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7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT) 7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT)

Description

In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at

Subjects

blueprint of life | blueprint of life | transcription | transcription | stem cells | stem cells | differentiation | differentiation | human tissues | human tissues | tissue regeneration | tissue regeneration | human disease | human disease | RNA and protein expression patterns | RNA and protein expression patterns | transcriptional regulation | transcriptional regulation | specialized gene expression programs | specialized gene expression programs | genome | genome | multipotent | multipotent | terminally differentiated | terminally differentiated | pluripotency | pluripotency | master regulators | master regulators | chromatin regulators | chromatin regulators | developmental defects | developmental defects | cancer | cancer

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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21M.030 Introduction to World Music (MIT) 21M.030 Introduction to World Music (MIT)

Description

This course explores the ways that music is both shaped by and gives shape to the cultural settings in which it is performed, through studying selected musical traditions from around the world. Specific case studies will be examined closely through listening, analysis, and hands-on instruction. The syllabus centers around weekly listening assignments and readings from a textbook with CDs, supplemented by hands-on workshops, lecture/demonstrations and concerts by master musicians from around the world. This course explores the ways that music is both shaped by and gives shape to the cultural settings in which it is performed, through studying selected musical traditions from around the world. Specific case studies will be examined closely through listening, analysis, and hands-on instruction. The syllabus centers around weekly listening assignments and readings from a textbook with CDs, supplemented by hands-on workshops, lecture/demonstrations and concerts by master musicians from around the world.

Subjects

Enthomusicology | Enthomusicology | field study | field study | music analysis | music analysis | anthropology | anthropology | culture | culture | globalization | globalization | crossover | crossover | folk music | folk music | ethnic music | ethnic music | roots music | roots music | international music | international music | gamelan | gamelan | raga | raga | blues | blues

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Washington on Blue Peter

Description

This is a photograph of a Birthday Card Competition held by Blue Peter of the BBC in celebration of the 250th Anniversary of the Birth of George Washington in 1982. Reference: 5417/187/1 This collection of images has been assembled in support of the Washington Heritage Festival 2013. The celebration of Washington brings together a variety of different themes. Washington is a Town in the City of Sunderland, Tyne & Wear. It is traditionally associated with Coal Industry, and notably known as the home of the Washington Family, ancestors of the First President of the United States George Washington. However, in 1964 Washington was designated a New Town and drastically changed. With the introduction of new industry such as the Nissan Car Factory Washington experienced a huge redevelopment in both its economy and community. These Photographs are taken from the Records of the Washington Development Corporation; held at Tyne & Wear Archives. The records document this change in industry, landscape and community in Washington between 1964 & 1988, and consist of many photographs. For more information on the Washington Heritage Festival, 21st September 2013 please click here. (Copyright) These images are Crown Copyright. We're happy for you to share these digital images within the spirit of The Commons. Please cite 'Tyne & Wear Archives & Museums' when reusing. Certain restrictions on high quality reproductions and commercial use of the original physical version apply though; if you're unsure please email archives@twmuseums.org.uk

Subjects

northeast | iconic | memorable | event | nostalgic | development | community | bluepeter | birthdaycardcompetition | georgewashington | bluepeterdog | blackandwhitephotogarph | socialhistory | industrialheritage | abstract | digitalimage | coalindustry | traditional | newindustry | nissancarfactory | industry | washingtondevelopmentcorporation | 1964 | washington | newtown | washingtonfamily | firstpresident | unitedstatesofamerica | presidentgeorgewashington | ancestor | tynewear | cityofsunderland | town | northeastofengland | unitedkingdom | fascinating | interesting | unusual | washingtonheritagefestival2013 | washingtonheritagecollectionvisitsandevents | bbc | television | 250thanniversaryofthebirthofgeorgewashington | 1982 | paper | dog | room | drawings | shelf | toys | wall | furniture | handwriting | number | floor | artificiallight | shadow | men | woman | seated | presenters

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Passmore Edwards Room, 1993

Description

Picture taken by Lois Reynolds. IMAGELIBRARY/485 Persistent URL: archives.lse.ac.uk/dserve.exe?dsqServer=lib-4.lse.ac.uk&a...

Subjects

classroom | lightblue | blueceiling | desks

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The steamer 'Sultan Star' at Gallions Reach

Description

Reproduction ID: N40709 Maker: Unknown Date: circa 1930

Subjects

nationalmaritimemuseum | thames | ship | steamship | steamer | oceanliner | sssultanstar | tsssultanstar | sultanstar | crammelllairdandcompany | crammelllairdandco | crammelllairdco | bluestarline | bluestar | sunk | torpedoed | sunkbyu48 | u48 | crammelllairdcompany

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21M.295 American Popular Music (MIT) 21M.295 American Popular Music (MIT)

Description

This course surveys the development of popular music in the United States and in a cross-cultural milieu relative to the history and sociology of the last two hundred years. It examines the ethnic mixture that characterizes modern music, how it reflects many rich traditions and styles, and provides a background for understanding the musical vocabulary of current popular music styles. This course surveys the development of popular music in the United States and in a cross-cultural milieu relative to the history and sociology of the last two hundred years. It examines the ethnic mixture that characterizes modern music, how it reflects many rich traditions and styles, and provides a background for understanding the musical vocabulary of current popular music styles.

Subjects

American popular music | American popular music | Tin Pan Alley | Tin Pan Alley | blues | blues | hillbilly | hillbilly | swing | swing | post-war | post-war | Rock 'n' Roll | Rock 'n' Roll | British invasion | British invasion | outside the mainstream | outside the mainstream | grunge | grunge | 1960s | 1960s | 1970s | 1970s | 1980s | 1980s | 1990s | 1990s

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Moses Williams playing the diddley bow at the 1980 Folk Festival in White Springs

Description

Subjects

music | men | singing | florida | festivals | blues | microphone | musicalinstruments | hamiltoncounty | stringedinstruments | folkfestivals | whitesprings | instrumentalists | diddleybow | folkmusicians | africanamericanmen | africanamericanmusicians | bluesmusicians | artsperforming | floridafolkfestival | africanamericansingers | musicaltraditions | williamsmoses | folklorerevivalfestivals

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Pianist Ida Goodson performing at the Great Gulf Coast Arts Festival in Pensacola

Description

Subjects

music | women | florida | piano | festivals | blues | folkmusic | songs | gospel | pensacola | ethnicity | musicalinstruments | gospelmusic | folkfestivals | africanamericanwomen | materialculture | escambiacounty | folkmusicians | pianomusic | womenmusicians | africanamericanmusicians | bluesmusicians | artsperforming | greatgulfcoastartsfestival | gospelmusicians | musicaltraditions | owenblanton | africanamericangospelsingers | womenpianists | folklorerevivalfestivals | goodsonida

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Big Blue Button (Sharing Stories)

Description

Webinar on Big Blue Button at the University of the West of Scotland.

Subjects

webinar | sharing stories | 2013 | university of the west of scotland | uws | bigbluebutton | bbb | big blue button | video conferencing | None

License

Attribution-NonCommercial-ShareAlike 4.0 International Attribution-NonCommercial-ShareAlike 4.0 International http://creativecommons.org/licenses/by-nc-sa/4.0/ http://creativecommons.org/licenses/by-nc-sa/4.0/

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Ray Wagner Collection Image Ray Wagner Collection Image

Description

Subjects

airplane | airplane | aircraft | aircraft | aviation | aviation | tiger | tiger | blueangels | blueangels | f11 | f11 | militaryaviation | militaryaviation | grumman | grumman | navalaviation | navalaviation | grummantiger | grummantiger | grummanf11f | grummanf11f | f11f | f11f | f11tiger | f11tiger | f11ftiger | f11ftiger | grummanf11ftiger | grummanf11ftiger | grummanf11tiger | grummanf11tiger | grummanf11 | grummanf11

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2001078_037_75_018_026ac 2001078_037_75_018_026ac

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Subjects

liveoak | liveoak | bluebonnets | bluebonnets | indianpaintbrush | indianpaintbrush

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2001078_037_75_018_025ac 2001078_037_75_018_025ac

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Subjects

field | field | liveoak | liveoak | bluebonnets | bluebonnets | indianpaintbrush | indianpaintbrush

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2001078_037_75_018_024ac 2001078_037_75_018_024ac

Description

Subjects

field | field | fence | fence | liveoak | liveoak | bluebonnets | bluebonnets | indianpaintbrush | indianpaintbrush | countryhome | countryhome

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2001078_037_75_018_023ac 2001078_037_75_018_023ac

Description

Subjects

field | field | texas | texas | central | central | liveoak | liveoak | bluebonnets | bluebonnets | indianpaintbrush | indianpaintbrush

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2001078_037_75_018_021ac 2001078_037_75_018_021ac

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Subjects

barn | barn | vintage | vintage | wagon | wagon | texas | texas | central | central | liveoak | liveoak | phlox | phlox | bluebonnets | bluebonnets

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2001078_037_75_018_019ac 2001078_037_75_018_019ac

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Subjects

field | field | texas | texas | central | central | liveoak | liveoak | bluebonnets | bluebonnets | indianpaintbrush | indianpaintbrush

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Manatee in Blue Springs State Park - Orange City Manatee in Blue Springs State Park - Orange City

Description

Subjects

florida | florida | manatees | manatees | springs | springs | underwaterphotography | underwaterphotography | bluespringsstatepark | bluespringsstatepark | orangecity | orangecity

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Great blue heron at the Edward Ball Wakulla Springs State Park Great blue heron at the Edward Ball Wakulla Springs State Park

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Subjects

heron | heron | birds | birds | florida | florida | greatblueheron | greatblueheron | wakullacounty | wakullacounty | edwardballwakullaspringsstatepark | edwardballwakullaspringsstatepark

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Deck plans of the Quetta, ca. 1881 Deck plans of the Quetta, ca. 1881

Description

Subjects

shipwreck | shipwreck | blueprint | blueprint | queensland | queensland | statelibraryofqueensland | statelibraryofqueensland | quetta | quetta | thursdayisland | thursdayisland | slq | slq | maritimedisaster | maritimedisaster | albanyisland | albanyisland | claudiusbuchananwhish | claudiusbuchananwhish | aldolphuschannel | aldolphuschannel

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Deck plans for RMS Quetta, ca. 1881 Deck plans for RMS Quetta, ca. 1881

Description

Subjects

shipwreck | shipwreck | blueprint | blueprint | queensland | queensland | statelibraryofqueensland | statelibraryofqueensland | quetta | quetta | thursdayisland | thursdayisland | slq | slq | maritimedisaster | maritimedisaster | albanyisland | albanyisland | rmsquetta | rmsquetta | claudiusbuchananwhish | claudiusbuchananwhish | aldolphuschannel | aldolphuschannel

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The United Insurance Company, Brisbane Office [architectural drawing], Jun 1902 The United Insurance Company, Brisbane Office [architectural drawing], Jun 1902

Description

Subjects

architecture | architecture | design | design | united | united | brisbane | brisbane | company | company | blueprint | blueprint | queensland | queensland | insurance | insurance | 1902 | 1902 | statelibraryofqueensland | statelibraryofqueensland | federationarchitecture | federationarchitecture | slq | slq | unitedinsurancecompany | unitedinsurancecompany | robindods | robindods | halldods | halldods

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The United Insurance Company, Brisbane Office [architectural drawing], Jun 1902 The United Insurance Company, Brisbane Office [architectural drawing], Jun 1902

Description

Subjects

architecture | architecture | design | design | brisbane | brisbane | blueprint | blueprint | queensland | queensland | 1902 | 1902 | statelibraryofqueensland | statelibraryofqueensland | federationarchitecture | federationarchitecture | slq | slq | robindods | robindods | halldods | halldods

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Blue Point Siamese cats - Tallahassee Blue Point Siamese cats - Tallahassee

Description

Subjects

cats | cats | portraits | portraits | florida | florida | tallahassee | tallahassee | catbreeds | catbreeds | bluepointsiamesecats | bluepointsiamesecats

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Bluegrass musician Chubby Wise playing his fiddle in Florida Bluegrass musician Chubby Wise playing his fiddle in Florida

Description

Subjects

florida | florida | chubbywise | chubbywise | bluegrassmusicians | bluegrassmusicians | fiddlers | fiddlers | fiddles | fiddles | violins | violins

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Salting Meat For Foxes Salting Meat For Foxes

Description

Subjects

usnationalarchives | usnationalarchives | alaskadigitizationproject | alaskadigitizationproject | nara:arcid=23853649 | nara:arcid=23853649 | pribilofislands | pribilofislands | stgeorgeisland | stgeorgeisland | bluefox | bluefox | foxtrapping | foxtrapping | foxbreeding | foxbreeding | foxfeeding | foxfeeding | foxes | foxes | sealmeat | sealmeat | jamesjudge | jamesjudge | beringsea | beringsea | alaska | alaska | alaskamaritimenationalwildliferefuge | alaskamaritimenationalwildliferefuge | alaskamaritime | alaskamaritime | amnwr | amnwr

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