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7.349 Biological Computing: At the Crossroads of Engineering and Science (MIT) 7.349 Biological Computing: At the Crossroads of Engineering and Science (MIT)

Description

Imagine you are a salesman needing to visit 100 cities connected by a set of roads. Can you do it while stopping in each city only once? Even a supercomputer working at 1 trillion operations per second would take longer than the age of the universe to find a solution when considering each possibility in turn. In 1994, Leonard Adleman published a paper in which he described a solution, using the tools of molecular biology, for a smaller 7-city example of this problem. His paper generated enormous scientific and public interest, and kick-started the field of Biological Computing, the main subject of this discussion based seminar course. Students will analyze the Adleman paper, and the papers that preceded and followed it, with an eye for identifying the engineering and scientific aspects of Imagine you are a salesman needing to visit 100 cities connected by a set of roads. Can you do it while stopping in each city only once? Even a supercomputer working at 1 trillion operations per second would take longer than the age of the universe to find a solution when considering each possibility in turn. In 1994, Leonard Adleman published a paper in which he described a solution, using the tools of molecular biology, for a smaller 7-city example of this problem. His paper generated enormous scientific and public interest, and kick-started the field of Biological Computing, the main subject of this discussion based seminar course. Students will analyze the Adleman paper, and the papers that preceded and followed it, with an eye for identifying the engineering and scientific aspects of

Subjects

biological computing | biological computing | Leonard Adleman | Leonard Adleman | exquisite detection | exquisite detection | whole-cell computing | whole-cell computing | computation | computation | molecular biology | molecular biology | biotin-avidin | biotin-avidin | magnetic beads | magnetic beads | cellular processes | cellular processes | combinatorial problems | combinatorial problems | self-assembly | self-assembly | nanodevices | nanodevices | molecular machines | molecular machines | quorum sensing | quorum sensing | molecular switches | molecular switches | ciliates | ciliates | molecular gates | molecular gates | molecular circuits | molecular circuits | genetic switch | genetic switch | cellular networks | cellular networks | genetic networks | genetic networks | genetic circuits | genetic circuits

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3.012 Fundamentals of Materials Science (MIT) 3.012 Fundamentals of Materials Science (MIT)

Description

This course focuses on the fundamentals of structure, energetics, and bonding that underpin materials science. It is the introductory lecture class for sophomore students in Materials Science and Engineering, taken with 3.014 and 3.016 to create a unified introduction to the subject. Topics include: an introduction to thermodynamic functions and laws governing equilibrium properties, relating macroscopic behavior to atomistic and molecular models of materials; the role of electronic bonding in determining the energy, structure, and stability of materials; quantum mechanical descriptions of interacting electrons and atoms; materials phenomena, such as heat capacities, phase transformations, and multiphase equilibria to chemical reactions and magnetism; symmetry properties of molecules and s This course focuses on the fundamentals of structure, energetics, and bonding that underpin materials science. It is the introductory lecture class for sophomore students in Materials Science and Engineering, taken with 3.014 and 3.016 to create a unified introduction to the subject. Topics include: an introduction to thermodynamic functions and laws governing equilibrium properties, relating macroscopic behavior to atomistic and molecular models of materials; the role of electronic bonding in determining the energy, structure, and stability of materials; quantum mechanical descriptions of interacting electrons and atoms; materials phenomena, such as heat capacities, phase transformations, and multiphase equilibria to chemical reactions and magnetism; symmetry properties of molecules and s

Subjects

bonding | bonding | energetics | energetics | structure | structure | antibonding | antibonding | hydrogen | hydrogen | Quantum mechanics | Quantum mechanics | electron | electron | atom | atom | molecule | molecule | molecular dynamics | molecular dynamics | MD | MD | Symmetry properties | Symmetry properties | solid | solid | gas | gas | liquid | liquid | phase | phase | matter; molecular geometry | matter; molecular geometry | complex and disordered materials | complex and disordered materials | thermodynamics | thermodynamics | equilibrium property | equilibrium property | macroscopic behavior | macroscopic behavior | molecular model | molecular model | heat capacity | heat capacity | phase transformation | phase transformation | multiphase equilibria | multiphase equilibria | chemical reaction | chemical reaction | magnetism | magnetism | engineered alloy | engineered alloy | electronic and magnetic material | electronic and magnetic material | ionic solid | ionic solid | network solid | network solid | polymer | polymer | biomaterial | biomaterial | glass | glass | liquid crystal | liquid crystal | LCD | LCD | matter | matter | molecular geometry | molecular geometry

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7.342 Systems and Synthetic Biology: How the Cell Solves Problems (MIT) 7.342 Systems and Synthetic Biology: How the Cell Solves Problems (MIT)

Description

A millennial challenge in biology is to decipher how vast arrays of molecular interactions inside the cell work in concert to produce a cellular function. Systems biology, a new interdisciplinary field of science, brings together biologists and physicists to tackle this grand challenge through quantitative experiments and models. In this course, we will discuss the unifying principles that all organisms use to perform cellular functions. We will also discuss key challenges faced by a cell in both single and multi-cellular organisms. Finally, we will discuss how researchers in the field of synthetic biology are using the new knowledge gained from studying naturally-occurring biological systems to create artificial gene networks capable of performing new functions. This course is one of many A millennial challenge in biology is to decipher how vast arrays of molecular interactions inside the cell work in concert to produce a cellular function. Systems biology, a new interdisciplinary field of science, brings together biologists and physicists to tackle this grand challenge through quantitative experiments and models. In this course, we will discuss the unifying principles that all organisms use to perform cellular functions. We will also discuss key challenges faced by a cell in both single and multi-cellular organisms. Finally, we will discuss how researchers in the field of synthetic biology are using the new knowledge gained from studying naturally-occurring biological systems to create artificial gene networks capable of performing new functions. This course is one of many

Subjects

systems biology | systems biology | synthetic biology | synthetic biology | cell | cell | cellular functions | cellular functions | biological systems | biological systems | artificial gene networks | artificial gene networks | molecular interactions | molecular interactions | molecular biology | molecular biology | genes | genes | RNA | RNA | proteins | proteins | macromolecules | macromolecules | intracellular biochemical interactions | intracellular biochemical interactions | extracellular molecules | extracellular molecules | gene expression | gene expression | stochastic gene expression | stochastic gene expression

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5.04 Principles of Inorganic Chemistry II (MIT) 5.04 Principles of Inorganic Chemistry II (MIT)

Description

This course provides a systematic presentation of the chemical applications of group theory with emphasis on the formal development of the subject and its applications to the physical methods of inorganic chemical compounds. Against the backdrop of electronic structure, the electronic, vibrational, and magnetic properties of transition metal complexes are presented and their investigation by the appropriate spectroscopy described. This course provides a systematic presentation of the chemical applications of group theory with emphasis on the formal development of the subject and its applications to the physical methods of inorganic chemical compounds. Against the backdrop of electronic structure, the electronic, vibrational, and magnetic properties of transition metal complexes are presented and their investigation by the appropriate spectroscopy described.

Subjects

inorganic chemistry | inorganic chemistry | group theory | group theory | electronic structure of molecules | electronic structure of molecules | transition metal complexes | transition metal complexes | spectroscopy | spectroscopy | symmetry elements | symmetry elements | mathematical groups | mathematical groups | character tables | character tables | molecular point groups | molecular point groups | Huckel Theory | Huckel Theory | N-Dimensional cyclic systems | N-Dimensional cyclic systems | solid state theory | solid state theory | band theory | band theory | frontier molecular orbitals | frontier molecular orbitals | similarity transformations | similarity transformations | complexes | complexes | organometallic complexes | organometallic complexes | two electron bond | two electron bond | vibrational spectroscopy | vibrational spectroscopy | symmetry | symmetry | overtones | overtones | normal coordinat analysis | normal coordinat analysis | AOM | AOM | single electron CFT | single electron CFT | tanabe-sugano diagram | tanabe-sugano diagram | ligand | ligand | crystal field theory | crystal field theory | LCAO | LCAO

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20.462J Molecular Principles of Biomaterials (BE.462J) (MIT) 20.462J Molecular Principles of Biomaterials (BE.462J) (MIT)

Description

Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S

Subjects

Analysis | Analysis | design | design | molecular scale | molecular scale | biological systems | biological systems | biotechnology | biotechnology | biomedical engineering | biomedical engineering | molecular interactions | molecular interactions | synthetic molecules | synthetic molecules | synthesis | synthesis | processing approaches | processing approaches | cell functions | cell functions | materials science | materials science | tissue engineering | tissue engineering | drug delivery | drug delivery | biosensors | biosensors | cell-guiding surfaces | cell-guiding surfaces | BE.462J | BE.462J | BE.462 | BE.462 | 3.962 | 3.962

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3.012 Fundamentals of Materials Science (MIT) 3.012 Fundamentals of Materials Science (MIT)

Description

This subject describes the fundamentals of bonding, energetics, and structure that underpin materials science. From electrons to silicon to DNA: the role of electronic bonding in determining the energy, structure, and stability of materials. Quantum mechanical descriptions of interacting electrons and atoms. Symmetry properties of molecules and solids. Structure of complex and disordered materials. Introduction to thermodynamic functions and laws governing equilibrium properties, relating macroscopic behavior to molecular models of materials. Develops basis for understanding a broad range of materials phenomena, from heat capacities, phase transformations, and multiphase equilibria to chemical reactions and magnetism. Fundamentals are taught using real-world examples such as engineered all This subject describes the fundamentals of bonding, energetics, and structure that underpin materials science. From electrons to silicon to DNA: the role of electronic bonding in determining the energy, structure, and stability of materials. Quantum mechanical descriptions of interacting electrons and atoms. Symmetry properties of molecules and solids. Structure of complex and disordered materials. Introduction to thermodynamic functions and laws governing equilibrium properties, relating macroscopic behavior to molecular models of materials. Develops basis for understanding a broad range of materials phenomena, from heat capacities, phase transformations, and multiphase equilibria to chemical reactions and magnetism. Fundamentals are taught using real-world examples such as engineered all

Subjects

fundamentals of bonding | energetics | and structure | fundamentals of bonding | energetics | and structure | Quantum mechanical descriptions of interacting electrons and atoms | Quantum mechanical descriptions of interacting electrons and atoms | Symmetry properties of molecules and solids | Symmetry properties of molecules and solids | complex and disordered materials | complex and disordered materials | thermodynamic functions | thermodynamic functions | equilibrium properties | equilibrium properties | macroscopic behavior | macroscopic behavior | molecular models | molecular models | heat capacities | heat capacities | phase transformations | phase transformations | multiphase equilibria | multiphase equilibria | chemical reactions | chemical reactions | magnetism | magnetism | engineered alloys | engineered alloys | electronic and magnetic materials | electronic and magnetic materials | ionic and network solids | ionic and network solids | polymers | polymers | biomaterials | biomaterials | energetics | energetics | structure | structure | materials science | materials science | electrons | electrons | silicon | silicon | DNA | DNA | electronic bonding | electronic bonding | energy | energy | stability | stability | quantum mechanics | quantum mechanics | atoms | atoms | interactions | interactions | symmetry | symmetry | molecules | molecules | solids | solids | complex material | complex material | disorderd materials | disorderd materials | thermodynamic laws | thermodynamic laws | electronic materials | electronic materials | magnetic materials | magnetic materials | ionic solids | ionic solids | network solids | network solids | statistical mechanics | statistical mechanics | microstates | microstates | microscopic complexity | microscopic complexity | entropy | entropy

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7.014 Introductory Biology (MIT) 7.014 Introductory Biology (MIT)

Description

The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.7.014 focuses on the application of these fundamental principles, toward an understanding of microorganisms as geochemical agents responsible for the evolution and renewal of the biosphere and of their role in human health The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.7.014 focuses on the application of these fundamental principles, toward an understanding of microorganisms as geochemical agents responsible for the evolution and renewal of the biosphere and of their role in human health

Subjects

microorganisms | microorganisms | geochemistry | geochemistry | geochemical agents | geochemical agents | biosphere | biosphere | bacterial genetics | bacterial genetics | carbon metabolism | carbon metabolism | energy metabolism | energy metabolism | productivity | productivity | biogeochemical cycles | biogeochemical cycles | molecular evolution | molecular evolution | population genetics | population genetics | evolution | evolution | population growth | population growth | biology | biology | biochemistry | biochemistry | genetics | genetics | molecular biology | molecular biology | recombinant DNA | recombinant DNA | cell cycle | cell cycle | cell signaling | cell signaling | cloning | cloning | stem cells | stem cells | cancer | cancer | immunology | immunology | virology | virology | genomics | genomics | molecular medicine | molecular medicine | DNA | DNA | RNA | RNA | proteins | proteins | replication | replication | transcription | transcription | mRNA | mRNA | translation | translation | ribosome | ribosome | nervous system | nervous system | amino acids | amino acids | polypeptide chain | polypeptide chain | cell biology | cell biology | neurobiology | neurobiology | gene regulation | gene regulation | protein structure | protein structure | protein synthesis | protein synthesis | gene structure | gene structure | PCR | PCR | polymerase chain reaction | polymerase chain reaction | protein localization | protein localization | endoplasmic reticulum | endoplasmic reticulum | ecology | ecology | communities | communities

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18.417 Introduction to Computational Molecular Biology (MIT) 18.417 Introduction to Computational Molecular Biology (MIT)

Description

This course introduces the basic computational methods used to understand the cell on a molecular level. It covers subjects such as the sequence alignment algorithms: dynamic programming, hashing, suffix trees, and Gibbs sampling. Furthermore, it focuses on computational approaches to: genetic and physical mapping; genome sequencing, assembly, and annotation; RNA expression and secondary structure; protein structure and folding; and molecular interactions and dynamics. This course introduces the basic computational methods used to understand the cell on a molecular level. It covers subjects such as the sequence alignment algorithms: dynamic programming, hashing, suffix trees, and Gibbs sampling. Furthermore, it focuses on computational approaches to: genetic and physical mapping; genome sequencing, assembly, and annotation; RNA expression and secondary structure; protein structure and folding; and molecular interactions and dynamics.

Subjects

basic computational methods cell on a molecular level | basic computational methods cell on a molecular level | sequence alignment algorithms | sequence alignment algorithms | dynamic programming | dynamic programming | hashing | hashing | suffix trees | suffix trees | Gibbs sampling | Gibbs sampling | genetic and physical mapping | genetic and physical mapping | genome sequencing | genome sequencing | assembly | assembly | and annotation | and annotation | RNA expression and secondary structure | RNA expression and secondary structure | protein structure and folding | protein structure and folding | and molecular interactions and dynamics | and molecular interactions and dynamics | annotation | annotation | molecular interactions and dynamics | molecular interactions and dynamics

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BE.462J Molecular Principles of Biomaterials (MIT) BE.462J Molecular Principles of Biomaterials (MIT)

Description

Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S

Subjects

Analysis | Analysis | design | design | molecular scale | molecular scale | biological systems | biological systems | biotechnology | biotechnology | biomedical engineering | biomedical engineering | molecular interactions | molecular interactions | synthetic molecules | synthetic molecules | synthesis | synthesis | processing approaches | processing approaches | cell functions | cell functions | materials science | materials science | tissue engineering | tissue engineering | drug delivery | drug delivery | biosensors | biosensors | cell-guiding surfaces | cell-guiding surfaces | 3.962J | 3.962J | BE.462 | BE.462 | 3.962 | 3.962

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20.462J Molecular Principles of Biomaterials (MIT) 20.462J Molecular Principles of Biomaterials (MIT)

Description

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces. This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Subjects

biomaterials | biomaterials | biomaterial engineering | biomaterial engineering | biotechnology | biotechnology | cell-guiding surface | cell-guiding surface | molecular biomaterials | molecular biomaterials | drug release | drug release | polymers | polymers | pulsatile release | pulsatile release | polymerization | polymerization | polyer erosion | polyer erosion | tissue engineering | tissue engineering | hydrogels | hydrogels | adhesion | adhesion | migration | migration | drug diffusion | drug diffusion | molecular switches | molecular switches | molecular motors | molecular motors | nanoparticles | nanoparticles | microparticles | microparticles | vaccines | vaccines | drug targeting | drug targeting | micro carriers | micro carriers | nano carriers | nano carriers | intracellular drug delivery | intracellular drug delivery | 20.462 | 20.462 | 3.962 | 3.962

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20.011J Statistical Thermodynamics of Biomolecular Systems (BE.011J) (MIT) 20.011J Statistical Thermodynamics of Biomolecular Systems (BE.011J) (MIT)

Description

This course provides an introduction to the physical chemistry of biological systems. Topics include: connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics, chemical potentials, equilibrium states, binding cooperativity, behavior of macromolecules in solution and at interfaces, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials. This course provides an introduction to the physical chemistry of biological systems. Topics include: connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics, chemical potentials, equilibrium states, binding cooperativity, behavior of macromolecules in solution and at interfaces, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.

Subjects

physical chemistry of biological systems | physical chemistry of biological systems | macroscopic thermodynamic properties | macroscopic thermodynamic properties | microscopic molecular properties | microscopic molecular properties | statistical mechanics | statistical mechanics | chemical potentials | chemical potentials | equilibrium states | equilibrium states | binding cooperativity | binding cooperativity | behavior of macromolecules in solution and at interfaces | behavior of macromolecules in solution and at interfaces | solvation | solvation | protein structure | protein structure | genomic analysis | genomic analysis | single molecule biomechanics | single molecule biomechanics | biomaterials | biomaterials | BE.011J | BE.011J | BE.011 | BE.011 | 2.772 | 2.772

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20.410J Molecular, Cellular and Tissue Biomechanics (BE.410J) (MIT) 20.410J Molecular, Cellular and Tissue Biomechanics (BE.410J) (MIT)

Description

This course develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include: structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels will also be investigated. This course was originally co-developed by Professors Alan Grodzinsky, Roger Kamm, and L. Mahadevan. This course develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include: structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels will also be investigated. This course was originally co-developed by Professors Alan Grodzinsky, Roger Kamm, and L. Mahadevan.

Subjects

Scaling laws | Scaling laws | continuum mechanics | continuum mechanics | biomechanical phenomena | biomechanical phenomena | length scales | length scales | tissue structure | tissue structure | molecular basis for macroscopic properties | molecular basis for macroscopic properties | chemical and electrical effects on mechanical behavior | chemical and electrical effects on mechanical behavior | cell mechanics | motility and adhesion | cell mechanics | motility and adhesion | biomembranes | biomembranes | biomolecular mechanics and molecular motors | biomolecular mechanics and molecular motors | Experimental methods | Experimental methods | BE.410J | BE.410J | BE.410 | BE.410 | 2.798 | 2.798 | 6.524 | 6.524

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BE.011J Statistical Thermodynamics of Biomolecular Systems (MIT) BE.011J Statistical Thermodynamics of Biomolecular Systems (MIT)

Description

This course provides an introduction to the physical chemistry of biological systems. Topics include: connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics, chemical potentials, equilibrium states, binding cooperativity, behavior of macromolecules in solution and at interfaces, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.Technical RequirementsMATLAB® software is required to run the .m and .fig files found on this course site. This course provides an introduction to the physical chemistry of biological systems. Topics include: connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics, chemical potentials, equilibrium states, binding cooperativity, behavior of macromolecules in solution and at interfaces, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.Technical RequirementsMATLAB® software is required to run the .m and .fig files found on this course site.

Subjects

physical chemistry of biological systems | physical chemistry of biological systems | macroscopic thermodynamic properties | macroscopic thermodynamic properties | microscopic molecular properties | microscopic molecular properties | statistical mechanics | statistical mechanics | chemical potentials | chemical potentials | equilibrium states | equilibrium states | binding cooperativity | binding cooperativity | behavior of macromolecules in solution and at interfaces | behavior of macromolecules in solution and at interfaces | solvation | solvation | protein structure | protein structure | genomic analysis | genomic analysis | single molecule biomechanics | single molecule biomechanics | biomaterials | biomaterials | 2.772J | 2.772J | BE.011 | BE.011 | 2.772 | 2.772

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10.520 Molecular Aspects of Chemical Engineering (MIT) 10.520 Molecular Aspects of Chemical Engineering (MIT)

Description

This class covers molecular-level engineering and analysis of chemical processes. The use of chemical bonding, reactivity, and other key concepts in the design and tailoring of organic systems are discussed in this class. Specific class topics include application and development of structure-property relationships, and descriptions of the chemical forces and structural factors that govern supramolecular and interfacial phenomena for molecular and polymeric systems. This class covers molecular-level engineering and analysis of chemical processes. The use of chemical bonding, reactivity, and other key concepts in the design and tailoring of organic systems are discussed in this class. Specific class topics include application and development of structure-property relationships, and descriptions of the chemical forces and structural factors that govern supramolecular and interfacial phenomena for molecular and polymeric systems.

Subjects

molecular-level engineering | molecular-level engineering | analysis of chemical processes | analysis of chemical processes | chemical bonding | chemical bonding | reactivity | reactivity | design of organic systems | design of organic systems | tailoring of organic systems | tailoring of organic systems | application and development of structure-property relationships | application and development of structure-property relationships | descriptions of the chemical forces and structural factors that govern supramolecular and interfacial phenomena for molecular and polymeric systems | descriptions of the chemical forces and structural factors that govern supramolecular and interfacial phenomena for molecular and polymeric systems

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BE.410J Molecular, Cellular and Tissue Biomechanics (MIT) BE.410J Molecular, Cellular and Tissue Biomechanics (MIT)

Description

This course develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include: structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels will also be investigated.This course was originally co-developed by Professors Alan Grodzinsky, Roger Kamm, and L. Mahadevan. This course develops and applies scaling laws and the methods of continuum mechanics to biomechanical phenomena over a range of length scales. Topics include: structure of tissues and the molecular basis for macroscopic properties; chemical and electrical effects on mechanical behavior; cell mechanics, motility and adhesion; biomembranes; biomolecular mechanics and molecular motors. Experimental methods for probing structures at the tissue, cellular, and molecular levels will also be investigated.This course was originally co-developed by Professors Alan Grodzinsky, Roger Kamm, and L. Mahadevan.

Subjects

Scaling laws | Scaling laws | continuum mechanics | continuum mechanics | biomechanical phenomena | biomechanical phenomena | length scales | length scales | tissue structure | tissue structure | molecular basis for macroscopic properties | molecular basis for macroscopic properties | chemical and electrical effects on mechanical behavior | chemical and electrical effects on mechanical behavior | cell mechanics | motility and adhesion | cell mechanics | motility and adhesion | biomembranes | biomembranes | biomolecular mechanics and molecular motors | biomolecular mechanics and molecular motors | Experimental methods | Experimental methods | 2.798J | 2.798J | 6.524J | 6.524J | 10.537 | 10.537 | BE.410 | BE.410 | 2.798 | 2.798 | 6.524 | 6.524

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HST.035 Principle and Practice of Human Pathology (MIT) HST.035 Principle and Practice of Human Pathology (MIT)

Description

This course provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and diagnostic medicine. Topics include:Cellular Mechanisms of DiseaseMolecular PathologyPathology of Major Organ SystemsReview of Diagnostic Tools from Traditional Surgical Pathology to Diagnostic SpectroscopyFunctional and Molecular ImagingMolecular DiagnosticsIn addition to lectures, one of the two weekly sessions includes a 2-3 hour laboratory component. Periodically, time will also be devoted to minicases.LecturersProf. Jon AsterProf. Frederick BieberProf. Carlo BrugnaraProf. Robert B. ColvinProf. Christopher CrumProf. Douglas DockeryProf. Mel FeanyProf. Michael FeldProf. Jonathan FletcherProf. Michael GimbroneProf. Todd GolubProf. Frank B. HuProf. Donald IngberProf. Hart LidovProf. This course provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and diagnostic medicine. Topics include:Cellular Mechanisms of DiseaseMolecular PathologyPathology of Major Organ SystemsReview of Diagnostic Tools from Traditional Surgical Pathology to Diagnostic SpectroscopyFunctional and Molecular ImagingMolecular DiagnosticsIn addition to lectures, one of the two weekly sessions includes a 2-3 hour laboratory component. Periodically, time will also be devoted to minicases.LecturersProf. Jon AsterProf. Frederick BieberProf. Carlo BrugnaraProf. Robert B. ColvinProf. Christopher CrumProf. Douglas DockeryProf. Mel FeanyProf. Michael FeldProf. Jonathan FletcherProf. Michael GimbroneProf. Todd GolubProf. Frank B. HuProf. Donald IngberProf. Hart LidovProf.

Subjects

human pathology | human pathology | disease mechanisms | disease mechanisms | cellular pathology | cellular pathology | molecular pathology | molecular pathology | diagnostic tools | diagnostic tools | surgical pathology | surgical pathology | diagnostic spectroscopy | diagnostic spectroscopy | functional imaging | functional imaging | molecular imaging | molecular imaging | molecular diagnostics | molecular diagnostics | medicine | medicine | immune system | immune system | transplantation | transplantation | diagnosis | diagnosis | neoplasia | neoplasia | pathobiology | pathobiology | pathophysiology | pathophysiology

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BE.442 Molecular Structure of Biological Materials (MIT) BE.442 Molecular Structure of Biological Materials (MIT)

Description

Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular design of new biological materials for nanotechnology, biocomputing and regenerative medicine. Graduate students are expected to complete additional coursework. Basic molecular structural principles of biological materials. Molecular structures of various materials of biological origin, including collagen, silk, bone, protein adhesives, GFP, self-assembling peptides. Molecular design of new biological materials for nanotechnology, biocomputing and regenerative medicine. Graduate students are expected to complete additional coursework.

Subjects

biological materials | biological materials | molecular structure | molecular structure | self assembly | self assembly | molecular design | molecular design | bioelectronics | bioelectronics | molecular computing | molecular computing | tissue engineering | tissue engineering

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3.012 Fundamentals of Materials Science (MIT)

Description

This course focuses on the fundamentals of structure, energetics, and bonding that underpin materials science. It is the introductory lecture class for sophomore students in Materials Science and Engineering, taken with 3.014 and 3.016 to create a unified introduction to the subject. Topics include: an introduction to thermodynamic functions and laws governing equilibrium properties, relating macroscopic behavior to atomistic and molecular models of materials; the role of electronic bonding in determining the energy, structure, and stability of materials; quantum mechanical descriptions of interacting electrons and atoms; materials phenomena, such as heat capacities, phase transformations, and multiphase equilibria to chemical reactions and magnetism; symmetry properties of molecules and s

Subjects

bonding | energetics | structure | antibonding | hydrogen | Quantum mechanics | electron | atom | molecule | molecular dynamics | MD | Symmetry properties | solid | gas | liquid | phase | matter; molecular geometry | complex and disordered materials | thermodynamics | equilibrium property | macroscopic behavior | molecular model | heat capacity | phase transformation | multiphase equilibria | chemical reaction | magnetism | engineered alloy | electronic and magnetic material | ionic solid | network solid | polymer | biomaterial | glass | liquid crystal | LCD | matter | molecular geometry

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7.349 Biological Computing: At the Crossroads of Engineering and Science (MIT)

Description

Imagine you are a salesman needing to visit 100 cities connected by a set of roads. Can you do it while stopping in each city only once? Even a supercomputer working at 1 trillion operations per second would take longer than the age of the universe to find a solution when considering each possibility in turn. In 1994, Leonard Adleman published a paper in which he described a solution, using the tools of molecular biology, for a smaller 7-city example of this problem. His paper generated enormous scientific and public interest, and kick-started the field of Biological Computing, the main subject of this discussion based seminar course. Students will analyze the Adleman paper, and the papers that preceded and followed it, with an eye for identifying the engineering and scientific aspects of

Subjects

biological computing | Leonard Adleman | exquisite detection | whole-cell computing | computation | molecular biology | biotin-avidin | magnetic beads | cellular processes | combinatorial problems | self-assembly | nanodevices | molecular machines | quorum sensing | molecular switches | ciliates | molecular gates | molecular circuits | genetic switch | cellular networks | genetic networks | genetic circuits

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5.61 Physical Chemistry (MIT) 5.61 Physical Chemistry (MIT)

Description

This course presents an introduction to quantum mechanics. It begins with an examination of the historical development of quantum theory, properties of particles and waves, wave mechanics and applications to simple systems -- the particle in a box, the harmonic oscillator, the rigid rotor and the hydrogen atom. The lectures continue with a discussion of atomic structure and the Periodic Table. The final lectures cover applications to chemical bonding including valence bond and molecular orbital theory, molecular structure, spectroscopy.AcknowledgementsThe material for 5.61 has evolved over a period of many years, and, accordingly, several faculty members have contributed to the development of the course contents. The original version of the lecture notes that are available on OCW was prepa This course presents an introduction to quantum mechanics. It begins with an examination of the historical development of quantum theory, properties of particles and waves, wave mechanics and applications to simple systems -- the particle in a box, the harmonic oscillator, the rigid rotor and the hydrogen atom. The lectures continue with a discussion of atomic structure and the Periodic Table. The final lectures cover applications to chemical bonding including valence bond and molecular orbital theory, molecular structure, spectroscopy.AcknowledgementsThe material for 5.61 has evolved over a period of many years, and, accordingly, several faculty members have contributed to the development of the course contents. The original version of the lecture notes that are available on OCW was prepa

Subjects

physical chemistry | physical chemistry | quantum mechanics | quantum mechanics | quantum chemistry | quantum chemistry | particles and waves; wave mechanics | particles and waves; wave mechanics | atomic structure | atomic structure | valence orbital | valence orbital | molecular orbital theory | molecular orbital theory | molecular structure | molecular structure | photochemistry | photochemistry | particles and waves | wave mechanics | particles and waves | wave mechanics

License

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5.62 Physical Chemistry II (MIT) 5.62 Physical Chemistry II (MIT)

Description

This subject deals primarily with elementary statistical mechanics, transport properties, kinetic theory, solid state, reaction rate theory, and chemical reaction dynamics.AcknowledgementsThe lecture note materials for this course include contributions from Professor Sylvia T. Ceyer. The Staff for this course would like to acknowledge that these course materials include contributions from past instructors, textbooks, and other members of the MIT Chemistry Department affiliated with course #5.62. Since the following works have evolved over a period of many years, no single source can be attributed. This subject deals primarily with elementary statistical mechanics, transport properties, kinetic theory, solid state, reaction rate theory, and chemical reaction dynamics.AcknowledgementsThe lecture note materials for this course include contributions from Professor Sylvia T. Ceyer. The Staff for this course would like to acknowledge that these course materials include contributions from past instructors, textbooks, and other members of the MIT Chemistry Department affiliated with course #5.62. Since the following works have evolved over a period of many years, no single source can be attributed.

Subjects

physical chemistry | physical chemistry | partition functions | partition functions | atomic degrees of freedom | atomic degrees of freedom | molecular degrees of freedom | molecular degrees of freedom | chemical equilibrium | chemical equilibrium | thermodynamics | thermodynamics | intermolecular potentials | intermolecular potentials | equations of state | equations of state | solid state chemistry | solid state chemistry | einstein and debye solids | einstein and debye solids | kinetic theory | kinetic theory | rate theory | rate theory | chemical kinetics | chemical kinetics | transition state theory | transition state theory | RRKM theory | RRKM theory | collision theory | collision theory | equipartition | equipartition | fermi-dirac statistics | fermi-dirac statistics | boltzmann statistics | boltzmann statistics | bose-einstein statistics | bose-einstein statistics | statistical mechanics | statistical mechanics

License

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20.320 Biomolecular Kinetics and Cell Dynamics (MIT) 20.320 Biomolecular Kinetics and Cell Dynamics (MIT)

Description

This class covers analysis of kinetics and dynamics of molecular and cellular processes across a hierarchy of scales, including intracellular, extracellular, and cell population levels; a spectrum of biotechnology applications are also taken into consideration. Topics include gene regulation networks; nucleic acid hybridization; signal transduction pathways; and cell populations in tissues and bioreactors. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling. This class covers analysis of kinetics and dynamics of molecular and cellular processes across a hierarchy of scales, including intracellular, extracellular, and cell population levels; a spectrum of biotechnology applications are also taken into consideration. Topics include gene regulation networks; nucleic acid hybridization; signal transduction pathways; and cell populations in tissues and bioreactors. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

Subjects

kinetics of molecular processes | kinetics of molecular processes | dynamics of molecular processes | dynamics of molecular processes | kinetics of cellular processes | kinetics of cellular processes | dynamics of cellular processes | dynamics of cellular processes | intracellular scale | intracellular scale | extracellular scale | extracellular scale | and cell population scale | and cell population scale | biotechnology applications | biotechnology applications | gene regulation networks | gene regulation networks | nucleic acid hybridization | nucleic acid hybridization | signal transduction pathways | signal transduction pathways | cell populations in tissues | cell populations in tissues | cell populations in bioreactors | cell populations in bioreactors | experimental methods | experimental methods | quantitative analysis | quantitative analysis | computational modeling | computational modeling | cell population scale | cell population scale

License

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7.27 Principles of Human Disease (MIT) 7.27 Principles of Human Disease (MIT)

Description

This course covers current understanding of, and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Topics include: The Genetics of Simple and Complex Traits; Karyotypic Analysis and Positional Cloning; Genetic Diagnosis; The Roles of Oncogenes and Tumor Suppressors in Tumor Initiation, Progression, and Treatment; The Interaction between Genetics and Environment; Animal Models of Human Disease; Cancer; and Conventional and Gene Therapy Treatment Strategies. This course covers current understanding of, and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Topics include: The Genetics of Simple and Complex Traits; Karyotypic Analysis and Positional Cloning; Genetic Diagnosis; The Roles of Oncogenes and Tumor Suppressors in Tumor Initiation, Progression, and Treatment; The Interaction between Genetics and Environment; Animal Models of Human Disease; Cancer; and Conventional and Gene Therapy Treatment Strategies.

Subjects

human disease | human disease | molecular basis of genetic disease | molecular basis of genetic disease | molecular basis of cancer | molecular basis of cancer | cellular basis of genetic disease | cellular basis of genetic disease | cellular basis of cancer | cellular basis of cancer | genetics of simple and complex traits | genetics of simple and complex traits | karyotypic analysis | karyotypic analysis | positional cloning | positional cloning | genetic diagnosis | genetic diagnosis | roles of oncogenes | roles of oncogenes | tumor suppressors | tumor suppressors | tumor initiation | tumor initiation | tumor progression | tumor progression | tumor treatment | tumor treatment | interaction between genetics and environment | interaction between genetics and environment | animal models of human disease | animal models of human disease | cancer | cancer | conventional treatment strategies | conventional treatment strategies | gene therapy treatment strategies | gene therapy treatment strategies

License

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7.016 Introductory Biology (MIT) 7.016 Introductory Biology (MIT)

Description

7.016 Introductory Biology provides an introduction to fundamental principles of biochemistry, molecular biology and genetics for understanding the functions of living systems. Taught for the first time in Fall 2013, this course covers examples of the use of chemical biology and twenty-first-century molecular genetics in understanding human health and therapeutic intervention. The MIT Biology Department Introductory Biology courses, 7.012, 7.013, 7.014, 7.015, and 7.016 all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as the structure and synthesis of proteins, how these mol 7.016 Introductory Biology provides an introduction to fundamental principles of biochemistry, molecular biology and genetics for understanding the functions of living systems. Taught for the first time in Fall 2013, this course covers examples of the use of chemical biology and twenty-first-century molecular genetics in understanding human health and therapeutic intervention. The MIT Biology Department Introductory Biology courses, 7.012, 7.013, 7.014, 7.015, and 7.016 all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as the structure and synthesis of proteins, how these mol

Subjects

biochemistry | biochemistry | molecular biology | molecular biology | genetics | genetics | human genetics | human genetics | pedigrees | pedigrees | biochemical genetics | biochemical genetics | chemical biology | chemical biology | molecular genetics | molecular genetics | recombinant DNA technology | recombinant DNA technology | cell biology | cell biology | cancer | cancer | viruses | viruses | HIV | HIV | bacteria | bacteria | antibiotics | antibiotics | human health | human health | therapeutic intervention | therapeutic intervention | cell signaling | cell signaling | evolution | evolution | reproduction | reproduction | infectious diseases | infectious diseases | therapeutics | therapeutics

License

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5.62 Physical Chemistry II (MIT) 5.62 Physical Chemistry II (MIT)

Description

This course covers elementary statistical mechanics, transport properties, kinetic theory, solid state, reaction rate theory, and chemical reaction dynamics. Acknowledgements The staff for this course would like to acknowledge that these course materials include contributions from past instructors, textbooks, and other members of the MIT Chemistry Department affiliated with course #5.62. Since the following works have evolved over a period of many years, no single source can be attributed. This course covers elementary statistical mechanics, transport properties, kinetic theory, solid state, reaction rate theory, and chemical reaction dynamics. Acknowledgements The staff for this course would like to acknowledge that these course materials include contributions from past instructors, textbooks, and other members of the MIT Chemistry Department affiliated with course #5.62. Since the following works have evolved over a period of many years, no single source can be attributed.

Subjects

physical chemistry | physical chemistry | partition functions | partition functions | atomic degrees of freedom | atomic degrees of freedom | molecular degrees of freedom | molecular degrees of freedom | chemical equilibrium | chemical equilibrium | thermodynamics | thermodynamics | intermolecular potentials | intermolecular potentials | equations of state | equations of state | solid state chemistry | solid state chemistry | einstein and debye solids | einstein and debye solids | kinetic theory | kinetic theory | rate theory | rate theory | chemical kinetics | chemical kinetics | transition state theory | transition state theory | RRKM theory | RRKM theory | collision theory | collision theory | equipartition | equipartition | fermi-dirac statistics | fermi-dirac statistics | boltzmann statistics | boltzmann statistics | bose-einstein statistics | bose-einstein statistics | statistical mechanics | statistical mechanics

License

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