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15.136J Principles and Practice of Drug Development (MIT) 15.136J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate. This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

15.136 | 15.136 | 7.547 | 7.547 | 10.547 | 10.547 | ESD.691 | ESD.691 | HST.920 | HST.920 | pharmaceutical | pharmaceutical | biopharmaceutical | biopharmaceutical | drug discovery | drug discovery | preclinical development | preclinical development | clinical investigation | clinical investigation | major issues of developing drugs | major issues of developing drugs | major stages of developing drugs | major stages of developing drugs | manufacturing issues | manufacturing issues | regulatory issues | regulatory issues | economic considerations of drug development process | economic considerations of drug development process | financial considerations of drug development process | financial considerations of drug development process | clinical perspective | clinical perspective | life sciences perspective on drug development | life sciences perspective on drug development | management sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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10.547J Principles and Practice of Drug Development (MIT) 10.547J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate. This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

pharmaceutical | pharmaceutical | biopharmaceutical | biopharmaceutical | drug discovery | drug discovery | preclinical development | preclinical development | clinical investigation | clinical investigation | major issues of developing drugs | major issues of developing drugs | major stages of developing drugs | major stages of developing drugs | manufacturing issues | manufacturing issues | regulatory issues | regulatory issues | economic considerations of drug development process | economic considerations of drug development process | financial considerations of drug development process | financial considerations of drug development process | clinical perspective | clinical perspective | life sciences perspective on drug development | life sciences perspective on drug development | management sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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10.547J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

pharmaceutical | biopharmaceutical | drug discovery | preclinical development | clinical investigation | major issues of developing drugs | major stages of developing drugs | manufacturing issues | regulatory issues | economic considerations of drug development process | financial considerations of drug development process | clinical perspective | life sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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10.547J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

pharmaceutical | biopharmaceutical | drug discovery | preclinical development | clinical investigation | major issues of developing drugs | major stages of developing drugs | manufacturing issues | regulatory issues | economic considerations of drug development process | financial considerations of drug development process | clinical perspective | life sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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10.547J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

pharmaceutical | biopharmaceutical | drug discovery | preclinical development | clinical investigation | major issues of developing drugs | major stages of developing drugs | manufacturing issues | regulatory issues | economic considerations of drug development process | financial considerations of drug development process | clinical perspective | life sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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15.136J Principles and Practice of Drug Development (MIT)

Description

This course serves as a description and critical assessment of the major issues and stages of developing a pharmaceutical or biopharmaceutical. Topics covered include drug discovery, preclinical development, clinical investigation, manufacturing and regulatory issues considered for small and large molecules, and economic and financial considerations of the drug development process. A multidisciplinary perspective is provided by the faculty, who represent clinical, life, and management sciences. Various industry guests also participate.

Subjects

15.136 | 7.547 | 10.547 | ESD.691 | HST.920 | pharmaceutical | biopharmaceutical | drug discovery | preclinical development | clinical investigation | major issues of developing drugs | major stages of developing drugs | manufacturing issues | regulatory issues | economic considerations of drug development process | financial considerations of drug development process | clinical perspective | life sciences perspective on drug development | management sciences perspective on drug development | pharmaceutical industry guests

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.343 Network Medicine: Using Systems Biology and Signaling Networks to Create Novel Cancer Therapeutics (MIT) 7.343 Network Medicine: Using Systems Biology and Signaling Networks to Create Novel Cancer Therapeutics (MIT)

Description

In this course, we will survey the primary systems biology literature, particularly as it pertains to understanding and treating various forms of cancer. We will consider various computational and experimental techniques being used in the field of systems biology, focusing on how systems principles have helped advance biological understanding. We will also discuss the application of the principles of systems biology and network biology to drug development, an emerging discipline called "network medicine." This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive sett In this course, we will survey the primary systems biology literature, particularly as it pertains to understanding and treating various forms of cancer. We will consider various computational and experimental techniques being used in the field of systems biology, focusing on how systems principles have helped advance biological understanding. We will also discuss the application of the principles of systems biology and network biology to drug development, an emerging discipline called "network medicine." This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive sett

Subjects

systems biology | systems biology | network medicine | network medicine | cancer | cancer | cancer therapeutics | cancer therapeutics | quantitative high-throughput data acquisition | quantitative high-throughput data acquisition | genomic analysis | genomic analysis | signaling network biology | signaling network biology | statistical/computational modeling | statistical/computational modeling | network biology | network biology | drug development | drug development

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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20.453J Biomedical Information Technology (MIT) 20.453J Biomedical Information Technology (MIT)

Description

This course teaches the design of contemporary information systems for biological and medical data. Examples are chosen from biology and medicine to illustrate complete life cycle information systems, beginning with data acquisition, following to data storage and finally to retrieval and analysis. Design of appropriate databases, client-server strategies, data interchange protocols, and computational modeling architectures. Students are expected to have some familiarity with scientific application software and a basic understanding of at least one contemporary programming language (e.g. C, C++, Java, Lisp, Perl, Python). A major term project is required of all students. This subject is open to motivated seniors having a strong interest in biomedical engineering and information system desig This course teaches the design of contemporary information systems for biological and medical data. Examples are chosen from biology and medicine to illustrate complete life cycle information systems, beginning with data acquisition, following to data storage and finally to retrieval and analysis. Design of appropriate databases, client-server strategies, data interchange protocols, and computational modeling architectures. Students are expected to have some familiarity with scientific application software and a basic understanding of at least one contemporary programming language (e.g. C, C++, Java, Lisp, Perl, Python). A major term project is required of all students. This subject is open to motivated seniors having a strong interest in biomedical engineering and information system desig

Subjects

20.453 | 20.453 | 2.771 | 2.771 | HST.958 | HST.958 | imaging | imaging | medical imaging | medical imaging | metadata | metadata | molecular biology | molecular biology | medical records | medical records | DICOM | DICOM | RDF | RDF | OWL | OWL | SPARQL | SPARQL | SBML | SBML | CellML | CellML | semantic web | semantic web | BioHaystack | BioHaystack | database | database | schema | schema | ExperiBase | ExperiBase | genomics | genomics | proteomics | proteomics | bioinformatics | bioinformatics | computational biology | computational biology | clinical decision support | clinical decision support | clinical trial | clinical trial | microarray | microarray | gel electrophoresis | gel electrophoresis | diagnosis | diagnosis | pathway modeling | pathway modeling | XML | XML | SQL | SQL | relational database | relational database | biological data | biological data | ontologies | ontologies | drug development | drug development | drug discovery | drug discovery | drug target | drug target | pharmaceutical | pharmaceutical | gene sequencing | gene sequencing

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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20.201 Mechanisms of Drug Actions (MIT) 20.201 Mechanisms of Drug Actions (MIT)

Description

This course addresses the scientific basis for the development of new drugs. The first half of the semester begins with an overview of the drug discovery process, followed by fundamental principles of pharmacokinetics, pharmacodynamics, metabolism, and the mechanisms by which drugs cause therapeutic and toxic responses. The second half of the semester applies those principles to case studies and literature discussions of current problems with specific drugs, drug classes, and therapeutic targets. This course addresses the scientific basis for the development of new drugs. The first half of the semester begins with an overview of the drug discovery process, followed by fundamental principles of pharmacokinetics, pharmacodynamics, metabolism, and the mechanisms by which drugs cause therapeutic and toxic responses. The second half of the semester applies those principles to case studies and literature discussions of current problems with specific drugs, drug classes, and therapeutic targets.

Subjects

drugs | drugs | medicine | medicine | pharmaceutical | pharmaceutical | pharmacology | pharmacology | toxicology | toxicology | drug actions | drug actions | therapeutics | therapeutics | histology | histology | pathophysiology | pathophysiology | drug therapy | drug therapy | drug transporters | drug transporters | drug metabolism | drug metabolism | drug toxicity | drug toxicity | drug development | drug development | uptake | uptake | transport | transport | case study | case study | biochemistry | biochemistry | Pharmacokinetics | Pharmacokinetics | Pharmacogenetics | Pharmacogenetics | Omeprazole | Omeprazole | antibiotics | antibiotics | Oncology | Oncology | Statins | Statins | Sarilumab | Sarilumab | cystic fibrosis | cystic fibrosis

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Drug development process: combating pain

Description

Drug development process: combating pain, is a free course offering a brief introduction to the process of new drug discovery; from identification of a suitable candidate drug molecule to the development of a commercial drug product available in the clinic for pain relief or as an anti-inflammatory. First published on Wed, 16 Aug 2017 as Drug development process: combating pain. To find out more visit The Open University's Openlearn website. Creative-Commons 2017

Subjects

Health | Science | Maths & Technology | Chemistry | drug discovery | drug development | anti-inflammatory drug development | medicinal chemistry | molecular modelling in drug design | S827_1

License

Licensed under a Creative Commons Attribution - NonCommercial-ShareAlike 2.0 Licence - see http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Drug development process: combating pain

Description

Subjects

Science | Chemistry | Health Sciences | drug discovery | drug development | anti-inflammatory drug development | medicinal chemistry | molecular modelling in drug design | S827_1

License

Except for third party materials and otherwise stated in the acknowledgement section (see our terms and conditions http://www.open.ac.uk/conditions) this content is made available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Licence. - http://creativecommons.org/licenses/by-nc-sa/4.0 Except for third party materials and otherwise stated in the acknowledgement section (see our terms and conditions http://www.open.ac.uk/conditions) this content is made available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Licence. - http://creativecommons.org/licenses/by-nc-sa/4.0

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From information to structure

Description

Dr Brian Marsden aims to make structural and chemical biology data accessible to non-experts, by providing computational resources including data management, sample tracking, in silico modelling support plus provision of public access to SGC data. Protein structures are powerful tools in the development of medical drugs, but they are not very accessible to non-specialists. Research informatics presents these structures more simply and interactively, and helps scientists make decisions. This will hopefully accelerate the development of new medicines. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

protein | structural | chemical | biology | drug development | informatics | protein | structural | chemical | biology | drug development | informatics

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Drug development process: combating pain

Description

Subjects

Health | Technology | Chemistry | drug discovery | drug development | anti-inflammatory drug development | medicinal chemistry | molecular modelling in drug design | S827_1

License

Except for third party materials and otherwise stated in the acknowledgement section (see our terms and conditions http://www.open.ac.uk/conditions) this content is made available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Licence. - http://creativecommons.org/licenses/by-nc-sa/4.0 Except for third party materials and otherwise stated in the acknowledgement section (see our terms and conditions http://www.open.ac.uk/conditions) this content is made available under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 Licence. - http://creativecommons.org/licenses/by-nc-sa/4.0

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Curated collection of Pharmacology resources

Description

This is an evaluated collection of links to resources for learning and teaching subjects relating to Pharmacology. This forms part of the UK Centre for Bioscience OeRBITAL project.

Subjects

ukoer | pharmacology | oerbital | autonomic pharmacology | cardiovascular pharmacology | clinical pharmacology and therapeutics | drug development | experimental preparations and techniques | pharmacogenomics | pharmacological principles | pharmacology podcasts | Biological sciences | C000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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7.343 Network Medicine: Using Systems Biology and Signaling Networks to Create Novel Cancer Therapeutics (MIT)

Description

In this course, we will survey the primary systems biology literature, particularly as it pertains to understanding and treating various forms of cancer. We will consider various computational and experimental techniques being used in the field of systems biology, focusing on how systems principles have helped advance biological understanding. We will also discuss the application of the principles of systems biology and network biology to drug development, an emerging discipline called "network medicine." This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive sett

Subjects

systems biology | network medicine | cancer | cancer therapeutics | quantitative high-throughput data acquisition | genomic analysis | signaling network biology | statistical/computational modeling | network biology | drug development

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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20.201 Mechanisms of Drug Actions (MIT)

Description

This course addresses the scientific basis for the development of new drugs. The first half of the semester begins with an overview of the drug discovery process, followed by fundamental principles of pharmacokinetics, pharmacodynamics, metabolism, and the mechanisms by which drugs cause therapeutic and toxic responses. The second half of the semester applies those principles to case studies and literature discussions of current problems with specific drugs, drug classes, and therapeutic targets.

Subjects

drugs | medicine | pharmaceutical | pharmacology | toxicology | drug actions | therapeutics | histology | pathophysiology | drug therapy | drug transporters | drug metabolism | drug toxicity | drug development | uptake | transport | case study | biochemistry | Pharmacokinetics | Pharmacogenetics | Omeprazole | antibiotics | Oncology | Statins | Sarilumab | cystic fibrosis

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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20.453J Biomedical Information Technology (MIT)

Description

This course teaches the design of contemporary information systems for biological and medical data. Examples are chosen from biology and medicine to illustrate complete life cycle information systems, beginning with data acquisition, following to data storage and finally to retrieval and analysis. Design of appropriate databases, client-server strategies, data interchange protocols, and computational modeling architectures. Students are expected to have some familiarity with scientific application software and a basic understanding of at least one contemporary programming language (e.g. C, C++, Java, Lisp, Perl, Python). A major term project is required of all students. This subject is open to motivated seniors having a strong interest in biomedical engineering and information system desig

Subjects

20.453 | 2.771 | HST.958 | imaging | medical imaging | metadata | molecular biology | medical records | DICOM | RDF | OWL | SPARQL | SBML | CellML | semantic web | BioHaystack | database | schema | ExperiBase | genomics | proteomics | bioinformatics | computational biology | clinical decision support | clinical trial | microarray | gel electrophoresis | diagnosis | pathway modeling | XML | SQL | relational database | biological data | ontologies | drug development | drug discovery | drug target | pharmaceutical | gene sequencing

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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