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7.346 Fine-Tuning the Synapse: Synaptic Functions and Dysfunction (MIT) 7.346 Fine-Tuning the Synapse: Synaptic Functions and Dysfunction (MIT)

Description

The synapse is the fundamental element by which neurons transmit, receive and transform information in the brain. Synapses are functionally diverse, and a single neuron in the brain receives up to 10,000 synapses. Given the enormous complexity of the nervous system, how does a neuron integrate, encode and retrieve information? How is information processed beyond a single cell within the context of a neuronal circuit? Fundamental synaptic mechanisms underlie expression of higher-order brain functions, such as learning and memory, and cognition. Conversely, the disruption of synaptic processes contributes to the development of neurological disorders. In this course, students will learn to critically analyze the primary research literature to explore how synapses are studied and to understand The synapse is the fundamental element by which neurons transmit, receive and transform information in the brain. Synapses are functionally diverse, and a single neuron in the brain receives up to 10,000 synapses. Given the enormous complexity of the nervous system, how does a neuron integrate, encode and retrieve information? How is information processed beyond a single cell within the context of a neuronal circuit? Fundamental synaptic mechanisms underlie expression of higher-order brain functions, such as learning and memory, and cognition. Conversely, the disruption of synaptic processes contributes to the development of neurological disorders. In this course, students will learn to critically analyze the primary research literature to explore how synapses are studied and to understand

Subjects

Synapse | Synapse | synaptic mechanisms | synaptic mechanisms | plasticity | plasticity | excitatory synapses | excitatory synapses | inhibitory synapses | inhibitory synapses | excitation-inhibition balance | excitation-inhibition balance | neuropsychiatric disorders | neuropsychiatric disorders | electrophysiology | electrophysiology | optogenetics | optogenetics | neural circuits | neural circuits | synaptic vesicle fusion | synaptic vesicle fusion | glia | glia | synapse formation | synapse formation | canonical microcircuits | canonical microcircuits

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.346 Fine-Tuning the Synapse: Synaptic Functions and Dysfunction (MIT)

Description

The synapse is the fundamental element by which neurons transmit, receive and transform information in the brain. Synapses are functionally diverse, and a single neuron in the brain receives up to 10,000 synapses. Given the enormous complexity of the nervous system, how does a neuron integrate, encode and retrieve information? How is information processed beyond a single cell within the context of a neuronal circuit? Fundamental synaptic mechanisms underlie expression of higher-order brain functions, such as learning and memory, and cognition. Conversely, the disruption of synaptic processes contributes to the development of neurological disorders. In this course, students will learn to critically analyze the primary research literature to explore how synapses are studied and to understand

Subjects

Synapse | synaptic mechanisms | plasticity | excitatory synapses | inhibitory synapses | excitation-inhibition balance | neuropsychiatric disorders | electrophysiology | optogenetics | neural circuits | synaptic vesicle fusion | glia | synapse formation | canonical microcircuits

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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9.09J Cellular Neurobiology (MIT) 9.09J Cellular Neurobiology (MIT)

Description

This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system. This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.

Subjects

neurobiology | neurobiology | structure | structure | function | function | nervous system | nervous system | cellular | cellular | neurons | neurons | excitable cells | excitable cells | biophysics | biophysics | synaptic transmission | synaptic transmission | neurochemistry | neurochemistry | neurodevelopment | neurodevelopment | visual system | visual system | neuromuscular junction | neuromuscular junction | membrane channels | membrane channels | signaling | signaling | ion channels | ion channels | action potential | action potential | neurotransmitters | neurotransmitters | biochemistry | biochemistry | synapses | synapses | learning | learning | memory | memory | axons | axons | hearing | hearing | thermoreception | thermoreception | pain | pain | cognitive function | cognitive function | 9.09 | 9.09 | 7.29 | 7.29

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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[Cathedral Interior] [Cathedral Interior]

Description

Subjects

cathedrals | cathedrals | churches | churches | naves | naves | apses | apses | altars | altars | sculpture | sculpture | interiors | interiors

License

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Mont Saint-Michel Abbey. Apse of the Church

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.01394 Title: Mont Saint-Michel Abbey. Apse of the Church Photographer: Neurdein Frčres (French, active ca. 1863-1912) Building Date: ca. 1400-ca. 1499 Photograph date: ca. 1865-ca. 1895 Location: Europe: France; Mont Saint-Michel Materials: albumen print Image: 10.8268 x 8.4646 in.; 27.5 x 21.5 cm Style: Late Gothic Provenance: Gift of Andrew Dickson White Persistent URI: hdl.handle.net/1813.001/5tkx There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | montsaintmichelfrance | abbeylemontsaintmichelfrance | abbeys | churches | religiousbuildings | tracery | flyingbuttresses | crockets | lancetwindows | stainedglass | apses | culidentifier:value=155309001394 | culidentifier:lunafield=accessionnumber

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Choir Screen, Cathedral Church of the Blessed Virgin Mary, Salisbury

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.00086 Title: Choir Screen, Cathedral Church of the Blessed Virgin Mary, Salisbury Photograph date: ca. 1865-ca. 1895 Building Date: 1220-ca.1260 Location: Europe: United Kingdom; Salisbury Materials: albumen print Image: 4.25 x 7.375 in.; 10.795 x 18.7325 cm Style: Gothic Provenance: Gift of Andrew Dickson White Persistent URI: hdl.handle.net/1813.001/5s8m There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | religiousinteriors | cathedrals | pulpits | groupedcolumns | apses | salisburycathedralsalisburyengland | altars | wroughtiron | screens | roodscreens | pierssupportingelements | culidentifier:value=155309000086 | culidentifier:lunafield=accessionnumber

License

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Bourges Cathedral, Apse

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.01312 Title: Bourges Cathedral, Apse Building Date: 1190-1275 Photograph date: ca. 1865-ca. 1886 Location: Europe: France; Bourges Materials: albumen print Image: 10.9055 x 8.0709 in.; 27.7 x 20.5 cm Style: High Gothic Provenance: Gift of Andrew Dickson White Persistent URI: hdl.handle.net/1813.001/5th2 There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | cathedralofsaintstephenbourgesfrance | cathédralesaintétiennebourgesfrance | cathedrals | religiousbuildings | apses | flyingbuttresses | spires | oculi | walledgardens | culidentifier:value=155309001312 | culidentifier:lunafield=accessionnumber

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Parish Church of Saint Pierre at Caen. Apse

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.01522 Title: Parish Church of Saint Pierre at Caen. Apse Photographer: Bisson Freres (French, 1841-1862) Photograph date: 1858 Building Date: ca. 1200-ca. 1599 Location: Europe: France; Caen Materials: albumen print Image: 17.9134 x 12.874 in.; 45.5 x 32.7 cm Style: High Gothic Provenance: Gift of Andrew Dickson White Persistent URI: hdl.handle.net/1813.001/5tr8 There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | saintpierrechurchcaenfrance | churches | religiousbuildings | apses | flyingbuttresses | oculi | tracery | baskets | peddlers | streetlightingunits | stainedglass | archedwindows | churchtowers | culidentifier:value=155309001522 | culidentifier:lunafield=accessionnumber

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9.09J Cellular Neurobiology (MIT)

Description

This course serves as an introduction to the structure and function of the nervous system. Emphasis is placed on the cellular properties of neurons and other excitable cells. Topics covered include the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, and the integration of information in simple systems and the visual system.

Subjects

neurobiology | structure | function | nervous system | cellular | neurons | excitable cells | biophysics | synaptic transmission | neurochemistry | neurodevelopment | visual system | neuromuscular junction | membrane channels | signaling | ion channels | action potential | neurotransmitters | biochemistry | synapses | learning | memory | axons | hearing | thermoreception | pain | cognitive function | 9.09 | 7.29

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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Parish Church of Saint Pierre at Caen. Apse

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.01521 Title: Parish Church of Saint Pierre at Caen. Apse Photographer: Bisson Freres (French, 1841-1862) Photograph date: 1858 Building Date: ca. 1200-ca. 1599 Location: Europe: France; Caen Materials: albumen print Image: 18.1496 x 14.4882 in.; 46.1 x 36.8 cm Style: High Gothic Provenance: Gift of Andrew Dickson White Persistent URI: hdl.handle.net/1813.001/5tr7 There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | saintpierrechurchcaenfrance | churches | religiousbuildings | apses | flyingbuttresses | churchtowers | tracery | gargoyles | constructionviews | stainedglass | archedwindows | culidentifier:value=155309001521 | culidentifier:lunafield=accessionnumber

License

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Interior, Worcester Cathedral

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.00084 Title: Interior, Worcester Cathedral Photograph date: ca. 1865-ca. 1885 Building Date: 1084-1374 Location: Europe: United Kingdom; Worcester Materials: albumen print Image: 6.25 x 8.375 in.; 15.875 x 21.2725 cm Style: Gothic Provenance: Gift of Andrew Dickson White Persistent URI: hdl.handle.net/1813.001/5s8j There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | religiousinteriors | cathedrals | naves | choirs | tracery | apses | tombs | funerarysculpture | groupedcolumns | trefoils | culidentifier:value=155309000084 | culidentifier:lunafield=accessionnumber

License

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Murano. Cathedral of Santa Maria and San Donato

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.01651 Title: Murano. Cathedral of Santa Maria and San Donato Photographer: Carlo Naya (Italian, 1816-1882) Building Date: ca. 1100-ca. 1150 Photograph date: 1875 Location: Europe: Italy; Murano Materials: albumen print Image: 10.5118 x 13.7402 in.; 26.7 x 34.9 cm Style: Romanesque Provenance: Transfer from the College of Architecture, Art and Planning Persistent URI: hdl.handle.net/1813.001/5tvp There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | cathedralofsantamariaandsandonatomuranoveniceitaly | cathedrals | religiousbuildings | apses | arches | niches | churchtowers | geometricpatterns | brick | roofingtiles | culidentifier:value=155309001651 | culidentifier:lunafield=accessionnumber

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Molfetta Cathedral

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.01645 Title: Molfetta Cathedral Building Date: ca. 1100-ca. 1199 Photograph date: ca. 1865-ca. 1895 Location: Europe: Italy; Molfetta Materials: albumen print Image: 10.748 x 15.5118 in.; 27.3 x 39.4 cm Style: Romanesque Provenance: Gift of Willard Fiske Persistent URI: hdl.handle.net/1813.001/5tvh There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | cathedralmolfettaitaly | cathedrals | religiousbuildings | apses | windows | pilasters | grotesques | culidentifier:value=155309001645 | culidentifier:lunafield=accessionnumber

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Monreale Cathedral (Interior)

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.01650 Title: Monreale Cathedral (Interior) Photographer: Giuseppe Incorpora (Italian, active ca. 1860-ca. 1879) Building Date: 1172-1176 Photograph date: ca. 1865-ca. 1885 Location: Europe: Italy; Monreale Materials: albumen print Image: 8.0709 x 10.1181 in.; 20.5 x 25.7 cm Style: Romanesque Provenance: Transfer from the College of Architecture, Art and Planning Persistent URI: hdl.handle.net/1813.001/5tvn There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | cathedralmonrealesicilyitaly | religiousinteriors | mosaics | apses | frescoes | capitals | aisles | clerestories | altars | culidentifier:value=155309001650 | culidentifier:lunafield=accessionnumber

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Cologne. Sankt Maria im Kapitol

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.01543 Title: Cologne. Sankt Maria im Kapitol Photograph date: ca. 1865-ca. 1880 Building Date: ca. 900-1065 Location: Europe: Germany; Cologne Materials: albumen print Image: 15.4331 x 18.7402 in.; 39.2 x 47.6 cm Style: Romanesque Provenance: Gift of Andrew Dickson White Persistent URI: hdl.handle.net/1813.001/5trz There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | santamariaimkapitolcolognegermany | churches | religiousbuildings | apses | arches | steeples | arcades | culidentifier:value=155309001543 | culidentifier:lunafield=accessionnumber | köln | deutschland | kirche | stmariaimkapitol | germany

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Interior, Church of Saint Mary Redcliffe, Bristol

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.00087 Title: Interior, Church of Saint Mary Redcliffe, Bristol Building Date: 1327-1380 Photograph date: ca. 1865-ca. 1885 Location: Europe: United Kingdom; Bristol Materials: albumen print Image: 7.874 x 5.625 in.; 20 x 14.2875 cm Style: Gothic Provenance: Gift of Andrew Dickson White Persistent URI: hdl.handle.net/1813.001/5s8n There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | churches | religiousinteriors | stainedglass | naves | altars | ribbedvaults | tracery | memorials | armor | apses | churchofsaintmaryredcliffebristolengland | culidentifier:value=155309000087 | culidentifier:lunafield=accessionnumber

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Cologne. Sankt Aposteln Church

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.01544 Title: Cologne. Sankt Aposteln Church Photograph date: ca. 1865-ca. 1880 Building Date: 1020-ca. 1220 Location: Europe: Germany; Cologne Materials: albumen print Image: 19.0945 x 16.1811 in.; 48.5 x 41.1 cm Style: Romanesque Provenance: Gift of Andrew Dickson White Persistent URI: hdl.handle.net/1813.001/5ts0 There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | saktapostelnchurchcolognegermany | churches | religiousbuildings | steeples | churchtowers | arcades | arches | cityviews | urbanviews | streetscapes | neumarktsquarecolognegermany | squaresopenspaces | apses | culidentifier:value=155309001544 | culidentifier:lunafield=accessionnumber | köln | deutschland | staposteln

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Cathedral of Saint-Caprais, Agen

Description

Collection: A. D. White Architectural Photographs, Cornell University Library Accession Number: 15/5/3090.01257 Title: Cathedral of Saint-Caprais, Agen Building Date: ca. 1100-ca. 1199 Photograph date: ca. 1865-ca. 1886 Location: Europe: France; Agen Materials: albumen print : 8.5039 x 6.6929 in.; 21.6 x 17 cm Provenance: Gift of Andrew Dickson White Persistent URI: hdl.handle.net/1813.001/5tf4 There are no known copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source. We had some help with the geocoding from Web Services by Yahoo!

Subjects

cornelluniversitylibrary | cathedralofsaintcapraisagenfrance | cathedrals | religiousbuildings | apses | corbels | culidentifier:value=155309001257 | culidentifier:lunafield=accessionnumber

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