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7.342 G-Protein Coupled Receptors: Vision and Disease (MIT) 7.342 G-Protein Coupled Receptors: Vision and Disease (MIT)

Description

How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR

Subjects

allergies | allergies | hypertension | hypertension | depression | depression | obesity | obesity | central nervous system disorders | central nervous system disorders | G-protein coupled receptors | G-protein coupled receptors | GPCR | GPCR | cell-surface receptors | cell-surface receptors | George Wald | George Wald | vision | vision | chromophore | chromophore | transducin | transducin | metarhodopsin II | metarhodopsin II | homodimers | homodimers | heterodimers | heterodimers | retinitis pigmentosa | retinitis pigmentosa | night blindness | night blindness | Dopamine | Dopamine | antihistamines | antihistamines | Claviceps purpurea | Claviceps purpurea | Human chemokine receptor 5 | Human chemokine receptor 5 | CCR5 | CCR5 | HIV-1 | HIV-1 | CCR5-delta32 | CCR5-delta32 | Olfactory receptors | Olfactory receptors | Taste receptors | Taste receptors

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.342 G-Protein Coupled Receptors: Vision and Disease (MIT)

Description

How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR

Subjects

allergies | hypertension | depression | obesity | central nervous system disorders | G-protein coupled receptors | GPCR | cell-surface receptors | George Wald | vision | chromophore | transducin | metarhodopsin II | homodimers | heterodimers | retinitis pigmentosa | night blindness | Dopamine | antihistamines | Claviceps purpurea | Human chemokine receptor 5 | CCR5 | HIV-1 | CCR5-delta32 | Olfactory receptors | Taste receptors

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-alllifesciencescourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

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