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7.345 Evolution of the Immune System (MIT) 7.345 Evolution of the Immune System (MIT)

Description

In this course, evolutionary pathways that have led to the development of innate and adaptive immunity are analyzed, the conserved and unique features of the immune response from bacteria to higher vertebrates is traced, and factors, such as adaptive changes in pathogens that have shaped the evolution of immune system are identified.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. In this course, evolutionary pathways that have led to the development of innate and adaptive immunity are analyzed, the conserved and unique features of the immune response from bacteria to higher vertebrates is traced, and factors, such as adaptive changes in pathogens that have shaped the evolution of immune system are identified.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting.

Subjects

immune system | immune system | immunology | immunology | evolution of immune system | evolution of immune system | immune defence | immune defence | phagocytosis | phagocytosis | innate immunity | innate immunity | adaptive immunity | adaptive immunity | immunological memory | immunological memory | immune response | immune response | defence mechanisms | defence mechanisms | pathogens | pathogens | self discrimination | self discrimination | non-self discrimination | non-self discrimination | recognition | recognition | immune receptors | immune receptors | antigen | antigen

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.340 Immune Evasion: How Sneaky Pathogens Avoid Host Surveillance (MIT) 7.340 Immune Evasion: How Sneaky Pathogens Avoid Host Surveillance (MIT)

Description

Every infection consists of a battle between the invading pathogen and the resisting host. To be successful, a pathogen must escape the many defenses of the host immune system until it can replicate and spread to another host. A pathogen must prevent one of three stages of immune function: detection, activation, or effector function. Examples of disease-specific immune evasion and the mechanisms used by pathogens to prevail over their hosts' immune systems are discussed. Also considered is what these host-pathogen interactions reveal about the normal function of the immune system and basic cell biological processes, such as protein maturation and degradation. Every infection consists of a battle between the invading pathogen and the resisting host. To be successful, a pathogen must escape the many defenses of the host immune system until it can replicate and spread to another host. A pathogen must prevent one of three stages of immune function: detection, activation, or effector function. Examples of disease-specific immune evasion and the mechanisms used by pathogens to prevail over their hosts' immune systems are discussed. Also considered is what these host-pathogen interactions reveal about the normal function of the immune system and basic cell biological processes, such as protein maturation and degradation.

Subjects

immunology | immunology | immune system | immune system | immune evasion | immune evasion | pathogen | pathogen | effector function | effector function | infections | infections | Human cytomegalovirus | Human cytomegalovirus | Human Immunodeficiency Virus | Human Immunodeficiency Virus | CD4 cells | CD4 cells | CD8 cells | CD8 cells | T cells | T cells | surace receptors | surace receptors | cell lysis | cell lysis | host-pathogen interactions | host-pathogen interactions | host surveillance | host surveillance | antibodies | antibodies | MHC class I | MHC class I | blood-borne pathogens | blood-borne pathogens | macrophages | macrophages | phagocytosis | phagocytosis | endocytosis | endocytosis | degradation | degradation | antigen | antigen | apoptosis | apoptosis | cytokines | cytokines | immune response | immune response

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.345 Evolution of the Immune System (MIT)

Description

In this course, evolutionary pathways that have led to the development of innate and adaptive immunity are analyzed, the conserved and unique features of the immune response from bacteria to higher vertebrates is traced, and factors, such as adaptive changes in pathogens that have shaped the evolution of immune system are identified.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting.

Subjects

immune system | immunology | evolution of immune system | immune defence | phagocytosis | innate immunity | adaptive immunity | immunological memory | immune response | defence mechanisms | pathogens | self discrimination | non-self discrimination | recognition | immune receptors | antigen

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.345 Evolution of the Immune System (MIT)

Description

In this course, evolutionary pathways that have led to the development of innate and adaptive immunity are analyzed, the conserved and unique features of the immune response from bacteria to higher vertebrates is traced, and factors, such as adaptive changes in pathogens that have shaped the evolution of immune system are identified.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting.

Subjects

immune system | immunology | evolution of immune system | immune defence | phagocytosis | innate immunity | adaptive immunity | immunological memory | immune response | defence mechanisms | pathogens | self discrimination | non-self discrimination | recognition | immune receptors | antigen

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.340 Immune Evasion: How Sneaky Pathogens Avoid Host Surveillance (MIT)

Description

Every infection consists of a battle between the invading pathogen and the resisting host. To be successful, a pathogen must escape the many defenses of the host immune system until it can replicate and spread to another host. A pathogen must prevent one of three stages of immune function: detection, activation, or effector function. Examples of disease-specific immune evasion and the mechanisms used by pathogens to prevail over their hosts' immune systems are discussed. Also considered is what these host-pathogen interactions reveal about the normal function of the immune system and basic cell biological processes, such as protein maturation and degradation.

Subjects

immunology | immune system | immune evasion | pathogen | effector function | infections | Human cytomegalovirus | Human Immunodeficiency Virus | CD4 cells | CD8 cells | T cells | surace receptors | cell lysis | host-pathogen interactions | host surveillance | antibodies | MHC class I | blood-borne pathogens | macrophages | phagocytosis | endocytosis | degradation | antigen | apoptosis | cytokines | immune response

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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HIV immunology for Vaccine Design

Description

Dr Seph Borrow tells us how her research on HIV Immunology helps design better vaccines. There is an urgent need for vaccines to combat persistent infections like HIV. Dr Seph Borrow is studying factors affecting virus control by HIV-specific CD8+ T cells, to inform the design of T cell-based HIV vaccines. She is also exploring the possibility of harnessing innate immune responses to combat HIV. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

protective immunity | immune response | hiv | innate response | protective immunity | immune response | hiv | innate response

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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7.340 Under the Radar Screen: How Bugs Trick Our Immune Defenses (MIT) 7.340 Under the Radar Screen: How Bugs Trick Our Immune Defenses (MIT)

Description

In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about

Subjects

HIV | HIV | mycobacterium tuberculosis | mycobacterium tuberculosis | malaria | malaria | influenza | influenza | immune system | immune system | pathogens | pathogens | viruses | viruses | bacteria | bacteria | parasites | parasites | microbes | microbes | phagocytosis | phagocytosis | ubiquitin/proteasome pathway | ubiquitin/proteasome pathway | MHC I/II antigen presentation | MHC I/II antigen presentation | Salmonella | Salmonella | pathogen-associated molecular patterns | pathogen-associated molecular patterns | PAMP | PAMP | Toll-like receptors | Toll-like receptors | TLR | TLR | Vaccinia virus | Vaccinia virus | Proteasome | Proteasome | Ubiquitin; deubiquinating enzymes | Ubiquitin; deubiquinating enzymes | DUB | DUB | Herpes simplex virus | Herpes simplex virus | HSV | HSV | Yersinia | Yersinia | viral budding | viral budding | Human cytomegalovirus | Human cytomegalovirus | HCMV | HCMV | Histocompatiblity | Histocompatiblity | AIDS | AIDS | Kaposi Sarcoma-Associated Herpes virus | Kaposi Sarcoma-Associated Herpes virus | Mixoma virus | Mixoma virus | Epstein Barr virus | Epstein Barr virus | EBV | EBV | Burkitt?s B cell lymphoma | Burkitt?s B cell lymphoma

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.340 Ubiquitination: The Proteasome and Human Disease (MIT) 7.340 Ubiquitination: The Proteasome and Human Disease (MIT)

Description

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, spe This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, spe

Subjects

ubiquitination | ubiquitination | ubiquitin | ubiquitin | proteasome | proteasome | post-translational mechanisms | post-translational mechanisms | ubiquitin-conjugation system | ubiquitin-conjugation system | neurodegenerative diseases | neurodegenerative diseases | immune response | immune response | cell cycle regulation | cell cycle regulation | apoptosis | apoptosis | signal transduction pathways | signal transduction pathways | tumorigenesis | tumorigenesis | protein degradation | protein degradation | Endoplasmic Reticulum Associated Degradation Pathway | Endoplasmic Reticulum Associated Degradation Pathway | ligases | ligases | translocated proteins | translocated proteins | misfolded proteins | misfolded proteins | trafficking membranes | trafficking membranes | cell cycle control | cell cycle control | programmed cell death | programmed cell death | Huntington's Disease | Huntington's Disease | Von Hippel-Lindau Disease | Von Hippel-Lindau Disease

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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MAS.S63 Engineering Health: Towards the Tricorder (MIT) MAS.S63 Engineering Health: Towards the Tricorder (MIT)

Description

Students will learn to fabricate, remix, and design detection and monitoring devices for health following the core focus of the Tricorder: a portable, handheld diagnostic device which can brings health solutions to consumers at home or in remote parts of the world. Inspired by the Tricorder X-Prize (with a purse of $10 million), students will aim to create specific component technologies that integrate into a comprehensive Tricorder mechanism capable of reading vital signs and specific disease biomarker detection. Component areas will include optical, electric, biochemical, and molecular diagnostics. Students will learn to fabricate, remix, and design detection and monitoring devices for health following the core focus of the Tricorder: a portable, handheld diagnostic device which can brings health solutions to consumers at home or in remote parts of the world. Inspired by the Tricorder X-Prize (with a purse of $10 million), students will aim to create specific component technologies that integrate into a comprehensive Tricorder mechanism capable of reading vital signs and specific disease biomarker detection. Component areas will include optical, electric, biochemical, and molecular diagnostics.

Subjects

Medical | Medical | tricorder | tricorder | prototyping | prototyping | diagnostic | diagnostic | health | health | microscopy | microscopy | imaging | imaging | antibodies | antibodies | Crusher | Crusher | nanoparticles | nanoparticles | sensor | sensor | pulse | pulse | bones | bones | McCoy | McCoy | biomarker | biomarker | nerd | nerd | microfluid | microfluid | Beverly | Beverly | immunoassay | immunoassay | immune | immune | telemedicine | telemedicine

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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B0095P0016

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia | mucous | membranesicteric | membranes

License

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B0095P0015

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

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B0095P0014

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

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B0095P0013

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

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B0095P0012

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

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B0095P0011

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

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B0095P0010

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

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B0095P0009

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

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B0095P0016

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia | mucous | membranesicteric | membranes

License

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B0095P0008

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

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B0095P0015

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

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B0095P0007

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia | mucousmembranes | ictericmucousmembranes | yellowmucousmembranes | jaundicemucousmembranes

License

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B0095P0014

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

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B0095P0013

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

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B0095P0012

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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B0095P0011

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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