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7.340 Avoiding Genomic Instability: DNA Replication, the Cell Cycle, and Cancer (MIT) 7.340 Avoiding Genomic Instability: DNA Replication, the Cell Cycle, and Cancer (MIT)

Description

In this class we will learn about how the process of DNA replication is regulated throughout the cell cycle and what happens when DNA replication goes awry. How does the cell know when and where to begin replicating its DNA? How does a cell prevent its DNA from being replicated more than once? How does damaged DNA cause the cell to arrest DNA replication until that damage has been repaired? And how is the duplication of the genome coordinated with other essential processes? We will examine both classical and current papers from the scientific literature to provide answers to these questions and to gain insights into how biologists have approached such problems. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored f In this class we will learn about how the process of DNA replication is regulated throughout the cell cycle and what happens when DNA replication goes awry. How does the cell know when and where to begin replicating its DNA? How does a cell prevent its DNA from being replicated more than once? How does damaged DNA cause the cell to arrest DNA replication until that damage has been repaired? And how is the duplication of the genome coordinated with other essential processes? We will examine both classical and current papers from the scientific literature to provide answers to these questions and to gain insights into how biologists have approached such problems. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored f

Subjects

cell | cell | genetic material | genetic material | cell death | cell death | tumorigenesis | tumorigenesis | mutations | mutations | genes | genes | DNA replication | DNA replication | cell cycle | cell cycle | damaged DNA | damaged DNA | genome | genome | tumor formation | tumor formation | anti-cancer drugs | anti-cancer drugs | viruses | viruses | cellular controls | cellular controls

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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HMS Broke in dry dock after the Battle of Jutland HMS Broke in dry dock after the Battle of Jutland

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Subjects

roof | roof | sky | sky | people | people | blur | blur | industry | industry | wheel | wheel | metal | metal | wall | wall | buildings | buildings | wonderful | wonderful | children | children | belt | belt | interesting | interesting | wire | wire | workers | workers | support | support | industrial | industrial | ship | ship | dress | dress | darkness | darkness | panel | panel | post | post | unitedkingdom | unitedkingdom | britain | britain | timber | timber | mark | mark | coat | coat | debris | debris | grain | grain | platform | platform | vessel | vessel | battle | battle | rope | rope | destroyer | destroyer | deck | deck | fabric | fabric | maritime | maritime | isleofwight | isleofwight | porthole | porthole | gathering | gathering | damage | damage | unusual | unusual | ww1 | ww1 | damaged | damaged | striking | striking | naval | naval | adults | adults | greatwar | greatwar | drydock | drydock | tyneside | tyneside | firstworldwar | firstworldwar | wreckage | wreckage | warship | warship | fascinating | fascinating | digitalimage | digitalimage | collision | collision | wartime | wartime | eastcowes | eastcowes | rivertyne | rivertyne | royalnavy | royalnavy | industrialheritage | industrialheritage | northeastengland | northeastengland | blackandwhitephotograph | blackandwhitephotograph | shipbuildingheritage | shipbuildingheritage | maritimeheritage | maritimeheritage | battleofjutland | battleofjutland | june1916 | june1916 | jsamuelwhite | jsamuelwhite | shiprepairing | shiprepairing | 1june1916 | 1june1916 | hmsbroke | hmsbroke | thebattleofjutland | thebattleofjutland | hmssparrowhawk | hmssparrowhawk | royalnavalvessel | royalnavalvessel | faulknorclassdestroyer | faulknorclassdestroyer

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Damage suffered by HMS Broke at the Battle of Jutland Damage suffered by HMS Broke at the Battle of Jutland

Description

Subjects

sky | sky | abstract | abstract | blur | blur | men | men | industry | industry | bar | bar | landscape | landscape | interesting | interesting | workers | workers | support | support | industrial | industrial | ship | ship | view | view | panel | panel | timber | timber | mark | mark | debris | debris | grain | grain | working | working | navy | navy | platform | platform | surreal | surreal | ground | ground | vessel | vessel | battle | battle | rope | rope | tools | tools | destroyer | destroyer | deck | deck | pile | pile | bow | bow | isleofwight | isleofwight | porthole | porthole | damage | damage | land | land | ladder | ladder | unusual | unusual | mast | mast | ww1 | ww1 | damaged | damaged | greatwar | greatwar | plank | plank | drydock | drydock | spectator | spectator | tyneside | tyneside | firstworldwar | firstworldwar | warship | warship | repairs | repairs | fascinating | fascinating | digitalimage | digitalimage | collision | collision | worldwar1 | worldwar1 | wartime | wartime | eastcowes | eastcowes | rivertyne | rivertyne | royalnavy | royalnavy | industrialheritage | industrialheritage | northeastengland | northeastengland | blackandwhitephotograph | blackandwhitephotograph | navalhistory | navalhistory | navalvessel | navalvessel | shipbuildingheritage | shipbuildingheritage | maritimeheritage | maritimeheritage | battleofjutland | battleofjutland | extraudinary | extraudinary | thegreatwar19141918 | thegreatwar19141918 | june1916 | june1916 | jsamuelwhite | jsamuelwhite | shiprepairing | shiprepairing | 1june1916 | 1june1916 | hmsbroke | hmsbroke | thebattleofjutland | thebattleofjutland | hmssparrowhawk | hmssparrowhawk | bowdamage | bowdamage | faulknorclassdestroyer | faulknorclassdestroyer

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Damaged car - Jacksonville Damaged car - Jacksonville

Description

Subjects

florida | florida | automobiles | automobiles | jacksonville | jacksonville | damagedautomobiles | damagedautomobiles | caraccidents | caraccidents | garages | garages

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Trains at station, Valentia Harbour, Co. Kerry Trains at station, Valentia Harbour, Co. Kerry

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Subjects

ireland | ireland | station | station | train | train | railway | railway | lastday | lastday | rails | rails | locomotive | locomotive | trucks | trucks | 1956 | 1956 | munster | munster | closure | closure | thepoint | thepoint | royalhotel | royalhotel | 1430 | 1430 | valentia | valentia | cokerry | cokerry | knightstown | knightstown | c201 | c201 | nationallibraryofireland | nationallibraryofireland | 201class | 201class | michaelmckenna | michaelmckenna | renardpoint | renardpoint | jamespo’dea | jamespo’dea | o’deaphotographiccollection | o’deaphotographiccollection | farranforetovalentiaharbour | farranforetovalentiaharbour | bombdamaged1973 | bombdamaged1973 | meighlevelcrossing | meighlevelcrossing | january30th1960 | january30th1960 | destroyedbybomb | destroyedbybomb | caherciveenclosure | caherciveenclosure | farranforeflyer | farranforeflyer

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13.400 Introduction to Naval Architecture (MIT) 13.400 Introduction to Naval Architecture (MIT)

Description

This course is an introduction to principles of naval architecture, ship geometry, hydrostatics, calculation and drawing of curves of form. It also explores concepts of  intact and damaged stability, hull structure strength calculations and ship resistance. Projects include analysis of ship lines drawings and ship model testing. This course is an introduction to principles of naval architecture, ship geometry, hydrostatics, calculation and drawing of curves of form. It also explores concepts of  intact and damaged stability, hull structure strength calculations and ship resistance. Projects include analysis of ship lines drawings and ship model testing.

Subjects

elementary principles of Naval Architecture | elementary principles of Naval Architecture | naval architecture tools | naval architecture tools | ship geometry | ship geometry | hydrostatics | hydrostatics | calculation | calculation | drawing | drawing | curves of form | curves of form | intact and damaged stability | intact and damaged stability | hull structure strength calculations | hull structure strength calculations | ship resistance | ship resistance | ship model testing | ship model testing | 2.701 | 2.701

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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2.701 Introduction to Naval Architecture (13.400) (MIT) 2.701 Introduction to Naval Architecture (13.400) (MIT)

Description

This course is an introduction to principles of naval architecture, ship geometry, hydrostatics, calculation and drawing of curves of form. It also explores concepts of  intact and damaged stability, hull structure strength calculations and ship resistance. Projects include analysis of ship lines drawings and ship model testing. This course was originally offered in Course 13 (Department of Ocean Engineering) as 13.400. In 2005, ocean engineering subjects became part of Course 2 (Department of Mechanical Engineering), and this course was renumbered 2.701. This course is an introduction to principles of naval architecture, ship geometry, hydrostatics, calculation and drawing of curves of form. It also explores concepts of  intact and damaged stability, hull structure strength calculations and ship resistance. Projects include analysis of ship lines drawings and ship model testing. This course was originally offered in Course 13 (Department of Ocean Engineering) as 13.400. In 2005, ocean engineering subjects became part of Course 2 (Department of Mechanical Engineering), and this course was renumbered 2.701.

Subjects

elementary principles of Naval Architecture | elementary principles of Naval Architecture | naval architecture tools | naval architecture tools | ship geometry | ship geometry | hydrostatics | hydrostatics | calculation | calculation | drawing | drawing | curves of form | curves of form | intact and damaged stability | intact and damaged stability | hull structure strength calculations | hull structure strength calculations | ship resistance | ship resistance | ship model testing | ship model testing | 13.400 | 13.400

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Messrs John Kelly Ltd. Damaged motor cycle. Messrs John Kelly Ltd. Damaged motor cycle.

Description

Subjects

ahpoole | ahpoole | arthurhenripoole | arthurhenripoole | poolecollection | poolecollection | glassnegative | glassnegative | nationallibraryofireland | nationallibraryofireland | damaged | damaged | exhaust | exhaust | baffles | baffles | silencer | silencer | stand | stand | motorcycle | motorcycle | damage | damage | crash | crash | cotton | cotton | cottonmotorcycleco | cottonmotorcycleco | cottonmotors | cottonmotors | wi966 | wi966 | johnkelly | johnkelly | garage | garage | waterford | waterford | japrestwich | japrestwich | japrestwichindustries | japrestwichindustries | cottonmotorcycle | cottonmotorcycle

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At Sommesous (LOC) At Sommesous (LOC)

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Subjects

church | church | wwi | wwi | libraryofcongress | libraryofcongress | damaged | damaged | 1914 | 1914 | eglise | eglise | stdenis | stdenis | sommesous | sommesous | agencemeurisse | agencemeurisse | sommesons | sommesons

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Portrait of Ollie Josephine Brookins - Malone Region, Florida

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Subjects

florida | maloneregion | olliebrookinshalstead | portraits | damagedphotographs

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Portrait of Cousin Talbot Capps - Tallahassee

Description

Subjects

portraits | florida | tallahassee | tintypes | tintedphotographs | damagedphotographs | talbotcapps

License

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Parker's Tiger Tim Toffee - TWCMS:G12131

Description

A tin of Parker's Tiger Tim Toffee with a blue, red, yellow, white and black label. Length: 160 mm Width: 95 mm Depth: 164 mm Manufactured by T.W. Parker & Co, Newcastle upon Tyne, Tyne and Wear, England, UK. 1914 - 18. Copyright Statement: (Copyright) We're happy for you to share these digital images within the spirit of The Commons. Please cite 'Tyne & Wear Archives & Museums' when reusing. Certain restrictions on high quality reproductions and commercial use of the original physical version apply though; if you're unsure please email sarah.younas@twmuseums.org.uk

Subjects

firstworldwar | ww1 | worlife | packaging | household | colourphotograph | parkerstigertimtoffee | tin | metal | container | product | blue | red | yellow | white | black | label | manufacturer | twparkerco | newcastleupontyne | tyneandwear | england | uk | 191418 | consumerism | sales | profit | advertising | rusty | lid | damaged | tiger | animal | curtain | bowtie | scarf | fur | stripe | body | head | eye | ear | nose | mouth | tongue | brow | hair | firstworldwarproductpackaging | scratch | dent | neutralbackground

License

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2.701 Introduction to Naval Architecture (13.400) (MIT)

Description

This course is an introduction to principles of naval architecture, ship geometry, hydrostatics, calculation and drawing of curves of form. It also explores concepts of  intact and damaged stability, hull structure strength calculations and ship resistance. Projects include analysis of ship lines drawings and ship model testing. This course was originally offered in Course 13 (Department of Ocean Engineering) as 13.400. In 2005, ocean engineering subjects became part of Course 2 (Department of Mechanical Engineering), and this course was renumbered 2.701.

Subjects

elementary principles of Naval Architecture | naval architecture tools | ship geometry | hydrostatics | calculation | drawing | curves of form | intact and damaged stability | hull structure strength calculations | ship resistance | ship model testing | 13.400

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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The 'Baron Aberdare' accident

Description

Reproduction ID: P1717 Maker: Unknown Date: December 1883 Find out more about this image on Collections

Subjects

nationalmaritimemuseum | cl0412 | cl0412fs | cl0412s1 | cl0412d7 | accident | capsized | docks | cause | salvage | ship | damage | survey | end | effort | tragedy | submerged | scuttling | disaster | cursed | rescue | tilt | calm | cold | oops | calamity | insured | the | damaged | trouble | cost | broken | scapegoat | recovery | loss

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7.340 Avoiding Genomic Instability: DNA Replication, the Cell Cycle, and Cancer (MIT)

Description

In this class we will learn about how the process of DNA replication is regulated throughout the cell cycle and what happens when DNA replication goes awry. How does the cell know when and where to begin replicating its DNA? How does a cell prevent its DNA from being replicated more than once? How does damaged DNA cause the cell to arrest DNA replication until that damage has been repaired? And how is the duplication of the genome coordinated with other essential processes? We will examine both classical and current papers from the scientific literature to provide answers to these questions and to gain insights into how biologists have approached such problems. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored f

Subjects

cell | genetic material | cell death | tumorigenesis | mutations | genes | DNA replication | cell cycle | damaged DNA | genome | tumor formation | anti-cancer drugs | viruses | cellular controls

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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HMS Broke in dry dock after the Battle of Jutland

Description

View of HMS Broke in dry dock on Tyneside, showing damage sustained at the Battle of Jutland, June 1916 (TWAM ref. DS.SWH/5/3/4/2/B602). HMS Broke was a Faulknor-class destroyer built by J. Samuel White, East Cowes, Isle of Wight. She was damaged during a collision with HMS Sparrowhawk on 1 June 1916. The Rivers Tyne and Wear were responsible for building many vessels, which served Britain during the First World War. This set remembers some of those warships that took part in the Battle of Jutland from 31 May to 1 June 1916. During the battle over 6,000 British sailors lost their lives and 14 Royal Naval vessels were sunk. The losses included the battlecruisers HMS Queen Mary and HMS Invincible, as well as the destroyers HMS Shark, HMS Sparrowhawk and HMS Turbulent, all built on Tyneside. Their memory lives on. (Copyright) We're happy for you to share these digital images within the spirit of The Commons. Please cite 'Tyne & Wear Archives & Museums' when reusing. Certain restrictions on high quality reproductions and commercial use of the original physical version apply though; if you're unsure please email archives@twmuseums.org.uk

Subjects

warship | destroyer | hmsbroke | battleofjutland | rivertyne | firstworldwar | ww1 | greatwar | royalnavy | ship | vessel | drydock | damage | tyneside | northeastengland | industry | industrial | shiprepairing | damaged | thebattleofjutland | shipbuildingheritage | maritimeheritage | industrialheritage | blackandwhitephotograph | maritime | unusual | interesting | fascinating | striking | digitalimage | june1916 | faulknorclassdestroyer | jsamuelwhite | eastcowes | collision | isleofwight | hmssparrowhawk | 1june1916 | britain | unitedkingdom | wartime | battle | royalnavalvessel | naval | metal | panel | wonderful | porthole | wreckage | deck | wheel | workers | buildings | sky | roof | wall | post | blur | grain | mark | platform | support | debris | darkness | timber | people | gathering | children | adults | fabric | rope | wire | belt | dress | coat

License

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Damage suffered by HMS Broke at the Battle of Jutland

Description

View of HMS Broke in dry dock on Tyneside, showing bow damage sustained at the Battle of Jutland, June 1916 (TWAM ref. DS.SWH/5/3/4/2/B600). HMS Broke was a Faulknor-class destroyer built by J. Samuel White, East Cowes, Isle of Wight. She was damaged during a collision with HMS Sparrowhawk on 1 June 1916. The Rivers Tyne and Wear were responsible for building many vessels, which served Britain during the First World War. This set remembers some of those warships that took part in the Battle of Jutland from 31 May to 1 June 1916. During the battle over 6,000 British sailors lost their lives and 14 Royal Naval vessels were sunk. The losses included the battlecruisers HMS Queen Mary and HMS Invincible, as well as the destroyers HMS Shark, HMS Sparrowhawk and HMS Turbulent, all built on Tyneside. Their memory lives on. (Copyright) We're happy for you to share these digital images within the spirit of The Commons. Please cite 'Tyne & Wear Archives & Museums' when reusing. Certain restrictions on high quality reproductions and commercial use of the original physical version apply though; if you're unsure please email archives@twmuseums.org.uk

Subjects

warship | destroyer | hmsbroke | battleofjutland | rivertyne | firstworldwar | ww1 | greatwar | royalnavy | ship | vessel | drydock | damage | tyneside | northeastengland | industry | industrial | shiprepairing | damaged | thebattleofjutland | shipbuildingheritage | maritimeheritage | industrialheritage | abstract | blackandwhitephotograph | digitalimage | fascinating | interesting | unusual | extraudinary | navy | thegreatwar19141918 | worldwar1 | june1916 | navalhistory | faulknorclassdestroyer | jsamuelwhite | eastcowes | isleofwight | collision | hmssparrowhawk | 1june1916 | wartime | battle | navalvessel | sky | workers | ground | rope | deck | mast | debris | pile | grain | mark | timber | platform | ladder | plank | tools | support | panel | porthole | bar | blur | spectator | working | men | landscape | view | land | repairs | bowdamage | bow | surreal

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Turbinia

Description

A photograph of the damaged Turbinia, taken by W. Parry in 1907. In January that year 'Turbinia' was moored at Wallsend when she was hit by the 'Crosby', a ship launched from Robert Stephenson's shipyard on the other side of the Tyne. The Crosby crashed into her with such momentum that 'Turbinia' was pushed on to the shore. However, the Marine Steam Turbine Company was able to repair her. Reference: TWCMS: 2003.434 (Copyright) We're happy for you to share this digital image within the spirit of The Commons. Please cite 'Tyne & Wear Archives & Museums' when reusing. Certain restrictions on high quality reproductions and commercial use of the original physical version apply though; if you're unsure - for image licensing enquiries please follow this link www.twmuseums.org.uk/image-licensing/

Subjects

turbinia | parry | 1907 | wallsend | crosby | robertstephensons | tyne | ship | shipyard | boat | navy | officers | construction | marine | sea | museum | newcastle | twam | tyneandwear | tyneandweararchivesandmuseums | northeast | blackandwhitephotos | oldphotographs | steamturbine | damaged | shipbuilding | repair | supports | broken | collided | marinesteamturbinecompany

License

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Turbinia - Wallsend

Description

A photograph showing 'Turbinia' in the dock at Wallsend, taken by W. Parry in 1907. She had been damaged during the launching of a ship at Robert Stephenson's shipyard on the other side of the Tyne. The damage is visible on Turbinia's side. This was repaired in time to steam alongside the liner 'Mauretania' when she was launched later that year. Reference: TWCMS: 2003.423 (Copyright) We're happy for you to share this digital image within the spirit of The Commons. Please cite 'Tyne & Wear Archives & Museums' when reusing. Certain restrictions on high quality reproductions and commercial use of the original physical version apply though; if you're unsure - for image licensing enquiries please follow this link www.twmuseums.org.uk/image-licensing/

Subjects

turbinia | wallsend | parry | 1907 | launching | robertstephenson | steam | mauretania | ship | shipyard | boat | navy | officers | construction | marine | sea | museum | newcastle | twam | tyneandwear | tyneandweararchivesandmuseums | northeast | blackandwhitephotos | oldphotographs | sepiaphotograph | shipbuilders | dock | digitalimage | wparry | damaged | structure | vessel | timber | floor | deck | ladder | platform | tyne | side | repairs | newcastleupontyne | northeastofengland | unitedkingdom | maritimeheritage | unsual | fascinating | industry | doorway | building | window | wall | roof | slope | stone | debris | crane | grain | mark | hook | pile | logs | stairs | rail | rope | puddle | reflection | post | cylinder | cabin | vent | pipe | visitors | people | blur | signage

License

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13.400 Introduction to Naval Architecture (MIT)

Description

This course is an introduction to principles of naval architecture, ship geometry, hydrostatics, calculation and drawing of curves of form. It also explores concepts of  intact and damaged stability, hull structure strength calculations and ship resistance. Projects include analysis of ship lines drawings and ship model testing.

Subjects

elementary principles of Naval Architecture | naval architecture tools | ship geometry | hydrostatics | calculation | drawing | curves of form | intact and damaged stability | hull structure strength calculations | ship resistance | ship model testing | 2.701

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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2.701 Introduction to Naval Architecture (13.400) (MIT)

Description

This course is an introduction to principles of naval architecture, ship geometry, hydrostatics, calculation and drawing of curves of form. It also explores concepts of  intact and damaged stability, hull structure strength calculations and ship resistance. Projects include analysis of ship lines drawings and ship model testing. This course was originally offered in Course 13 (Department of Ocean Engineering) as 13.400. In 2005, ocean engineering subjects became part of Course 2 (Department of Mechanical Engineering), and this course was renumbered 2.701.

Subjects

elementary principles of Naval Architecture | naval architecture tools | ship geometry | hydrostatics | calculation | drawing | curves of form | intact and damaged stability | hull structure strength calculations | ship resistance | ship model testing | 13.400

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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