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20.201 Mechanisms of Drug Actions (MIT) 20.201 Mechanisms of Drug Actions (MIT)

Description

This course addresses the scientific basis for the development of new drugs. The first half of the semester begins with an overview of the drug discovery process, followed by fundamental principles of pharmacokinetics, pharmacodynamics, metabolism, and the mechanisms by which drugs cause therapeutic and toxic responses. The second half of the semester applies those principles to case studies and literature discussions of current problems with specific drugs, drug classes, and therapeutic targets. This course addresses the scientific basis for the development of new drugs. The first half of the semester begins with an overview of the drug discovery process, followed by fundamental principles of pharmacokinetics, pharmacodynamics, metabolism, and the mechanisms by which drugs cause therapeutic and toxic responses. The second half of the semester applies those principles to case studies and literature discussions of current problems with specific drugs, drug classes, and therapeutic targets.

Subjects

drugs | drugs | medicine | medicine | pharmaceutical | pharmaceutical | pharmacology | pharmacology | toxicology | toxicology | drug actions | drug actions | therapeutics | therapeutics | histology | histology | pathophysiology | pathophysiology | drug therapy | drug therapy | drug transporters | drug transporters | drug metabolism | drug metabolism | drug toxicity | drug toxicity | drug development | drug development | uptake | uptake | transport | transport | case study | case study | biochemistry | biochemistry | Pharmacokinetics | Pharmacokinetics | Pharmacogenetics | Pharmacogenetics | Omeprazole | Omeprazole | antibiotics | antibiotics | Oncology | Oncology | Statins | Statins | Sarilumab | Sarilumab | cystic fibrosis | cystic fibrosis

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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10.547J Principles and Practice of Drug Development (MIT) 10.547J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate. This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

pharmaceutical | pharmaceutical | biopharmaceutical | biopharmaceutical | drug discovery | drug discovery | preclinical development | preclinical development | clinical investigation | clinical investigation | major issues of developing drugs | major issues of developing drugs | major stages of developing drugs | major stages of developing drugs | manufacturing issues | manufacturing issues | regulatory issues | regulatory issues | economic considerations of drug development process | economic considerations of drug development process | financial considerations of drug development process | financial considerations of drug development process | clinical perspective | clinical perspective | life sciences perspective on drug development | life sciences perspective on drug development | management sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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15.136J Principles and Practice of Drug Development (MIT) 15.136J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate. This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

15.136 | 15.136 | 7.547 | 7.547 | 10.547 | 10.547 | ESD.691 | ESD.691 | HST.920 | HST.920 | pharmaceutical | pharmaceutical | biopharmaceutical | biopharmaceutical | drug discovery | drug discovery | preclinical development | preclinical development | clinical investigation | clinical investigation | major issues of developing drugs | major issues of developing drugs | major stages of developing drugs | major stages of developing drugs | manufacturing issues | manufacturing issues | regulatory issues | regulatory issues | economic considerations of drug development process | economic considerations of drug development process | financial considerations of drug development process | financial considerations of drug development process | clinical perspective | clinical perspective | life sciences perspective on drug development | life sciences perspective on drug development | management sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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9.98 Neuropharmacology (MIT) 9.98 Neuropharmacology (MIT)

Description

The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology. This course is offered during the Independent Activities Period (IAP), which is a special 4-week term at MIT that runs from the first week of January until the end of the month. The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology. This course is offered during the Independent Activities Period (IAP), which is a special 4-week term at MIT that runs from the first week of January until the end of the month.

Subjects

antidepressant | antidepressant | psychopharmacology | psychopharmacology | neurology | neurology | neuroscience | neuroscience | pharmacology | pharmacology | synapse | synapse | seratonin | seratonin | drug | drug | disposition | disposition | tolerance | tolerance | physical dependence model | physical dependence model | depot binding | depot binding | classic antipsychotic drugs | classic antipsychotic drugs | experimental substance use | experimental substance use | anabolic steroid dependence | anabolic steroid dependence | biobehavioral effects | biobehavioral effects | positive reinforcement model | positive reinforcement model | phenethylamine hallucinogens | phenethylamine hallucinogens | discriminative stimulus effects | discriminative stimulus effects | nicotine reinforcement | nicotine reinforcement | somatodendritic autoreceptors | somatodendritic autoreceptors | selected brain areas | selected brain areas | many psychoactive drugs | many psychoactive drugs | terminal autoreceptors | terminal autoreceptors | abstinence signs | abstinence signs | motor side effects | motor side effects | drug reinforcement | drug reinforcement | other psychostimulants | other psychostimulants | postsynaptic cell | postsynaptic cell | nicotine tolerance | nicotine tolerance | abstinent smokers | abstinent smokers | behavioral tolerance | behavioral tolerance | chronic drug use | chronic drug use | susceptibility models | susceptibility models

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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20.201 Mechanisms of Drug Actions (MIT) 20.201 Mechanisms of Drug Actions (MIT)

Description

This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered. This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.

Subjects

pharmacology | pharmacology | toxicology | toxicology | drug actions | drug actions | therapeutics | therapeutics | histology | histology | pathophysiology | pathophysiology | drug therapy | drug therapy | drug transporters | drug transporters | drug metabolism | drug metabolism | drug toxicity | drug toxicity | drup development | drup development | uptake | uptake | transport | transport

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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20.462J Molecular Principles of Biomaterials (MIT) 20.462J Molecular Principles of Biomaterials (MIT)

Description

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces. This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Subjects

biomaterials | biomaterials | biomaterial engineering | biomaterial engineering | biotechnology | biotechnology | cell-guiding surface | cell-guiding surface | molecular biomaterials | molecular biomaterials | drug release | drug release | polymers | polymers | pulsatile release | pulsatile release | polymerization | polymerization | polyer erosion | polyer erosion | tissue engineering | tissue engineering | hydrogels | hydrogels | adhesion | adhesion | migration | migration | drug diffusion | drug diffusion | molecular switches | molecular switches | molecular motors | molecular motors | nanoparticles | nanoparticles | microparticles | microparticles | vaccines | vaccines | drug targeting | drug targeting | micro carriers | micro carriers | nano carriers | nano carriers | intracellular drug delivery | intracellular drug delivery | 20.462 | 20.462 | 3.962 | 3.962

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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15.136J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

15.136 | 7.547 | 10.547 | ESD.691 | HST.920 | pharmaceutical | biopharmaceutical | drug discovery | preclinical development | clinical investigation | major issues of developing drugs | major stages of developing drugs | manufacturing issues | regulatory issues | economic considerations of drug development process | financial considerations of drug development process | clinical perspective | life sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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10.547J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

pharmaceutical | biopharmaceutical | drug discovery | preclinical development | clinical investigation | major issues of developing drugs | major stages of developing drugs | manufacturing issues | regulatory issues | economic considerations of drug development process | financial considerations of drug development process | clinical perspective | life sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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20.201 Mechanisms of Drug Actions (MIT)

Description

This course addresses the scientific basis for the development of new drugs. The first half of the semester begins with an overview of the drug discovery process, followed by fundamental principles of pharmacokinetics, pharmacodynamics, metabolism, and the mechanisms by which drugs cause therapeutic and toxic responses. The second half of the semester applies those principles to case studies and literature discussions of current problems with specific drugs, drug classes, and therapeutic targets.

Subjects

drugs | medicine | pharmaceutical | pharmacology | toxicology | drug actions | therapeutics | histology | pathophysiology | drug therapy | drug transporters | drug metabolism | drug toxicity | drug development | uptake | transport | case study | biochemistry | Pharmacokinetics | Pharmacogenetics | Omeprazole | antibiotics | Oncology | Statins | Sarilumab | cystic fibrosis

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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10.547J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

pharmaceutical | biopharmaceutical | drug discovery | preclinical development | clinical investigation | major issues of developing drugs | major stages of developing drugs | manufacturing issues | regulatory issues | economic considerations of drug development process | financial considerations of drug development process | clinical perspective | life sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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10.547J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

pharmaceutical | biopharmaceutical | drug discovery | preclinical development | clinical investigation | major issues of developing drugs | major stages of developing drugs | manufacturing issues | regulatory issues | economic considerations of drug development process | financial considerations of drug development process | clinical perspective | life sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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STS.062J Drugs, Politics, and Culture (MIT) STS.062J Drugs, Politics, and Culture (MIT)

Description

This class examines the relationship between a number of mind-altering substances and cultural processes. We look at the relationship between drugs and such phenomena as poverty, religion, technology, inter-generational conflict, colonialism, and global capitalism. We read about the physiological and psychological effects of these substances -- ranging from alcohol to LSD, cocaine and ecstasy -- and ask why different societies prohibit and sanction different drugs. We examine the use of mind-altering substances in a number of "traditional" societies, and follow the development of a global trade in such substances as sugar, coffee, tea, nicotine, cocaine, and marijuana concurrent with the evolution of global capitalism. We look at the use of LSD as a mind-control substance by the CIA and This class examines the relationship between a number of mind-altering substances and cultural processes. We look at the relationship between drugs and such phenomena as poverty, religion, technology, inter-generational conflict, colonialism, and global capitalism. We read about the physiological and psychological effects of these substances -- ranging from alcohol to LSD, cocaine and ecstasy -- and ask why different societies prohibit and sanction different drugs. We examine the use of mind-altering substances in a number of "traditional" societies, and follow the development of a global trade in such substances as sugar, coffee, tea, nicotine, cocaine, and marijuana concurrent with the evolution of global capitalism. We look at the use of LSD as a mind-control substance by the CIA and

Subjects

drugs | drugs | politics | politics | society | society | cross-cultural perspective | cross-cultural perspective | mind-altering substances | mind-altering substances | habit-forming substances | habit-forming substances | global trade | global trade | sugar | sugar | opium | opium | cocaine | cocaine | capitalism | capitalism | alcohol | alcohol | alcohol abuse | alcohol abuse | LSD | LSD | Prozac | Prozac | war on drugs | war on drugs | tobacco | tobacco | drug laws. | drug laws. | STS.062 | STS.062 | 21A.344 | 21A.344

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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STS.062J Drugs, Politics, and Culture (MIT) STS.062J Drugs, Politics, and Culture (MIT)

Description

Examines the relationship between drugs, politics, and society in cross-cultural perspective; use of mind-altering and habit-forming substances by "traditional societies"; the development of a global trade in sugar, opium, and cocaine with the rise of capitalism; and the use and abuse of alcohol, LSD, and Prozac in the US. Finishes by looking at the war on drugs, shifting attitudes to tobacco, and by evaluating America's drug laws. Examines the relationship between drugs, politics, and society in cross-cultural perspective; use of mind-altering and habit-forming substances by "traditional societies"; the development of a global trade in sugar, opium, and cocaine with the rise of capitalism; and the use and abuse of alcohol, LSD, and Prozac in the US. Finishes by looking at the war on drugs, shifting attitudes to tobacco, and by evaluating America's drug laws.

Subjects

drugs | drugs | politics | politics | society | society | cross-cultural perspective | cross-cultural perspective | mind-altering substances | mind-altering substances | habit-forming substances | habit-forming substances | global trade | global trade | sugar | sugar | opium | opium | cocaine | cocaine | capitalism | capitalism | alcohol | alcohol | alcohol abuse | alcohol abuse | LSD | LSD | Prozac | Prozac | war on drugs | war on drugs | tobacco | tobacco | drug laws | drug laws | STS.062 | STS.062 | 21A.344 | 21A.344

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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20.453J Biomedical Information Technology (MIT) 20.453J Biomedical Information Technology (MIT)

Description

This course teaches the design of contemporary information systems for biological and medical data. Examples are chosen from biology and medicine to illustrate complete life cycle information systems, beginning with data acquisition, following to data storage and finally to retrieval and analysis. Design of appropriate databases, client-server strategies, data interchange protocols, and computational modeling architectures. Students are expected to have some familiarity with scientific application software and a basic understanding of at least one contemporary programming language (e.g. C, C++, Java, Lisp, Perl, Python). A major term project is required of all students. This subject is open to motivated seniors having a strong interest in biomedical engineering and information system desig This course teaches the design of contemporary information systems for biological and medical data. Examples are chosen from biology and medicine to illustrate complete life cycle information systems, beginning with data acquisition, following to data storage and finally to retrieval and analysis. Design of appropriate databases, client-server strategies, data interchange protocols, and computational modeling architectures. Students are expected to have some familiarity with scientific application software and a basic understanding of at least one contemporary programming language (e.g. C, C++, Java, Lisp, Perl, Python). A major term project is required of all students. This subject is open to motivated seniors having a strong interest in biomedical engineering and information system desig

Subjects

20.453 | 20.453 | 2.771 | 2.771 | HST.958 | HST.958 | imaging | imaging | medical imaging | medical imaging | metadata | metadata | molecular biology | molecular biology | medical records | medical records | DICOM | DICOM | RDF | RDF | OWL | OWL | SPARQL | SPARQL | SBML | SBML | CellML | CellML | semantic web | semantic web | BioHaystack | BioHaystack | database | database | schema | schema | ExperiBase | ExperiBase | genomics | genomics | proteomics | proteomics | bioinformatics | bioinformatics | computational biology | computational biology | clinical decision support | clinical decision support | clinical trial | clinical trial | microarray | microarray | gel electrophoresis | gel electrophoresis | diagnosis | diagnosis | pathway modeling | pathway modeling | XML | XML | SQL | SQL | relational database | relational database | biological data | biological data | ontologies | ontologies | drug development | drug development | drug discovery | drug discovery | drug target | drug target | pharmaceutical | pharmaceutical | gene sequencing | gene sequencing

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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9.98 Neuropharmacology (MIT)

Description

The neuropharmacology course will discuss the drug-induced changes in functioning of the nervous system. The specific focus of this course will be to provide a description of the cellular and molecular actions of drugs on synaptic transmission. This course will also refer to specific diseases of the nervous system and their treatment in addition to giving an overview of the techniques used for the study of neuropharmacology. This course is offered during the Independent Activities Period (IAP), which is a special 4-week term at MIT that runs from the first week of January until the end of the month.

Subjects

antidepressant | psychopharmacology | neurology | neuroscience | pharmacology | synapse | seratonin | drug | disposition | tolerance | physical dependence model | depot binding | classic antipsychotic drugs | experimental substance use | anabolic steroid dependence | biobehavioral effects | positive reinforcement model | phenethylamine hallucinogens | discriminative stimulus effects | nicotine reinforcement | somatodendritic autoreceptors | selected brain areas | many psychoactive drugs | terminal autoreceptors | abstinence signs | motor side effects | drug reinforcement | other psychostimulants | postsynaptic cell | nicotine tolerance | abstinent smokers | behavioral tolerance | chronic drug use | susceptibility models

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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20.201 Mechanisms of Drug Actions (MIT)

Description

This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.

Subjects

pharmacology | toxicology | drug actions | therapeutics | histology | pathophysiology | drug therapy | drug transporters | drug metabolism | drug toxicity | drup development | uptake | transport

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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20.201 Mechanisms of Drug Actions (MIT)

Description

This course covers the chemical and biological analysis of the metabolism and distribution of drugs, toxins and chemicals in animals and humans, and the mechanism by which they cause therapeutic and toxic responses. Metabolism and toxicity as a basis for drug development is also covered.

Subjects

pharmacology | toxicology | drug actions | therapeutics | histology | pathophysiology | drug therapy | drug transporters | drug metabolism | drug toxicity | drup development | uptake | transport

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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Drug development process: combating pain

Description

Subjects

Health | Technology | Chemistry | drug discovery | drug development | anti-inflammatory drug development | medicinal chemistry | molecular modelling in drug design | S827_1

License

Except for third party materials and otherwise stated in the acknowledgement section (see our terms and conditions http://www.open.ac.uk/conditions) this content is made available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Licence. - http://creativecommons.org/licenses/by-nc-sa/4.0 Except for third party materials and otherwise stated in the acknowledgement section (see our terms and conditions http://www.open.ac.uk/conditions) this content is made available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Licence. - http://creativecommons.org/licenses/by-nc-sa/4.0

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9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT) 9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT)

Description

This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. The class focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); it also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation, and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems they control. This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. The class focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); it also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation, and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems they control.

Subjects

neurotransmission | neurotransmission | nerve terminals | nerve terminals | monoamine transmitters | monoamine transmitters | acetylcholine | acetylcholine | serotonin | serotonin | dopamine | dopamine | norepinephrine | norepinephrine | amino acid and peptide transmitters | amino acid and peptide transmitters | neuromodulators | neuromodulators | adenosine | adenosine | neurotransmitter synthesis | neurotransmitter synthesis | release | release | inactivation | inactivation | receptor-mediated | receptor-mediated | second-messenger | second-messenger | neurotransmitter | neurotransmitter | antidepressant | antidepressant | brain lipid | brain lipid | blood brain barrier | blood brain barrier | parkinson's disease | parkinson's disease | seratonin | seratonin | depression | depression | glutamate | glutamate | aspartate | aspartate | NDMA | NDMA | drug | drug | drug discovery | drug discovery | pharmaceutical | pharmaceutical | signaling pathway | signaling pathway | receptor | receptor | spinal cord | spinal cord | marijuana | marijuana | adensosine | adensosine | histamine | histamine

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.345 The War on Superbugs: Antibiotic Development and the Emergence of Drug-Resistant Bacteria (MIT) 7.345 The War on Superbugs: Antibiotic Development and the Emergence of Drug-Resistant Bacteria (MIT)

Description

Bacteria and fungi have produced antibiotics, small molecules that can prevent the growth of or kill bacteria by inhibiting essential biological pathways, as a defense mechanism long before humans walked the earth. The discovery of antibiotics and their implementation in the clinic radically changed modern medicine, saving countless lives by treating infections that were once difficult to cure, such as syphilis, strep throat and tuberculosis. During this course, we will cover many aspects of antibiotics including techniques used to discover these inhibitors, their mode of action and use in medicine. For example, we will learn about the techniques used to discover antibiotics, such as penicillin and vancomycin. We will discuss antibiotic-resistant bacteria and the molecular mechanisms under Bacteria and fungi have produced antibiotics, small molecules that can prevent the growth of or kill bacteria by inhibiting essential biological pathways, as a defense mechanism long before humans walked the earth. The discovery of antibiotics and their implementation in the clinic radically changed modern medicine, saving countless lives by treating infections that were once difficult to cure, such as syphilis, strep throat and tuberculosis. During this course, we will cover many aspects of antibiotics including techniques used to discover these inhibitors, their mode of action and use in medicine. For example, we will learn about the techniques used to discover antibiotics, such as penicillin and vancomycin. We will discuss antibiotic-resistant bacteria and the molecular mechanisms under

Subjects

superbugs | superbugs | antibiotics | antibiotics | drug-resistance | drug-resistance | bacteria | bacteria | infection | infection | penicillin | penicillin | drug discovery | drug discovery | vancomycin | vancomycin

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9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT) 9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT)

Description

This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. We focus on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); we also examine amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. The involvement of particular neurotransmitters in human diseases is considered. This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. We focus on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); we also examine amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. The involvement of particular neurotransmitters in human diseases is considered.

Subjects

Neurotransmitter | Neurotransmitter | antidepressant | antidepressant | brain lipid | brain lipid | blood brain barrier | blood brain barrier | dopamine | dopamine | parkinson's disease | parkinson's disease | serotonin | serotonin | depression | depression | glutamate | glutamate | aspartate | aspartate | NDMA | NDMA | drug | drug | drug discovery | drug discovery | pharmaceutical | pharmaceutical | signaling pathway | signaling pathway | receptor | receptor | spinal cord | spinal cord | marijuana | marijuana | adensosine | adensosine | histamine. | histamine.

License

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ES.S10 Drugs and the Brain (MIT) ES.S10 Drugs and the Brain (MIT)

Description

This class is a multidisciplinary introduction to pharmacology, neurotransmitters, drug mechanisms, and brain diseases from addiction to schizophrenia. From Abilify® to Zyrtec®, the world is full of fascinating drugs. If you are poisoned by sarin nerve gas, you may be able to save your life by huffing some BZ nerve gas. This class will explain that chemical curiosity, along with a host of other interesting tidbits of pharmacology. The structure of the class interleaves basic concepts with specific examples and entertaining tangents, so it is not loaded with boring abstract theory. In the first class you will learn what a neurotransmitter is, and you will immediately apply that knowledge when we discuss the mechanism of caffeine. The class is highly multidisciplinary, including topi This class is a multidisciplinary introduction to pharmacology, neurotransmitters, drug mechanisms, and brain diseases from addiction to schizophrenia. From Abilify® to Zyrtec®, the world is full of fascinating drugs. If you are poisoned by sarin nerve gas, you may be able to save your life by huffing some BZ nerve gas. This class will explain that chemical curiosity, along with a host of other interesting tidbits of pharmacology. The structure of the class interleaves basic concepts with specific examples and entertaining tangents, so it is not loaded with boring abstract theory. In the first class you will learn what a neurotransmitter is, and you will immediately apply that knowledge when we discuss the mechanism of caffeine. The class is highly multidisciplinary, including topi

Subjects

brain | brain | drugs | drugs | pharmacology | pharmacology | neurotransmitters | neurotransmitters | drug mechanisms | drug mechanisms | brain disease | brain disease | addiction | addiction | schizophrenia | schizophrenia

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Drug development process: combating pain

Description

Subjects

Science | Chemistry | Health Sciences | drug discovery | drug development | anti-inflammatory drug development | medicinal chemistry | molecular modelling in drug design | S827_1

License

Except for third party materials and otherwise stated in the acknowledgement section (see our terms and conditions http://www.open.ac.uk/conditions) this content is made available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Licence. - http://creativecommons.org/licenses/by-nc-sa/4.0 Except for third party materials and otherwise stated in the acknowledgement section (see our terms and conditions http://www.open.ac.uk/conditions) this content is made available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Licence. - http://creativecommons.org/licenses/by-nc-sa/4.0

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3.051J Materials for Biomedical Applications (MIT) 3.051J Materials for Biomedical Applications (MIT)

Description

This course gives an introduction to the interactions between proteins, cells and surfaces of biomaterials. It includes surface chemistry and physics of selected metals, polymers and ceramics, modification of biomaterials surfaces, and surface characterization methodology; quantitative assays of cell behavior in culture and methods of statistical analysis; organ replacement therapies and acute and chronic response to implanted biomaterials. The course includes topics in biosensors, drug delivery and tissue engineering. This course gives an introduction to the interactions between proteins, cells and surfaces of biomaterials. It includes surface chemistry and physics of selected metals, polymers and ceramics, modification of biomaterials surfaces, and surface characterization methodology; quantitative assays of cell behavior in culture and methods of statistical analysis; organ replacement therapies and acute and chronic response to implanted biomaterials. The course includes topics in biosensors, drug delivery and tissue engineering.

Subjects

Interactions between proteins | Interactions between proteins | cells | cells | Surface chemistry and physics of metals | Surface chemistry and physics of metals | polymers and ceramics | polymers and ceramics | Surface characterization methodology | Surface characterization methodology | Quantitative assays of cell behavior | Quantitative assays of cell behavior | Organ replacement therapies | Organ replacement therapies | Acute and chronic response to implanted biomaterials | Acute and chronic response to implanted biomaterials | Biosensors | Biosensors | drug delivery and tissue engineering | drug delivery and tissue engineering | Interactions between proteins | cells | Interactions between proteins | cells | Surface chemistry and physics of metals | polymers and ceramics | Surface chemistry and physics of metals | polymers and ceramics | Biosensors | drug delivery and tissue engineering | Biosensors | drug delivery and tissue engineering | BE.340J | BE.340J | 3.051 | 3.051 | BE.340 | BE.340 | 20.340 | 20.340

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Artemisinin therapy for malaria by Professor Nick White

Description

Professor Nick White talks about the future of artemisinin and other drug therapies for malaria. Malaria kills more than half a million people every year. Following a number of groundbreaking clinical trials, Professor Nick White and his Thailand team successfully demonstrated the effectiveness of artemisinin drug therapy for malaria in adults, children and infants. He also pioneered artemisinin combination therapy, the first-line treatment for malaria worldwide. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

Global health | artemisinin | drug discovery | drug resistance | malaria | Global health | artemisinin | drug discovery | drug resistance | malaria

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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