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7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT) 7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT)

Description

In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at

Subjects

blueprint of life | blueprint of life | transcription | transcription | stem cells | stem cells | differentiation | differentiation | human tissues | human tissues | tissue regeneration | tissue regeneration | human disease | human disease | RNA and protein expression patterns | RNA and protein expression patterns | transcriptional regulation | transcriptional regulation | specialized gene expression programs | specialized gene expression programs | genome | genome | multipotent | multipotent | terminally differentiated | terminally differentiated | pluripotency | pluripotency | master regulators | master regulators | chromatin regulators | chromatin regulators | developmental defects | developmental defects | cancer | cancer

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT)

Description

In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at

Subjects

blueprint of life | transcription | stem cells | differentiation | human tissues | tissue regeneration | human disease | RNA and protein expression patterns | transcriptional regulation | specialized gene expression programs | genome | multipotent | terminally differentiated | pluripotency | master regulators | chromatin regulators | developmental defects | cancer

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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https://ocw.mit.edu/rss/all/mit-allsimplifiedchinesecourses.xml

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7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT)

Description

In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at

Subjects

blueprint of life | transcription | stem cells | differentiation | human tissues | tissue regeneration | human disease | RNA and protein expression patterns | transcriptional regulation | specialized gene expression programs | genome | multipotent | terminally differentiated | pluripotency | master regulators | chromatin regulators | developmental defects | cancer

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-alllifesciencescourses.xml

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