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7.88J Protein Folding Problem (MIT) 7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects. This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

amino acid sequence | amino acid sequence | polypeptide chains | polypeptide chains | sequence determinants | sequence determinants | folding | folding | synthesized polypeptide chains within cells | synthesized polypeptide chains within cells | unfolding and refolding of proteins in vitro | unfolding and refolding of proteins in vitro | folding intermediates aggregation | folding intermediates aggregation | competing off-pathway reactions | competing off-pathway reactions | chaperonins | chaperonins | isomerases | isomerases | helper proteins | helper proteins | protein recovery problems | protein recovery problems | biotechnology industry | biotechnology industry | protein folding defects | protein folding defects | 3-D conformation | 3-D conformation | globular proteins | globular proteins | fibrous proteins | fibrous proteins | kinetics | kinetics | in vitro refolding | in vitro refolding | pathways | pathways | in vivo folding | in vivo folding | synthesized proteins | synthesized proteins | aggregation | aggregation | protein misfolding | protein misfolding | human disease | human disease | protein folding | protein folding | genome sequences | genome sequences | 7.88 | 7.88 | 5.48 | 5.48 | 7.24 | 7.24 | 10.543 | 10.543

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20.320 Biomolecular Kinetics and Cell Dynamics (MIT) 20.320 Biomolecular Kinetics and Cell Dynamics (MIT)

Description

This class covers analysis of kinetics and dynamics of molecular and cellular processes across a hierarchy of scales, including intracellular, extracellular, and cell population levels; a spectrum of biotechnology applications are also taken into consideration. Topics include gene regulation networks; nucleic acid hybridization; signal transduction pathways; and cell populations in tissues and bioreactors. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling. This class covers analysis of kinetics and dynamics of molecular and cellular processes across a hierarchy of scales, including intracellular, extracellular, and cell population levels; a spectrum of biotechnology applications are also taken into consideration. Topics include gene regulation networks; nucleic acid hybridization; signal transduction pathways; and cell populations in tissues and bioreactors. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

Subjects

kinetics of molecular processes | kinetics of molecular processes | dynamics of molecular processes | dynamics of molecular processes | kinetics of cellular processes | kinetics of cellular processes | dynamics of cellular processes | dynamics of cellular processes | intracellular scale | intracellular scale | extracellular scale | extracellular scale | and cell population scale | and cell population scale | biotechnology applications | biotechnology applications | gene regulation networks | gene regulation networks | nucleic acid hybridization | nucleic acid hybridization | signal transduction pathways | signal transduction pathways | cell populations in tissues | cell populations in tissues | cell populations in bioreactors | cell populations in bioreactors | experimental methods | experimental methods | quantitative analysis | quantitative analysis | computational modeling | computational modeling | cell population scale | cell population scale

License

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7.A12 Freshman Seminar: Structural Basis of Genetic Material: Nucleic Acids (MIT) 7.A12 Freshman Seminar: Structural Basis of Genetic Material: Nucleic Acids (MIT)

Description

Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick, the information on detailed molecular structures of DNA and RNA, namely, the foundation of genetic material, has expanded rapidly. This discovery is the beginning of the "Big Bang" of molecular biology and biotechnology. In this seminar, students discuss, from a historical perspective and current developments, the importance of pursuing the detailed structural basis of genetic materials. Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick, the information on detailed molecular structures of DNA and RNA, namely, the foundation of genetic material, has expanded rapidly. This discovery is the beginning of the "Big Bang" of molecular biology and biotechnology. In this seminar, students discuss, from a historical perspective and current developments, the importance of pursuing the detailed structural basis of genetic materials.

Subjects

nucleic acids | nucleic acids | DNA | DNA | RNA | RNA | genetics | genetics | genes | genes | genetic material | genetic material | double helix | double helix | molecular biology | molecular biology | biotechnology | biotechnology | structure | structure | function | function | heredity | heredity | complementarity | complementarity | biological materials | biological materials | genetic code | genetic code | oligonucleotides | oligonucleotides | supercoiled DNA | supercoiled DNA | polyribosome | polyribosome | tRNA | tRNA | reverse transcription | reverse transcription | central dogma | central dogma | transcription | transcription

License

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20.462J Molecular Principles of Biomaterials (BE.462J) (MIT) 20.462J Molecular Principles of Biomaterials (BE.462J) (MIT)

Description

Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S

Subjects

Analysis | Analysis | design | design | molecular scale | molecular scale | biological systems | biological systems | biotechnology | biotechnology | biomedical engineering | biomedical engineering | molecular interactions | molecular interactions | synthetic molecules | synthetic molecules | synthesis | synthesis | processing approaches | processing approaches | cell functions | cell functions | materials science | materials science | tissue engineering | tissue engineering | drug delivery | drug delivery | biosensors | biosensors | cell-guiding surfaces | cell-guiding surfaces | BE.462J | BE.462J | BE.462 | BE.462 | 3.962 | 3.962

License

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HST.508 Genomics and Computational Biology (MIT) HST.508 Genomics and Computational Biology (MIT)

Description

Includes audio/video content: AV lectures. This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed. In addition to the regular lecture sessions, supplementary sections are scheduled to address issues related to Perl, Mathematica and biology. Includes audio/video content: AV lectures. This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed. In addition to the regular lecture sessions, supplementary sections are scheduled to address issues related to Perl, Mathematica and biology.

Subjects

sequence | sequence | structure | structure | function | function | complex biological networks | complex biological networks | quantative modeling | quantative modeling | functional genomics analyses | functional genomics analyses | algorithms | algorithms | statistics | statistics | database | database | simulation | simulation | applied medicine | applied medicine | biotechnology | biotechnology | drug discovery | drug discovery | computational biology | computational biology | genetic engineering | genetic engineering

License

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BE.462J Molecular Principles of Biomaterials (MIT) BE.462J Molecular Principles of Biomaterials (MIT)

Description

Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S

Subjects

Analysis | Analysis | design | design | molecular scale | molecular scale | biological systems | biological systems | biotechnology | biotechnology | biomedical engineering | biomedical engineering | molecular interactions | molecular interactions | synthetic molecules | synthetic molecules | synthesis | synthesis | processing approaches | processing approaches | cell functions | cell functions | materials science | materials science | tissue engineering | tissue engineering | drug delivery | drug delivery | biosensors | biosensors | cell-guiding surfaces | cell-guiding surfaces | 3.962J | 3.962J | BE.462 | BE.462 | 3.962 | 3.962

License

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20.462J Molecular Principles of Biomaterials (MIT) 20.462J Molecular Principles of Biomaterials (MIT)

Description

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces. This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Subjects

biomaterials | biomaterials | biomaterial engineering | biomaterial engineering | biotechnology | biotechnology | cell-guiding surface | cell-guiding surface | molecular biomaterials | molecular biomaterials | drug release | drug release | polymers | polymers | pulsatile release | pulsatile release | polymerization | polymerization | polyer erosion | polyer erosion | tissue engineering | tissue engineering | hydrogels | hydrogels | adhesion | adhesion | migration | migration | drug diffusion | drug diffusion | molecular switches | molecular switches | molecular motors | molecular motors | nanoparticles | nanoparticles | microparticles | microparticles | vaccines | vaccines | drug targeting | drug targeting | micro carriers | micro carriers | nano carriers | nano carriers | intracellular drug delivery | intracellular drug delivery | 20.462 | 20.462 | 3.962 | 3.962

License

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6.092 Bioinformatics and Proteomics (MIT) 6.092 Bioinformatics and Proteomics (MIT)

Description

This interdisciplinary course provides a hands-on approach to students in the topics of bioinformatics and proteomics. Lectures and labs cover sequence analysis, microarray expression analysis, Bayesian methods, control theory, scale-free networks, and biotechnology applications. Designed for those with a computational and/or engineering background, it will include current real-world examples, actual implementations, and engineering design issues. Where applicable, engineering issues from signal processing, network theory, machine learning, robotics and other domains will be expounded upon. This interdisciplinary course provides a hands-on approach to students in the topics of bioinformatics and proteomics. Lectures and labs cover sequence analysis, microarray expression analysis, Bayesian methods, control theory, scale-free networks, and biotechnology applications. Designed for those with a computational and/or engineering background, it will include current real-world examples, actual implementations, and engineering design issues. Where applicable, engineering issues from signal processing, network theory, machine learning, robotics and other domains will be expounded upon.

Subjects

bioinformatics | bioinformatics | proteomics | proteomics | sequence analysis | sequence analysis | microarray expression analysis | microarray expression analysis | Bayesian methods | Bayesian methods | control theory | control theory | scale-free networks | scale-free networks | biotechnology applications | biotechnology applications | real-world examples | real-world examples | actual implementations | actual implementations | engineering design issues | engineering design issues | signal processing | signal processing | network theory | network theory | machine learning | machine learning | robotics | robotics

License

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Biotechnology

Description

This course will introduce the student to the major concepts of biotechnology. The student will discuss genetic engineering of plants and animals and the current major medical, environmental, and agricultural applications of each. There are also a variety of topics that this course will cover after ranging from nanobiotechnology to environmental biotechnology. This free course may be completed online at any time. See course site for detailed overview and learning outcomes. (Biology 403)

Subjects

biology | biotechnology | technology | genes | engineering | genetically modified | genetics | forensics | dna | genomics | proteomics | defects | therapy | renewable energy | environmental | immunology | stem cell | Biological sciences | C000

License

Attribution 2.0 UK: England & Wales Attribution 2.0 UK: England & Wales http://creativecommons.org/licenses/by/2.0/uk/ http://creativecommons.org/licenses/by/2.0/uk/

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Virtual Global Health: Computational Modeling and Simulation

Description

Recorded April 29, 2013. Bruce Y. Lee, MD, MBA is Associate Professor of Medicine and Biomedical Informatics at the University of Pittsburgh and Core Faculty for the RAND-University of Pittsburgh Health Institute. At the University of Pittsburgh, he founded and directs the Public Health and Infectious Diseases Computational and Operations Research (PHICOR) group that specializes in designing economic, and operational computer models that help decision makers tackle infectious diseases of global importance. He is the Scientific Lead for the HERMES Project and the RHEA Project. His current funding includes grants from the Bill and Melinda Gates Foundation, the National Institutes of Health (NIH), Centers for Disease Control and Prevention (CDC), National Science Foundation (NSF), National Library of Medicine (NLM), and the Pennsylvania Department of Health. His previous positions include serving as Senior Manager at Quintiles Transnational where he led teams that developed economic and operational models for a variety of clients in the pharmaceutical, biotechnology, and medical device industries, working in biotechnology equity research at Montgomery Securities, and co-founding Integrigen, a biotechnology/bioinformatics company. Dr. Lee has authored over 150 scientific publications (including over 80 first author and over 35 last author) as well as three books: "Principles and Practice of Clinical Trial Medicine", "What If... ? : Survival Guide for Physicians, and "Medical Notes : Clinical Medicine Pocket Guide". Dr. Lee is an Associate Editor for Vaccine and Area Editor for Wiley Series on Modeling and Simulation. He and his work have garnered attention in leading media outlets such as the New York Times, Los Angeles Times, Businessweek, U.S. News and World Report, Nature Medicine, and National Public Radio (NPR). Dr. Lee received his B.A. from Harvard University, M.D. from Harvard Medical School, and M.B.A. from the Stanford Graduate School of Business. He is board-certified in Internal Medicine, having completed his residency training at the University of California, San Diego.

Subjects

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7.88J Protein Folding Problem (MIT) 7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects. This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

License

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15.391 Early Stage Capital (MIT) 15.391 Early Stage Capital (MIT)

Description

15.391 examines the elements of raising early stage capital, focusing on start-up ventures and the early stages of company development. This course also prepares entrepreneurs to make the best use of outside advisors, and to negotiate effective long-term relationships with funding sources. Working in teams, students interact with venture capitalists and other professionals throughout the semester. Disclaimer: The web sites for this course and the materials they offer are provided for educational use only. They are not a substitute for the advice of an attorney and no attorney-client relationship is created by using them. All materials are provided "as-is", without any express or implied warranties. 15.391 examines the elements of raising early stage capital, focusing on start-up ventures and the early stages of company development. This course also prepares entrepreneurs to make the best use of outside advisors, and to negotiate effective long-term relationships with funding sources. Working in teams, students interact with venture capitalists and other professionals throughout the semester. Disclaimer: The web sites for this course and the materials they offer are provided for educational use only. They are not a substitute for the advice of an attorney and no attorney-client relationship is created by using them. All materials are provided "as-is", without any express or implied warranties.

Subjects

raising venture capital | raising venture capital | starting business | starting business | structuring deals | structuring deals | valuating companies | valuating companies | entrepreneurship | entrepreneurship | venture capitalist | venture capitalist | finding early stage capital | finding early stage capital | negotiate investments | negotiate investments | new business laws | new business laws | financial simulations | financial simulations | build relationships | build relationships | start-up ventures | start-up ventures | company development | company development | using outside advisors | using outside advisors | funding sources | funding sources | term sheet | term sheet | VC | VC | entrepreneur | entrepreneur | pursuing seed money | pursuing seed money | biotechnology | biotechnology | biotech | biotech | angel financing | angel financing | first round money | first round money

License

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STS.011 American Science: Ethical Conflicts and Political Choices (MIT) STS.011 American Science: Ethical Conflicts and Political Choices (MIT)

Description

Includes audio/video content: AV special element video. We will explore the changing political choices and ethical dilemmas of American scientists from the atomic scientists of World War II to biologists in the present wrestling with the questions raised by cloning and other biotechnologies. As well as asking how we would behave if confronted with the same choices, we will try to understand the choices scientists have made by seeing them in their historical and political contexts. Some of the topics covered include: the original development of nuclear weapons and the bombing of Hiroshima and Nagasaki; the effects of the Cold War on American science; the space shuttle disasters; debates on the use of nuclear power, wind power, and biofuels; abuse of human subjects in psychological and othe Includes audio/video content: AV special element video. We will explore the changing political choices and ethical dilemmas of American scientists from the atomic scientists of World War II to biologists in the present wrestling with the questions raised by cloning and other biotechnologies. As well as asking how we would behave if confronted with the same choices, we will try to understand the choices scientists have made by seeing them in their historical and political contexts. Some of the topics covered include: the original development of nuclear weapons and the bombing of Hiroshima and Nagasaki; the effects of the Cold War on American science; the space shuttle disasters; debates on the use of nuclear power, wind power, and biofuels; abuse of human subjects in psychological and othe

Subjects

risk | risk | science | science | society | society | ethics | ethics | politics | politics | technology | technology | history | history | controversy | controversy | atomic | atomic | whistleblowing | whistleblowing | GMO | GMO | genetic engineering | genetic engineering | nuclear | nuclear | space exploration | space exploration | energy | energy | policy | policy | debate | debate | museum | museum | archeology | archeology | war | war | terrorism | terrorism | tradeoff | tradeoff | decision making | decision making | medicine | medicine | health care policy | health care policy | biotechnology | biotechnology | climate change | climate change | global warming | global warming | human subjects | human subjects

License

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HST.950J Engineering Biomedical Information: From Bioinformatics to Biosurveillance (MIT) HST.950J Engineering Biomedical Information: From Bioinformatics to Biosurveillance (MIT)

Description

This course provides an interdisciplinary introduction to the technological advances in biomedical informatics and their applications at the intersection of computer science and biomedical research. This course provides an interdisciplinary introduction to the technological advances in biomedical informatics and their applications at the intersection of computer science and biomedical research.

Subjects

biomedical informatics | biomedical informatics | bioinformatics | bioinformatics | biomedical research | biomedical research | biological computing | biological computing | biomedical computing | biomedical computing | computational genomics | computational genomics | genomics | genomics | microarrays | microarrays | proteomics | proteomics | pharmacogenomics | pharmacogenomics | genomic privacy | genomic privacy | clinical informatics | clinical informatics | biosurveillance | biosurveillance | privacy | privacy | biotechnology | biotechnology

License

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20.442 Molecular Structure of Biological Materials (BE.442) (MIT) 20.442 Molecular Structure of Biological Materials (BE.442) (MIT)

Description

This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to gi This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to gi

Subjects

protein | protein | hydration | hydration | amino acid | amino acid | ECM | ECM | extracellular matrix | extracellular matrix | peptide | peptide | helix | helix | DNA | DNA | RNA | RNA | biomaterial | biomaterial | biotech | biotech | biotechnology | biotechnology | nanomaterial | nanomaterial | beta-sheet | beta-sheet | beta sheet | beta sheet | molecular structure | molecular structure | bioengineering | bioengineering | silk | silk | biomimetic | biomimetic | self-assembly | self-assembly | keratin | keratin | collagen | collagen | adhesive | adhesive | GFP | GFP | fluorescent | fluorescent | polymer | polymer | lipid | lipid

License

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STS.001 Technology in American History (MIT) STS.001 Technology in American History (MIT)

Description

This course will consider the ways in which technology, broadly defined, has contributed to the building of American society from colonial times to the present. This course has three primary goals: to train students to ask critical questions of both technology and the broader American culture of which it is a part; to provide an historical perspective with which to frame and address such questions; and to encourage students to be neither blind critics of new technologies, nor blind advocates for technologies in general, but thoughtful and educated participants in the democratic process. This course will consider the ways in which technology, broadly defined, has contributed to the building of American society from colonial times to the present. This course has three primary goals: to train students to ask critical questions of both technology and the broader American culture of which it is a part; to provide an historical perspective with which to frame and address such questions; and to encourage students to be neither blind critics of new technologies, nor blind advocates for technologies in general, but thoughtful and educated participants in the democratic process.

Subjects

colonization | colonization | Civil War | Civil War | World War II | World War II | Cold War | Cold War | industrialization | industrialization | mass production | mass production | craftsmanship | craftsmanship | transportation | transportation | Taylorism | Taylorism | aeronautics | aeronautics | systems approach | systems approach | computers | computers | control | control | automation | automation | nature | nature | popular culture | popular culture | terrorism | terrorism | engineering | engineering | hobbyist | hobbyist | communications | communications | Internet | Internet | machine age | machine age | Apollo program | Apollo program | biotechnology | biotechnology | environment | environment

License

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STS.014 Principles and Practice of Science Communication (MIT) STS.014 Principles and Practice of Science Communication (MIT)

Description

This course helps in developing skills as science communicators through projects and analysis of theoretical principles. Case studies explore the emergence of popular science communication over the past two centuries and consider the relationships among authors, audiences and media. Project topics are identified early in the term and students work with MIT Museum staff. Projects may include physical exhibits, practical demonstrations, or scripts for public programs. This course helps in developing skills as science communicators through projects and analysis of theoretical principles. Case studies explore the emergence of popular science communication over the past two centuries and consider the relationships among authors, audiences and media. Project topics are identified early in the term and students work with MIT Museum staff. Projects may include physical exhibits, practical demonstrations, or scripts for public programs.

Subjects

public understanding of science | public understanding of science | science writing | science writing | museum | museum | exhibit | exhibit | debate | debate | journalism | journalism | stem cell | stem cell | recombinant DNA | recombinant DNA | intelligent design | intelligent design | GMA | GMA | genetically modified food | genetically modified food | biotechnology | biotechnology | bioengineering | bioengineering | risk | risk | journal | journal | newspaper | newspaper | radio | radio | fraud | fraud | cloning | cloning | evolution | evolution | controversy | controversy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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STS.320 Environmental Conflict and Social Change (MIT) STS.320 Environmental Conflict and Social Change (MIT)

Description

This graduate-level class explores the complex interrelationships among humans and natural environments, focusing on non-western parts of the world in addition to Europe and the United States. It uses environmental conflict to draw attention to competing understandings and uses of "nature" as well as the local, national and transnational power relationships in which environmental interactions are embedded. In addition to utilizing a range of theoretical perspectives, this subject draws upon a series of ethnographic case studies of environmental conflicts in various parts of the world. This graduate-level class explores the complex interrelationships among humans and natural environments, focusing on non-western parts of the world in addition to Europe and the United States. It uses environmental conflict to draw attention to competing understandings and uses of "nature" as well as the local, national and transnational power relationships in which environmental interactions are embedded. In addition to utilizing a range of theoretical perspectives, this subject draws upon a series of ethnographic case studies of environmental conflicts in various parts of the world.

Subjects

Anthropology | Anthropology | complex interrelationships | complex interrelationships | humans | humans | natural environments | natural environments | conflict | conflict | access | access | land rights | land rights | hunting | hunting | fishing | fishing | environmental regulations | environmental regulations | scientific | scientific | popular | popular | knowledge | knowledge | biotechnology | biotechnology | hazardous waste | hazardous waste | social | social | economic | economic | political | political | environmental | environmental | stakes | stakes | forest | forest | agricultural | agricultural | marine | marine | urban | urban | cultural | cultural | historical | historical | power relationships | power relationships | local | local | national | national | international levels. nature | international levels. nature | European thought | European thought | theoretical paradigms | theoretical paradigms | ethnographic | ethnographic | East Africa | East Africa | South Asia | South Asia | Southeast Asia | Southeast Asia | Eastern Europe | Eastern Europe | North America | North America

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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What Matters to Me and Why: Michele Goodwin

Description

Chancellor?s Professor of Law Michele Goodwin?s research concerns the role of law in the promotion and regulation of medicine, science and biotechnology. She researches and teaches in the areas of constitutional law, property, biotechnology, bioethics and cultural politics. Her scholarship defines new ways of thinking about supply, demand and access to sophisticated medical technologies, spanning genetics (human and modified organisms) to organ transplantation, assisted reproductive technology and creating families. Recorded on April 08, 2015.

Subjects

License

http://creativecommons.org/licenses/by-sa/3.0/

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HST.508 Genomics and Computational Biology (MIT)

Description

This course will assess the relationships among sequence, structure, and function in complex biological networks as well as progress in realistic modeling of quantitative, comprehensive, functional genomics analyses. Exercises will include algorithmic, statistical, database, and simulation approaches and practical applications to medicine, biotechnology, drug discovery, and genetic engineering. Future opportunities and current limitations will be critically addressed. In addition to the regular lecture sessions, supplementary sections are scheduled to address issues related to Perl, Mathematica and biology.

Subjects

sequence | structure | function | complex biological networks | quantative modeling | functional genomics analyses | algorithms | statistics | database | simulation | applied medicine | biotechnology | drug discovery | computational biology | genetic engineering

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.88J Protein Folding Problem (MIT) 7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects. This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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21A.500J Technology and Culture (MIT) 21A.500J Technology and Culture (MIT)

Description

This subject examines relationships among technology, culture, and politics in a range of social and historical settings. The class is organized around two topics: Identity and infrastructure, and will combine interactive lectures, film screenings, readings, and discussion. This subject examines relationships among technology, culture, and politics in a range of social and historical settings. The class is organized around two topics: Identity and infrastructure, and will combine interactive lectures, film screenings, readings, and discussion.

Subjects

21A.500 | 21A.500 | STS.075 | STS.075 | technology | technology | technology and culture | technology and culture | biotechnology | biotechnology | computers and the self | computers and the self | digital world | digital world | science and religion | science and religion | racial economy | racial economy | ethics | ethics | technoscience | technoscience | bioterrorism | bioterrorism | cloning | cloning | genetically modified food | genetically modified food | GMO | GMO | gender identity | gender identity | information age | information age

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

amino acid sequence | polypeptide chains | sequence determinants | folding | synthesized polypeptide chains within cells | unfolding and refolding of proteins in vitro | folding intermediates aggregation | competing off-pathway reactions | chaperonins | isomerases | helper proteins | protein recovery problems | biotechnology industry | protein folding defects | 3-D conformation | globular proteins | fibrous proteins | kinetics | in vitro refolding | pathways | in vivo folding | synthesized proteins | aggregation | protein misfolding | human disease | protein folding | genome sequences | 7.88 | 5.48 | 7.24 | 10.543

License

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6.931 Development of Inventions and Creative Ideas (MIT) 6.931 Development of Inventions and Creative Ideas (MIT)

Description

This course examines the role of the engineer as patent expert and as technical witness in court and patent interference and related proceedings. It discusses the rights and obligations of engineers in connection with educational institutions, government, and large and small businesses. It compares various manners of transplanting inventions into business operations, including development of New England and other U.S. electronics and biotechnology industries and their different types of institutions. The course also considers American systems of incentive to creativity apart from the patent laws in the atomic energy and space fields. Acknowledgment The instructors would like to thank Joanne Rines and Elijah Ercolino for their efforts in preparing this course. This course examines the role of the engineer as patent expert and as technical witness in court and patent interference and related proceedings. It discusses the rights and obligations of engineers in connection with educational institutions, government, and large and small businesses. It compares various manners of transplanting inventions into business operations, including development of New England and other U.S. electronics and biotechnology industries and their different types of institutions. The course also considers American systems of incentive to creativity apart from the patent laws in the atomic energy and space fields. Acknowledgment The instructors would like to thank Joanne Rines and Elijah Ercolino for their efforts in preparing this course.

Subjects

patents | patents | inventions | inventions | United States | United States | Alexander Graham Bell | Alexander Graham Bell | telephone patent | telephone patent | innovation | innovation | inventors | inventors | rights | rights | law | law | courts | courts | modernization | modernization | ideas | ideas | creativity | creativity | original | original | American Telephone and Telegraph Company | American Telephone and Telegraph Company | Congress | Congress | Constitution | Constitution | Patent Act | Patent Act | Thomas Edison | Thomas Edison

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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20.380J Biological Engineering Design (MIT) 20.380J Biological Engineering Design (MIT)

Description

This course illustrates how knowledge and principles of biology, biochemistry, and engineering are integrated to create new products for societal benefit. It uses a case study format to examine recently developed products of pharmaceutical and biotechnology industries: how a product evolves from initial idea, through patents, testing, evaluation, production, and marketing. Emphasizes scientific and engineering principles; the responsibility scientists, engineers, and business executives have for the consequences of their technology; and instruction and practice in written and oral communication. The topic focus of this class will vary from year to year. This version looks at inflammation underlying many diseases, specifically its role in cancer, diabetes, and cardiovascular disease. This course illustrates how knowledge and principles of biology, biochemistry, and engineering are integrated to create new products for societal benefit. It uses a case study format to examine recently developed products of pharmaceutical and biotechnology industries: how a product evolves from initial idea, through patents, testing, evaluation, production, and marketing. Emphasizes scientific and engineering principles; the responsibility scientists, engineers, and business executives have for the consequences of their technology; and instruction and practice in written and oral communication. The topic focus of this class will vary from year to year. This version looks at inflammation underlying many diseases, specifically its role in cancer, diabetes, and cardiovascular disease.

Subjects

inflammation | inflammation | biomedical engineering | biomedical engineering | cancer | cancer | diabetes | diabetes | obesity | obesity | cardiovascular disease | cardiovascular disease | biomedical entrepreneurship | biomedical entrepreneurship | biomedical startup | biomedical startup

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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