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7.341 Bench to Bedside: Molecularly Targeted Therapies in Blood Disorders and Malignancy (MIT) 7.341 Bench to Bedside: Molecularly Targeted Therapies in Blood Disorders and Malignancy (MIT)

Description

Where do new drugs and treatments come from? This class will take you from the test tubes and mice of the laboratory to the treatment of patients with deadly blood disorders. Students will learn how to think as a scientist through discussion of primary research papers describing the discoveries of several novel treatments. Topics such as gene therapy, the potential of drugs based on RNA interference and the reprogramming of somatic cells into stem cells for regenerative medicine will be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instruct Where do new drugs and treatments come from? This class will take you from the test tubes and mice of the laboratory to the treatment of patients with deadly blood disorders. Students will learn how to think as a scientist through discussion of primary research papers describing the discoveries of several novel treatments. Topics such as gene therapy, the potential of drugs based on RNA interference and the reprogramming of somatic cells into stem cells for regenerative medicine will be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instruct

Subjects

molecularly targeted therapy | molecularly targeted therapy | blood disorders | blood disorders | chronic myelogenous leukemia | chronic myelogenous leukemia | CML | CML | Gleevec | Gleevec | chromosomal translocation | chromosomal translocation | stem cells | stem cells | blood cells | blood cells | hematopoiesis | hematopoiesis | hematopoieteic stem cell | hematopoieteic stem cell | genetic disorder | genetic disorder | Leukemia | Leukemia

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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HST.161 Molecular Biology and Genetics in Modern Medicine (MIT) HST.161 Molecular Biology and Genetics in Modern Medicine (MIT)

Description

This course provides a foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. It develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics are reviewed. We translate clinical understanding into analysis at the level of the gene, chromosome and molecule; we cover the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. Material in the course extends beyond basic principles to current research activity in human genetics. This course provides a foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. It develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics are reviewed. We translate clinical understanding into analysis at the level of the gene, chromosome and molecule; we cover the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. Material in the course extends beyond basic principles to current research activity in human genetics.

Subjects

Genetics | Genetics | genes | genes | genetic disorders | genetic disorders | inborn error | inborn error | muscular dystrophy | muscular dystrophy | PKU | PKU | phenylketoneuria | phenylketoneuria | cancer | cancer | tumors | tumors | gene therapy | gene therapy | disease | disease | birth defects | birth defects | chromosomes | chromosomes | leukemia | leukemia | RNAi | RNAi | hemophilia | hemophilia | thalassemia | thalassemia | deafness | deafness | mutations | mutations | hypertrophic cardiomyopathy | hypertrophic cardiomyopathy | epigenetics | epigenetics | rett syndrome | rett syndrome | prenatal diagnosis | prenatal diagnosis | LOD scores | LOD scores | gene linkage | gene linkage | mitochondrial disorders | mitochondrial disorders | degenerative disorders | degenerative disorders | complex traits | complex traits | Mendelian inheritance | Mendelian inheritance

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Chromatin Remodelling

Description

Dr Erika Mancini explains how malfunctions in the regulation of chromatin structure often leads to complex multi-system diseases and cancer, notably leukemia. Dr Erika Mancini is interested in the role of chromatin in the regulation of gene transcription. All our cells contain the same set of genes, but only some of them are transcribed at any point in a particular tissue. Regulation of gene transcription is strongly linked to chromatin, physical packaging of the DNA within the nucleus. Molecular Mechanisms influencing DNA packaging Chromatin plays an important role in the regulation of gene expression. The movement of nucleosomes, packing and unpacking DNA, is governed by chromatin remodelling ATPases. Malfunctions in the regulation of chromatin structure often leads to complex multi-sy Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

disease | leukemia | chromatin remodelling | transcription regulation | Medicine | gene | heart diseases | disease | leukemia | chromatin remodelling | transcription regulation | Medicine | gene | heart diseases

License

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Chromatin Remodelling

Description

Dr Erika Mancini explains how malfunctions in the regulation of chromatin structure often leads to complex multi-system diseases and cancer, notably leukemia. Dr Erika Mancini is interested in the role of chromatin in the regulation of gene transcription. All our cells contain the same set of genes, but only some of them are transcribed at any point in a particular tissue. Regulation of gene transcription is strongly linked to chromatin, physical packaging of the DNA within the nucleus. Molecular Mechanisms influencing DNA packaging Chromatin plays an important role in the regulation of gene expression. The movement of nucleosomes, packing and unpacking DNA, is governed by chromatin remodelling ATPases. Malfunctions in the regulation of chromatin structure often leads to complex multi-sy Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

disease | leukemia | chromatin remodelling | transcription regulation | Medicine | gene | heart diseases | disease | leukemia | chromatin remodelling | transcription regulation | Medicine | gene | heart diseases

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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7.342 Personal Genomics and Medicine: What's in Your Genome? (MIT) 7.342 Personal Genomics and Medicine: What's in Your Genome? (MIT)

Description

Human genome sequencing has revolutionized our understanding of disease susceptibility, drug metabolism and human ancestry. This course will explore how these advances have been made possible by revolutionary new sequencing methodologies that have decreased costs and increased throughput of genome analysis, making it possible to examine genetic correlates for a variety of biological processes and disorders. The course will combine discussions of primary scientific research papers with hands-on data analysis and small group presentations. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a Human genome sequencing has revolutionized our understanding of disease susceptibility, drug metabolism and human ancestry. This course will explore how these advances have been made possible by revolutionary new sequencing methodologies that have decreased costs and increased throughput of genome analysis, making it possible to examine genetic correlates for a variety of biological processes and disorders. The course will combine discussions of primary scientific research papers with hands-on data analysis and small group presentations. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a

Subjects

genome sequencing | genome sequencing | genome analysis | genome analysis | disease susceptibility | disease susceptibility | drug metabolism | drug metabolism | human ancestry | human ancestry | mitochondrial DNA | mitochondrial DNA | tyrosine kinase inhibitors | tyrosine kinase inhibitors | BCR-ABL gene fusion | BCR-ABL gene fusion | PCSK9 inhibitors | PCSK9 inhibitors | hypercholesterolemia | hypercholesterolemia | genetic testing | genetic testing | next generation sequencing | next generation sequencing | Single-nucleotide polymorphisms (SNPs) | Single-nucleotide polymorphisms (SNPs) | copy number variations (CNVs) | copy number variations (CNVs) | genome-wide association studies (GWAS) | genome-wide association studies (GWAS) | Chronic myelogenous leukemia (CML) | Chronic myelogenous leukemia (CML) | mosaics | mosaics | chimeras | chimeras | bioinformatics | bioinformatics

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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D0000P0436

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

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D0000P0435

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

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D0000P0434

Description

Blood smear from a dog with leukaemia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

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D0000P0433

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

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D0000P0432

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

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D0000P0430

Description

Blood smear from a dog with leukaemia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

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D0000P0431

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

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D0000P0429

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

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D0000P0436

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

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D0000P0435

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

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D0000P0434

Description

Blood smear from a dog with leukaemia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

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D0000P0433

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

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D0000P0432

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

Click to get HTML | Click to get attribution | Click to get URL

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D0000P0430

Description

Blood smear from a dog with leukaemia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

Click to get HTML | Click to get attribution | Click to get URL

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D0000P0431

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

Click to get HTML | Click to get attribution | Click to get URL

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D0000P0429

Description

Blood smear from a dog with leukeamia, possibly myeloid

Subjects

canine | dog | caninebloodsmear | bloodsmear | blood | smear | myeloid | svmsvet | leukaemia | leukemia | redbloodcell | erythrocyte

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

Attribution

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7.342 Personal Genomics and Medicine: What's in Your Genome? (MIT)

Description

Human genome sequencing has revolutionized our understanding of disease susceptibility, drug metabolism and human ancestry. This course will explore how these advances have been made possible by revolutionary new sequencing methodologies that have decreased costs and increased throughput of genome analysis, making it possible to examine genetic correlates for a variety of biological processes and disorders. The course will combine discussions of primary scientific research papers with hands-on data analysis and small group presentations. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a

Subjects

genome sequencing | genome analysis | disease susceptibility | drug metabolism | human ancestry | mitochondrial DNA | tyrosine kinase inhibitors | BCR-ABL gene fusion | PCSK9 inhibitors | hypercholesterolemia | genetic testing | next generation sequencing | Single-nucleotide polymorphisms (SNPs) | copy number variations (CNVs) | genome-wide association studies (GWAS) | Chronic myelogenous leukemia (CML) | mosaics | chimeras | bioinformatics

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-allcourses.xml

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7.341 Bench to Bedside: Molecularly Targeted Therapies in Blood Disorders and Malignancy (MIT)

Description

Where do new drugs and treatments come from? This class will take you from the test tubes and mice of the laboratory to the treatment of patients with deadly blood disorders. Students will learn how to think as a scientist through discussion of primary research papers describing the discoveries of several novel treatments. Topics such as gene therapy, the potential of drugs based on RNA interference and the reprogramming of somatic cells into stem cells for regenerative medicine will be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instruct

Subjects

molecularly targeted therapy | blood disorders | chronic myelogenous leukemia | CML | Gleevec | chromosomal translocation | stem cells | blood cells | hematopoiesis | hematopoieteic stem cell | genetic disorder | Leukemia

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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HST.161 Molecular Biology and Genetics in Modern Medicine (MIT)

Description

This course provides a foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. It develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics are reviewed. We translate clinical understanding into analysis at the level of the gene, chromosome and molecule; we cover the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. Material in the course extends beyond basic principles to current research activity in human genetics.

Subjects

Genetics | genes | genetic disorders | inborn error | muscular dystrophy | PKU | phenylketoneuria | cancer | tumors | gene therapy | disease | birth defects | chromosomes | leukemia | RNAi | hemophilia | thalassemia | deafness | mutations | hypertrophic cardiomyopathy | epigenetics | rett syndrome | prenatal diagnosis | LOD scores | gene linkage | mitochondrial disorders | degenerative disorders | complex traits | Mendelian inheritance

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-alllifesciencescourses.xml

Attribution

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