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B0095P0007

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia | mucousmembranes | ictericmucousmembranes | yellowmucousmembranes | jaundicemucousmembranes

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B0095P0007

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia | mucousmembranes | ictericmucousmembranes | yellowmucousmembranes | jaundicemucousmembranes

License

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6.021J Quantitative Physiology: Cells and Tissues (MIT) 6.021J Quantitative Physiology: Cells and Tissues (MIT)

Description

This course is jointly offered through four departments, available to both undergraduates and graduates. This course introduces the principles of mass transport and electrical signal generation for biological membranes, cells, and tissues. Topics covered include: mass transport through membranes (diffusion, osmosis, chemically mediated, and active transport), electric properties of cells (ion transport), equilibrium, resting, and action potentials, kinetic and molecular properties of single voltage-gated ion channels. Laboratory and computer exercises illustrate the course concepts. Students engage in extensive written and oral communication exercises. This course is worth 4 Engineering Design Points.Technical RequirementsMATLAB® software is required to run the .m files f This course is jointly offered through four departments, available to both undergraduates and graduates. This course introduces the principles of mass transport and electrical signal generation for biological membranes, cells, and tissues. Topics covered include: mass transport through membranes (diffusion, osmosis, chemically mediated, and active transport), electric properties of cells (ion transport), equilibrium, resting, and action potentials, kinetic and molecular properties of single voltage-gated ion channels. Laboratory and computer exercises illustrate the course concepts. Students engage in extensive written and oral communication exercises. This course is worth 4 Engineering Design Points.Technical RequirementsMATLAB® software is required to run the .m files f

Subjects

quantitative physiology | quantitative physiology | cells | cells | tissues | tissues | mass transport | mass transport | electrical signal generation | electrical signal generation | biological membranes | biological membranes | membranes | membranes | diffusion | diffusion | osmosis | osmosis | chemically mediated transport | chemically mediated transport | active transport | active transport | ion transport | ion transport | 6.021 | 6.021 | 2.791 | 2.791 | 2.794 | 2.794 | 6.521 | 6.521 | BE.370 | BE.370 | BE.470 | BE.470 | HST.541 | HST.541

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8.592 Statistical Physics in Biology (MIT) 8.592 Statistical Physics in Biology (MIT)

Description

Statistical Physics in Biology is a survey of problems at the interface of statistical physics and modern biology. Topics include: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, and phylogenetic trees; physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, and elements of protein folding; Considerations of force, motion, and packaging; protein motors, membranes. We also look at collective behavior of biological elements, cellular networks, neural networks, and evolution.Technical RequirementsAny number of biological sequence comparison software tools can be used to import the .fna files found on this course site. Statistical Physics in Biology is a survey of problems at the interface of statistical physics and modern biology. Topics include: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, and phylogenetic trees; physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, and elements of protein folding; Considerations of force, motion, and packaging; protein motors, membranes. We also look at collective behavior of biological elements, cellular networks, neural networks, and evolution.Technical RequirementsAny number of biological sequence comparison software tools can be used to import the .fna files found on this course site.

Subjects

Bioinformatics | Bioinformatics | DNA | DNA | gene finding | gene finding | sequence comparison | sequence comparison | phylogenetic trees | phylogenetic trees | biopolymers | biopolymers | DNA double helix | DNA double helix | secondary structure of RNA | secondary structure of RNA | protein folding | protein folding | protein motors | membranes | protein motors | membranes | cellular networks | cellular networks | neural networks | neural networks | evolution | evolution | statistical physics | statistical physics | molecular biology | molecular biology | deoxyribonucleic acid | deoxyribonucleic acid | genes | genes | genetics | genetics | gene sequencing | gene sequencing | phylogenetics | phylogenetics | double helix | double helix | RNA | RNA | ribonucleic acid | ribonucleic acid | force | force | motion | motion | packaging | packaging | protein motors | protein motors | membranes | membranes | biochemistry | biochemistry | genome | genome | optimization | optimization | partitioning | partitioning | pattern recognition | pattern recognition | collective behavior | collective behavior

License

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6.021J Quantitative Physiology: Cells and Tissues (MIT) 6.021J Quantitative Physiology: Cells and Tissues (MIT)

Description

In this subject, we consider two basic topics in cellular biophysics, posed here as questions: Which molecules are transported across cellular membranes, and what are the mechanisms of transport? How do cells maintain their compositions, volume, and membrane potential? How are potentials generated across the membranes of cells? What do these potentials do? Although the questions posed are fundamentally biological questions, the methods for answering these questions are inherently multidisciplinary. As we will see throughout the course, the role of mathematical models is to express concepts precisely enough that precise conclusions can be drawn. In connection with all the topics covered, we will consider both theory and experiment. For the student, the educational value of examining the i In this subject, we consider two basic topics in cellular biophysics, posed here as questions: Which molecules are transported across cellular membranes, and what are the mechanisms of transport? How do cells maintain their compositions, volume, and membrane potential? How are potentials generated across the membranes of cells? What do these potentials do? Although the questions posed are fundamentally biological questions, the methods for answering these questions are inherently multidisciplinary. As we will see throughout the course, the role of mathematical models is to express concepts precisely enough that precise conclusions can be drawn. In connection with all the topics covered, we will consider both theory and experiment. For the student, the educational value of examining the i

Subjects

quantitative physiology | quantitative physiology | cells | cells | tissues | tissues | mass transport | mass transport | electrical signal generation | electrical signal generation | biological membranes | biological membranes | membranes | membranes | diffusion | diffusion | osmosis | osmosis | chemically mediated transport | chemically mediated transport | active transport | active transport | ion transport | ion transport | equilibrium potential | equilibrium potential | resting potential | resting potential | action potential | action potential | voltage-gated ion channels | voltage-gated ion channels | 6.021 | 6.021 | 2.791 | 2.791 | 2.794 | 2.794 | 6.521 | 6.521 | 20.370 | 20.370 | 20.470 | 20.470 | HST.541 | HST.541

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.06 Cell Biology (MIT) 7.06 Cell Biology (MIT)

Description

This course deals with the biology of cells of higher organisms: The structure, function, and biosynthesis of cellular membranes and organelles; cell growth and oncogenic transformation; transport, receptors, and cell signaling; the cytoskeleton, the extracellular matrix, and cell movements; chromatin structure and RNA synthesis. This course deals with the biology of cells of higher organisms: The structure, function, and biosynthesis of cellular membranes and organelles; cell growth and oncogenic transformation; transport, receptors, and cell signaling; the cytoskeleton, the extracellular matrix, and cell movements; chromatin structure and RNA synthesis.

Subjects

Biology | Biology | cells | cells | organisms | organisms | biosynthesis | biosynthesis | cellular membranes | cellular membranes | organelles | organelles | cell growth | cell growth | oncogenic transformation | oncogenic transformation | transport | transport | receptors | receptors | cell signaling | cell signaling | cytoskeleton | cytoskeleton | extracellular matrix | extracellular matrix | matrix | matrix | cell movements | cell movements | chromatin | chromatin | RNA | RNA | RNA synthesis | RNA synthesis

License

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8.592J Statistical Physics in Biology (MIT) 8.592J Statistical Physics in Biology (MIT)

Description

Statistical Physics in Biology is a survey of problems at the interface of statistical physics and modern biology. Topics include: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, and phylogenetic trees; physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, and elements of protein folding; considerations of force, motion, and packaging; protein motors, membranes. We also look at collective behavior of biological elements, cellular networks, neural networks, and evolution. Statistical Physics in Biology is a survey of problems at the interface of statistical physics and modern biology. Topics include: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, and phylogenetic trees; physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, and elements of protein folding; considerations of force, motion, and packaging; protein motors, membranes. We also look at collective behavior of biological elements, cellular networks, neural networks, and evolution.

Subjects

Bioinformatics | Bioinformatics | DNA | DNA | gene finding | gene finding | sequence comparison | sequence comparison | phylogenetic trees | phylogenetic trees | biopolymers | biopolymers | DNA double helix | DNA double helix | secondary structure of RNA | secondary structure of RNA | protein folding | protein folding | protein motors | protein motors | membranes | membranes | cellular networks | cellular networks | neural networks | neural networks | evolution | evolution

License

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7.340 Ubiquitination: The Proteasome and Human Disease (MIT) 7.340 Ubiquitination: The Proteasome and Human Disease (MIT)

Description

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, spe This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, spe

Subjects

ubiquitination | ubiquitination | ubiquitin | ubiquitin | proteasome | proteasome | post-translational mechanisms | post-translational mechanisms | ubiquitin-conjugation system | ubiquitin-conjugation system | neurodegenerative diseases | neurodegenerative diseases | immune response | immune response | cell cycle regulation | cell cycle regulation | apoptosis | apoptosis | signal transduction pathways | signal transduction pathways | tumorigenesis | tumorigenesis | protein degradation | protein degradation | Endoplasmic Reticulum Associated Degradation Pathway | Endoplasmic Reticulum Associated Degradation Pathway | ligases | ligases | translocated proteins | translocated proteins | misfolded proteins | misfolded proteins | trafficking membranes | trafficking membranes | cell cycle control | cell cycle control | programmed cell death | programmed cell death | Huntington's Disease | Huntington's Disease | Von Hippel-Lindau Disease | Von Hippel-Lindau Disease

License

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A0014P0013

Description

Mucus membranes of a cat during anaesthesia induced with medetomidine

Subjects

svmsvet | cat | cats | feline | felines | mucousmembranes | mucousmembranecolour | catmucousmembranes | anaesthesia | medetomidine

License

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8.592J Statistical Physics in Biology (MIT) 8.592J Statistical Physics in Biology (MIT)

Description

Statistical Physics in Biology is a survey of problems at the interface of statistical physics and modern biology. Topics include: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, and phylogenetic trees; physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, and elements of protein folding; considerations of force, motion, and packaging; protein motors, membranes. We also look at collective behavior of biological elements, cellular networks, neural networks, and evolution. Statistical Physics in Biology is a survey of problems at the interface of statistical physics and modern biology. Topics include: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, and phylogenetic trees; physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, and elements of protein folding; considerations of force, motion, and packaging; protein motors, membranes. We also look at collective behavior of biological elements, cellular networks, neural networks, and evolution.

Subjects

8.592 | 8.592 | HST.452 | HST.452 | Statistical physics | Statistical physics | Bioinformatics | Bioinformatics | DNA | DNA | gene finding | gene finding | sequence comparison | sequence comparison | phylogenetic trees | phylogenetic trees | biopolymers | biopolymers | DNA double helix | DNA double helix | secondary structure of RNA | secondary structure of RNA | protein folding | protein folding | protein motors | protein motors | membranes | membranes | cellular networks | cellular networks | neural networks | neural networks | evolution | evolution

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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A0014P0013

Description

Mucus membranes of a cat during anaesthesia induced with medetomidine

Subjects

svmsvet | cat | cats | feline | felines | mucousmembranes | mucousmembranecolour | catmucousmembranes | anaesthesia | medetomidine

License

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B0095P0016

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia | mucous | membranesicteric | membranes

License

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9.013J Cell and Molecular Neurobiology (MIT) 9.013J Cell and Molecular Neurobiology (MIT)

Description

This course explores the major areas of cellular and molecular neurobiology, including excitable cells and membranes, ion channels and receptors, synaptic transmission, cell-type determination, axon guidance, neuronal cell biology, neurotrophin signaling and cell survival, synapse formation and neural plasticity. Material includes lectures and exams, and involves presentation and discussion of primary literature. It focuses on major concepts and recent advances in experimental neuroscience. This course explores the major areas of cellular and molecular neurobiology, including excitable cells and membranes, ion channels and receptors, synaptic transmission, cell-type determination, axon guidance, neuronal cell biology, neurotrophin signaling and cell survival, synapse formation and neural plasticity. Material includes lectures and exams, and involves presentation and discussion of primary literature. It focuses on major concepts and recent advances in experimental neuroscience.

Subjects

cellular | cellular | molecular neurobiology | molecular neurobiology | cells | cells | membranes | membranes | ion channels | ion channels | receptors | receptors | synaptic transmission | synaptic transmission | axon guidance | axon guidance | targeting | targeting | neuronal cell biology | neuronal cell biology | synapse formation | synapse formation | plasticity | plasticity

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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B0095P0016

Description

A cat with immune mediated haemolytic anaemia showing signs of jaundice

Subjects

svmsvet | cat | cats | feline | felines | b0095 | imha | immunemediatedhaemolyticanaemia | jaundice | ragdoll | ragdollcat | icterus | jaundicecat | felineimha | felineimmunemediateddisease | haemolyticanaemia | felinehaemolyticanaemia | felineicterus | haemolytic | anaemia | mucous | membranesicteric | membranes

License

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20.410J Molecular, Cellular and Tissue Biomechanics (BE.410J) (MIT) 20.410J Molecular, Cellular and Tissue Biomechanics (BE.410J) (MIT)

Description

This course develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include: structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels will also be investigated. This course was originally co-developed by Professors Alan Grodzinsky, Roger Kamm, and L. Mahadevan. This course develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include: structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels will also be investigated. This course was originally co-developed by Professors Alan Grodzinsky, Roger Kamm, and L. Mahadevan.

Subjects

Scaling laws | Scaling laws | continuum mechanics | continuum mechanics | biomechanical phenomena | biomechanical phenomena | length scales | length scales | tissue structure | tissue structure | molecular basis for macroscopic properties | molecular basis for macroscopic properties | chemical and electrical effects on mechanical behavior | chemical and electrical effects on mechanical behavior | cell mechanics | motility and adhesion | cell mechanics | motility and adhesion | biomembranes | biomembranes | biomolecular mechanics and molecular motors | biomolecular mechanics and molecular motors | Experimental methods | Experimental methods | BE.410J | BE.410J | BE.410 | BE.410 | 2.798 | 2.798 | 6.524 | 6.524

License

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6.021J Quantitative Physiology: Cells and Tissues (MIT)

Description

In this subject, we consider two basic topics in cellular biophysics, posed here as questions: Which molecules are transported across cellular membranes, and what are the mechanisms of transport? How do cells maintain their compositions, volume, and membrane potential? How are potentials generated across the membranes of cells? What do these potentials do? Although the questions posed are fundamentally biological questions, the methods for answering these questions are inherently multidisciplinary. As we will see throughout the course, the role of mathematical models is to express concepts precisely enough that precise conclusions can be drawn. In connection with all the topics covered, we will consider both theory and experiment. For the student, the educational value of examining the i

Subjects

quantitative physiology | cells | tissues | mass transport | electrical signal generation | biological membranes | membranes | diffusion | osmosis | chemically mediated transport | active transport | ion transport | equilibrium potential | resting potential | action potential | voltage-gated ion channels | 6.021 | 2.791 | 2.794 | 6.521 | 20.370 | 20.470 | HST.541

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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BE.410J Molecular, Cellular and Tissue Biomechanics (MIT) BE.410J Molecular, Cellular and Tissue Biomechanics (MIT)

Description

This course develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include: structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels will also be investigated.This course was originally co-developed by Professors Alan Grodzinsky, Roger Kamm, and L. Mahadevan. This course develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include: structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels will also be investigated.This course was originally co-developed by Professors Alan Grodzinsky, Roger Kamm, and L. Mahadevan.

Subjects

Scaling laws | Scaling laws | continuum mechanics | continuum mechanics | biomechanical phenomena | biomechanical phenomena | length scales | length scales | tissue structure | tissue structure | molecular basis for macroscopic properties | molecular basis for macroscopic properties | chemical and electrical effects on mechanical behavior | chemical and electrical effects on mechanical behavior | cell mechanics | motility and adhesion | cell mechanics | motility and adhesion | biomembranes | biomembranes | biomolecular mechanics and molecular motors | biomolecular mechanics and molecular motors | Experimental methods | Experimental methods | 2.798J | 2.798J | 6.524J | 6.524J | 10.537 | 10.537 | BE.410 | BE.410 | 2.798 | 2.798 | 6.524 | 6.524

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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9.013J Cellular and Molecular Neurobiology: The Brain and Cognitive Sciences III (MIT) 9.013J Cellular and Molecular Neurobiology: The Brain and Cognitive Sciences III (MIT)

Description

Subject covers all major areas of cellular and molecular neurobiology including excitable cells and membranes, ion channels and receptors, synaptic transmission, cell type determination, axon guidance and targeting, neuronal cell biology, synapse formation and plasticity. Includes lectures and exams, and involves presentation and discussion of primary literature. Focus on major concepts and recent advances in experimental neuroscience. Subject covers all major areas of cellular and molecular neurobiology including excitable cells and membranes, ion channels and receptors, synaptic transmission, cell type determination, axon guidance and targeting, neuronal cell biology, synapse formation and plasticity. Includes lectures and exams, and involves presentation and discussion of primary literature. Focus on major concepts and recent advances in experimental neuroscience.

Subjects

cellular | cellular | molecular neurobiology | molecular neurobiology | cells | cells | membranes | membranes | receptors | receptors | synaptic transmission | synaptic transmission | axon guidance | axon guidance | targeting | targeting | neuronal cell biology | neuronal cell biology | synapse formation | synapse formation | plasticity | plasticity | 9.013 | 9.013 | 7.68 | 7.68

License

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Targeting cancer mechanisms

Description

Professor Robert Gilbert's research focuses on the molecular mechanisms underlying membrane pore formation and cell adhesion. Switching mechanisms within our cells are in part responsible for their development. MicroRNAs control a whole set of proteins associated with stem cell biology, particularly cancer stem cells. Targeting these components raises the potential for new anti-cancer therapeutics, which work by switching off protein production rather than inhibiting them later. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

molecular | cell membranes | cell adhesion | cancer | stem cells | molecular | cell membranes | cell adhesion | cancer | stem cells

License

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6.021J Quantitative Physiology: Cells and Tissues (MIT)

Description

This course is jointly offered through four departments, available to both undergraduates and graduates. This course introduces the principles of mass transport and electrical signal generation for biological membranes, cells, and tissues. Topics covered include: mass transport through membranes (diffusion, osmosis, chemically mediated, and active transport), electric properties of cells (ion transport), equilibrium, resting, and action potentials, kinetic and molecular properties of single voltage-gated ion channels. Laboratory and computer exercises illustrate the course concepts. Students engage in extensive written and oral communication exercises. This course is worth 4 Engineering Design Points.Technical RequirementsMATLAB® software is required to run the .m files f

Subjects

quantitative physiology | cells | tissues | mass transport | electrical signal generation | biological membranes | membranes | diffusion | osmosis | chemically mediated transport | active transport | ion transport | 6.021 | 2.791 | 2.794 | 6.521 | BE.370 | BE.470 | HST.541

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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8.592 Statistical Physics in Biology (MIT)

Description

Statistical Physics in Biology is a survey of problems at the interface of statistical physics and modern biology. Topics include: bioinformatic methods for extracting information content of DNA; gene finding, sequence comparison, and phylogenetic trees; physical interactions responsible for structure of biopolymers; DNA double helix, secondary structure of RNA, and elements of protein folding; Considerations of force, motion, and packaging; protein motors, membranes. We also look at collective behavior of biological elements, cellular networks, neural networks, and evolution.Technical RequirementsAny number of biological sequence comparison software tools can be used to import the .fna files found on this course site.

Subjects

Bioinformatics | DNA | gene finding | sequence comparison | phylogenetic trees | biopolymers | DNA double helix | secondary structure of RNA | protein folding | protein motors | membranes | cellular networks | neural networks | evolution | statistical physics | molecular biology | deoxyribonucleic acid | genes | genetics | gene sequencing | phylogenetics | double helix | RNA | ribonucleic acid | force | motion | packaging | protein motors | membranes | biochemistry | genome | optimization | partitioning | pattern recognition | collective behavior

License

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B0049P0037

Description

Mucous membranes of an anesthetised cat

Subjects

svmsvet | cat | cats | feline | felines | mucousmembranes | mucousmembranecolour | mm | anaesthetisedcat

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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BE.410J Molecular, Cellular and Tissue Biomechanics (MIT)

Description

This course develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include: structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels will also be investigated.This course was originally co-developed by Professors Alan Grodzinsky, Roger Kamm, and L. Mahadevan.

Subjects

Scaling laws | continuum mechanics | biomechanical phenomena | length scales | tissue structure | molecular basis for macroscopic properties | chemical and electrical effects on mechanical behavior | cell mechanics | motility and adhesion | biomembranes | biomolecular mechanics and molecular motors | Experimental methods | 2.798J | 6.524J | 10.537 | BE.410 | 2.798 | 6.524

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.340 Ubiquitination: The Proteasome and Human Disease (MIT)

Description

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. This seminar provides a deeper understanding of the post-translational mechanisms evolved by eukaryotic cells to target proteins for degradation. Students learn how proteins are recognized and degraded by specific machinery (the proteasome) through their previous tagging with another small protein, ubiquitin. Additional topics include principles of ubiquitin-proteasome function, its control of the most important cellular pathways, and the implication of this system in different human diseases. Finally, spe

Subjects

ubiquitination | ubiquitin | proteasome | post-translational mechanisms | ubiquitin-conjugation system | neurodegenerative diseases | immune response | cell cycle regulation | apoptosis | signal transduction pathways | tumorigenesis | protein degradation | Endoplasmic Reticulum Associated Degradation Pathway | ligases | translocated proteins | misfolded proteins | trafficking membranes | cell cycle control | programmed cell death | Huntington's Disease | Von Hippel-Lindau Disease

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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9.013J Cellular and Molecular Neurobiology: The Brain and Cognitive Sciences III (MIT)

Description

Subject covers all major areas of cellular and molecular neurobiology including excitable cells and membranes, ion channels and receptors, synaptic transmission, cell type determination, axon guidance and targeting, neuronal cell biology, synapse formation and plasticity. Includes lectures and exams, and involves presentation and discussion of primary literature. Focus on major concepts and recent advances in experimental neuroscience.

Subjects

cellular | molecular neurobiology | cells | membranes | receptors | synaptic transmission | axon guidance | targeting | neuronal cell biology | synapse formation | plasticity | 9.013 | 7.68

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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