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Glenn on Middeck Glenn on Middeck

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osteoporsisexperimentinorbitosteomiddeckjohnglennsts95 | osteoporsisexperimentinorbitosteomiddeckjohnglennsts95 | osteoporsisexperimentinorbitosteomiddeckjohnglennsts95discovery | osteoporsisexperimentinorbitosteomiddeckjohnglennsts95discovery

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STS-53 STS-53

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1992 | 1992 | discovery | discovery | december2 | december2 | davidwalker | davidwalker | december9 | december9 | michaelclifford | michaelclifford | guionbluford | guionbluford | sts53 | sts53 | robertcabana | robertcabana | jamesvoss | jamesvoss

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Glenn Photographs from the Flight Deck Glenn Photographs from the Flight Deck

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sts95discoveryjohnglennflightdeck | sts95discoveryjohnglennflightdeck

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STS-41 STS-41

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discovery | discovery | spaceshuttle | spaceshuttle | rocket | rocket | launch | launch

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STS-33 STS-33

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spaceshuttle | spaceshuttle | launch | launch | discovery | discovery | night | night | shuttle | shuttle

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Drug Discovery

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Professor Chas Bountra explains how new drugs can offer novel treatments for neurodegenerative and gastrointestinal diseases, as well as pain disorders. Professor Chas Bountra is interested in identifying and validating target proteins for drug discovery. Various technologies and strategies have allowed him to progress promising clinical candidates into Phase I, II, III studies, and to market. Drug candidates are first selected by screening compounds capable of binding to a target protein. Those compounds are then tested in various assay systems, healthy volunteers and finally in patients. Academic research excels at defining good target proteins. Pharmaceutical companies then facilitate the transition from basic research to clinical trials, producing new therapies for patients. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

Medicine | drug discovery | target validation | structural biology | disease | Medicine | drug discovery | target validation | structural biology | disease

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http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Chemistry, epigenetics and drugs

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Alteration of gene expression is fundamental to many diseases. A better understanding of how epigenetic proteins affect diseases provides a starting point for therapy development and the discovery of new drug. Professor Paul Brennan research focusses on epigenetics: the mechanisms that control gene expression. He studies how chemical probes interfere with epigenetic enyzmes that can be targeted to treat various diseases. Epigenetics combined with disease biology will ultimately accelerate drug discovery. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

gene expression | Epigenetics | proteins | drug discovery | enzymes | gene expression | Epigenetics | proteins | drug discovery | enzymes

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Chemistry, epigenetics and drugs

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Alteration of gene expression is fundamental to many diseases. A better understanding of how epigenetic proteins affect diseases provides a starting point for therapy development and the discovery of new drug. Professor Paul Brennan research focusses on epigenetics: the mechanisms that control gene expression. He studies how chemical probes interfere with epigenetic enyzmes that can be targeted to treat various diseases. Epigenetics combined with disease biology will ultimately accelerate drug discovery. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

gene expression | Epigenetics | proteins | drug discovery | enzymes | gene expression | Epigenetics | proteins | drug discovery | enzymes

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Seven FLATs at STS-63 Launch Seven FLATs at STS-63 Launch

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flats | flats | funk | funk | cobb | cobb | kennedyspacecenter | kennedyspacecenter | ksc | ksc | cagle | cagle | steadman | steadman | ratley | ratley | jessen | jessen | eileencollins | eileencollins | launchpad39b | launchpad39b | firstladyastronauttrainees | firstladyastronauttrainees | mercury13 | mercury13 | sts63discovery | sts63discovery | truhill | truhill

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9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT) 9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT)

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This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. The class focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); it also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation, and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems they control. This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. The class focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); it also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation, and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems they control.

Subjects

neurotransmission | neurotransmission | nerve terminals | nerve terminals | monoamine transmitters | monoamine transmitters | acetylcholine | acetylcholine | serotonin | serotonin | dopamine | dopamine | norepinephrine | norepinephrine | amino acid and peptide transmitters | amino acid and peptide transmitters | neuromodulators | neuromodulators | adenosine | adenosine | neurotransmitter synthesis | neurotransmitter synthesis | release | release | inactivation | inactivation | receptor-mediated | receptor-mediated | second-messenger | second-messenger | neurotransmitter | neurotransmitter | antidepressant | antidepressant | brain lipid | brain lipid | blood brain barrier | blood brain barrier | parkinson's disease | parkinson's disease | seratonin | seratonin | depression | depression | glutamate | glutamate | aspartate | aspartate | NDMA | NDMA | drug | drug | drug discovery | drug discovery | pharmaceutical | pharmaceutical | signaling pathway | signaling pathway | receptor | receptor | spinal cord | spinal cord | marijuana | marijuana | adensosine | adensosine | histamine | histamine

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Kathryn Sullivan Kathryn Sullivan

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astronaut | astronaut | kathrynsullivan | kathrynsullivan | atlantis | atlantis | challenger | challenger | discovery | discovery

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STS-51I STS-51I

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1985 | 1985 | discovery | discovery | september3 | september3 | august27 | august27 | joeengle | joeengle | williamfisher | williamfisher | johnlounge | johnlounge | jamesvanhoften | jamesvanhoften | richardcovey | richardcovey

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STS.003 The Rise of Modern Science (MIT) STS.003 The Rise of Modern Science (MIT)

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This course studies the development of modern science from the seventeenth century to the present, focusing on Europe and the United States. Key questions include: What is science, and how is it done? How are discoveries made and accepted? What is the nature of scientific progress? What is the impact of science on society? What is the impact of society on science? Topics will be drawn from the histories of physics, chemistry, biology, psychology, and medicine.AcknowledgementThis class is based on the one originally designed and taught by Prof. David Jones. His Spring 2005 version can be viewed by following the link under Archived Courses on the right side of this page. This course studies the development of modern science from the seventeenth century to the present, focusing on Europe and the United States. Key questions include: What is science, and how is it done? How are discoveries made and accepted? What is the nature of scientific progress? What is the impact of science on society? What is the impact of society on science? Topics will be drawn from the histories of physics, chemistry, biology, psychology, and medicine.AcknowledgementThis class is based on the one originally designed and taught by Prof. David Jones. His Spring 2005 version can be viewed by following the link under Archived Courses on the right side of this page.

Subjects

technology; | technology; | technology | technology | society | society | modern | modern | seventeenth century | seventeenth century | present | present | discovery | discovery | progress | progress | history | history | physics | physics | chemistry | chemistry | biology | biology | genetics | genetics | geology | geology | medicine | medicine | psychology | psychology | computer science | computer science | race | race | ethics | ethics | scientific revolution | scientific revolution | warfare | warfare | evolution | evolution | Freud | Freud | Einstein | Einstein | Darwin | Darwin | experiment | experiment | eugenics | eugenics | technology and society | technology and society | policy | policy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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STS-51D STS-51D

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1985 | 1985 | discovery | discovery | april12 | april12 | april19 | april19 | davidgriggs | davidgriggs | charleswalker | charleswalker | donaldwilliams | donaldwilliams | sts51d | sts51d | jakegarn | jakegarn | karolbobko | karolbobko | rheaseddon | rheaseddon | jefferyhoffman | jefferyhoffman

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Sunlight over Earth as seen by STS-29 crew Sunlight over Earth as seen by STS-29 crew

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cloud | cloud | discovery | discovery | sts29 | sts29 | earthobservations | earthobservations

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STS-70 STS-70

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1995 | 1995 | discovery | discovery | maryweber | maryweber | july13 | july13 | july22 | july22 | donaldthomas | donaldthomas | sts70 | sts70 | nancycurrie | nancycurrie | kevinkregel | kevinkregel | terencehenricks | terencehenricks

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Kathryn Sullivan Kathryn Sullivan

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kathrynsullivan | kathrynsullivan | astronaut | astronaut | atlantis | atlantis | discovery | discovery | challenger | challenger

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The STS-26 Return to Flight Crew The STS-26 Return to Flight Crew

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georgenelson | georgenelson | discovery | discovery | sts26 | sts26 | frederickhauck | frederickhauck | mikelounge | mikelounge | davidhilmers | davidhilmers | richardcovey | richardcovey

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STS-82 STS-82

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1997 | 1997 | discovery | discovery | spaceshuttle | spaceshuttle | missionpatch | missionpatch | february11 | february11 | hst | hst | february21 | february21 | marklee | marklee | hubblespacetelescope | hubblespacetelescope | stevensmith | stevensmith | josephtanner | josephtanner | scotthorowitz | scotthorowitz | stevenhawley | stevenhawley | sts82 | sts82 | kennethbowersox | kennethbowersox | gregoryharbaugh | gregoryharbaugh

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STS-82 Rollout STS-82 Rollout

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discovery | discovery | rollout | rollout | sts82 | sts82

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7.345 The War on Superbugs: Antibiotic Development and the Emergence of Drug-Resistant Bacteria (MIT) 7.345 The War on Superbugs: Antibiotic Development and the Emergence of Drug-Resistant Bacteria (MIT)

Description

Bacteria and fungi have produced antibiotics, small molecules that can prevent the growth of or kill bacteria by inhibiting essential biological pathways, as a defense mechanism long before humans walked the earth. The discovery of antibiotics and their implementation in the clinic radically changed modern medicine, saving countless lives by treating infections that were once difficult to cure, such as syphilis, strep throat and tuberculosis. During this course, we will cover many aspects of antibiotics including techniques used to discover these inhibitors, their mode of action and use in medicine. For example, we will learn about the techniques used to discover antibiotics, such as penicillin and vancomycin. We will discuss antibiotic-resistant bacteria and the molecular mechanisms under Bacteria and fungi have produced antibiotics, small molecules that can prevent the growth of or kill bacteria by inhibiting essential biological pathways, as a defense mechanism long before humans walked the earth. The discovery of antibiotics and their implementation in the clinic radically changed modern medicine, saving countless lives by treating infections that were once difficult to cure, such as syphilis, strep throat and tuberculosis. During this course, we will cover many aspects of antibiotics including techniques used to discover these inhibitors, their mode of action and use in medicine. For example, we will learn about the techniques used to discover antibiotics, such as penicillin and vancomycin. We will discuss antibiotic-resistant bacteria and the molecular mechanisms under

Subjects

superbugs | superbugs | antibiotics | antibiotics | drug-resistance | drug-resistance | bacteria | bacteria | infection | infection | penicillin | penicillin | drug discovery | drug discovery | vancomycin | vancomycin

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Standing on the Edge of the Bay Standing on the Edge of the Bay

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eva | eva | discovery | discovery | hst | hst | spacewalk | spacewalk | pfr | pfr | hubblespacetelescope | hubblespacetelescope | jamesnewman | jamesnewman | extravehicularactivity | extravehicularactivity | sts51 | sts51 | portablefootrestraint | portablefootrestraint

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Moon Framed Moon Framed

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moon | moon | discovery | discovery | sts95 | sts95 | omspod | omspod | orbitalmaneuveringsystem | orbitalmaneuveringsystem

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STS-64 STS-64

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1994 | 1994 | discovery | discovery | marklee | marklee | carlmeade | carlmeade | september30 | september30 | susanhelms | susanhelms | september9 | september9 | richardrichards | richardrichards | jerrylinenger | jerrylinenger | sts64 | sts64 | blainehammond | blainehammond

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Karen Nyberg Karen Nyberg

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karennyberg | karennyberg | astronaut | astronaut | discovery | discovery

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