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7.342 G-Protein Coupled Receptors: Vision and Disease (MIT) 7.342 G-Protein Coupled Receptors: Vision and Disease (MIT)

Description

How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR

Subjects

allergies | allergies | hypertension | hypertension | depression | depression | obesity | obesity | central nervous system disorders | central nervous system disorders | G-protein coupled receptors | G-protein coupled receptors | GPCR | GPCR | cell-surface receptors | cell-surface receptors | George Wald | George Wald | vision | vision | chromophore | chromophore | transducin | transducin | metarhodopsin II | metarhodopsin II | homodimers | homodimers | heterodimers | heterodimers | retinitis pigmentosa | retinitis pigmentosa | night blindness | night blindness | Dopamine | Dopamine | antihistamines | antihistamines | Claviceps purpurea | Claviceps purpurea | Human chemokine receptor 5 | Human chemokine receptor 5 | CCR5 | CCR5 | HIV-1 | HIV-1 | CCR5-delta32 | CCR5-delta32 | Olfactory receptors | Olfactory receptors | Taste receptors | Taste receptors

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT) 9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT)

Description

This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. The class focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); it also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation, and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems they control. This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. The class focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); it also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation, and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems they control.

Subjects

neurotransmission | neurotransmission | nerve terminals | nerve terminals | monoamine transmitters | monoamine transmitters | acetylcholine | acetylcholine | serotonin | serotonin | dopamine | dopamine | norepinephrine | norepinephrine | amino acid and peptide transmitters | amino acid and peptide transmitters | neuromodulators | neuromodulators | adenosine | adenosine | neurotransmitter synthesis | neurotransmitter synthesis | release | release | inactivation | inactivation | receptor-mediated | receptor-mediated | second-messenger | second-messenger | neurotransmitter | neurotransmitter | antidepressant | antidepressant | brain lipid | brain lipid | blood brain barrier | blood brain barrier | parkinson's disease | parkinson's disease | seratonin | seratonin | depression | depression | glutamate | glutamate | aspartate | aspartate | NDMA | NDMA | drug | drug | drug discovery | drug discovery | pharmaceutical | pharmaceutical | signaling pathway | signaling pathway | receptor | receptor | spinal cord | spinal cord | marijuana | marijuana | adensosine | adensosine | histamine | histamine

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT) 9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT)

Description

This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. We focus on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); we also examine amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. The involvement of particular neurotransmitters in human diseases is considered. This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. We focus on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); we also examine amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. The involvement of particular neurotransmitters in human diseases is considered.

Subjects

Neurotransmitter | Neurotransmitter | antidepressant | antidepressant | brain lipid | brain lipid | blood brain barrier | blood brain barrier | dopamine | dopamine | parkinson's disease | parkinson's disease | serotonin | serotonin | depression | depression | glutamate | glutamate | aspartate | aspartate | NDMA | NDMA | drug | drug | drug discovery | drug discovery | pharmaceutical | pharmaceutical | signaling pathway | signaling pathway | receptor | receptor | spinal cord | spinal cord | marijuana | marijuana | adensosine | adensosine | histamine. | histamine.

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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B0000P0050

Description

An ampoule of Zantac, Active ingredient Ranitidine

Subjects

svmsvet | drug | drugs | injectable | ampoule | vial | zantac | ranitidine | h2antagonist | histaminereceptorantagonist

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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B0000P0050

Description

An ampoule of Zantac, Active ingredient Ranitidine

Subjects

svmsvet | drug | drugs | injectable | ampoule | vial | zantac | ranitidine | h2antagonist | histaminereceptorantagonist

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT)

Description

This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. We focus on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); we also examine amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. The involvement of particular neurotransmitters in human diseases is considered.

Subjects

Neurotransmitter | antidepressant | brain lipid | blood brain barrier | dopamine | parkinson's disease | serotonin | depression | glutamate | aspartate | NDMA | drug | drug discovery | pharmaceutical | signaling pathway | receptor | spinal cord | marijuana | adensosine | histamine.

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.342 G-Protein Coupled Receptors: Vision and Disease (MIT)

Description

How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR

Subjects

allergies | hypertension | depression | obesity | central nervous system disorders | G-protein coupled receptors | GPCR | cell-surface receptors | George Wald | vision | chromophore | transducin | metarhodopsin II | homodimers | heterodimers | retinitis pigmentosa | night blindness | Dopamine | antihistamines | Claviceps purpurea | Human chemokine receptor 5 | CCR5 | HIV-1 | CCR5-delta32 | Olfactory receptors | Taste receptors

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT)

Description

This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. The class focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); it also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation, and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems they control.

Subjects

neurotransmission | nerve terminals | monoamine transmitters | acetylcholine | serotonin | dopamine | norepinephrine | amino acid and peptide transmitters | neuromodulators | adenosine | neurotransmitter synthesis | release | inactivation | receptor-mediated | second-messenger | neurotransmitter | antidepressant | brain lipid | blood brain barrier | parkinson's disease | seratonin | depression | glutamate | aspartate | NDMA | drug | drug discovery | pharmaceutical | signaling pathway | receptor | spinal cord | marijuana | adensosine | histamine

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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X0000P0100

Description

A 1ml vial of chlorphenamine.

Subjects

svmsvet | chlorphenamine | antihistamine | vial | drug | drugs

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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X0000P0100

Description

A 1ml vial of chlorphenamine.

Subjects

svmsvet | chlorphenamine | antihistamine | vial | drug | drugs

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

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9.15 Biochemistry and Pharmacology of Synaptic Transmission (MIT)

Description

This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. We focus on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); we also examine amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. The involvement of particular neurotransmitters in human diseases is considered.

Subjects

Neurotransmitter | antidepressant | brain lipid | blood brain barrier | dopamine | parkinson's disease | serotonin | depression | glutamate | aspartate | NDMA | drug | drug discovery | pharmaceutical | signaling pathway | receptor | spinal cord | marijuana | adensosine | histamine.

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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C0000P0041

Description

piriton

Subjects

svmsvet | drugs | antihistamine | tablets | chlorphenaminemaleate

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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C0000P0041

Description

piriton

Subjects

svmsvet | drugs | antihistamine | tablets | chlorphenaminemaleate

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

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