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BE.442 Molecular Structure of Biological Materials (MIT) BE.442 Molecular Structure of Biological Materials (MIT)

Description

This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to gi This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to gi

Subjects

protein | protein | hydration | hydration | amino acid | amino acid | ECM | ECM | extracellular matrix | extracellular matrix | peptide | peptide | helix | helix | DNA | DNA | RNA | RNA | biomaterial | biomaterial | biotech | biotech | biotechnology | biotechnology | nanomaterial | nanomaterial | beta-sheet | beta-sheet | beta sheet | beta sheet | molecular structure | molecular structure | bioengineering | bioengineering | silk | silk | biomimetic | biomimetic | self-assembly | self-assembly | keratin | keratin | collagen | collagen | adhesive | adhesive | GFP | GFP | fluorescent | fluorescent | polymer | polymer | lipid | lipid

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20.320 Biomolecular Kinetics and Cell Dynamics (MIT)

Description

This class covers analysis of kinetics and dynamics of molecular and cellular processes across a hierarchy of scales, including intracellular, extracellular, and cell population levels; a spectrum of biotechnology applications are also taken into consideration. Topics include gene regulation networks; nucleic acid hybridization; signal transduction pathways; and cell populations in tissues and bioreactors. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

Subjects

kinetics of molecular processes | dynamics of molecular processes | kinetics of cellular processes | dynamics of cellular processes | intracellular scale | extracellular scale | and cell population scale | biotechnology applications | gene regulation networks | nucleic acid hybridization | signal transduction pathways | cell populations in tissues | cell populations in bioreactors | experimental methods | quantitative analysis | computational modeling | cell population scale

License

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20.442 Molecular Structure of Biological Materials (BE.442) (MIT) 20.442 Molecular Structure of Biological Materials (BE.442) (MIT)

Description

This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to gi This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to gi

Subjects

protein | protein | hydration | hydration | amino acid | amino acid | ECM | ECM | extracellular matrix | extracellular matrix | peptide | peptide | helix | helix | DNA | DNA | RNA | RNA | biomaterial | biomaterial | biotech | biotech | biotechnology | biotechnology | nanomaterial | nanomaterial | beta-sheet | beta-sheet | beta sheet | beta sheet | molecular structure | molecular structure | bioengineering | bioengineering | silk | silk | biomimetic | biomimetic | self-assembly | self-assembly | keratin | keratin | collagen | collagen | adhesive | adhesive | GFP | GFP | fluorescent | fluorescent | polymer | polymer | lipid | lipid

License

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7.A12 Freshman Seminar: Structural Basis of Genetic Material: Nucleic Acids (MIT)

Description

Since the discovery of the structure of the DNA double helix in 1953 by Watson and Crick, the information on detailed molecular structures of DNA and RNA, namely, the foundation of genetic material, has expanded rapidly. This discovery is the beginning of the "Big Bang" of molecular biology and biotechnology. In this seminar, students discuss, from a historical perspective and current developments, the importance of pursuing the detailed structural basis of genetic materials.

Subjects

nucleic acids | DNA | RNA | genetics | genes | genetic material | double helix | molecular biology | biotechnology | structure | function | heredity | complementarity | biological materials | genetic code | oligonucleotides | supercoiled DNA | polyribosome | tRNA | reverse transcription | central dogma | transcription

License

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20.462J Molecular Principles of Biomaterials (MIT)

Description

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Subjects

biomaterials | biomaterial engineering | biotechnology | cell-guiding surface | molecular biomaterials | drug release | polymers | pulsatile release | polymerization | polyer erosion | tissue engineering | hydrogels | adhesion | migration | drug diffusion | molecular switches | molecular motors | nanoparticles | microparticles | vaccines | drug targeting | micro carriers | nano carriers | intracellular drug delivery | 20.462 | 3.962

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20.320 Biomolecular Kinetics and Cell Dynamics (MIT)

Description

This class covers analysis of kinetics and dynamics of molecular and cellular processes across a hierarchy of scales, including intracellular, extracellular, and cell population levels; a spectrum of biotechnology applications are also taken into consideration. Topics include gene regulation networks; nucleic acid hybridization; signal transduction pathways; and cell populations in tissues and bioreactors. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

Subjects

kinetics of molecular processes | dynamics of molecular processes | kinetics of cellular processes | dynamics of cellular processes | intracellular scale | extracellular scale | and cell population scale | biotechnology applications | gene regulation networks | nucleic acid hybridization | signal transduction pathways | cell populations in tissues | cell populations in bioreactors | experimental methods | quantitative analysis | computational modeling | cell population scale

License

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HST.510 Genomics, Computing, Economics, and Society (MIT) HST.510 Genomics, Computing, Economics, and Society (MIT)

Description

This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports. This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports.

Subjects

genomics | genomics | bioengineering | bioengineering | biological engineering | biological engineering | personalized medicine | personalized medicine | informatics | informatics | bioinformatics | bioinformatics | human genome | human genome | stem cells | stem cells | genetically modified organisms | genetically modified organisms | biophysics | biophysics | bioethics | bioethics | society | society | bioeconomics | bioeconomics | statistics | statistics | modeling | modeling | datamining | datamining | systems biology | systems biology | technology development | technology development | biotechnology | biotechnology | public policy | public policy | health policy | health policy | business | business | economics | economics

License

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20.320 Analysis of Biomolecular and Cellular Systems (MIT) 20.320 Analysis of Biomolecular and Cellular Systems (MIT)

Description

This course focuses on computational and experimental analysis of biological systems across a hierarchy of scales, including genetic, molecular, cellular, and cell population levels. The two central themes of the course are modeling of complex dynamic systems and protein design and engineering. Topics include gene sequence analysis, molecular modeling, metabolic and gene regulation networks, signal transduction pathways and cell populations in tissues. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling. This course focuses on computational and experimental analysis of biological systems across a hierarchy of scales, including genetic, molecular, cellular, and cell population levels. The two central themes of the course are modeling of complex dynamic systems and protein design and engineering. Topics include gene sequence analysis, molecular modeling, metabolic and gene regulation networks, signal transduction pathways and cell populations in tissues. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

Subjects

biological engineering | biological engineering | kinase | kinase | PyMOL | PyMOL | PyRosetta | PyRosetta | MATLAB | MATLAB | Michaelis-Menten | Michaelis-Menten | bioreactor | bioreactor | bromodomain | bromodomain | protein-ligand interactions | protein-ligand interactions | titration analysis | titration analysis | fractional separation | fractional separation | isothermal titration calorimetry | isothermal titration calorimetry | ITC | ITC | mass spectrometry | mass spectrometry | MS | MS | co-immunoprecipitation | co-immunoprecipitation | Co-IP | Co-IP | Forster resonance energy transfer | Forster resonance energy transfer | FRET | FRET | primary ligation assay | primary ligation assay | PLA | PLA | surface plasmon resonance | surface plasmon resonance | SPR | SPR | enzyme kinetics | enzyme kinetics | kinase engineering | kinase engineering | competitive inhibition | competitive inhibition | epidermal growth factor receptor | epidermal growth factor receptor | mitogen-activated protein kinase | mitogen-activated protein kinase | MAPK | MAPK | genome editing | genome editing | Imatinib | Imatinib | Gleevec | Gleevec | Glivec | Glivec | drug delivery | drug delivery | kinetics of molecular processes | kinetics of molecular processes | dynamics of molecular processes | dynamics of molecular processes | kinetics of cellular processes | kinetics of cellular processes | dynamics of cellular processes | dynamics of cellular processes | intracellular scale | intracellular scale | extracellular scale | extracellular scale | and cell population scale | and cell population scale | biotechnology applications | biotechnology applications | gene regulation networks | gene regulation networks | nucleic acid hybridization | nucleic acid hybridization | signal transduction pathways | signal transduction pathways | cell populations in tissues | cell populations in tissues | cell populations in bioreactors | cell populations in bioreactors | experimental methods | experimental methods | quantitative analysis | quantitative analysis | computational modeling | computational modeling

License

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21A.355J The Anthropology of Biology (MIT) 21A.355J The Anthropology of Biology (MIT)

Description

If the twentieth century was the century of physics, the twenty-first promises to be the century of biology. This subject examines the cultural, political, and economic dimensions of biology in the age of genomics, biotechnological enterprise, biodiversity conservation, pharmaceutical bioprospecting, and synthetic biology. Although we examine such social concerns as bioterrorism, genetic modification, and cloning, this is not a class in bioethics, but rather an anthropological inquiry into how the substances and explanations of biology — increasingly cellular, molecular, genetic, and informatic — are changing, and with them broader ideas about the relationship between "nature" and "culture." Looking at such cultural artifacts as cell lines, biodiversity databases, and artif If the twentieth century was the century of physics, the twenty-first promises to be the century of biology. This subject examines the cultural, political, and economic dimensions of biology in the age of genomics, biotechnological enterprise, biodiversity conservation, pharmaceutical bioprospecting, and synthetic biology. Although we examine such social concerns as bioterrorism, genetic modification, and cloning, this is not a class in bioethics, but rather an anthropological inquiry into how the substances and explanations of biology — increasingly cellular, molecular, genetic, and informatic — are changing, and with them broader ideas about the relationship between "nature" and "culture." Looking at such cultural artifacts as cell lines, biodiversity databases, and artif

Subjects

synthetic biology | synthetic biology | genetics | genetics | Charles Darwin | Charles Darwin | evolution | evolution | eugenics | eugenics | bioprospecting | bioprospecting | ethics | ethics | biodiversity | biodiversity | race | race | molecular biology | molecular biology | sociology of science | sociology of science | construction of identity | construction of identity | intersex | intersex | biotechnology | biotechnology | narratives and metaphors | narratives and metaphors

License

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21A.303J Anthropology of Biology (MIT) 21A.303J Anthropology of Biology (MIT)

Description

This course applies the tools of anthropology to examine biology in the age of genomics, biotechnological enterprise, biodiversity conservation, pharmaceutical bioprospecting, and synthetic biology. It examines such social concerns such as bioterrorism, genetic modification, and cloning. It offers an anthropological inquiry into how the substances and explanations of biology—ecological, organismic, cellular, molecular, genetic, informatic—are changing. It examines such artifacts as cell lines, biodiversity databases, and artificial life models, and using primary sources in biology, social studies of the life sciences, and literary and cinematic materials, and asks how we might answer Erwin Schrodinger's 1944 question, "What Is Life?" today. This course applies the tools of anthropology to examine biology in the age of genomics, biotechnological enterprise, biodiversity conservation, pharmaceutical bioprospecting, and synthetic biology. It examines such social concerns such as bioterrorism, genetic modification, and cloning. It offers an anthropological inquiry into how the substances and explanations of biology—ecological, organismic, cellular, molecular, genetic, informatic—are changing. It examines such artifacts as cell lines, biodiversity databases, and artificial life models, and using primary sources in biology, social studies of the life sciences, and literary and cinematic materials, and asks how we might answer Erwin Schrodinger's 1944 question, "What Is Life?" today.

Subjects

21A.303 | 21A.303 | STS.060 | STS.060 | biology | biology | anthropology of biology | anthropology of biology | biopolitics | biopolitics | bioethics | bioethics | biodiversity | biodiversity | biotechnology | biotechnology

License

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20.462J Molecular Principles of Biomaterials (BE.462J) (MIT)

Description

Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S

Subjects

Analysis | design | molecular scale | biological systems | biotechnology | biomedical engineering | molecular interactions | synthetic molecules | synthesis | processing approaches | cell functions | materials science | tissue engineering | drug delivery | biosensors | cell-guiding surfaces | BE.462J | BE.462 | 3.962

License

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7.01SC Fundamentals of Biology (MIT) 7.01SC Fundamentals of Biology (MIT)

Description

Fundamentals of Biology focuses on the basic principles of biochemistry, molecular biology, genetics, and recombinant DNA. These principles are necessary to understanding the basic mechanisms of life and anchor the biological knowledge that is required to understand many of the challenges in everyday life, from human health and disease to loss of biodiversity and environmental quality. Fundamentals of Biology focuses on the basic principles of biochemistry, molecular biology, genetics, and recombinant DNA. These principles are necessary to understanding the basic mechanisms of life and anchor the biological knowledge that is required to understand many of the challenges in everyday life, from human health and disease to loss of biodiversity and environmental quality.

Subjects

amino acids | amino acids | carboxyl group | carboxyl group | amino group | amino group | side chains | side chains | polar | polar | hydrophobic | hydrophobic | primary structure | primary structure | secondary structure | secondary structure | tertiary structure | tertiary structure | quaternary structure | quaternary structure | x-ray crystallography | x-ray crystallography | alpha helix | alpha helix | beta sheet | beta sheet | ionic bond | ionic bond | non-polar bond | non-polar bond | van der Waals interactions | van der Waals interactions | proton gradient | proton gradient | cyclic photophosphorylation | cyclic photophosphorylation | sunlight | sunlight | ATP | ATP | chlorophyll | chlorophyll | chlorophyll a | chlorophyll a | electrons | electrons | hydrogen sulfide | hydrogen sulfide | biosynthesis | biosynthesis | non-cyclic photophosphorylation | non-cyclic photophosphorylation | photosystem II | photosystem II | photosystem I | photosystem I | cyanobacteria | cyanobacteria | chloroplast | chloroplast | stroma | stroma | thylakoid membrane | thylakoid membrane | Genetics | Genetics | Mendel | Mendel | Mendel's Laws | Mendel's Laws | cloning | cloning | restriction enzymes | restriction enzymes | vector | vector | insert DNA | insert DNA | ligase | ligase | library | library | E.Coli | E.Coli | phosphatase | phosphatase | yeast | yeast | transformation | transformation | ARG1 gene | ARG1 gene | ARG1 mutant yeast | ARG1 mutant yeast | yeast wild-type | yeast wild-type | cloning by complementation | cloning by complementation | Human Beta Globin gene | Human Beta Globin gene | protein tetramer | protein tetramer | vectors | vectors | antibodies | antibodies | human promoter | human promoter | splicing | splicing | mRNA | mRNA | cDNA | cDNA | reverse transcriptase | reverse transcriptase | plasmid | plasmid | electrophoresis | electrophoresis | DNA sequencing | DNA sequencing | primer | primer | template | template | capillary tube | capillary tube | laser detector | laser detector | human genome project | human genome project | recombinant DNA | recombinant DNA | clone | clone | primer walking | primer walking | subcloning | subcloning | computer assembly | computer assembly | shotgun sequencing | shotgun sequencing | open reading frame | open reading frame | databases | databases | polymerase chain reaction (PCR) | polymerase chain reaction (PCR) | polymerase | polymerase | nucleotides | nucleotides | Thermus aquaticus | Thermus aquaticus | Taq polymerase | Taq polymerase | thermocycler | thermocycler | resequencing | resequencing | in vitro fertilization | in vitro fertilization | pre-implantation diagnostics | pre-implantation diagnostics | forensics | forensics | genetic engineering | genetic engineering | DNA sequences | DNA sequences | therapeutic proteins | therapeutic proteins | E. coli | E. coli | disease-causing mutations | disease-causing mutations | cleavage of DNA | cleavage of DNA | bacterial transformation | bacterial transformation | recombinant DNA revolution | recombinant DNA revolution | biotechnology industry | biotechnology industry | Robert Swanson | Robert Swanson | toxin gene | toxin gene | pathogenic bacterium | pathogenic bacterium | biomedical research | biomedical research | S. Pyogenes | S. Pyogenes | origin of replication | origin of replication

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7.346 Virus-host Interactions in Infectious Diseases (MIT) 7.346 Virus-host Interactions in Infectious Diseases (MIT)

Description

Co-evolution and adaptation between viruses and humans are often portrayed as a zero-sum biological arms race. Viruses enter host cells equipped with an array of mechanisms to evade the host defense responses and replicate. The rapid rate of mutation of viruses permits evolution of various methodologies for infection, which in turn drive development of non-specific but highly effective host mechanisms to restrict infection. This class will discuss the varied solutions each side has developed as a means for survival. We will use examples drawn from human disease-causing pathogens that contribute seriously to the global health burden, including HIV, influenza and dengue virus. Primary research papers will be discussed to help students learn to pose scientific questions and design and conduct Co-evolution and adaptation between viruses and humans are often portrayed as a zero-sum biological arms race. Viruses enter host cells equipped with an array of mechanisms to evade the host defense responses and replicate. The rapid rate of mutation of viruses permits evolution of various methodologies for infection, which in turn drive development of non-specific but highly effective host mechanisms to restrict infection. This class will discuss the varied solutions each side has developed as a means for survival. We will use examples drawn from human disease-causing pathogens that contribute seriously to the global health burden, including HIV, influenza and dengue virus. Primary research papers will be discussed to help students learn to pose scientific questions and design and conduct

Subjects

virus | virus | host | host | infection | infection | protein-protein interactions | protein-protein interactions | host mimicry | host mimicry | intra-cellular trafficking | intra-cellular trafficking | host-cell machinery | host-cell machinery | signaling pathways | signaling pathways | antiviral proteins | antiviral proteins | HIV | HIV | influenza | influenza | dengue virus | dengue virus | biotechnology | biotechnology | vaccine development | vaccine development | host sensors | host sensors | IFN production | IFN production | Secreted IFN | Secreted IFN | filoviruses | filoviruses | hCMV | hCMV | IFITM proteins | IFITM proteins

License

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7.341 Harnessing the Biosphere: Natural Products and Biotechnology (MIT) 7.341 Harnessing the Biosphere: Natural Products and Biotechnology (MIT)

Description

What do the organisms of the biosphere, specifically microorganisms, have to offer to biotechnological endeavors? In this course we will focus on the production of biomolecules using microbial systems. We will discuss potential growth substrates (such as agricultural waste and carbon dioxide) that can be used and learn about both established and cutting-edge manipulation techniques in the field of synthetic biology. We will also cover the production of biofuels, bioplastics, amino acids (e.g. lysine), food additives (e.g. monosodium glutamate, MSG), specialty chemicals (e.g. succinate), and biopharmaceuticals (e.g. plasmids for gene therapy). This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an What do the organisms of the biosphere, specifically microorganisms, have to offer to biotechnological endeavors? In this course we will focus on the production of biomolecules using microbial systems. We will discuss potential growth substrates (such as agricultural waste and carbon dioxide) that can be used and learn about both established and cutting-edge manipulation techniques in the field of synthetic biology. We will also cover the production of biofuels, bioplastics, amino acids (e.g. lysine), food additives (e.g. monosodium glutamate, MSG), specialty chemicals (e.g. succinate), and biopharmaceuticals (e.g. plasmids for gene therapy). This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an

Subjects

microorganisms | microorganisms | biomolecules | biomolecules | microbial systems | microbial systems | synthetic biology | synthetic biology | biofuels | biofuels | bioplastics | bioplastics | amino acids | amino acids | lysine | lysine | food additives | food additives | monosodium glutamate (MSG) | monosodium glutamate (MSG) | specialty chemicals | specialty chemicals | succinate | succinate | biopharmaceuticals | biopharmaceuticals | enzymes | enzymes | antibiotics and biocompatible materials | antibiotics and biocompatible materials | microbial biotechnology | microbial biotechnology | genetic engineering | genetic engineering

License

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20.109 Laboratory Fundamentals in Biological Engineering (MIT) 20.109 Laboratory Fundamentals in Biological Engineering (MIT)

Description

Includes audio/video content: AV special element video. This course introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, data analysis, and scientific communication form the underpinnings of this subject. Three discovery-based experimental modules focus on RNA engineering, protein engineering, and cell-biomaterial engineering.This OCW site is based on the source OpenWetWare class Wiki, 20.109(S10): Laboratory Fundamentals of Biological Engineering. Includes audio/video content: AV special element video. This course introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, data analysis, and scientific communication form the underpinnings of this subject. Three discovery-based experimental modules focus on RNA engineering, protein engineering, and cell-biomaterial engineering.This OCW site is based on the source OpenWetWare class Wiki, 20.109(S10): Laboratory Fundamentals of Biological Engineering.

Subjects

biology | biology | bioengineering | bioengineering | biotechnology | biotechnology | RNA engineering | RNA engineering | protein engineering | protein engineering | biomaterial engineering | biomaterial engineering | assay | assay | lab protocol | lab protocol

License

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6.092 Bioinformatics and Proteomics (MIT)

Description

This interdisciplinary course provides a hands-on approach to students in the topics of bioinformatics and proteomics. Lectures and labs cover sequence analysis, microarray expression analysis, Bayesian methods, control theory, scale-free networks, and biotechnology applications. Designed for those with a computational and/or engineering background, it will include current real-world examples, actual implementations, and engineering design issues. Where applicable, engineering issues from signal processing, network theory, machine learning, robotics and other domains will be expounded upon.

Subjects

bioinformatics | proteomics | sequence analysis | microarray expression analysis | Bayesian methods | control theory | scale-free networks | biotechnology applications | real-world examples | actual implementations | engineering design issues | signal processing | network theory | machine learning | robotics

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BE.462J Molecular Principles of Biomaterials (MIT)

Description

Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S

Subjects

Analysis | design | molecular scale | biological systems | biotechnology | biomedical engineering | molecular interactions | synthetic molecules | synthesis | processing approaches | cell functions | materials science | tissue engineering | drug delivery | biosensors | cell-guiding surfaces | 3.962J | BE.462 | 3.962

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.346 RNAi: A Revolution in Biology and Therapeutics (MIT) 7.346 RNAi: A Revolution in Biology and Therapeutics (MIT)

Description

Despite centuries of effort, modern medicine still struggles to find the source of disease and to provide specific treatment without side effects. Both traditional small molecules and protein-based therapeutics have achieved only limited success. What is the next therapeutic frontier? The answer may be RNA interference. In this course, we will focus on the therapeutic potential of RNAi. We will discuss its discovery functions in normal biological processes, utility as an experimental tool, potential for therapeutic use, and pursuit by the biotechnology industry. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current Despite centuries of effort, modern medicine still struggles to find the source of disease and to provide specific treatment without side effects. Both traditional small molecules and protein-based therapeutics have achieved only limited success. What is the next therapeutic frontier? The answer may be RNA interference. In this course, we will focus on the therapeutic potential of RNAi. We will discuss its discovery functions in normal biological processes, utility as an experimental tool, potential for therapeutic use, and pursuit by the biotechnology industry. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current

Subjects

RNAi | RNAi | RNA interface | RNA interface | therapeutics | therapeutics | siRNA | siRNA | miRNA | miRNA | shRNA | shRNA

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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[Aerial View, Texas City Plant, Monsanto Chemical Co.]

Description

Subjects

aerialviews | aerials | gulfcoast | industrialfacilities | storagetanks | chemicalplants | chemicalindustries | agriculturalchemicals | agriculturalbiotechnology | monsantochemicalcompany

License

No known copyright restrictions

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Curated collection of Plant Sciences resources

Description

This is an evaluated collection of links to resources for learning and teaching subjects relating to Plant Sciences. This forms part of the UK Centre for Bioscience OeRBITAL project.

Subjects

ukoer | biotechnology | oerbital | plant sciences | physiology | taxonomy | evolution | plant anatomy | plant biochemistry | Biological sciences | C000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Curated collection of Molecular Biology resources

Description

This is an evaluated collection of links to resources for learning and teaching subjects relating to Molecular Biology. This forms part of the UK Centre for Bioscience OeRBITAL project.

Subjects

ukoer | oerbital | molecular biology | molecular structure and function | cell biology | signal transduction | biotechnology | bioinformatics | bioenergetics and metabolism | Biological sciences | C000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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If I could just stop loving you: Anti-love drugs and the ethics of a chemical break-up

Description

Emotional pain and difficulty in relationships is potentially dangerous and destructive. In this talk, I explore some of the potential uses and misuses of anti-love biotechnology from a scientific and ethical perspective. "Love hurts" - as the saying goes - and a certain degree of pain and difficulty in intimate relationships is unavoidable. Sometimes it may even be beneficial, since, as it is often argued, some types (and amounts) of suffering can lead to personal growth, self-discovery, and a range of other essential components of a life well-lived. But other times, love is downright dangerous. Either it can trap a person in a cycle of violence, as in some domestic abuse cases, or it can prevent a person from moving on with her life or forming healthier relationships. The idea of an Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

ethics | philosophy | love | emotions | drug | ethics | philosophy | love | emotions | drug

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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[Aerial View, Texas City Plant, Monsanto Chemical Co.]

Description

Subjects

naturalgas | gulfcoast | industrialfacilities | storagetanks | agriculturalchemicals | agriculturalbiotechnology | monsantochemicalcompany

License

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20.442 Molecular Structure of Biological Materials (BE.442) (MIT)

Description

This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to gi

Subjects

protein | hydration | amino acid | ECM | extracellular matrix | peptide | helix | DNA | RNA | biomaterial | biotech | biotechnology | nanomaterial | beta-sheet | beta sheet | molecular structure | bioengineering | silk | biomimetic | self-assembly | keratin | collagen | adhesive | GFP | fluorescent | polymer | lipid

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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