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7.345 Using Simple Organisms to Model Human Diseases (MIT) 7.345 Using Simple Organisms to Model Human Diseases (MIT)

Description

How do scientists discover the basic biology underlying human diseases? Simple organisms such as baker’s yeast, nematodes, fruit flies, zebrafish, mice and rats have allowed biologists to investigate disease at multiple levels, from molecules to behavior. In this course students will learn strategies of disease modeling by critically reading and discussing primary research articles. We will explore current models of neurodegenerative diseases such as Parkinson’s disease, childhood genetic diseases such as Fragile X syndrome, as well as models of deafness and wound healing. Our goal will be to understand the strategies biologists use to build appropriate models of human disease and to appreciate both the power and limitations of using simple organisms to analyze human disease. T How do scientists discover the basic biology underlying human diseases? Simple organisms such as baker’s yeast, nematodes, fruit flies, zebrafish, mice and rats have allowed biologists to investigate disease at multiple levels, from molecules to behavior. In this course students will learn strategies of disease modeling by critically reading and discussing primary research articles. We will explore current models of neurodegenerative diseases such as Parkinson’s disease, childhood genetic diseases such as Fragile X syndrome, as well as models of deafness and wound healing. Our goal will be to understand the strategies biologists use to build appropriate models of human disease and to appreciate both the power and limitations of using simple organisms to analyze human disease. T

Subjects

human disease | human disease | yeast | yeast | nematodes | nematodes | fruit flies | fruit flies | zebrafish | zebrafish | mice | mice | rats | rats | Parkinson's disease | Parkinson's disease | Fragile X syndrome | Fragile X syndrome | deafness | deafness | wound healing | wound healing | experimental organisms | experimental organisms | genetic models | genetic models | Huntington's disease | Huntington's disease | Drosophila melanogaster | Drosophila melanogaster

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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15.347 Doctoral Seminar in Research Methods I (MIT) 15.347 Doctoral Seminar in Research Methods I (MIT)

Description

This course is designed to lay the foundations of good empirical research in the social sciences. It does not deal with specific techniques per se, but rather with the assumptions and the logic underlying social research. Students become acquainted with a variety of approaches to research design, and are helped to develop their own research projects and to evaluate the products of empirical research. This course is designed to lay the foundations of good empirical research in the social sciences. It does not deal with specific techniques per se, but rather with the assumptions and the logic underlying social research. Students become acquainted with a variety of approaches to research design, and are helped to develop their own research projects and to evaluate the products of empirical research.

Subjects

good empirical research | good empirical research | social sciences | social sciences | assumptions and the logic underlying social research | assumptions and the logic underlying social research | research design | research design | research projects | research projects | products of empirical research | products of empirical research

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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11.233 Research Design for Policy Analysis and Planning (MIT) 11.233 Research Design for Policy Analysis and Planning (MIT)

Description

This course develops skills in research design for policy analysis and planning. The emphasis is on the logic of the research process and its constituent elements. The course relies on a seminar format so students are expected to read all of the assigned materials and come to class prepared to discuss key themes, ideas, and controversies. Since the materials draw broadly on the social sciences, and since students have diverse interests and methodological preferences, ongoing themes in our discussions will be linking concepts to planning scholarship in general and considering how different epistemological orientations and methodological techniques map on to planning specializations. This course develops skills in research design for policy analysis and planning. The emphasis is on the logic of the research process and its constituent elements. The course relies on a seminar format so students are expected to read all of the assigned materials and come to class prepared to discuss key themes, ideas, and controversies. Since the materials draw broadly on the social sciences, and since students have diverse interests and methodological preferences, ongoing themes in our discussions will be linking concepts to planning scholarship in general and considering how different epistemological orientations and methodological techniques map on to planning specializations.

Subjects

policy and planning research | policy and planning research | theories | theories | research questions | research questions | research proposals | research proposals | research design | research design | experimental designs | experimental designs | research ethics | research ethics | sampling | sampling | surveys | surveys | questionnaires | questionnaires | interviewing | interviewing | case studies | case studies | field research | field research | participatory research | participatory research | action research | action research | unobtrusive measures | unobtrusive measures

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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15.347 Doctoral Seminar in Research Methods I (MIT) 15.347 Doctoral Seminar in Research Methods I (MIT)

Description

This course is designed to lay the foundations of good empirical research in the social sciences. It does not deal with specific techniques per se, but rather with the assumptions and the logic underlying social research. Students become acquainted with a variety of approaches to research design, and are helped to develop their own research projects and to evaluate the products of empirical research. This course is designed to lay the foundations of good empirical research in the social sciences. It does not deal with specific techniques per se, but rather with the assumptions and the logic underlying social research. Students become acquainted with a variety of approaches to research design, and are helped to develop their own research projects and to evaluate the products of empirical research.

Subjects

good empirical research | good empirical research | social sciences | social sciences | assumptions and the logic underlying social research | assumptions and the logic underlying social research | research design | research design | research projects | research projects | products of empirical research | products of empirical research

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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16.410 Principles of Autonomy and Decision Making (MIT) 16.410 Principles of Autonomy and Decision Making (MIT)

Description

This course surveys a variety of reasoning, optimization, and decision-making methodologies for creating highly autonomous systems and decision support aids. The focus is on principles, algorithms, and their applications, taken from the disciplines of artificial intelligence and operations research. Reasoning paradigms include logic and deduction, heuristic and constraint-based search, model-based reasoning, planning and execution, reasoning under uncertainty, and machine learning. Optimization paradigms include linear, integer and dynamic programming. Decision-making paradigms include decision theoretic planning, and Markov decision processes. This course is offered both to undergraduate (16.410) students as a professional area undergraduate subject, in the field of aerospace information This course surveys a variety of reasoning, optimization, and decision-making methodologies for creating highly autonomous systems and decision support aids. The focus is on principles, algorithms, and their applications, taken from the disciplines of artificial intelligence and operations research. Reasoning paradigms include logic and deduction, heuristic and constraint-based search, model-based reasoning, planning and execution, reasoning under uncertainty, and machine learning. Optimization paradigms include linear, integer and dynamic programming. Decision-making paradigms include decision theoretic planning, and Markov decision processes. This course is offered both to undergraduate (16.410) students as a professional area undergraduate subject, in the field of aerospace information

Subjects

autonomy | autonomy | decision | decision | decision-making | decision-making | reasoning | reasoning | optimization | optimization | autonomous | autonomous | autonomous systems | autonomous systems | decision support | decision support | algorithms | algorithms | artificial intelligence | artificial intelligence | a.i. | a.i. | operations | operations | operations research | operations research | logic | logic | deduction | deduction | heuristic search | heuristic search | constraint-based search | constraint-based search | model-based reasoning | model-based reasoning | planning | planning | execution | execution | uncertainty | uncertainty | machine learning | machine learning | linear programming | linear programming | dynamic programming | dynamic programming | integer programming | integer programming | network optimization | network optimization | decision analysis | decision analysis | decision theoretic planning | decision theoretic planning | Markov decision process | Markov decision process | scheme | scheme | propositional logic | propositional logic | constraints | constraints | Markov processes | Markov processes | computational performance | computational performance | satisfaction | satisfaction | learning algorithms | learning algorithms | system state | system state | state | state | search treees | search treees | plan spaces | plan spaces | model theory | model theory | decision trees | decision trees | function approximators | function approximators | optimization algorithms | optimization algorithms | limitations | limitations | tradeoffs | tradeoffs | search and reasoning | search and reasoning | game tree search | game tree search | local stochastic search | local stochastic search | stochastic | stochastic | genetic algorithms | genetic algorithms | constraint satisfaction | constraint satisfaction | propositional inference | propositional inference | rule-based systems | rule-based systems | rule-based | rule-based | model-based diagnosis | model-based diagnosis | neural nets | neural nets | reinforcement learning | reinforcement learning | web-based | web-based | search trees | search trees

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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16.410 Principles of Autonomy and Decision Making (MIT) 16.410 Principles of Autonomy and Decision Making (MIT)

Description

This course surveys a variety of reasoning, optimization, and decision-making methodologies for creating highly autonomous systems and decision support aids. The focus is on principles, algorithms, and their applications, taken from the disciplines of artificial intelligence and operations research. Reasoning paradigms include logic and deduction, heuristic and constraint-based search, model-based reasoning, planning and execution, reasoning under uncertainty, and machine learning. Optimization paradigms include linear, integer and dynamic programming. Decision-making paradigms include decision theoretic planning, and Markov decision processes. This course is offered both to undergraduate (16.410) students as a professional area undergraduate subject, in the field of aerospace information This course surveys a variety of reasoning, optimization, and decision-making methodologies for creating highly autonomous systems and decision support aids. The focus is on principles, algorithms, and their applications, taken from the disciplines of artificial intelligence and operations research. Reasoning paradigms include logic and deduction, heuristic and constraint-based search, model-based reasoning, planning and execution, reasoning under uncertainty, and machine learning. Optimization paradigms include linear, integer and dynamic programming. Decision-making paradigms include decision theoretic planning, and Markov decision processes. This course is offered both to undergraduate (16.410) students as a professional area undergraduate subject, in the field of aerospace information

Subjects

autonomy | autonomy | decision | decision | decision-making | decision-making | reasoning | reasoning | optimization | optimization | autonomous | autonomous | autonomous systems | autonomous systems | decision support | decision support | algorithms | algorithms | artificial intelligence | artificial intelligence | a.i. | a.i. | operations | operations | operations research | operations research | logic | logic | deduction | deduction | heuristic search | heuristic search | constraint-based search | constraint-based search | model-based reasoning | model-based reasoning | planning | planning | execution | execution | uncertainty | uncertainty | machine learning | machine learning | linear programming | linear programming | dynamic programming | dynamic programming | integer programming | integer programming | network optimization | network optimization | decision analysis | decision analysis | decision theoretic planning | decision theoretic planning | Markov decision process | Markov decision process | scheme | scheme | propositional logic | propositional logic | constraints | constraints | Markov processes | Markov processes | computational performance | computational performance | satisfaction | satisfaction | learning algorithms | learning algorithms | system state | system state | state | state | search treees | search treees | plan spaces | plan spaces | model theory | model theory | decision trees | decision trees | function approximators | function approximators | optimization algorithms | optimization algorithms | limitations | limitations | tradeoffs | tradeoffs | search and reasoning | search and reasoning | game tree search | game tree search | local stochastic search | local stochastic search | stochastic | stochastic | genetic algorithms | genetic algorithms | constraint satisfaction | constraint satisfaction | propositional inference | propositional inference | rule-based systems | rule-based systems | rule-based | rule-based | model-based diagnosis | model-based diagnosis | neural nets | neural nets | reinforcement learning | reinforcement learning | web-based | web-based | search trees | search trees

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Issues in research with children and young people Issues in research with children and young people

Description

This free course, Issues in research with children and young people, considers the aims and range of research with children and young people. Students consider how their own views and understandings about childhood and youth have arisen. Different definitions of research are explored through first-hand accounts by researchers across a range of disciplines and studies, from the small-scale to international studies studying children's lives across several countries. Attention is drawn to the role of both researchers and participants, raising issues about how children and young people can be directly involved in the research process. First published on Wed, 17 Feb 2016 as Issues in research with children and young people. To find out more visit The Open University's Openlearn website. Crea This free course, Issues in research with children and young people, considers the aims and range of research with children and young people. Students consider how their own views and understandings about childhood and youth have arisen. Different definitions of research are explored through first-hand accounts by researchers across a range of disciplines and studies, from the small-scale to international studies studying children's lives across several countries. Attention is drawn to the role of both researchers and participants, raising issues about how children and young people can be directly involved in the research process. First published on Wed, 17 Feb 2016 as Issues in research with children and young people. To find out more visit The Open University's Openlearn website. Crea

Subjects

Childhood & Youth | Childhood & Youth | Children and Young People | Children and Young People | EK313_1 | EK313_1 | children | children | research | research | youth | youth | childhood | childhood | methods | methods | young lives | young lives

License

Except for third party materials and otherwise stated (see http://www.open.ac.uk/conditions terms and conditions), this content is made available under a http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ Creative Commons Attribution-NonCommercial-ShareAlike 2.0 Licence Licensed under a Creative Commons Attribution - NonCommercial-ShareAlike 2.0 Licence - see http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ - Original copyright The Open University

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7.342 Pluripotent Stem Cells and Genome Engineering for Modeling Human Diseases (MIT) 7.342 Pluripotent Stem Cells and Genome Engineering for Modeling Human Diseases (MIT)

Description

One of the major priorities in biomedical research is understanding the molecular events that establish the complex processes involved in human development and the relationships of these processes to human disease and disease progression. In this class, we will explore stem cell biology and the way in which it has developed and shaped our ability to study complex human disease. We will introduce the field of stem cell biology and genome engineering through critical reading of both the classical and newest primary research literature. In addition, this course will discuss specific disease model systems and their benefits / limitations for understanding the disease and treating human patients. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT One of the major priorities in biomedical research is understanding the molecular events that establish the complex processes involved in human development and the relationships of these processes to human disease and disease progression. In this class, we will explore stem cell biology and the way in which it has developed and shaped our ability to study complex human disease. We will introduce the field of stem cell biology and genome engineering through critical reading of both the classical and newest primary research literature. In addition, this course will discuss specific disease model systems and their benefits / limitations for understanding the disease and treating human patients. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT

Subjects

stem cells | stem cells | genome engineering | genome engineering | pluripotency | pluripotency | disease progression | disease progression | embryonic stem cells | embryonic stem cells | induced pluripotent stem cells | induced pluripotent stem cells | transgenic animals | transgenic animals | regenerative medicine | regenerative medicine | CRISPR/cas9 | CRISPR/cas9 | Nuclear Transfer | Nuclear Transfer | Cellular Reprogramming | Cellular Reprogramming

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Pre-sessional econometrics Pre-sessional econometrics

Description

Richard joined the School of Economics in 1998 as a Research Fellow, became a Lecturer in August 2001 and was promoted to Asociate Professor in August 2004. He is a Research Fellow in the Leverhulme Centre for Research on Globalisation and Economic Policy, and his current work for the Centre relates to structural adjustment in UK and foreign labour markets, covering sectoral mobility and unemployment durations. Before coming to Nottingham, he worked as a Research Associate in the economics department at Manchester University, where he also completed his Ph.D. His research interests are primarily in applied labour economics and applied microeconometrics. His recent work includes papers on linked employer-employee data, employer search and matching, labour mobility and unemployment. Richard joined the School of Economics in 1998 as a Research Fellow, became a Lecturer in August 2001 and was promoted to Asociate Professor in August 2004. He is a Research Fellow in the Leverhulme Centre for Research on Globalisation and Economic Policy, and his current work for the Centre relates to structural adjustment in UK and foreign labour markets, covering sectoral mobility and unemployment durations. Before coming to Nottingham, he worked as a Research Associate in the economics department at Manchester University, where he also completed his Ph.D. His research interests are primarily in applied labour economics and applied microeconometrics. His recent work includes papers on linked employer-employee data, employer search and matching, labour mobility and unemployment. As taught Autumn 2011 ‘Pre-Sessional Econometrics'' Module Guide Module Code: L14202 Total Credits: 0 Offering School: Economics Suitable for study at: postgraduate Level The content presented here provides information for prospective students on module L14202 – ‘Pre-Sessional Econometrics’, offered by the School of Economics, University of Nottingham. The module is conveyed by Dr R Upward. Dr Richard Upward, School of Economics, University of Nottingham. Richard joined the School of Economics in 1998 as a Research Fellow, became a Lecturer in August 2001 and was promoted to Asociate Professor in August 2004. He is a Research Fellow in the Leverhulme Centre for Research on Globalisation and Economic Policy, and his current work for the Centre relates to structural adju As taught Autumn 2011 ‘Pre-Sessional Econometrics'' Module Guide Module Code: L14202 Total Credits: 0 Offering School: Economics Suitable for study at: postgraduate Level The content presented here provides information for prospective students on module L14202 – ‘Pre-Sessional Econometrics’, offered by the School of Economics, University of Nottingham. The module is conveyed by Dr R Upward. Dr Richard Upward, School of Economics, University of Nottingham. Richard joined the School of Economics in 1998 as a Research Fellow, became a Lecturer in August 2001 and was promoted to Asociate Professor in August 2004. He is a Research Fellow in the Leverhulme Centre for Research on Globalisation and Economic Policy, and his current work for the Centre relates to structural adju

Subjects

UNow | UNow | UKOER | UKOER | L14202 | L14202

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Except for third party materials (materials owned by someone other than The University of Nottingham) and where otherwise indicated, the copyright in the content provided in this resource is owned by The University of Nottingham and licensed under a Creative Commons Attribution-NonCommercial-ShareAlike UK 2.0 Licence (BY-NC-SA) Except for third party materials (materials owned by someone other than The University of Nottingham) and where otherwise indicated, the copyright in the content provided in this resource is owned by The University of Nottingham and licensed under a Creative Commons Attribution-NonCommercial-ShareAlike UK 2.0 Licence (BY-NC-SA)

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7.27 Principles of Human Disease (MIT) 7.27 Principles of Human Disease (MIT)

Description

This course covers current understanding of, and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Topics include: The Genetics of Simple and Complex Traits; Karyotypic Analysis and Positional Cloning; Genetic Diagnosis; The Roles of Oncogenes and Tumor Suppressors in Tumor Initiation, Progression, and Treatment; The Interaction between Genetics and Environment; Animal Models of Human Disease; Cancer; and Conventional and Gene Therapy Treatment Strategies. This course covers current understanding of, and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Topics include: The Genetics of Simple and Complex Traits; Karyotypic Analysis and Positional Cloning; Genetic Diagnosis; The Roles of Oncogenes and Tumor Suppressors in Tumor Initiation, Progression, and Treatment; The Interaction between Genetics and Environment; Animal Models of Human Disease; Cancer; and Conventional and Gene Therapy Treatment Strategies.

Subjects

human disease | human disease | molecular basis of genetic disease | molecular basis of genetic disease | molecular basis of cancer | molecular basis of cancer | cellular basis of genetic disease | cellular basis of genetic disease | cellular basis of cancer | cellular basis of cancer | genetics of simple and complex traits | genetics of simple and complex traits | karyotypic analysis | karyotypic analysis | positional cloning | positional cloning | genetic diagnosis | genetic diagnosis | roles of oncogenes | roles of oncogenes | tumor suppressors | tumor suppressors | tumor initiation | tumor initiation | tumor progression | tumor progression | tumor treatment | tumor treatment | interaction between genetics and environment | interaction between genetics and environment | animal models of human disease | animal models of human disease | cancer | cancer | conventional treatment strategies | conventional treatment strategies | gene therapy treatment strategies | gene therapy treatment strategies

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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9.10 Cognitive Neuroscience (MIT) 9.10 Cognitive Neuroscience (MIT)

Description

Explores the relations between neural systems and cognition, emphasizing attention, vision, language, motor control, and memory. Introduces basic neuroanatomy, functional imaging techniques, and behavioral measures of cognition. Discusses methods by which inferences about the brain bases of cognition are made. Considers evidence from patients with neurological diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease, Balint's syndrome, amnesia, and focal lesions from stroke) and from normal human participants. An additional project is required for graduate credit. Alternate years. Explores the relations between neural systems and cognition, emphasizing attention, vision, language, motor control, and memory. Introduces basic neuroanatomy, functional imaging techniques, and behavioral measures of cognition. Discusses methods by which inferences about the brain bases of cognition are made. Considers evidence from patients with neurological diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease, Balint's syndrome, amnesia, and focal lesions from stroke) and from normal human participants. An additional project is required for graduate credit. Alternate years.

Subjects

emphasizing attention | emphasizing attention | vision | vision | language | language | motor control | motor control | memory | memory | functional imaging techniques | functional imaging techniques | cognition | cognition | neurological diseases (Alzheimer's disease) | neurological diseases (Alzheimer's disease) | Parkinson's disease | Parkinson's disease | Huntington's disease | Huntington's disease | Balint's syndrome | Balint's syndrome | amnesia | amnesia | focal lesions from stroke | focal lesions from stroke

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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17.869 Political Science Scope and Methods (MIT) 17.869 Political Science Scope and Methods (MIT)

Description

This course is designed to provide an introduction to a variety of empirical research methods used by political scientists. The primary aims of the course are to make you a more sophisticated consumer of diverse empirical research and to allow you to conduct sophisticated independent work in your junior and senior years. This is not a course in data analysis. Rather, it is a course on how to approach political science research. This course is designed to provide an introduction to a variety of empirical research methods used by political scientists. The primary aims of the course are to make you a more sophisticated consumer of diverse empirical research and to allow you to conduct sophisticated independent work in your junior and senior years. This is not a course in data analysis. Rather, it is a course on how to approach political science research.

Subjects

political science | political science | empirical research | empirical research | scientific method | scientific method | research design | research design | models | models | samping | samping | statistical analysis | statistical analysis | measurement | measurement | ethics | ethics | empirical | empirical | research | research | scientific | scientific | methods | methods | statistics | statistics | statistical | statistical | analysis | analysis | political | political | politics | politics | science | science | design | design | sampling | sampling | theoretical | theoretical | observation | observation | data | data | case studies | case studies | cases | cases | empirical research methods | empirical research methods | political scientists | political scientists | empirical analysis | empirical analysis | theoretical analysis | theoretical analysis | research projects | research projects | department faculty | department faculty | inference | inference | writing | writing | revision | revision | oral presentations | oral presentations | experimental method | experimental method | theories | theories | political implications | political implications

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Validated Ovid Medline Search Assessment Tool Validated Ovid Medline Search Assessment Tool

Description

Content Type:  Resource The University of Michigan Search Assessment (UMMSA) tool for Ovid Medline is a matrix that measures the use of identified search elements and other criteria of importance. UMMSA is customized to apply to a specific question. Since the first step in effectively searching the medical literature is to identify a “searchable question,” the searcher is expected to identify an appropriate search question, based on an introduced clinical scenario, as well as an appropriate search strategy. There are eleven search criteria for which points are awarded and two search elements for which points are deducted. This tool has been used in collaborative teaching settings facilitated by physicians and h Content Type:  Resource The University of Michigan Search Assessment (UMMSA) tool for Ovid Medline is a matrix that measures the use of identified search elements and other criteria of importance. UMMSA is customized to apply to a specific question. Since the first step in effectively searching the medical literature is to identify a “searchable question,” the searcher is expected to identify an appropriate search question, based on an introduced clinical scenario, as well as an appropriate search strategy. There are eleven search criteria for which points are awarded and two search elements for which points are deducted. This tool has been used in collaborative teaching settings facilitated by physicians and h

Subjects

ACGME Competencies | ACGME Competencies | Evidence-based Medicine | Evidence-based Medicine | faculty development | faculty development | Graduate Medical Education | Graduate Medical Education | MEDLINE | MEDLINE | PBL | PBL | Practice-based Learning and Improvement | Practice-based Learning and Improvement | PubMed | PubMed | Undergraduate Medical Education | Undergraduate Medical Education

License

http://creativecommons.org/licenses/by-nc/4.0/

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9.10 Cognitive Neuroscience (MIT) 9.10 Cognitive Neuroscience (MIT)

Description

This course explores the cognitive and neural processes that support attention, vision, language, motor control, navigation, and memory. It introduces basic neuroanatomy, functional imaging techniques, and behavioral measures of cognition, and discusses methods by which inferences about the brain bases of cognition are made. We consider evidence from patients with neurological diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease, Balint's syndrome, amnesia, and focal lesions from stroke) and from normal human participants. This course explores the cognitive and neural processes that support attention, vision, language, motor control, navigation, and memory. It introduces basic neuroanatomy, functional imaging techniques, and behavioral measures of cognition, and discusses methods by which inferences about the brain bases of cognition are made. We consider evidence from patients with neurological diseases (Alzheimer's disease, Parkinson's disease, Huntington's disease, Balint's syndrome, amnesia, and focal lesions from stroke) and from normal human participants.

Subjects

emphasizing attention | emphasizing attention | vision | vision | language | language | motor control | motor control | memory | memory | functional imaging techniques | functional imaging techniques | cognition | cognition | neurological diseases | neurological diseases | Alzheimer's disease | Alzheimer's disease | Parkinson's disease | Parkinson's disease | Huntington's disease | Huntington's disease | Balint's syndrome | Balint's syndrome | amnesia | amnesia | focal lesions | focal lesions | stroke | stroke

License

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BURN - Biosciences Undergraduate Research at Nottingham BURN - Biosciences Undergraduate Research at Nottingham

Description

Dr Martin Luck is Associate Professor of Animal Physiology at the University of Nottingham. After reading Animal Physiology at Nottingham, he moved to the University of Leeds to complete a Masters in Steroid Endocrinology and a PhD in Physiology. He carried out post-doctoral research at the University of Southampton and then moved to Hamburg, Germany where he led a research group investigating ovarian follicular development. He returned to Nottingham as an academic in 1990. Dr Luck also has a BA in Mathematics, is a Fellow of the Society of Biology and the Higher Education Academy and is Chair of the Management Board of Bioscience Horizons, the National Undergraduate Research Journal. He has held teaching advisory posts at the University and been a consultant for the Quality Assurance Agen Dr Martin Luck is Associate Professor of Animal Physiology at the University of Nottingham. After reading Animal Physiology at Nottingham, he moved to the University of Leeds to complete a Masters in Steroid Endocrinology and a PhD in Physiology. He carried out post-doctoral research at the University of Southampton and then moved to Hamburg, Germany where he led a research group investigating ovarian follicular development. He returned to Nottingham as an academic in 1990. Dr Luck also has a BA in Mathematics, is a Fellow of the Society of Biology and the Higher Education Academy and is Chair of the Management Board of Bioscience Horizons, the National Undergraduate Research Journal. He has held teaching advisory posts at the University and been a consultant for the Quality Assurance Agen This is a module framework. It can be viewed online or downloaded as a zip file. Research produced 2006 - 2009. BURN brings final year undergraduate research work to public view in a professional and relevant way. The students represented here have risen to the challenges of doing rigorous research and presenting their work to a wider audience. Their articles show the distance they have travelled during their studies. They also demonstrate the inquiry and critical thinking skills that have been developed. As graduates, they will be able to exploit these valuable skills in their careers, whether they continue in science or whatever path they may choose. Suitable for undergraduate study Coordinated by Dr Martin Luck, School of Biosciences Dr Martin Luck is Associate Professor of Animal This is a module framework. It can be viewed online or downloaded as a zip file. Research produced 2006 - 2009. BURN brings final year undergraduate research work to public view in a professional and relevant way. The students represented here have risen to the challenges of doing rigorous research and presenting their work to a wider audience. Their articles show the distance they have travelled during their studies. They also demonstrate the inquiry and critical thinking skills that have been developed. As graduates, they will be able to exploit these valuable skills in their careers, whether they continue in science or whatever path they may choose. Suitable for undergraduate study Coordinated by Dr Martin Luck, School of Biosciences Dr Martin Luck is Associate Professor of Animal

Subjects

UNow | UNow | biosciences | biosciences | undergraduate research | undergraduate research | UKOER | UKOER

License

Except for third party materials (materials owned by someone other than The University of Nottingham) and where otherwise indicated, the copyright in the content provided in this resource is owned by The University of Nottingham and licensed under a Creative Commons Attribution-NonCommercial-ShareAlike UK 2.0 Licence (BY-NC-SA) Except for third party materials (materials owned by someone other than The University of Nottingham) and where otherwise indicated, the copyright in the content provided in this resource is owned by The University of Nottingham and licensed under a Creative Commons Attribution-NonCommercial-ShareAlike UK 2.0 Licence (BY-NC-SA)

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7.340 Unusual Biology: The Science of Emerging Pathogens (MIT) 7.340 Unusual Biology: The Science of Emerging Pathogens (MIT)

Description

Infectious diseases represent a serious global public health problem. They have the potential to kill millions of people, whether they emerge naturally as outbreaks or pandemics, or deliberately through bioterrorism. Some examples of diseases caused by emerging pathogens are the Bubonic Plague, Toxoplasmosis, African Sleeping Sickness, and Chagas Disease. Each day, infectious disease scientists serve on the front lines protecting us from such threats. In this course students will learn how to design and critique experiments through the discussion of primary research articles that explore the molecular basis of disease caused by emerging pathogens. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students w Infectious diseases represent a serious global public health problem. They have the potential to kill millions of people, whether they emerge naturally as outbreaks or pandemics, or deliberately through bioterrorism. Some examples of diseases caused by emerging pathogens are the Bubonic Plague, Toxoplasmosis, African Sleeping Sickness, and Chagas Disease. Each day, infectious disease scientists serve on the front lines protecting us from such threats. In this course students will learn how to design and critique experiments through the discussion of primary research articles that explore the molecular basis of disease caused by emerging pathogens. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students w

Subjects

pathogens | pathogens | Infectious diseases | Infectious diseases | parasite | parasite | host cell | host cell | gene expression | gene expression | Toxoplasma rhoptry protein 16 (ROP16) | Toxoplasma rhoptry protein 16 (ROP16) | Toxoplasma gondii | Toxoplasma gondii | STAT6 | STAT6 | Plasmodium falciparum | Plasmodium falciparum | malaria | malaria | RON8 | RON8 | Trypanosoma cruzi | Trypanosoma cruzi | Chagas disease | Chagas disease | Listeria monocytogenes | Listeria monocytogenes | Leishmaniasis | Leishmaniasis | Francisella | Francisella | pathogen proliferation | pathogen proliferation

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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9.10 Cognitive Neuroscience (MIT) 9.10 Cognitive Neuroscience (MIT)

Description

Course topics explore the relations between neural systems and cognition, emphasizing attention, vision, language, motor control, and memory. An introduction to basic neuroanatomy, functional imaging techniques, and behavioral measures of cognition is given with discussion of methods by which inferences about the brain bases of cognition are made. Evidence from patients with neurological diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Balint's syndrome, amnesia, and focal lesions from stroke is given as well as from normal human participants. Course topics explore the relations between neural systems and cognition, emphasizing attention, vision, language, motor control, and memory. An introduction to basic neuroanatomy, functional imaging techniques, and behavioral measures of cognition is given with discussion of methods by which inferences about the brain bases of cognition are made. Evidence from patients with neurological diseases such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Balint's syndrome, amnesia, and focal lesions from stroke is given as well as from normal human participants.

Subjects

emphasizing attention | emphasizing attention | vision | vision | language | language | motor control | motor control | memory | memory | functional imaging techniques | functional imaging techniques | cognition | cognition | neurological diseases | neurological diseases | Alzheimer's disease | Alzheimer's disease | Parkinson's disease | Parkinson's disease | Huntington's disease | Huntington's disease | Balint's syndrome | Balint's syndrome | amnesia | amnesia | focal lesions | focal lesions | stroke | stroke

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.88J Protein Folding and Human Disease (MIT) 7.88J Protein Folding and Human Disease (MIT)

Description

This course covers amino acid sequence control of protein folding, misfolding, amyloid polymerization and aggregation. Readings and discussions address topics such as chaperone structure and function, folding and assembly of fibrous proteins, and pathologies associated with protein misfolding and aggregation in Alzheimer's, Parkinson's, Huntington's and other protein deposition diseases. Students are required to write and present a research paper. This course covers amino acid sequence control of protein folding, misfolding, amyloid polymerization and aggregation. Readings and discussions address topics such as chaperone structure and function, folding and assembly of fibrous proteins, and pathologies associated with protein misfolding and aggregation in Alzheimer's, Parkinson's, Huntington's and other protein deposition diseases. Students are required to write and present a research paper.

Subjects

protein folding | protein folding | misfolding | misfolding | aggregation | aggregation | protein structures | protein structures | folding intermediates | folding intermediates | off-pathway aggregation | off-pathway aggregation | amyloid formation | amyloid formation | Key chaperones | Key chaperones | chaperonins | chaperonins | human protein deposition diseases | human protein deposition diseases | Alzheimer’s disease | Alzheimer’s disease | Parkinson’s disease | Parkinson’s disease | Huntington’s disease | Huntington’s disease | amyloids | amyloids | prions | prions | amino acid sequence | amino acid sequence | amyloid polymerization | amyloid polymerization | chaperone structure and function | chaperone structure and function | folding and assembly of fibrous proteins | folding and assembly of fibrous proteins

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.340 Ubiquitination: The Proteasome and Human Disease (MIT) 7.340 Ubiquitination: The Proteasome and Human Disease (MIT)

Description

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, spe This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, spe

Subjects

ubiquitination | ubiquitination | ubiquitin | ubiquitin | proteasome | proteasome | post-translational mechanisms | post-translational mechanisms | ubiquitin-conjugation system | ubiquitin-conjugation system | neurodegenerative diseases | neurodegenerative diseases | immune response | immune response | cell cycle regulation | cell cycle regulation | apoptosis | apoptosis | signal transduction pathways | signal transduction pathways | tumorigenesis | tumorigenesis | protein degradation | protein degradation | Endoplasmic Reticulum Associated Degradation Pathway | Endoplasmic Reticulum Associated Degradation Pathway | ligases | ligases | translocated proteins | translocated proteins | misfolded proteins | misfolded proteins | trafficking membranes | trafficking membranes | cell cycle control | cell cycle control | programmed cell death | programmed cell death | Huntington's Disease | Huntington's Disease | Von Hippel-Lindau Disease | Von Hippel-Lindau Disease

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.343 Protein Folding, Misfolding and Human Disease (MIT) 7.343 Protein Folding, Misfolding and Human Disease (MIT)

Description

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. The instructor for this course, Dr. Kosinski-Collins, is a member of the HHMI Education Group. Maintenance of the complex three-dimensional structure adopted by a protein in the cell is vital for function. Oftentimes, as a consequence of environmental stress, genetic mutation, and/or infection, the folded structure of a protein gets altered and multiple proteins stick and fall out of solution in a process known as aggregation. In many protein aggregation diseases, incorrectly folded proteins self-associate, for This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. The instructor for this course, Dr. Kosinski-Collins, is a member of the HHMI Education Group. Maintenance of the complex three-dimensional structure adopted by a protein in the cell is vital for function. Oftentimes, as a consequence of environmental stress, genetic mutation, and/or infection, the folded structure of a protein gets altered and multiple proteins stick and fall out of solution in a process known as aggregation. In many protein aggregation diseases, incorrectly folded proteins self-associate, for

Subjects

protein folding | protein folding | misfolded proteins | misfolded proteins | Mad Cow | Mad Cow | Creutzfedt-Jakob Disease | Creutzfedt-Jakob Disease | Alzheimer's Disease | Alzheimer's Disease | Huntington's Disease | Huntington's Disease | protein aggregation | protein aggregation | self-associate | self-associate | cell death | cell death | dementia | dementia | prions | prions | bovine spongiform encephalopathy | bovine spongiform encephalopathy | kuru | kuru | scrapie | scrapie | protein structure | protein structure | amyloid protein | amyloid protein | amyloidosis | amyloidosis | polyglutamine repeats | polyglutamine repeats | fibrils | fibrils

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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DATUM for Health: Research data management training for health studies

Description

The DATUM for Health training programme is aimed at postgraduate research (i.e. doctoral) students (PGR) in health studies, including those whose PhD has a health focus but who are not necessarily registered in a school/faculty of health/medicine (e.g. in psychology, social sciences). The programme covers both generic and discipline-specific issues, focussing on the management of qualitative, unstructured data, and is suitable for students at any stage of their PhD. It aims to provide PGR students with the knowledge to manage their research data at every stage in the data lifecycle, from its creation to its final storage or destruction. Students learn how to use their data more effectively and efficiently, how to store and destroy it securely, and how to make it available to a wider audien

Subjects

research | researchers | research data | research data management | research data management training | data management | data management training | organising research data | organising data | study skills | research skills | health | medicine | doctoral students | postgraduate research students | qualitative data | unstructured data | data curation | data curation lifecycle | pgr students | phd students | datum | datum for health | data | health data | curation research data | data organisation | organisation research data | rdm | jisc research data management training materials | jisc rdmtrain | RDMTrain

License

Attribution-NonCommercial-ShareAlike 3.0 Unported Attribution-NonCommercial-ShareAlike 3.0 Unported http://creativecommons.org/licenses/by-nc-sa/3.0/ http://creativecommons.org/licenses/by-nc-sa/3.0/

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HST.502 Survival Skills for Researchers: The Responsible Conduct of Research (MIT) HST.502 Survival Skills for Researchers: The Responsible Conduct of Research (MIT)

Description

This course is designed to provide graduate students and postdoctoral associates with techniques that enhance both validity and responsible conduct in scientific practice. Lectures present practical steps for developing skills in scientific research and are combined with discussion of cases. The course covers study design, preparation of proposals and manuscripts, peer review, authorship, use of humans and non-human animals in research, allegations of misconduct, and intellectual property. Also discussed are mentoring relationships and career options. Aspects of responsible research conduct are integrated into lectures and case discussion as appropriate to the specific topic. This course also satisfies the training grant requirements of the NIH for education in the responsible conduct This course is designed to provide graduate students and postdoctoral associates with techniques that enhance both validity and responsible conduct in scientific practice. Lectures present practical steps for developing skills in scientific research and are combined with discussion of cases. The course covers study design, preparation of proposals and manuscripts, peer review, authorship, use of humans and non-human animals in research, allegations of misconduct, and intellectual property. Also discussed are mentoring relationships and career options. Aspects of responsible research conduct are integrated into lectures and case discussion as appropriate to the specific topic. This course also satisfies the training grant requirements of the NIH for education in the responsible conduct

Subjects

scientific practice | scientific practice | proposal development | proposal development | peer review | peer review | medical research | medical research | human subject review | human subject review | animal research | animal research | misconduct | misconduct | intellectual property | intellectual property | grant writing | grant writing | career development | career development

License

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11.027 City to City: Comparing, Researching and Writing about Cities (MIT) 11.027 City to City: Comparing, Researching and Writing about Cities (MIT)

Description

This course introduces undergraduate planning students to the role of the planner in researching issues in cities both in the United States and abroad. This course is a practical, hands-on workshop that challenges students to research, write and present their ideas on two different cities: A U.S. City (preferably somewhere close) and Copenhagen. Students will be equipped to: select and research a thesis topic, work professionally with faculty and other experts on the topic of their choice, and research, write and present. This course introduces undergraduate planning students to the role of the planner in researching issues in cities both in the United States and abroad. This course is a practical, hands-on workshop that challenges students to research, write and present their ideas on two different cities: A U.S. City (preferably somewhere close) and Copenhagen. Students will be equipped to: select and research a thesis topic, work professionally with faculty and other experts on the topic of their choice, and research, write and present.

Subjects

Copenhagen | Copenhagen | Denmark | Denmark | Boston | Boston | Massachusetts | Massachusetts | United States | United States | presentations | presentations | intereviews | intereviews | research | research | writing | writing | comparative research | comparative research | editing | editing | suburbs | suburbs | waterfront | waterfront | politics | politics | transportation | transportation | transit | transit | bicycles | bicycles | culture | culture | history | history

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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11.233 Crafting Research Questions and Qualitative Methodology (MIT) 11.233 Crafting Research Questions and Qualitative Methodology (MIT)

Description

This course covers approaches to research and evaluation in the planning field, for those preparing to write 1st-year doctoral and other research papers. Topics include narrowing down research interests, using quantitative and qualitative techniques complementarily, and interviewing and other fieldwork challenges. The course uses a seminar-type format in which readings, class discussions, and assignments are built around (1) generic themes that run across the research interests and paper topics of students in the class, and (2) lessons about methodology to be learned from the case comparison studies assigned. This course covers approaches to research and evaluation in the planning field, for those preparing to write 1st-year doctoral and other research papers. Topics include narrowing down research interests, using quantitative and qualitative techniques complementarily, and interviewing and other fieldwork challenges. The course uses a seminar-type format in which readings, class discussions, and assignments are built around (1) generic themes that run across the research interests and paper topics of students in the class, and (2) lessons about methodology to be learned from the case comparison studies assigned.

Subjects

research | research | evaluation | evaluation | methodology | methodology | research proposals | research proposals | writing | writing | fieldwork | fieldwork | interviewing | interviewing | organizations | organizations | NGO's | NGO's | government | government | urban planning | urban planning | cities | cities | redevelopment | redevelopment | craft and technique | craft and technique | PhD dissertation writing | PhD dissertation writing

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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17.878 Qualitative Research: Design and Methods (MIT) 17.878 Qualitative Research: Design and Methods (MIT)

Description

This course is intended for graduate students planning to conduct qualitative research in a variety of different settings. Its topics include: Case studies, interviews, documentary evidence, participant observation, and survey research. The primary goal of this course is to assist students in preparing their (Masters and PhD) dissertation proposals. This course is intended for graduate students planning to conduct qualitative research in a variety of different settings. Its topics include: Case studies, interviews, documentary evidence, participant observation, and survey research. The primary goal of this course is to assist students in preparing their (Masters and PhD) dissertation proposals.

Subjects

qualitative research | qualitative research | survey research | survey research | interviewing | interviewing | participant observation | participant observation | case studies | case studies | social science | social science | social science research | social science research | research design | research design | documentary evidence | documentary evidence | fieldwork | fieldwork

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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