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HST.510 Genomics, Computing, Economics, and Society (MIT)

Description

This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports.

Subjects

genomics | bioengineering | biological engineering | personalized medicine | informatics | bioinformatics | human genome | stem cells | genetically modified organisms | biophysics | bioethics | society | bioeconomics | statistics | modeling | datamining | systems biology | technology development | biotechnology | public policy | health policy | business | economics

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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STS.011 American Science: Ethical Conflicts and Political Choices (MIT)

Description

We will explore the changing political choices and ethical dilemmas of American scientists from the atomic scientists of World War II to biologists in the present wrestling with the questions raised by cloning and other biotechnologies. As well as asking how we would behave if confronted with the same choices, we will try to understand the choices scientists have made by seeing them in their historical and political contexts. Some of the topics covered include: the original development of nuclear weapons and the bombing of Hiroshima and Nagasaki; the effects of the Cold War on American science; the space shuttle disasters; debates on the use of nuclear power, wind power, and biofuels; abuse of human subjects in psychological and other experiments; deliberations on genetically modified food

Subjects

risk | science | society | ethics | politics | technology | history | controversy | atomic | whistleblowing | GMO | genetic engineering | nuclear | space exploration | energy | policy | debate | museum | archeology | war | terrorism | tradeoff | decision making | medicine | health care policy | biotechnology | climate change | global warming | human subjects

License

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STS.001 Technology in American History (MIT)

Description

This course will consider the ways in which technology, broadly defined, has contributed to the building of American society from colonial times to the present. This course has three primary goals: to train students to ask critical questions of both technology and the broader American culture of which it is a part; to provide an historical perspective with which to frame and address such questions; and to encourage students to be neither blind critics of new technologies, nor blind advocates for technologies in general, but thoughtful and educated participants in the democratic process.

Subjects

colonization | Civil War | World War II | Cold War | industrialization | mass production | craftsmanship | transportation | Taylorism | aeronautics | systems approach | computers | control | automation | nature | popular culture | terrorism | engineering | hobbyist | communications | Internet | machine age | Apollo program | biotechnology | environment

License

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STS.014 Principles and Practice of Science Communication (MIT)

Description

This course helps in developing skills as science communicators through projects and analysis of theoretical principles. Case studies explore the emergence of popular science communication over the past two centuries and consider the relationships among authors, audiences and media. Project topics are identified early in the term and students work with MIT Museum staff. Projects may include physical exhibits, practical demonstrations, or scripts for public programs.

Subjects

public understanding of science | science writing | museum | exhibit | debate | journalism | stem cell | recombinant DNA | intelligent design | GMA | genetically modified food | biotechnology | bioengineering | risk | journal | newspaper | radio | fraud | cloning | evolution | controversy

License

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STS.320 Environmental Conflict and Social Change (MIT)

Description

This graduate-level class explores the complex interrelationships among humans and natural environments, focusing on non-western parts of the world in addition to Europe and the United States. It uses environmental conflict to draw attention to competing understandings and uses of "nature" as well as the local, national and transnational power relationships in which environmental interactions are embedded. In addition to utilizing a range of theoretical perspectives, this subject draws upon a series of ethnographic case studies of environmental conflicts in various parts of the world.

Subjects

Anthropology | complex interrelationships | humans | natural environments | conflict | access | land rights | hunting | fishing | environmental regulations | scientific | popular | knowledge | biotechnology | hazardous waste | social | economic | political | environmental | stakes | forest | agricultural | marine | urban | cultural | historical | power relationships | local | national | international levels. nature | European thought | theoretical paradigms | ethnographic | East Africa | South Asia | Southeast Asia | Eastern Europe | North America

License

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Achieving public dialogue

Description

There are a wide range of interactions between ‘science’ and ‘the public’. Examples range from visiting a museum, or indulging in a science-related hobby, to reading a newspaper article about a breakthrough in the techniques of therapeutic cloning. Many of these interactions could be said to be ‘passive’. This unit explores the practicalities of the public becoming more ‘active’ in the direction of science practice by ‘two-way’ interactions, with dialogue taking place between science and some part of ‘the public’,

Subjects

science and nature | biotechnology | concensus_conference | consultation | decision making | democs | gm_crops | gm_nation | public_opinion | radioactive_waste | science | science_4_public | science_policy | Education | X000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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7.346 Virus-host Interactions in Infectious Diseases (MIT)

Description

Co-evolution and adaptation between viruses and humans are often portrayed as a zero-sum biological arms race. Viruses enter host cells equipped with an array of mechanisms to evade the host defense responses and replicate. The rapid rate of mutation of viruses permits evolution of various methodologies for infection, which in turn drive development of non-specific but highly effective host mechanisms to restrict infection. This class will discuss the varied solutions each side has developed as a means for survival. We will use examples drawn from human disease-causing pathogens that contribute seriously to the global health burden, including HIV, influenza and dengue virus. Primary research papers will be discussed to help students learn to pose scientific questions and design and conduct

Subjects

virus | host | infection | protein-protein interactions | host mimicry | intra-cellular trafficking | host-cell machinery | signaling pathways | antiviral proteins | HIV | influenza | dengue virus | biotechnology | vaccine development | host sensors | IFN production | Secreted IFN | filoviruses | hCMV | IFITM proteins

License

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7.341 Harnessing the Biosphere: Natural Products and Biotechnology (MIT)

Description

What do the organisms of the biosphere, specifically microorganisms, have to offer to biotechnological endeavors? In this course we will focus on the production of biomolecules using microbial systems. We will discuss potential growth substrates (such as agricultural waste and carbon dioxide) that can be used and learn about both established and cutting-edge manipulation techniques in the field of synthetic biology. We will also cover the production of biofuels, bioplastics, amino acids (e.g. lysine), food additives (e.g. monosodium glutamate, MSG), specialty chemicals (e.g. succinate), and biopharmaceuticals (e.g. plasmids for gene therapy). This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an

Subjects

microorganisms | biomolecules | microbial systems | synthetic biology | biofuels | bioplastics | amino acids | lysine | food additives | monosodium glutamate (MSG) | specialty chemicals | succinate | biopharmaceuticals | enzymes | antibiotics and biocompatible materials | microbial biotechnology | genetic engineering

License

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7.01SC Fundamentals of Biology (MIT)

Description

Fundamentals of Biology focuses on the basic principles of biochemistry, molecular biology, genetics, and recombinant DNA. These principles are necessary to understanding the basic mechanisms of life and anchor the biological knowledge that is required to understand many of the challenges in everyday life, from human health and disease to loss of biodiversity and environmental quality.

Subjects

amino acids | carboxyl group | amino group | side chains | polar | hydrophobic | primary structure | secondary structure | tertiary structure | quaternary structure | x-ray crystallography | alpha helix | beta sheet | ionic bond | non-polar bond | van der Waals interactions | proton gradient | cyclic photophosphorylation | sunlight | ATP | chlorophyll | chlorophyll a | electrons | hydrogen sulfide | biosynthesis | non-cyclic photophosphorylation | photosystem II | photosystem I | cyanobacteria | chloroplast | stroma | thylakoid membrane | Genetics | Mendel | Mendel's Laws | cloning | restriction enzymes | vector | insert DNA | ligase | library | E.Coli | phosphatase | yeast | transformation | ARG1 gene | ARG1 mutant yeast | yeast wild-type | cloning by complementation | Human Beta Globin gene | protein tetramer | vectors | antibodies | human promoter | splicing | mRNA | cDNA | reverse transcriptase | plasmid | electrophoresis | DNA sequencing | primer | template | capillary tube | laser detector | human genome project | recombinant DNA | clone | primer walking | subcloning | computer assembly | shotgun sequencing | open reading frame | databases | polymerase chain reaction (PCR) | polymerase | nucleotides | Thermus aquaticus | Taq polymerase | thermocycler | resequencing | in vitro fertilization | pre-implantation diagnostics | forensics | genetic engineering | DNA sequences | therapeutic proteins | E. coli | disease-causing mutations | cleavage of DNA | bacterial transformation | recombinant DNA revolution | biotechnology industry | Robert Swanson | toxin gene | pathogenic bacterium | biomedical research | S. Pyogenes | origin of replication

License

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7.346 RNAi: A Revolution in Biology and Therapeutics (MIT)

Description

Despite centuries of effort, modern medicine still struggles to find the source of disease and to provide specific treatment without side effects. Both traditional small molecules and protein-based therapeutics have achieved only limited success. What is the next therapeutic frontier? The answer may be RNA interference. In this course, we will focus on the therapeutic potential of RNAi. We will discuss its discovery functions in normal biological processes, utility as an experimental tool, potential for therapeutic use, and pursuit by the biotechnology industry. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current

Subjects

RNAi | RNA interface | therapeutics | siRNA | miRNA | shRNA

License

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6.931 Development of Inventions and Creative Ideas (MIT)

Description

This course examines the role of the engineer as patent expert and as technical witness in court and patent interference and related proceedings. It discusses the rights and obligations of engineers in connection with educational institutions, government, and large and small businesses. It compares various manners of transplanting inventions into business operations, including development of New England and other U.S. electronics and biotechnology industries and their different types of institutions. The course also considers American systems of incentive to creativity apart from the patent laws in the atomic energy and space fields. Acknowledgment The instructors would like to thank Joanne Rines and Elijah Ercolino for their efforts in preparing this course.

Subjects

patents | inventions | United States | Alexander Graham Bell | telephone patent | innovation | inventors | rights | law | courts | modernization | ideas | creativity | original | American Telephone and Telegraph Company | Congress | Constitution | Patent Act | Thomas Edison

License

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15.391 Early Stage Capital (MIT)

Description

15.391 examines the elements of raising early stage capital, focusing on start-up ventures and the early stages of company development. This course also prepares entrepreneurs to make the best use of outside advisors, and to negotiate effective long-term relationships with funding sources. Working in teams, students interact with venture capitalists and other professionals throughout the semester. Disclaimer: The web sites for this course and the materials they offer are provided for educational use only. They are not a substitute for the advice of an attorney and no attorney-client relationship is created by using them. All materials are provided "as-is", without any express or implied warranties.

Subjects

raising venture capital | starting business | structuring deals | valuating companies | entrepreneurship | venture capitalist | finding early stage capital | negotiate investments | new business laws | financial simulations | build relationships | start-up ventures | company development | using outside advisors | funding sources | term sheet | VC | entrepreneur | pursuing seed money | biotechnology | biotech | angel financing | first round money

License

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HST.950J Engineering Biomedical Information: From Bioinformatics to Biosurveillance (MIT)

Description

This course provides an interdisciplinary introduction to the technological advances in biomedical informatics and their applications at the intersection of computer science and biomedical research.

Subjects

biomedical informatics | bioinformatics | biomedical research | biological computing | biomedical computing | computational genomics | genomics | microarrays | proteomics | pharmacogenomics | genomic privacy | clinical informatics | biosurveillance | privacy | biotechnology

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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21A.355J The Anthropology of Biology (MIT)

Description

If the twentieth century was the century of physics, the twenty-first promises to be the century of biology. This subject examines the cultural, political, and economic dimensions of biology in the age of genomics, biotechnological enterprise, biodiversity conservation, pharmaceutical bioprospecting, and synthetic biology. Although we examine such social concerns as bioterrorism, genetic modification, and cloning, this is not a class in bioethics, but rather an anthropological inquiry into how the substances and explanations of biology — increasingly cellular, molecular, genetic, and informatic — are changing, and with them broader ideas about the relationship between "nature" and "culture." Looking at such cultural artifacts as cell lines, biodiversity databases, and artif

Subjects

synthetic biology | genetics | Charles Darwin | evolution | eugenics | bioprospecting | ethics | biodiversity | race | molecular biology | sociology of science | construction of identity | intersex | biotechnology | narratives and metaphors

License

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20.320 Analysis of Biomolecular and Cellular Systems (MIT)

Description

This course focuses on computational and experimental analysis of biological systems across a hierarchy of scales, including genetic, molecular, cellular, and cell population levels. The two central themes of the course are modeling of complex dynamic systems and protein design and engineering. Topics include gene sequence analysis, molecular modeling, metabolic and gene regulation networks, signal transduction pathways and cell populations in tissues. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

Subjects

biological engineering | kinase | PyMOL | PyRosetta | MATLAB | Michaelis-Menten | bioreactor | bromodomain | protein-ligand interactions | titration analysis | fractional separation | isothermal titration calorimetry | ITC | mass spectrometry | MS | co-immunoprecipitation | Co-IP | Forster resonance energy transfer | FRET | primary ligation assay | PLA | surface plasmon resonance | SPR | enzyme kinetics | kinase engineering | competitive inhibition | epidermal growth factor receptor | mitogen-activated protein kinase | MAPK | genome editing | Imatinib | Gleevec | Glivec | drug delivery | kinetics of molecular processes | dynamics of molecular processes | kinetics of cellular processes | dynamics of cellular processes | intracellular scale | extracellular scale | and cell population scale | biotechnology applications | gene regulation networks | nucleic acid hybridization | signal transduction pathways | cell populations in tissues | cell populations in bioreactors | experimental methods | quantitative analysis | computational modeling

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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20.109 Laboratory Fundamentals in Biological Engineering (MIT)

Description

This course introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, data analysis, and scientific communication form the underpinnings of this subject. Three discovery-based experimental modules focus on RNA engineering, protein engineering, and cell-biomaterial engineering.This OCW site is based on the source OpenWetWare class Wiki, 20.109(S10): Laboratory Fundamentals of Biological Engineering.

Subjects

biology | bioengineering | biotechnology | RNA engineering | protein engineering | biomaterial engineering | assay | lab protocol

License

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20.380J Biological Engineering Design (MIT)

Description

This course illustrates how knowledge and principles of biology, biochemistry, and engineering are integrated to create new products for societal benefit. It uses a case study format to examine recently developed products of pharmaceutical and biotechnology industries: how a product evolves from initial idea, through patents, testing, evaluation, production, and marketing. Emphasizes scientific and engineering principles; the responsibility scientists, engineers, and business executives have for the consequences of their technology; and instruction and practice in written and oral communication. The topic focus of this class will vary from year to year. This version looks at inflammation underlying many diseases, specifically its role in cancer, diabetes, and cardiovascular disease.

Subjects

inflammation | biomedical engineering | cancer | diabetes | obesity | cardiovascular disease | biomedical entrepreneurship | biomedical startup

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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21A.355J The Anthropology of Biology (MIT)

Description

If the twentieth century was the century of physics, the twenty-first promises to be the century of biology. This subject examines the cultural, political, and economic dimensions of biology in the age of genomics, biotechnological enterprise, biodiversity conservation, pharmaceutical bioprospecting, and synthetic biology. Although we examine such social concerns as bioterrorism, genetic modification, and cloning, this is not a class in bioethics, but rather an anthropological inquiry into how the substances and explanations of biology — increasingly cellular, molecular, genetic, and informatic — are changing, and with them broader ideas about the relationship between "nature" and "culture." Looking at such cultural artifacts as cell lines, biodiversity databases, and artif

Subjects

synthetic biology | genetics | Charles Darwin | evolution | eugenics | bioprospecting | ethics | biodiversity | race | molecular biology | sociology of science | construction of identity | intersex | biotechnology | narratives and metaphors

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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20.442 Molecular Structure of Biological Materials (BE.442) (MIT)

Description

This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to gi

Subjects

protein | hydration | amino acid | ECM | extracellular matrix | peptide | helix | DNA | RNA | biomaterial | biotech | biotechnology | nanomaterial | beta-sheet | beta sheet | molecular structure | bioengineering | silk | biomimetic | self-assembly | keratin | collagen | adhesive | GFP | fluorescent | polymer | lipid

License

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21A.500J Technology and Culture (MIT)

Description

This subject examines relationships among technology, culture, and politics in a range of social and historical settings. The class is organized around two topics: Identity and infrastructure, and will combine interactive lectures, film screenings, readings, and discussion.

Subjects

21A.500 | STS.075 | technology | technology and culture | biotechnology | computers and the self | digital world | science and religion | racial economy | ethics | technoscience | bioterrorism | cloning | genetically modified food | GMO | gender identity | information age

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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STS.001 Technology in American History (MIT)

Description

This course will consider the ways in which technology, broadly defined, has contributed to the building of American society from colonial times to the present. This course has three primary goals: to train students to ask critical questions of both technology and the broader American culture of which it is a part; to provide an historical perspective with which to frame and address such questions; and to encourage students to be neither blind critics of new technologies, nor blind advocates for technologies in general, but thoughtful and educated participants in the democratic process.

Subjects

colonization | Civil War | World War II | Cold War | industrialization | mass production | craftsmanship | transportation | Taylorism | aeronautics | systems approach | computers | control | automation | nature | popular culture | terrorism | engineering | hobbyist | communications | Internet | machine age | Apollo program | biotechnology | environment

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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21A.303J Anthropology of Biology (MIT)

Description

This course applies the tools of anthropology to examine biology in the age of genomics, biotechnological enterprise, biodiversity conservation, pharmaceutical bioprospecting, and synthetic biology. It examines such social concerns such as bioterrorism, genetic modification, and cloning. It offers an anthropological inquiry into how the substances and explanations of biology—ecological, organismic, cellular, molecular, genetic, informatic—are changing. It examines such artifacts as cell lines, biodiversity databases, and artificial life models, and using primary sources in biology, social studies of the life sciences, and literary and cinematic materials, and asks how we might answer Erwin Schrodinger's 1944 question, "What Is Life?" today.

Subjects

21A.303 | STS.060 | biology | anthropology of biology | biopolitics | bioethics | biodiversity | biotechnology

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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20.442 Molecular Structure of Biological Materials (BE.442) (MIT)

Description

This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to gi

Subjects

protein | hydration | amino acid | ECM | extracellular matrix | peptide | helix | DNA | RNA | biomaterial | biotech | biotechnology | nanomaterial | beta-sheet | beta sheet | molecular structure | bioengineering | silk | biomimetic | self-assembly | keratin | collagen | adhesive | GFP | fluorescent | polymer | lipid

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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20.442 Molecular Structure of Biological Materials (BE.442) (MIT)

Description

This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to gi

Subjects

protein | hydration | amino acid | ECM | extracellular matrix | peptide | helix | DNA | RNA | biomaterial | biotech | biotechnology | nanomaterial | beta-sheet | beta sheet | molecular structure | bioengineering | silk | biomimetic | self-assembly | keratin | collagen | adhesive | GFP | fluorescent | polymer | lipid

License

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BE.442 Molecular Structure of Biological Materials (MIT)

Description

This course, intended for both graduate and upper level undergraduate students, will focus on understanding of the basic molecular structural principles of biological materials. It will address the molecular structures of various materials of biological origin, such as several types of collagen, silk, spider silk, wool, hair, bones, shells, protein adhesives, GFP, and self-assembling peptides. It will also address molecular design of new biological materials applying the molecular structural principles. The long-term goal of this course is to teach molecular design of new biological materials for a broad range of applications. A brief history of biological materials and its future perspective as well as its impact to the society will also be discussed. Several experts will be invited to gi

Subjects

protein | hydration | amino acid | ECM | extracellular matrix | peptide | helix | DNA | RNA | biomaterial | biotech | biotechnology | nanomaterial | beta-sheet | beta sheet | molecular structure | bioengineering | silk | biomimetic | self-assembly | keratin | collagen | adhesive | GFP | fluorescent | polymer | lipid

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-allarchivedcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

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