Searching for defects : 76 results found | RSS Feed for this search

1 2 3

3.40J Physical Metallurgy (MIT) 3.40J Physical Metallurgy (MIT)

Description

This course examines how the presence of 1-, 2- and 3D defects and second phases control the mechanical, electromagnetic and chemical behavior of metals and alloys. It considers point, line and interfacial defects in the context of structural transformations including annealing, spinodal decomposition, nucleation, growth, and particle coarsening. In addition, it concentrates on structure-function relationships, and in particular how grain size, interstitial and substitutional solid solutions, and second-phase particles impact mechanical and other properties. Examples include microelectronic circuitry, magnetic memory and drug delivery applications. This course examines how the presence of 1-, 2- and 3D defects and second phases control the mechanical, electromagnetic and chemical behavior of metals and alloys. It considers point, line and interfacial defects in the context of structural transformations including annealing, spinodal decomposition, nucleation, growth, and particle coarsening. In addition, it concentrates on structure-function relationships, and in particular how grain size, interstitial and substitutional solid solutions, and second-phase particles impact mechanical and other properties. Examples include microelectronic circuitry, magnetic memory and drug delivery applications.

Subjects

1- | 2- and 3D defects | 1- | 2- and 3D defects | second phases | second phases | mechanical | electromagnetic and chemical behavior of metals and alloys | mechanical | electromagnetic and chemical behavior of metals and alloys | point | line and interfacial defects | point | line and interfacial defects | structural transformations | structural transformations | annealing | annealing | spinodal decomposition | spinodal decomposition | nucleation | nucleation | growth | growth | particle coarsening | particle coarsening | structure-function relationships | structure-function relationships | grain size | grain size | interstitial and substitutional solid solutions | interstitial and substitutional solid solutions | second-phase particles | second-phase particles | microelectronic circuitry | microelectronic circuitry | magnetic memory | magnetic memory | drug delivery applications | drug delivery applications | 3.40 | 3.40 | 22.71 | 22.71

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allarchivedcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

7.88J Protein Folding Problem (MIT) 7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects. This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

amino acid sequence | amino acid sequence | polypeptide chains | polypeptide chains | sequence determinants | sequence determinants | folding | folding | synthesized polypeptide chains within cells | synthesized polypeptide chains within cells | unfolding and refolding of proteins in vitro | unfolding and refolding of proteins in vitro | folding intermediates aggregation | folding intermediates aggregation | competing off-pathway reactions | competing off-pathway reactions | chaperonins | chaperonins | isomerases | isomerases | helper proteins | helper proteins | protein recovery problems | protein recovery problems | biotechnology industry | biotechnology industry | protein folding defects | protein folding defects | 3-D conformation | 3-D conformation | globular proteins | globular proteins | fibrous proteins | fibrous proteins | kinetics | kinetics | in vitro refolding | in vitro refolding | pathways | pathways | in vivo folding | in vivo folding | synthesized proteins | synthesized proteins | aggregation | aggregation | protein misfolding | protein misfolding | human disease | human disease | protein folding | protein folding | genome sequences | genome sequences | 7.88 | 7.88 | 5.48 | 5.48 | 7.24 | 7.24 | 10.543 | 10.543

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allarchivedcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT) 7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT)

Description

In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at

Subjects

blueprint of life | blueprint of life | transcription | transcription | stem cells | stem cells | differentiation | differentiation | human tissues | human tissues | tissue regeneration | tissue regeneration | human disease | human disease | RNA and protein expression patterns | RNA and protein expression patterns | transcriptional regulation | transcriptional regulation | specialized gene expression programs | specialized gene expression programs | genome | genome | multipotent | multipotent | terminally differentiated | terminally differentiated | pluripotency | pluripotency | master regulators | master regulators | chromatin regulators | chromatin regulators | developmental defects | developmental defects | cancer | cancer

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allcourses-7.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

3.40J Physical Metallurgy (MIT)

Description

This course examines how the presence of 1-, 2- and 3D defects and second phases control the mechanical, electromagnetic and chemical behavior of metals and alloys. It considers point, line and interfacial defects in the context of structural transformations including annealing, spinodal decomposition, nucleation, growth, and particle coarsening. In addition, it concentrates on structure-function relationships, and in particular how grain size, interstitial and substitutional solid solutions, and second-phase particles impact mechanical and other properties. Examples include microelectronic circuitry, magnetic memory and drug delivery applications.

Subjects

1- | 2- and 3D defects | second phases | mechanical | electromagnetic and chemical behavior of metals and alloys | point | line and interfacial defects | structural transformations | annealing | spinodal decomposition | nucleation | growth | particle coarsening | structure-function relationships | grain size | interstitial and substitutional solid solutions | second-phase particles | microelectronic circuitry | magnetic memory | drug delivery applications | 3.40 | 22.71

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-allarchivedcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

An essay on gleets: wherein the defects of the actual method of treating those complaints of the urethra are pointed out, and an effectual way of curing them indicated. By J. P. Marat, M.D. An essay on gleets: wherein the defects of the actual method of treating those complaints of the urethra are pointed out, and an effectual way of curing them indicated. By J. P. Marat, M.D.

Description

ebook version of An essay on gleets: wherein the defects of the actual method of treating those complaints of the urethra are pointed out, and an effectual way of curing them indicated. By J. P. Marat, M.D. ebook version of An essay on gleets: wherein the defects of the actual method of treating those complaints of the urethra are pointed out, and an effectual way of curing them indicated. By J. P. Marat, M.D.

Subjects

kind | kind | ECCO | ECCO | text | text | CC BY-SA | CC BY-SA

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://www.ota.ox.ac.uk/catalogue/epubfeed.rss

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

Crystal defects illustrated in brick walls

Description

The resource includes images on how crystal defects and other concepts of crystallography can be illustrated in natural and manmade structures.

Subjects

crystallography | crystal defects | photo | the university of liverpool | corematerials | ukoer | Engineering | H000

License

Attribution 2.0 UK: England & Wales Attribution 2.0 UK: England & Wales http://creativecommons.org/licenses/by/2.0/uk/ http://creativecommons.org/licenses/by/2.0/uk/

Site sourced from

http://dspace.jorum.ac.uk/oai/request?verb=ListRecords&metadataPrefix=oai_dc

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

7.88J Protein Folding Problem (MIT) 7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects. This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allcourses-7.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

21L.485 Modern Fiction (MIT) 21L.485 Modern Fiction (MIT)

Description

Tradition and innovation in representative fiction of the early modern period. Recurring themes include the role of the artist in the modern period; the representation of psychological and sexual experience; and the virtues (and defects) of the aggressively experimental character. Works by Conrad, Kipling, Babel, Kafka, James, Lawrence, Mann, Ford Madox Ford, Joyce, Woolf, Faulkner, and Nabokov. Tradition and innovation in representative fiction of the early modern period. Recurring themes include the role of the artist in the modern period; the representation of psychological and sexual experience; and the virtues (and defects) of the aggressively experimental character. Works by Conrad, Kipling, Babel, Kafka, James, Lawrence, Mann, Ford Madox Ford, Joyce, Woolf, Faulkner, and Nabokov.

Subjects

Thomas Hardy | Thomas Hardy | Jude the Obscure | Jude the Obscure | Joseph Conrad | Joseph Conrad | Lord Jim | Lord Jim | Rudyard Kipling | Rudyard Kipling | Kim | Kim | Ford Madox Ford | Ford Madox Ford | The Good Soldier | The Good Soldier | James Joyce | James Joyce | A Portrait of the Artist as a Young Man | A Portrait of the Artist as a Young Man | E.M. Forster | E.M. Forster | A Passage to India | A Passage to India | Virginia Woolf | Virginia Woolf | To the Lighthouse | To the Lighthouse

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

3.40J Physical Metallurgy (MIT) 3.40J Physical Metallurgy (MIT)

Description

The central point of this course is to provide a physical basis that links the structure of materials with their properties, focusing primarily on metals. With this understanding in hand, the concepts of alloy design and microstructural engineering are also discussed, linking processing and thermodynamics to the structure and properties of metals. The central point of this course is to provide a physical basis that links the structure of materials with their properties, focusing primarily on metals. With this understanding in hand, the concepts of alloy design and microstructural engineering are also discussed, linking processing and thermodynamics to the structure and properties of metals.

Subjects

point | point | line and interfacial defects | line and interfacial defects | stereographic projection | stereographic projection | annealing | annealing | spinodal decomposition | spinodal decomposition | nucleation | nucleation | growth | growth | particle coarsening | particle coarsening | structure-function relationships | structure-function relationships | interstitial and substitutional solid solutions | interstitial and substitutional solid solutions | processing and structure of metals | processing and structure of metals | strength | strength | stiffness | stiffness | and ductility | and ductility | crystallography | crystallography | phase transformations | phase transformations | microstructural evolution | microstructural evolution | steel | steel | aluminum | aluminum

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allcourses-3.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

3.14 Physical Metallurgy (MIT) 3.14 Physical Metallurgy (MIT)

Description

The central point of this course is to provide a physical basis that links the structure of metals with their properties. With this understanding in hand, the concepts of alloy design and microstructural engineering are also discussed, linking processing and thermodynamics to the structure and properties of metals. The central point of this course is to provide a physical basis that links the structure of metals with their properties. With this understanding in hand, the concepts of alloy design and microstructural engineering are also discussed, linking processing and thermodynamics to the structure and properties of metals.

Subjects

processing | structure | and properties of metals and alloys | processing | structure | and properties of metals and alloys | strength | stiffness | and ductility | strength | stiffness | and ductility | crystallography | defects | microstructure | crystallography | defects | microstructure | phase transformations | phase transformations | microstructural evolution | microstructural evolution | alloy thermodynamics and kinetics | alloy thermodynamics and kinetics | structural engineering alloys | structural engineering alloys | steel | steel | aluminum | aluminum

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allarchivedcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

8.325 Relativistic Quantum Field Theory III (MIT) 8.325 Relativistic Quantum Field Theory III (MIT)

Description

This course is the third and last term of the quantum field theory sequence. Its aim is the proper theoretical discussion of the physics of the standard model. Topics include: quantum chromodynamics; the Higgs phenomenon and a description of the standard model; deep-inelastic scattering and structure functions; basics of lattice gauge theory; operator products and effective theories; detailed structure of the standard model; spontaneously broken gauge theory and its quantization; instantons and theta-vacua; topological defects; introduction to supersymmetry. This course is the third and last term of the quantum field theory sequence. Its aim is the proper theoretical discussion of the physics of the standard model. Topics include: quantum chromodynamics; the Higgs phenomenon and a description of the standard model; deep-inelastic scattering and structure functions; basics of lattice gauge theory; operator products and effective theories; detailed structure of the standard model; spontaneously broken gauge theory and its quantization; instantons and theta-vacua; topological defects; introduction to supersymmetry.

Subjects

gauge symmetry | gauge symmetry | confinement | confinement | renormalization | renormalization | asymptotic freedom | asymptotic freedom | anomalies | anomalies | instantons | instantons | zero modes | zero modes | gauge boson and Higgs spectrum | gauge boson and Higgs spectrum | fermion multiplets | fermion multiplets | CKM matrix | CKM matrix | unification in SU(5) and SO(10) | unification in SU(5) and SO(10) | phenomenology of Higgs sector | phenomenology of Higgs sector | lepton and baryon number violation | lepton and baryon number violation | nonperturbative (lattice) formulation | nonperturbative (lattice) formulation

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

TALAT Lecture 3207: Solidification Defects in Castings

Description

This lecture provides an introduction to the causes and remedies of the main solidification defects in castings. The students should be able to diagnose the major defects in castings and propose methods of preventing them. Basic knowledge of physics and foundry practice is assumed.

Subjects

aluminium | aluminum | european aluminium association | eaa | talat | training in aluminium application technologies | training | metallurgy | technology | lecture | machining | forming | casting | gas porosity | gas precipitation | air entrapment | cores | shrinkage porosity | macroporosity | microporosity | layer porosity | hot tears | cold cracks | sources of porosity | corematerials | ukoer | Engineering | H000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://dspace.jorum.ac.uk/oai/request?verb=ListRecords&metadataPrefix=oai_dc

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

8.513 Many-Body Theory for Condensed Matter Systems (MIT) 8.513 Many-Body Theory for Condensed Matter Systems (MIT)

Description

This course covers the concepts and physical pictures behind various phenomena that appear in interacting many-body systems. Visualization occurs through concentration on path integral, mean-field theories and semi-classical picture of fluctuations around mean-field state. This course covers the concepts and physical pictures behind various phenomena that appear in interacting many-body systems. Visualization occurs through concentration on path integral, mean-field theories and semi-classical picture of fluctuations around mean-field state.

Subjects

second quantization | second quantization | path-integrals | path-integrals | condensed matter | condensed matter | Goldstone modes | Goldstone modes | rigidity | rigidity | topological defects | topological defects | Mean field theory | Mean field theory | Landau Fermi Liquid Theory | Landau Fermi Liquid Theory | BCS superconductivity | BCS superconductivity | Quantum Phase Transitions | Quantum Phase Transitions | Renormalization group | Renormalization group | Duality transformations | Duality transformations | Luttinger Liquid Theory | Luttinger Liquid Theory | bosonization | bosonization | broken symmetry | broken symmetry | fractionalization | fractionalization | Fractional quantum Hall effect | Fractional quantum Hall effect | spin liquids | spin liquids | gauge theories in condensed matter | gauge theories in condensed matter

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

7.88J Protein Folding Problem (MIT) 7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects. This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allsimplifiedchinesecourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

amino acid sequence | polypeptide chains | sequence determinants | folding | synthesized polypeptide chains within cells | unfolding and refolding of proteins in vitro | folding intermediates aggregation | competing off-pathway reactions | chaperonins | isomerases | helper proteins | protein recovery problems | biotechnology industry | protein folding defects | 3-D conformation | globular proteins | fibrous proteins | kinetics | in vitro refolding | pathways | in vivo folding | synthesized proteins | aggregation | protein misfolding | human disease | protein folding | genome sequences | 7.88 | 5.48 | 7.24 | 10.543

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-allarchivedcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

22.14 Materials in Nuclear Engineering (MIT) 22.14 Materials in Nuclear Engineering (MIT)

Description

In this course, we will lay the foundation for understanding how materials behave in nuclear systems. In particular, we will build on a solid base of nuclear material fundamentals in order to understand radiation damage and effects in fuels and structural materials. This course consists of a series of directed readings, lectures on video, problem sets, short research projects, and class discussions with worked examples. We will start with an overview of nuclear materials, where they are found in nuclear systems, and how they fail. We will then develop the formalism in crystallography as a common language for materials scientists everywhere. This will be followed by the development of phase diagrams from thermodynamics, which predict how binary alloy systems evolve towards equilibrium. Then In this course, we will lay the foundation for understanding how materials behave in nuclear systems. In particular, we will build on a solid base of nuclear material fundamentals in order to understand radiation damage and effects in fuels and structural materials. This course consists of a series of directed readings, lectures on video, problem sets, short research projects, and class discussions with worked examples. We will start with an overview of nuclear materials, where they are found in nuclear systems, and how they fail. We will then develop the formalism in crystallography as a common language for materials scientists everywhere. This will be followed by the development of phase diagrams from thermodynamics, which predict how binary alloy systems evolve towards equilibrium. Then

Subjects

radiation materials science | radiation materials science | radiation damage to materials | radiation damage to materials | radiation induced segregation | radiation induced segregation | void swelling | void swelling | radiation induced hardening | radiation induced hardening | radiation induced embrittlement | radiation induced embrittlement | nuclear power plant | nuclear power plant | phase diagram | phase diagram | defects | defects | deformation | deformation | radiation effects | radiation effects | irradiation | irradiation

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT)

Description

In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at

Subjects

blueprint of life | transcription | stem cells | differentiation | human tissues | tissue regeneration | human disease | RNA and protein expression patterns | transcriptional regulation | specialized gene expression programs | genome | multipotent | terminally differentiated | pluripotency | master regulators | chromatin regulators | developmental defects | cancer

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-alllifesciencescourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT)

Description

In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at

Subjects

blueprint of life | transcription | stem cells | differentiation | human tissues | tissue regeneration | human disease | RNA and protein expression patterns | transcriptional regulation | specialized gene expression programs | genome | multipotent | terminally differentiated | pluripotency | master regulators | chromatin regulators | developmental defects | cancer

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-allsimplifiedchinesecourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

HST.161 Molecular Biology and Genetics in Modern Medicine (MIT) HST.161 Molecular Biology and Genetics in Modern Medicine (MIT)

Description

This course provides a foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. It develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics are reviewed. We translate clinical understanding into analysis at the level of the gene, chromosome and molecule; we cover the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. Material in the course extends beyond basic principles to current research activity in human genetics. This course provides a foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. It develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics are reviewed. We translate clinical understanding into analysis at the level of the gene, chromosome and molecule; we cover the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. Material in the course extends beyond basic principles to current research activity in human genetics.

Subjects

Genetics | Genetics | genes | genes | genetic disorders | genetic disorders | inborn error | inborn error | muscular dystrophy | muscular dystrophy | PKU | PKU | phenylketoneuria | phenylketoneuria | cancer | cancer | tumors | tumors | gene therapy | gene therapy | disease | disease | birth defects | birth defects | chromosomes | chromosomes | leukemia | leukemia | RNAi | RNAi | hemophilia | hemophilia | thalassemia | thalassemia | deafness | deafness | mutations | mutations | hypertrophic cardiomyopathy | hypertrophic cardiomyopathy | epigenetics | epigenetics | rett syndrome | rett syndrome | prenatal diagnosis | prenatal diagnosis | LOD scores | LOD scores | gene linkage | gene linkage | mitochondrial disorders | mitochondrial disorders | degenerative disorders | degenerative disorders | complex traits | complex traits | Mendelian inheritance | Mendelian inheritance

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allcourses-HST.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

TALAT Lecture 3207: Solidification Defects in Castings

Description

This lecture provides an introduction to the causes and remedies of the main solidification defects in castings. The students should be able to diagnose the major defects in castings and propose methods of preventing them. Basic knowledge of physics and foundry practice is assumed.

Subjects

aluminium | aluminum | european aluminium association | EAA | Training in Aluminium Application Technologies | training | metallurgy | technology | lecture | machining | forming | casting | gas porosity | gas precipitation | air entrapment | cores | shrinkage porosity | macroporosity | microporosity | layer porosity | hot tears | cold cracks | sources of porosity | corematerials | ukoer

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://core.materials.ac.uk/rss/talat.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

21L.485 20th-Century Fiction (MIT) 21L.485 20th-Century Fiction (MIT)

Description

Tradition and innovation in representative fiction of the early modern period. Recurring themes: the role of the artist in the modern period, the representation of psychological and sexual experience, the virtues (and defects) of the aggressively experimental character of so many modern books. Works by such writers as Conrad, Kipling, Isaac Babel, Kafka, James, Lawrence, Mann, Ford Madox Ford, Joyce, Woolf, Faulkner, and Nabokov. Tradition and innovation in representative fiction of the early modern period. Recurring themes: the role of the artist in the modern period, the representation of psychological and sexual experience, the virtues (and defects) of the aggressively experimental character of so many modern books. Works by such writers as Conrad, Kipling, Isaac Babel, Kafka, James, Lawrence, Mann, Ford Madox Ford, Joyce, Woolf, Faulkner, and Nabokov.

Subjects

modernism | modernism | experimental fiction | experimental fiction | Virginia Woolf | Virginia Woolf | James Joyce | James Joyce | Joseph Conrad | Joseph Conrad

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

Renal Disease

Description

Professor Chris Pugh tells us about the links between genetics, renal disease and oxygen sensing. The kidney plays a central role in our metabolism, by controlling various physiological balances. Genetics plays an important role in renal disease since gene defects lead to all sorts of malfunctions. Prof. Chris Pugh is working on the oxygen sensing functions of the body; whilst these were discovered in the context of erythropoietin production the underlying system controls about 1000 genes. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

tumour | oxygen | ischaemia and angiogenesis | hydroxylase | HIF | Physiology | tumour | oxygen | ischaemia and angiogenesis | hydroxylase | HIF | Physiology

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/video.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-allarchivedcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

Twist-escaped loops in the liquid crystalline polymer MBBA

Description

Once a weak shear flow is applied on the nematic liquid, there is a sudden and strong increase in the defect density. At a certain shear rate, the equilibrium density is reached after a while through the creation and annihilation of defects. This in-situ observation enables the study of a wide range of dynamic disclination behaviours during shear, such as disclination-joining, loop-contracting, loop-stretching and loop-breaking. The loops in this image result from type 1 disclinations 'escaping' into three-dimensions by twist.

Subjects

defect | escape | liquid crystalline polymer (LCP) | loop | polymer | shear | DoITPoMS | University of Cambridge | micrograph | corematerials | ukoer

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://core.materials.ac.uk/rss/doitpoms_images.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

The genetics of metabolic diseases

Description

A missing step in a metabolic pathway leads to the build-up of toxic compounds, and the lack of materials essential for normal function. Professor Wyatt Yue explores how genetic defects lead to disease at the molecular level, by determining 3D structures and biochemical properties of enzymes and protein complexes linked to congenital genetic errors. Professor Yue works closely with clinicians and paediatricians to decipher the underlying genetic, biochemical and cellular mechanisms of these diseases. His long-term aim is to help design novel therapeutic approaches for metabolic diseases. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

matabolic | genetics | enzymes | biochemical | cellular | mechanisms | matabolic | genetics | enzymes | biochemical | cellular | mechanisms

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/audio.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata