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7.343 A Love-Hate Relationship: Cholesterol in Health and Disease (MIT) 7.343 A Love-Hate Relationship: Cholesterol in Health and Disease (MIT)

Description

In this class, we will examine cholesterol's role in the cell and in the body as a whole, from its function as a structural component of the membrane to its function in signaling. We will discuss mechanisms of cholesterol sensing, mechanisms of feedback regulation in cells, cholesterol in the brain, cholesterol in the circulation, 'good cholesterol' and 'bad cholesterol,' cholesterol-related human disorders, and the drugs that deal with some of these disorders. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanc In this class, we will examine cholesterol's role in the cell and in the body as a whole, from its function as a structural component of the membrane to its function in signaling. We will discuss mechanisms of cholesterol sensing, mechanisms of feedback regulation in cells, cholesterol in the brain, cholesterol in the circulation, 'good cholesterol' and 'bad cholesterol,' cholesterol-related human disorders, and the drugs that deal with some of these disorders. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanc

Subjects

cholesterol | cholesterol | biosynthesis | biosynthesis | LDL | LDL | HDL | HDL | Smith-Lemli-Opitz Syndrome | Smith-Lemli-Opitz Syndrome | uptake | uptake | endocytosis | endocytosis | hypercholesterolemia | hypercholesterolemia | atherosclerosis | atherosclerosis | plaque | plaque | statins | statins | HMG-CoA | HMG-CoA | ezetimibe | ezetimibe | heart attack | heart attack | lipoprotein | lipoprotein | Fibrates | Fibrates | receptor | receptor | alzheimer's | alzheimer's

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Lowering Cholesterol Significantly: Archie Cochrane Lecture 2011

Description

Colin Baigent leads the CTSU's Vascular Overviews Group, which recently reported a meta-analysis of the findings among 170,000 participants in 26 randomised trials of cholesterol-lowering drugs in The Lancet. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

Medicine | Archie Cochrane | Health | cholesterol | Medicine | Archie Cochrane | Health | cholesterol | 2011-03-17

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Wider Statin Use Saves Lives

Description

Colin Baigent, Professor of Epidemiology, Clinical Trial Service Unit, Oxford, talks about why the drug Statin saves lives. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

clinical medicine | Epidemiology | ndm | statin | cholesterol | clinical medicine | Epidemiology | ndm | statin | cholesterol

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Wider Statin Use Saves Lives

Description

Colin Baigent, Professor of Epidemiology, Clinical Trial Service Unit, Oxford, talks about why the drug Statin saves lives. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

clinical medicine | Epidemiology | ndm | statin | cholesterol | clinical medicine | Epidemiology | ndm | statin | cholesterol

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Koreshan band performing at Bamboo Landing in Estero, Florida

Description

Subjects

musicians | florida | bamboo | bands | 1910s | performers | estero | leecounty | koreshans | esteroriver | statelibraryandarchivesofflorida | bamboolanding | koreshanunitycollection | vision:text=0674 | vision:outdoor=0912 | vision:car=0842

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Koreshan girls fishing on the Estero River, Florida

Description

Subjects

fishing | florida | rivers | recreation | 1910s | estero | leecounty | koreshans | youngwomen | esteroriver | statelibraryandarchivesofflorida | koreshanunitycollection

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on the Estero River, Florida

Description

Subjects

boats | florida | palmtrees | rivers | boating | 1910s | estero | leecounty | koreshans | esteroriver | statelibraryandarchivesofflorida | koreshanunitycollection | victoriamotorboat

License

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Koreshan Unity general store on the Estero River

Description

Subjects

florida | bridges | rivers | estero | leecounty | koreshans | us41 | tamiamitrail | generalstores | esteroriver | ushighway41 | statelibraryandarchivesofflorida | koreshanunitycollection | vision:sunset=0644 | vision:mountain=0628 | vision:sky=0603 | vision:outdoor=0736

License

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U.S. mail leaving the Estero post office

Description

Subjects

mail | florida | bridges | rivers | carts | estero | wagons | 1900s | leecounty | postoffices | mailmen | esteroriver | statelibraryandarchivesofflorida | koreshanunitycollection | vision:outdoor=0801 | muledrawncarts

License

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Unidentified young man in front of the Koreshan Unity general store on the Estero River

Description

Subjects

buildings | florida | postcards | 1910s | estero | unidentified | postoffices | youngmen | generalstores | esteroriver | africanamericanmen | statelibraryandarchivesofflorida | koreshanunitycollection | vision:text=0728 | vision:outdoor=0818

License

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Koreshan Unity general store on the Estero River

Description

Subjects

1920s | docks | boats | florida | rivers | estero | leecounty | koreshans | generalstores | esteroriver | statelibraryandarchivesofflorida | koreshanunitycollection | vision:outdoor=079

License

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Bamboo Landing on the Estero River

Description

Subjects

trees | docks | florida | rivers | benches | estero | 1900s | leecounty | landings | esteroriver | statelibraryandarchivesofflorida | bamboolanding | koreshanunitycollection | vision:mountain=0519 | vision:outdoor=099 | vision:sky=0682 | vision:street=059 | vision:snow=0809

License

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Group arriving by boat to the Koreshan Unity Solar Festival in Estero, Florida

Description

Subjects

travel | boats | florida | 1950s | rivers | postcards | boating | visitors | estero | leecounty | koreshans | groupportraits | solarfestival | esteroriver | statelibraryandarchivesofflorida | koreshanunitycollection | vision:mountain=0575 | vision:sky=0563 | vision:outdoor=0918

License

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On the Estero River with the Coast Guard Auxiliary Patrol

Description

Subjects

boats | florida | 1950s | boating | estero | leecounty | koreshans | unitedstatescoastguard | esteroriver | statelibraryandarchivesofflorida | koreshanunitycollection | vision:car=0751 | vision:outdoor=0944

License

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Koreshan boys rowing on the Estero River, Florida

Description

Subjects

water | boats | florida | rivers | boating | rowing | 1910s | estero | rowboats | leecounty | koreshans | esteroriver | statelibraryandarchivesofflorida | koreshanunitycollection | vision:mountain=0558 | vision:outdoor=0876

License

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7.342 Personal Genomics and Medicine: What's in Your Genome? (MIT) 7.342 Personal Genomics and Medicine: What's in Your Genome? (MIT)

Description

Human genome sequencing has revolutionized our understanding of disease susceptibility, drug metabolism and human ancestry. This course will explore how these advances have been made possible by revolutionary new sequencing methodologies that have decreased costs and increased throughput of genome analysis, making it possible to examine genetic correlates for a variety of biological processes and disorders. The course will combine discussions of primary scientific research papers with hands-on data analysis and small group presentations. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a Human genome sequencing has revolutionized our understanding of disease susceptibility, drug metabolism and human ancestry. This course will explore how these advances have been made possible by revolutionary new sequencing methodologies that have decreased costs and increased throughput of genome analysis, making it possible to examine genetic correlates for a variety of biological processes and disorders. The course will combine discussions of primary scientific research papers with hands-on data analysis and small group presentations. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a

Subjects

genome sequencing | genome sequencing | genome analysis | genome analysis | disease susceptibility | disease susceptibility | drug metabolism | drug metabolism | human ancestry | human ancestry | mitochondrial DNA | mitochondrial DNA | tyrosine kinase inhibitors | tyrosine kinase inhibitors | BCR-ABL gene fusion | BCR-ABL gene fusion | PCSK9 inhibitors | PCSK9 inhibitors | hypercholesterolemia | hypercholesterolemia | genetic testing | genetic testing | next generation sequencing | next generation sequencing | Single-nucleotide polymorphisms (SNPs) | Single-nucleotide polymorphisms (SNPs) | copy number variations (CNVs) | copy number variations (CNVs) | genome-wide association studies (GWAS) | genome-wide association studies (GWAS) | Chronic myelogenous leukemia (CML) | Chronic myelogenous leukemia (CML) | mosaics | mosaics | chimeras | chimeras | bioinformatics | bioinformatics

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Portrait of Koreshan Victor Bubbett - Estero Portrait of Koreshan Victor Bubbett - Estero

Description

Subjects

portraits | portraits | children | children | us | us | florida | florida | estero | estero | bubbett | bubbett | koreshanunity | koreshanunity | victorbubbett | victorbubbett

License

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Ranger Herb Smith with Sterculia seed pod at the Koreshan State Historic Site park in Estero Ranger Herb Smith with Sterculia seed pod at the Koreshan State Historic Site park in Estero

Description

Subjects

fruit | fruit | florida | florida | estero | estero | pods | pods | parkrangers | parkrangers | koreshanunity | koreshanunity | floridaparkservice | floridaparkservice

License

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7.343 A Love-Hate Relationship: Cholesterol in Health and Disease (MIT)

Description

In this class, we will examine cholesterol's role in the cell and in the body as a whole, from its function as a structural component of the membrane to its function in signaling. We will discuss mechanisms of cholesterol sensing, mechanisms of feedback regulation in cells, cholesterol in the brain, cholesterol in the circulation, 'good cholesterol' and 'bad cholesterol,' cholesterol-related human disorders, and the drugs that deal with some of these disorders. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanc

Subjects

cholesterol | biosynthesis | LDL | HDL | Smith-Lemli-Opitz Syndrome | uptake | endocytosis | hypercholesterolemia | atherosclerosis | plaque | statins | HMG-CoA | ezetimibe | heart attack | lipoprotein | Fibrates | receptor | alzheimer's

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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E0000P0120

Description

Box of PRID's

Subjects

svmsvet | prid | progesterone | intravaginal | device

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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E0000P0121

Description

Packet containing a CIDR

Subjects

svmsvet | cidr | reproduction | farm | control | syncronisation | progesterone | intravaginal | device

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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C0000P0065

Description

Subjects

svmsvet | drugs | progesterone | delvosteron | proligestone | injection

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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Diabetes complications

Description

Diabetes is an increasing problem among both adults and children. This unit looks at the way diabetes is managed once it has been diagnosed in order to reduce the risk of further complications. You will look at the role of each member of the team involved in the diabetes annual review and look at the risk factors involved with certain diabetes complications.

Subjects

science and nature | blood_glucose | blood pressure | bmi | cholesterol | diabetes | health | hyperglycaemia | ketone | lipids | monitoring | nephropathy | nutrition | obesity | renal_threshold | retinopathy | risk | risk_factors | Education | X000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Unidentified Koreshan children in a mule-drawn cart in Estero, Florida

Description

Subjects

children | florida | 1910s | carts | mules | estero | unidentified | leecounty | koreshans | statelibraryandarchivesofflorida | koreshanunitycollection | vision:outdoor=0785 | muledrawncarts

License

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Unidentified Koreshan women in Estero, Florida

Description

Subjects

fashion | florida | estero | unidentified | 1900s | leecounty | koreshans | groupportraits | statelibraryandarchivesofflorida | koreshanunitycollection | vision:people=099 | vision:face=099 | vision:groupshot=099 | vision:text=0588 | vision:mountain=0599 | vision:outdoor=0839

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