette for 28 May 1904 reports: ?TWO MINERS HAVE A NIGHT OUT. FRACAS ON A NO. SHIELDS FARM At North Shields Anthony Russell (27) and Robert Lightly (24), pitmen, Percy Main, were charged with being concerned together in stealing a duck, value 10s, the property of Mr Elwin on the 22nd inst. Joseph Elwin said that at 4.25 am he was awakened by his father, who told him that he had heard three shots fired. He got up and looked out of the window, and saw two men, each carrying a gun, on the field of the farm. He went out with another lad, and on getting up to men he saw that one was carrying a bundle, from which he saw a hare?s head protruding. He asked him why he had shot the hare on his father?s land. They made no reply and walked away. He then gave information to the police. On getting back to the farm he missed a duck. An officer spoke to arresting the defendants and charged them with stealing a duck. Lightly replied that Russell shot the duck and took it away. Russell replied that he burnt it. Mr Duncan, for the defence, said that there was no doubt they shot the duck, but it was not with a felonious intent. It appeared that on the Saturday night they had taken too much drink, and on the Sunday morning they got up at four o?clock and took their guns into the fields. Russell had seen a duck and the temptation had been too strong, and he had shot it. The Bench committed both defendants to prison for 14 days. The prisoners were afterwards charged with threatening Joseph Elwin. The prosecutor said that when he accused the two men of trespassing on the farm they both threatened to shoot him if he did not get out of their way. Lightly said that he would drill rabbit holes into him. Mr Duncan, for the defendants, denied the charges, and stated that Elwin challenged the men to fight. The defendants both denied the charge on oath. They were both bound over in the sum of 10 in their own recognisances and sureties of 10 each, or in default committed for 14 days; they were also ordered to pay the costs for both sides or in default go to prison for seven days. The defendant Lightly was charged with assaulting Elwin by striking him in the chest with his fist and with the muzzle end of the gun. The defendants were next charged with trespassing in search of game at Chirton Hill Farm on the same date. Mr Duncan submitted that the defendants had already been sufficiently punished for their offence, and the summons for trespass ought to be withdrawn, especially as it was taken out against the wish of Mr Elwin. The Chief Constable contradicted the latter statement. Mr Duncan said that Mr Elwin had stated in Court that he did not wish the case to proceed and therefore the summons could not stand. The Chief Constable sad that he himself was the informant in the case and he intended to go on with it. Mr Duncan took the ruling of the Court on the point, and Mr Kidd decided that the Chief Constable was acting within his rights. After hearing the evidence, the magistrates fined defendants 10s and costs or in default 14 days imprisonment to run concurrently with the other commitments?. These images are a selection from an album of photographs of prisoners brought before the North Shields Police Court between 1902 and 1916 in the collection of Tyne & Wear Archives (TWA ref DX1388/1). (Copyright) We're happy for you to share this digital image within the spirit of The Commons. Please cite 'Tyne & Wear Archives & Museums' when reusing. Certain restrictions on high quality reproductions and commercial use of the original physical version apply though; if you're unsure please email archives@twmuseums.org.uk.

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prisoner | crime | criminal | northshields | northtyneside | policestation | mugshot | imprisoned | cap | miner | larceny | theft | percymain | duck | gun

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Hotel Rueger, Richmond, Va.

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Description: Hotel Rueger, 9th and Bank Sts., Richmond, Va. Hotel Rueger is a modern, fireproof structure. Located in the heart of the business district, and occupying a commanding position overlooking the Capitol Square with its historic building and monuments, is ideally situated to afford comfort and convenience to the commercial traveler and tourist. Established in 1846, 'RUEGERS' is known the country wide for its excellent food and service. The Hotel is exclusively European Plan for ladies and gentlemen. It contains 130 bed-rooms, most of which are fitted with private baths and showers. Every room has a ceiling fan. Modern Garage attached to main building. Manufacturer: Lumitone Photoprint, New York Date Postmarked: 1934 Rights: This item is in the public domain. Acknowledgement of the Virginia Commonwealth University Libraries as a source is requested. Reference URL: dig.library.vcu.edu/u?/postcard,85 Collection: Rarely Seen Richmond: Early twentieth century Richmond as seen through vintage postcards

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7.344 RNA Interference: A New Tool for Genetic Analysis and Therapeutics (MIT)

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This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. To understand and treat any disease with a genetic basis or predisposition, scientists and clinicians need effective ways of manipulating the levels of genes and gene products. Conventional methods for the genetic modification of many experimental organisms are technically demanding and time consuming. Just over 5 years ago, a new mechanism of gene-silencing, termed RNA interference (RNAi), was discovered. In addition to being a fascinating biological process, RNAi provides a revolutionary technology that has a

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RNA interference | RNAi | RNA | genetic analysis | gene therapy | gene products | gene silencing | gene expression | human disease models | mRNA | genetic interference | short interfering RNA | siRNAs | expression vectors | RNA sequences | nucleotide fragments | microRNA | mRNA degradation | transgenic mice | lentivirus | knock-down animals | tissue specificity

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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John Dowson, arrested for stealing from a gas meter

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Name: John Dowson Arrested for: Larceny Arrested at: North Shields Police Station Arrested on: 7 February 1905 Tyne and Wear Archives ref: DX1388-1-65-John Dowson For an image of his accomplice Edward Roberts see www.flickr.com/photos/twm_news/19378323875/in/dateposted/. The Shields Daily News for 14 February 1905 reports: "THEFT FROM PENNY-IN-THE-SLOT METERS At North Shields Police Court to-day, before the Mayor and Mr J. Walton, Edward Roberts (19), messroom steward, Blyth and John Dowson (19), seaman, Wallsend, were charged with having stolen on the 30th ult. from an automatic gas meter at 33 Thrift Street the sum of 14s 8d, the moneys of the Tynemouth Gas Company. Mrs Cowey said that on the 30th ult. she was removing into the house when the accused came and asked to be allowed to look through. She told them the house was not to be let. In passing through one of the rooms Dowson put his hand on the gas meter and remarked it was very handy. They went away and next day witness found that the gas meter had been broken into and the box and money taken away. George Robson, a collector for the Gas Company said he had examined the meter and found that gas had been consumed to the value of 14s 8d. Sergt Hall said he arrested the accused in a lodging house on the 6th inst. He took them to the Bull Ring Police Station and charged them with the theft. They both replied: "Yes, that's right". There was a second charge against the prisoners of stealing from a gas meter at 37 Blyth Street, Percy Main, the sum of 2s 4d, the moneys of the Tynemouth Gas Company, between February 3 and 4. Similar evidence was given in this case. The accused, having obtained permission, were shown over the house and subsequently the money in the meter was missed. The prisoners admitted the charge and said that if the magistrates would allow them to go they would refund the money. Chief Constable Huish said he had only preferred two charges against the accused, but there were six or eight others. The prisoners were committed to gaol for 14 days in the second division for each offence - one month in all. The time spent in prison didn't deter Dowson and Roberts. Just over a month later The Shields Daily News for 18 March 1905 reported: "FOUND ON ENCLOSED PREMISES AT NORTH SHIELDS. SUSPICIOUS CHARACTERS SENT TO PRISON. At the North Shields Police Court this morning before Mr Isaac Black (in the chair) and Mr G.H. Stansfield - John Dowson (19), Gateshead and Edward Roberts (19), 53 Beaumont Street, Cowpen Quay, were charged on remand with being found on the enclosed premises of 9 Seymour Street, for an unlawful purpose, at 5 pm on the 16th inst. Both of the accused had been previously convicted of breaking into unoccupied houses and stealing money from gas meters, and they came out of prison as recently as Monday last. Mr Isaac Black (the chairman) said they had soon commenced again and as their recent imprisonment seemed to have been no caution to them, they would each be committed for six weeks with hard labour". These images are a selection from an album of photographs of prisoners brought before the North Shields Police Court between 1902 and 1916 in the collection of Tyne & Wear Archives (TWA ref DX1388/1). This set contains mugshots of boys and girls under the age of 21. This reflects the fact that until 1970 that was the legal age of majority in the UK. (Copyright) We're happy for you to share this digital image within the spirit of The Commons. Please cite 'Tyne & Wear Archives & Museums' when reusing. Certain restrictions on high quality reproductions and commercial use of the original physical version apply though; if you're unsure please email archives@twmuseums.org.uk.

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prisoner | crime | criminal | northshields | policestation | mugshot | imprisoned | arrested | cap | socialhistory | digitalimage | blackandwhitephotograph | criminalfacesofnorthshieldsthemen | johndowson | criminalrecord | publicrecords | larceny | northshieldspolicestation | 7february1905 | tyneandweararchivesrefdx1388165johndowson | northshieldspolicecourt | 19021916 | boy | male | neutralbackground | crease | fold | metalplate | screw | board | chalk | handwriting | unsual | fascinating | regno11 | finger | nail | holding | standing | attentive | cleanshaven | coat | button | shirt | hat | hair | grain | head | face | nose | eye | mouth | lip | ear | shoulder | chest | arm | blur | mark | skin | body | human | custody | theft | tynemouthgascompany | gasmeters

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Southern Railway Depot, (14th and Cary Sts.,) Richmond, Va.

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Description: The Southern is the second largest Railway system in the U.S. and its chief office, for stock holders meetings, is located in Richmond. Its principal passenger depot at Richmond shown in this view, stands within a few hundred yards of Mayo's Bridge, over James River. The waiting room is spacious and well appointed. The view also shows several colored hackmen, supremely 'at east,' awaiting the arrival of a Southern train. Manufacturer: Southern Bargain House, Richmond, Va. Date Postmarked: 1912 Rights: This item is in the public domain. Acknowledgement of the Virginia Commonwealth University Libraries as a source is requested. Reference URL: dig.library.vcu.edu/u?/postcard,307 Collection: Rarely Seen Richmond: Early twentieth century Richmond as seen through vintage postcards

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Organic Chemistry 51B. Lecture 25. Electrophilic Aromatic Substitution Part 2.

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UCI Chem 51B Organic Chemistry (Winter 2013) Lec 25. Organic Chemistry -- Electrophilic Aromatic Substitution -- Part 2 View the complete course: http://ocw.uci.edu/courses/chem_51b_organic_chemistry.html Instructor: David Van Vranken, Ph.D. License: Creative Commons BY-NC-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: This is the second quarter of the organic chemistry series. Topics covered include: Fundamental concepts relating to carbon compounds with emphasis on structural theory and the nature of chemical bonding, stereochemistry, reaction mechanisms, and spectroscopic, physical, and chemical properties of the principal classes of carbon compounds. This video is part of a 26-lecture undergraduate-level course titled "Organic Chemistry" taught at UC Irvine by Professor David Van Vranken. Organic Chemistry (Chem 51B) is part of OpenChem. http://ocw.uci.edu/collections/open_chemistry.html Recorded March 13, 2013. Index of Topics: 00:10- Red Tide Kills Record Number of Manatees 01:02- Molecular structure of brevetoxin A 02:56- 18.1: Five Important Electrophilic Aromatic Substitution Reactions 04:21- 18.5: Friedel-Crafts Alkylation with AlCl3 and Alkyl halides 09:37- 18.5: Friedel Crafts Alkylation without 14:32- 18.6, 18.7, 18.8: Substituents Affect Rates and Regiochemistry in E.A.S. 20:43- 18.9: Compare Arenium Ions to Explain Regiochemistry 26:41- 18.6: Substituents that favor ortho, para substitution 31:13- 18.6: Substituents that favor meta substitution 35:56- 18.6: L.P. Resonance Donor Effects Outcompete Inductive Effects 40:32- 18.7: Summary of EAS Substituent Effects-Know This Summary 45:43- 18.10: Special Rules for Friedel-Crafts Reactions 46:33- 18.9: Don't Confuse the directing group with the new substituent 49:58- 18.10: Special Rules fro Friedel-Crafts Reactions (revisited) Required attribution: Vranken, David Van. Organic Chemistry 51B (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_51b_organic_chemistry.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).

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14_Part of Clay Ward Richmond & Upper District Henrico Co.

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Title: 14_Part of Clay Ward Richmond & Upper District Henrico Co. Author: Baist, G. Wm. (George William), 1859-1927 Publication date: 1889 Description: Part of Clay Ward Richmond & Upper District Henrico Co. Bordered by W. Cary St. to the north, Howard St. to the east, the James River to the south and Temple St. to the west. Streets: Albemarle St.; Ashland St.; Beach St.; Belvidere St.; Beverly St.; Blair St.; Chaffin St.; Cherry St.; China St.; Church St.; Claiborne St.; Cumberland St.; Dance St.; Dobson St.; Green St.; Holly St.; Howard St.; Jacquelin St.; Kemper St.; Laurel St.; Linden St.; Maiden Lane; Pine St.; Randolph St.; Reservior [Reservoir] St.; Rowe St.; Spring St.; Staples St.; Taylor St.; W. Cary St.; Wallace St.; Washington St.; Winder St. Reference URL: dig.library.vcu.edu/u?/bai,8 Interactive Atlas URL: Plate 9 Collection: Baist Atlas of Richmond, VA (1889) Rights: This item is in the public domain. Acknowledgement of the Virginia Commonwealth University Libraries as a source is requested.

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General Chemistry 1B. Lecture 11. Global Warming: Why, When, and How

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UCI Chem 1B General Chemistry (Winter 2013) Lec 11. General Chemistry Global Warming -- Why, When, and How -- View the complete course: http://ocw.uci.edu/courses/chem_1b_general_chemistry.html Instructor: Donald R. Blake, Ph.D. License: Creative Commons BY-NC-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: UCI Chem 1B is the second quarter of General Chemistry and covers the following topics: properties of gases, liquids, solids; changes of state; properties of solutions; stoichiometry; thermochemistry; and thermodynamics. General Chemistry (Chem 1B) is part of OpenChem: http://ocw.uci.edu/collections/open_chemistry.html This video is part of a 17-lecture undergraduate-level course titled "General Chemistry" taught at UC Irvine by Professor Donald R. Blake. Recorded on February 19, 2013. Index of Topics: 0:01:26 Global Warming Theory 0:05:11 Why should we care? 0:18:56 Sun's Radiation Hitting Earth 0:20:34 Solar Terrestrial Radiation 0:23:09 What Makes a Gas a Greenhouse Gas 0:27:59 Sherry Rowland's Hand-Drawn Radiance Graph 0:31:32 Solar Radiation Hitting the Atmosphere 0:36:18 Sherry Rowland's Radiance Graph 0:37:38 What about the greenhouse gases & aerosols 0:41:06 Global Fossil-Fuel CO2 Annual Emissions 0:42:27 An Atlas of Pollution 0:43:42 Per Capita CO2 Emissions 0:44:05 Cumulative CO2 Emissions 0:45:31 Atmospheric CO2 at Mauna Loa Observatory 0:46:50 CO2, CH4, and Estimated Global Temperature 0:49:50 Paleoclimate Temperature Change 0:51:04 Temperature Change Consistent with Greenhouse Gases? 0:52:36 Increasing Melt Area on Greenland 0:54:12 Sea Ice Area 0:55:32 What Causes Sea Level Rise? 1:00:41 Myths or Spin 1:02:27 Infinity Pool Analogy 1:04:22 Fred Singer 1:05:02 Latest Global Temperature Data 1:06:13 Global Cooling 1:07:49 Ozone was the 80's AGW Required attribution: Blake, Donald R. General Chemistry 1B (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_1b_general_chemistry.html. [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License. (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US)

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21H.244 Imperial and Revolutionary Russia: Culture and Politics, 1700-1917 (MIT) 21H.244 Imperial and Revolutionary Russia: Culture and Politics, 1700-1917 (MIT)

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This course analyzes Russia's social, cultural, and political heritage in the 18th and 19th centuries, up to and including the Russian Revolution of 1917. It compares reforming and revolutionary impulses in the context of serfdom, the rise of the intelligentsia, and debates over capitalism. It focuses on historical and literary texts, especially the intersections between the two. This course analyzes Russia's social, cultural, and political heritage in the 18th and 19th centuries, up to and including the Russian Revolution of 1917. It compares reforming and revolutionary impulses in the context of serfdom, the rise of the intelligentsia, and debates over capitalism. It focuses on historical and literary texts, especially the intersections between the two.

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imperial russia | imperial russia | russian revolution | russian revolution | february revolution | february revolution | decemberists | decemberists | october revolution | october revolution | tolstoy | tolstoy | pushkin | pushkin | peter the great | peter the great | catherine the great | catherine the great | serfdoms | serfdoms | USSR | USSR | CCCP | CCCP

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Image from ?Eloisa to Abelard ? The second edition. (Verses to the memory of an unfortunate lady.-Florelio, a pastoral lamenting the death of the Marquis of Blandford, by Mr. Fenton.-Upon the death of her husband [Thomas Rowe] a poem, by Mrs. E. Singer.-A Ballad [T'was when the seas were roaring,] by Mr. Gay.-Richy and Sandy, a Pastoral on the death of ? Addison by A. Ramsey.-An explanation of Richy and Sandy by Mr. Burchet [in verse]. To ? A. Ramsey, on his Richy and Sandy, [verses,] by Mr. Burchet?, 002957341

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Image from ?Eloisa to Abelard ? The second edition. (Verses to the memory of an unfortunate lady.-Florelio, a pastoral lamenting the death of the Marquis of Blandford, by Mr. Fenton.-Upon the death of her husband [Thomas Rowe] a poem, by Mrs. E. Singer.-A Ballad [T'was when the seas were roaring,] by Mr. Gay.-Richy and Sandy, a Pastoral on the death of ? Addison by A. Ramsey.-An explanation of Richy and Sandy by Mr. Burchet [in verse]. To ? A. Ramsey, on his Richy and Sandy, [verses,] by Mr. Burchet?, 002957341 Author: POPE, Alexander the Poet Page: 7 Year: 1720 Place: London Publisher: B. Lintot View this image on Flickr View all the images from this book Following the link above will take you to the British Library?s integrated catalogue. You will be able to download a PDF of the book this image is taken from, as well as view the pages up close with the 'itemViewer?. Click on the 'related items? to search for the electronic version of this work.

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bldigital | bl_labs | britishlibrary | 1720 | similar_to_162457151052_place_of_publishing | new_train_of_thought

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Organic Chemistry 51C. Lecture 02. Reactivity of Carbonyl Compounds.

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UCI Chem 51C Organic Chemistry (Spring 2012) Lec 02. Organic Chemistry -- Reactivity of Carbonyl Compounds -- View the complete course: http://ocw.uci.edu/courses/chem_51c_organic_chemistry.html Instructor: James S. Nowick, Ph.D. License: Creative Commons BY-NC-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: This is the third quarter course in the organic chemistry series. Topics covered include: Fundamental concepts relating to carbon compounds with emphasis on structural theory and the nature of chemical bonding, stereochemistry, reaction mechanisms, and spectroscopic, physical, and chemical properties of the principal classes of carbon compounds. Organic Chemistry 51C is part of OpenChem. http://ocw.uci.edu/collections/open_chemistry.html Recorded on April 5, 2012 Index of Topics: -1:00 Reactivity with Nucleophilic -4:08 Resonance in a Carbonyl group -8:41 Nucleophiles and Carbonyls -18:09 LiAlH4 and NaBH4 -26:29 Example Reaction -32:38 Reduction -44:10 Hydride Reducing Agents -48:57 Sodium Hydride -54:02 Oxidation State -1:00:14 Reactivity Toward Nucleophiles -1:08:44 Making Racemic Mixtures -1:12:38 Chiral Hydride Reagent -1:16:05 Tert-Butyl Cyclohexanone Example Required attribution: Nowick, James S. Organic Chemistry 51C (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_51c_organic_chemistry.html [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).

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Organic Chemistry 51C. Lecture 05. Aldehydes and Ketones: Reactions.

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UCI Chem 51C Organic Chemistry (Spring 2012) Lec 05. Organic Chemistry -- Aldehydes and Ketones: Reactions -- View the complete course: http://ocw.uci.edu/courses/chem_51c_organic_chemistry.html Instructor: James S. Nowick, Ph.D. License: Creative Commons BY-NC-SA Terms of Use: http://ocw.uci.edu/info. More courses at http://ocw.uci.edu Description: This is the third quarter course in the organic chemistry series. Topics covered include: Fundamental concepts relating to carbon compounds with emphasis on structural theory and the nature of chemical bonding, stereochemistry, reaction mechanisms, and spectroscopic, physical, and chemical properties of the principal classes of carbon compounds. Organic Chemistry 51C is part of OpenChem. http://ocw.uci.edu/collections/open_chemistry.html Recorded on April 17, 2012 Index of Topics: 1:08-Carbonyls and Strongly Basic Nucleophiles 4:01-Weakly Basic Nucleophiles 9:56-Naming Carbonyls 14:22-Properties of Ketones and Aldehydes 16:59-Reactivity 19:38-IR Spectroscopy 26:04-Conjugation 32:12-NMR 37:52-Synthesis of Aldehydes and Ketones 47:14-Reactions with Nucleophiles 54:25-Acetylene and Hydrogen Cyanide Examples 1:00:16-Workup of Cyanide Anion Addition 1:04:15-Wittig Reaction 1:09:44-Wittig Reaction Mechanism 1:16:24-Making a Wittig Reagent 1:18:14-Wittig Reaction Examples 1:20:11-Stereoselectivity Required attribution: Nowick, James S. Organic Chemistry 51C (UCI OpenCourseWare: University of California, Irvine), http://ocw.uci.edu/courses/chem_51c_organic_chemistry.html [Access date]. License: Creative Commons Attribution-ShareAlike 3.0 United States License (http://creativecommons.org/licenses/by-sa/3.0/us/deed.en_US).

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Image from ?[The Beauties of England and Wales; or, Delineations, topographical, historical, and descriptive, of each country. Embellished with engravings. (vol. 1-6 by E. W. Brayley and J. Britton; vol. 7 by E. W. Brayley; vol. 8 by E. W. Brayley; vol. 9 by J. Britton; vol. 10, pt. 1, 2, by E. W. Brayley; vol. 10, pt. 3 by the Rev. Joseph Nightingale; vol. 10, pt. 4 by J. Norris Brewer; vol. 11 by the Rev. J. Evans and J. Britton; vol. 12, pt. 1 by the Rev. J. Hodgson and Mr. F. C. Laird; vol. 12, pt. 2 by J. N. Brewer; vol. 13 by the Rev. J. Nightingale; vol. 14 by Frederic Shoberl; vol. 15 by J. Britton, J. Norris Brewer, J. Hodgson, F. C. Laird; vol. 16 by John Bigland; vol. 17 by the Rev. J. Evans; vol. 18 by Thomas Rees.) L.P.]?, 000479757

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Image from ?[The Beauties of England and Wales; or, Delineations, topographical, historical, and descriptive, of each country. Embellished with engravings. (vol. 1-6 by E. W. Brayley and J. Britton; vol. 7 by E. W. Brayley; vol. 8 by E. W. Brayley; vol. 9 by J. Britton; vol. 10, pt. 1, 2, by E. W. Brayley; vol. 10, pt. 3 by the Rev. Joseph Nightingale; vol. 10, pt. 4 by J. Norris Brewer; vol. 11 by the Rev. J. Evans and J. Britton; vol. 12, pt. 1 by the Rev. J. Hodgson and Mr. F. C. Laird; vol. 12, pt. 2 by J. N. Brewer; vol. 13 by the Rev. J. Nightingale; vol. 14 by Frederic Shoberl; vol. 15 by J. Britton, J. Norris Brewer, J. Hodgson, F. C. Laird; vol. 16 by John Bigland; vol. 17 by the Rev. J. Evans; vol. 18 by Thomas Rees.) L.P.]?, 000479757 Author: Britton, John Volume: 17 Page: 206 Year: 1801 Place: London Publisher: Vernor, Hood & Sharpe, etc. View this image on Flickr View all the images from this book Following the link above will take you to the British Library?s integrated catalogue. You will be able to download a PDF of the book this image is taken from, as well as view the pages up close with the ?itemViewer?. Click on the 'related items? to search for the electronic version of this work. Open the page in the British Library?s itemViewer (page: 000206) Download the PDF for this book

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bldigital | bl_labs | britishlibrary | 1801 | similar_to_132200100897_place_of_publishing | similar_to_132200100897_bubblyness_avesize | similar_to_132200100897_bubblyness_x

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Image from ?[The Beauties of England and Wales; or, Delineations, topographical, historical, and descriptive, of each country. Embellished with engravings. (vol. 1-6 by E. W. Brayley and J. Britton; vol. 7 by E. W. Brayley; vol. 8 by E. W. Brayley; vol. 9 by J. Britton; vol. 10, pt. 1, 2, by E. W. Brayley; vol. 10, pt. 3 by the Rev. Joseph Nightingale; vol. 10, pt. 4 by J. Norris Brewer; vol. 11 by the Rev. J. Evans and J. Britton; vol. 12, pt. 1 by the Rev. J. Hodgson and Mr. F. C. Laird; vol. 12, pt. 2 by J. N. Brewer; vol. 13 by the Rev. J. Nightingale; vol. 14 by Frederic Shoberl; vol. 15 by J. Britton, J. Norris Brewer, J. Hodgson, F. C. Laird; vol. 16 by John Bigland; vol. 17 by the Rev. J. Evans; vol. 18 by Thomas Rees.) L.P.]?, 000479757

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Image from ?[The Beauties of England and Wales; or, Delineations, topographical, historical, and descriptive, of each country. Embellished with engravings. (vol. 1-6 by E. W. Brayley and J. Britton; vol. 7 by E. W. Brayley; vol. 8 by E. W. Brayley; vol. 9 by J. Britton; vol. 10, pt. 1, 2, by E. W. Brayley; vol. 10, pt. 3 by the Rev. Joseph Nightingale; vol. 10, pt. 4 by J. Norris Brewer; vol. 11 by the Rev. J. Evans and J. Britton; vol. 12, pt. 1 by the Rev. J. Hodgson and Mr. F. C. Laird; vol. 12, pt. 2 by J. N. Brewer; vol. 13 by the Rev. J. Nightingale; vol. 14 by Frederic Shoberl; vol. 15 by J. Britton, J. Norris Brewer, J. Hodgson, F. C. Laird; vol. 16 by John Bigland; vol. 17 by the Rev. J. Evans; vol. 18 by Thomas Rees.) L.P.]?, 000479757 Author: Britton, John Volume: 13 Page: 901 Year: 1801 Place: London Publisher: Vernor, Hood & Sharpe, etc. View this image on Flickr View all the images from this book Following the link above will take you to the British Library?s integrated catalogue. You will be able to download a PDF of the book this image is taken from, as well as view the pages up close with the ?itemViewer?. Click on the 'related items? to search for the electronic version of this work. Open the page in the British Library?s itemViewer (page: 000901) Download the PDF for this book

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bldigital | bl_labs | britishlibrary | 1801 | similar_to_154626320807_place_of_publishing | similar_to_154626320807_slantyness | similar_to_154626320807_bubblyness_x

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