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3.012 Fundamentals of Materials Science (MIT) 3.012 Fundamentals of Materials Science (MIT)

Description

This subject describes the fundamentals of bonding, energetics, and structure that underpin materials science. From electrons to silicon to DNA: the role of electronic bonding in determining the energy, structure, and stability of materials. Quantum mechanical descriptions of interacting electrons and atoms. Symmetry properties of molecules and solids. Structure of complex and disordered materials. Introduction to thermodynamic functions and laws governing equilibrium properties, relating macroscopic behavior to molecular models of materials. Develops basis for understanding a broad range of materials phenomena, from heat capacities, phase transformations, and multiphase equilibria to chemical reactions and magnetism. Fundamentals are taught using real-world examples such as engineered all This subject describes the fundamentals of bonding, energetics, and structure that underpin materials science. From electrons to silicon to DNA: the role of electronic bonding in determining the energy, structure, and stability of materials. Quantum mechanical descriptions of interacting electrons and atoms. Symmetry properties of molecules and solids. Structure of complex and disordered materials. Introduction to thermodynamic functions and laws governing equilibrium properties, relating macroscopic behavior to molecular models of materials. Develops basis for understanding a broad range of materials phenomena, from heat capacities, phase transformations, and multiphase equilibria to chemical reactions and magnetism. Fundamentals are taught using real-world examples such as engineered all

Subjects

fundamentals of bonding | energetics | and structure | fundamentals of bonding | energetics | and structure | Quantum mechanical descriptions of interacting electrons and atoms | Quantum mechanical descriptions of interacting electrons and atoms | Symmetry properties of molecules and solids | Symmetry properties of molecules and solids | complex and disordered materials | complex and disordered materials | thermodynamic functions | thermodynamic functions | equilibrium properties | equilibrium properties | macroscopic behavior | macroscopic behavior | molecular models | molecular models | heat capacities | heat capacities | phase transformations | phase transformations | multiphase equilibria | multiphase equilibria | chemical reactions | chemical reactions | magnetism | magnetism | engineered alloys | engineered alloys | electronic and magnetic materials | electronic and magnetic materials | ionic and network solids | ionic and network solids | polymers | polymers | biomaterials | biomaterials | energetics | energetics | structure | structure | materials science | materials science | electrons | electrons | silicon | silicon | DNA | DNA | electronic bonding | electronic bonding | energy | energy | stability | stability | quantum mechanics | quantum mechanics | atoms | atoms | interactions | interactions | symmetry | symmetry | molecules | molecules | solids | solids | complex material | complex material | disorderd materials | disorderd materials | thermodynamic laws | thermodynamic laws | electronic materials | electronic materials | magnetic materials | magnetic materials | ionic solids | ionic solids | network solids | network solids | statistical mechanics | statistical mechanics | microstates | microstates | microscopic complexity | microscopic complexity | entropy | entropy

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7.342 Systems and Synthetic Biology: How the Cell Solves Problems (MIT) 7.342 Systems and Synthetic Biology: How the Cell Solves Problems (MIT)

Description

A millennial challenge in biology is to decipher how vast arrays of molecular interactions inside the cell work in concert to produce a cellular function. Systems biology, a new interdisciplinary field of science, brings together biologists and physicists to tackle this grand challenge through quantitative experiments and models. In this course, we will discuss the unifying principles that all organisms use to perform cellular functions. We will also discuss key challenges faced by a cell in both single and multi-cellular organisms. Finally, we will discuss how researchers in the field of synthetic biology are using the new knowledge gained from studying naturally-occurring biological systems to create artificial gene networks capable of performing new functions. This course is one of many A millennial challenge in biology is to decipher how vast arrays of molecular interactions inside the cell work in concert to produce a cellular function. Systems biology, a new interdisciplinary field of science, brings together biologists and physicists to tackle this grand challenge through quantitative experiments and models. In this course, we will discuss the unifying principles that all organisms use to perform cellular functions. We will also discuss key challenges faced by a cell in both single and multi-cellular organisms. Finally, we will discuss how researchers in the field of synthetic biology are using the new knowledge gained from studying naturally-occurring biological systems to create artificial gene networks capable of performing new functions. This course is one of many

Subjects

systems biology | systems biology | synthetic biology | synthetic biology | cell | cell | cellular functions | cellular functions | biological systems | biological systems | artificial gene networks | artificial gene networks | molecular interactions | molecular interactions | molecular biology | molecular biology | genes | genes | RNA | RNA | proteins | proteins | macromolecules | macromolecules | intracellular biochemical interactions | intracellular biochemical interactions | extracellular molecules | extracellular molecules | gene expression | gene expression | stochastic gene expression | stochastic gene expression

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15.875 Applications of System Dynamics (MIT) 15.875 Applications of System Dynamics (MIT)

Description

15.875 is a project-based course that explores how organizations can use system dynamics to achieve important goals. In small groups, students learn modeling and consulting skills by working on a term-long project with real-life managers. A diverse set of businesses and organizations sponsor class projects, from start-ups to the Fortune 500. The course focuses on gaining practical insight from the system dynamics process, and appeals to people interested in system dynamics, consulting, or managerial policy-making. 15.875 is a project-based course that explores how organizations can use system dynamics to achieve important goals. In small groups, students learn modeling and consulting skills by working on a term-long project with real-life managers. A diverse set of businesses and organizations sponsor class projects, from start-ups to the Fortune 500. The course focuses on gaining practical insight from the system dynamics process, and appeals to people interested in system dynamics, consulting, or managerial policy-making.

Subjects

system dynamics process; modeling; business consulting; managerial policy-making; team project; standard method; process consultation; system consultation; system processes; modeling loops; analyzing loops; diffusion model; problem solving; reference modes; momentum policies; causal loop; client consultations; client consulting; molecules of structure; system dynamics models | system dynamics process; modeling; business consulting; managerial policy-making; team project; standard method; process consultation; system consultation; system processes; modeling loops; analyzing loops; diffusion model; problem solving; reference modes; momentum policies; causal loop; client consultations; client consulting; molecules of structure; system dynamics models | system dynamics process | system dynamics process | modeling | modeling | business consulting | business consulting | managerial policy-making | managerial policy-making | team project | team project | standard method | standard method | process consultation | process consultation | system consultation | system consultation | system processes | system processes | modeling loops | modeling loops | analyzing loops | analyzing loops | diffusion model | diffusion model | problem solving | problem solving | reference modes | reference modes | momentum policies | momentum policies | causal loop | causal loop | client consultations | client consultations | client consulting | client consulting | molecules of structure | molecules of structure | system dynamics models | system dynamics models

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5.111SC Principles of Chemical Science (MIT)

Description

This course provides an introduction to the chemistry of biological, inorganic, and organic molecules. The emphasis is on basic principles of atomic and molecular electronic structure, thermodynamics, acid-base and redox equilibria, chemical kinetics, and catalysis. One year of high school chemistry is the expected background for this freshman-level course. The aims include developing a unified and intuitive view of how electronic structure controls the three-dimensional shape of molecules, the physical and chemical properties of molecules in gases, liquids and solids, and ultimately the assembly of macromolecules as in polymers and DNA. Relationships between chemistry and other fundamental sciences such as biology and physics are emphasized, as are the relationships between the science of

Subjects

chemistry | biological molecules | inorganic molecules | organic molecules | atomic structure | molecular electronic structure | thermodynamics | acid-base equilibrium | redox equilibrium | chemical kinetics | catalysis

License

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5.13 Organic Chemistry II (MIT) 5.13 Organic Chemistry II (MIT)

Description

5.13 is an intermediate organic chemistry course that deals primarily with synthesis, structure determination, mechanism, and the relationships between structure and reactivity emphasized. Special topics in organic chemistry are included to illustrate the role of organic chemistry in biological systems, medicine, and in the chemical industry. 5.13 is an intermediate organic chemistry course that deals primarily with synthesis, structure determination, mechanism, and the relationships between structure and reactivity emphasized. Special topics in organic chemistry are included to illustrate the role of organic chemistry in biological systems, medicine, and in the chemical industry.

Subjects

intermediate organic chemistry | intermediate organic chemistry | organic | organic | organic molecules | organic molecules | stereochemistry | stereochemistry | reaction mechanisms | reaction mechanisms | synthesis of organic compounds | synthesis of organic compounds | synthesis | synthesis | structure determination | structure determination | mechanism | mechanism | structure | structure | reactivity | reactivity

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5.067 Crystal Structure Refinement (MIT) 5.067 Crystal Structure Refinement (MIT)

Description

This course in crystal structure refinement examines the practical aspects of crystal structure determination from data collection strategies to data reduction and basic and advanced refinement problems of organic and inorganic molecules. This course in crystal structure refinement examines the practical aspects of crystal structure determination from data collection strategies to data reduction and basic and advanced refinement problems of organic and inorganic molecules.

Subjects

chemistry | chemistry | crystal structure refinement | crystal structure refinement | practical aspects | practical aspects | crystal structure determination | crystal structure determination | data collection | data collection | strategies | strategies | data reduction | data reduction | refinement problems | refinement problems | organic | organic | inorganic | inorganic | molecules | molecules | SHELXL | SHELXL | hydrogen atoms | hydrogen atoms | disorder | disorder | pseudo symmetry | pseudo symmetry | merohedral twins | merohedral twins | pseudo-merohedral twins | pseudo-merohedral twins | twinning | twinning | non-merohedral twins | non-merohedral twins | PLATON | PLATON

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5.841 Crystal Structure Refinement (MIT) 5.841 Crystal Structure Refinement (MIT)

Description

This course in crystal structure refinement examines the practical aspects of crystal structure determination from data collection strategies to data reduction and basic and advanced refinement problems of organic and inorganic molecules. This course in crystal structure refinement examines the practical aspects of crystal structure determination from data collection strategies to data reduction and basic and advanced refinement problems of organic and inorganic molecules.

Subjects

chemistry | chemistry | crystal structure refinement | crystal structure refinement | practical aspects | practical aspects | crystal structure determination | crystal structure determination | data collection | data collection | strategies | strategies | data reduction | data reduction | refinement problems | refinement problems | organic | organic | inorganic | inorganic | molecules | molecules | SHELXL | SHELXL | hydrogen atoms | hydrogen atoms | disorder | disorder | pseudo symmetry | pseudo symmetry | merohedral twins | merohedral twins | pseudo-merohedral twins | pseudo-merohedral twins | twinning | twinning | non-merohedral twins | non-merohedral twins | PLATON | PLATON

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BE.462J Molecular Principles of Biomaterials (MIT) BE.462J Molecular Principles of Biomaterials (MIT)

Description

Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S

Subjects

Analysis | Analysis | design | design | molecular scale | molecular scale | biological systems | biological systems | biotechnology | biotechnology | biomedical engineering | biomedical engineering | molecular interactions | molecular interactions | synthetic molecules | synthetic molecules | synthesis | synthesis | processing approaches | processing approaches | cell functions | cell functions | materials science | materials science | tissue engineering | tissue engineering | drug delivery | drug delivery | biosensors | biosensors | cell-guiding surfaces | cell-guiding surfaces | 3.962J | 3.962J | BE.462 | BE.462 | 3.962 | 3.962

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BE.011J Statistical Thermodynamics of Biomolecular Systems (MIT) BE.011J Statistical Thermodynamics of Biomolecular Systems (MIT)

Description

This course provides an introduction to the physical chemistry of biological systems. Topics include: connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics, chemical potentials, equilibrium states, binding cooperativity, behavior of macromolecules in solution and at interfaces, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.Technical RequirementsMATLAB® software is required to run the .m and .fig files found on this course site. This course provides an introduction to the physical chemistry of biological systems. Topics include: connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics, chemical potentials, equilibrium states, binding cooperativity, behavior of macromolecules in solution and at interfaces, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.Technical RequirementsMATLAB® software is required to run the .m and .fig files found on this course site.

Subjects

physical chemistry of biological systems | physical chemistry of biological systems | macroscopic thermodynamic properties | macroscopic thermodynamic properties | microscopic molecular properties | microscopic molecular properties | statistical mechanics | statistical mechanics | chemical potentials | chemical potentials | equilibrium states | equilibrium states | binding cooperativity | binding cooperativity | behavior of macromolecules in solution and at interfaces | behavior of macromolecules in solution and at interfaces | solvation | solvation | protein structure | protein structure | genomic analysis | genomic analysis | single molecule biomechanics | single molecule biomechanics | biomaterials | biomaterials | 2.772J | 2.772J | BE.011 | BE.011 | 2.772 | 2.772

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20.462J Molecular Principles of Biomaterials (BE.462J) (MIT) 20.462J Molecular Principles of Biomaterials (BE.462J) (MIT)

Description

Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S Analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, biosensors, and cell-guiding surfaces.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.Microsoft® is a registered trademark or trademark of Microsoft Corporation in the U.S

Subjects

Analysis | Analysis | design | design | molecular scale | molecular scale | biological systems | biological systems | biotechnology | biotechnology | biomedical engineering | biomedical engineering | molecular interactions | molecular interactions | synthetic molecules | synthetic molecules | synthesis | synthesis | processing approaches | processing approaches | cell functions | cell functions | materials science | materials science | tissue engineering | tissue engineering | drug delivery | drug delivery | biosensors | biosensors | cell-guiding surfaces | cell-guiding surfaces | BE.462J | BE.462J | BE.462 | BE.462 | 3.962 | 3.962

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7.28 Molecular Biology (MIT) 7.28 Molecular Biology (MIT)

Description

Molecular Biology - Detailed analysis of the biochemical mechanisms that control the maintenance, expression and evolution of prokaryotic and eukaryotic genomes.Topics covered in 7.28 lectures and readings of primary literature include:DNA replication,DNA repair,genetic recombination,gene expression,RNA processing, andtranslation.The logic of experimental design and data analysis is emphasized. Presentations include lectures, reading assignments and group discussions. Writing assignments, Problem Sets (ungraded) and review sessions also contribute to the course content. Molecular Biology - Detailed analysis of the biochemical mechanisms that control the maintenance, expression and evolution of prokaryotic and eukaryotic genomes.Topics covered in 7.28 lectures and readings of primary literature include:DNA replication,DNA repair,genetic recombination,gene expression,RNA processing, andtranslation.The logic of experimental design and data analysis is emphasized. Presentations include lectures, reading assignments and group discussions. Writing assignments, Problem Sets (ungraded) and review sessions also contribute to the course content.

Subjects

genetic recombination | genetic recombination | DNA replication | DNA replication | gene regulation | gene regulation | molecules | molecules

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5.067 Crystal Structure Refinement (MIT) 5.067 Crystal Structure Refinement (MIT)

Description

This course in crystal structure refinement examines the practical aspects of crystal structure determination from data collection strategies to data reduction and basic and advanced refinement problems of organic and inorganic molecules. This course in crystal structure refinement examines the practical aspects of crystal structure determination from data collection strategies to data reduction and basic and advanced refinement problems of organic and inorganic molecules.

Subjects

chemistry | chemistry | crystal structure refinement | crystal structure refinement | practical aspects | practical aspects | crystal structure determination | crystal structure determination | data collection | data collection | strategies | strategies | data reduction | data reduction | refinement problems | refinement problems | organic | organic | inorganic | inorganic | molecules | molecules | SHELXL | SHELXL | hydrogen atoms | hydrogen atoms | disorder | disorder | pseudo symmetry | pseudo symmetry | merohedral twins | merohedral twins | pseudo-merohedral twins | pseudo-merohedral twins | twinning | twinning | non-merohedral twins | non-merohedral twins | PLATON | PLATON

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5.04 Principles of Inorganic Chemistry II (MIT) 5.04 Principles of Inorganic Chemistry II (MIT)

Description

This course provides a systematic presentation of the chemical applications of group theory with emphasis on the formal development of the subject and its applications to the physical methods of inorganic chemical compounds. Against the backdrop of electronic structure, the electronic, vibrational, and magnetic properties of transition metal complexes are presented and their investigation by the appropriate spectroscopy described. This course provides a systematic presentation of the chemical applications of group theory with emphasis on the formal development of the subject and its applications to the physical methods of inorganic chemical compounds. Against the backdrop of electronic structure, the electronic, vibrational, and magnetic properties of transition metal complexes are presented and their investigation by the appropriate spectroscopy described.

Subjects

inorganic chemistry | inorganic chemistry | group theory | group theory | electronic structure of molecules | electronic structure of molecules | transition metal complexes | transition metal complexes | spectroscopy | spectroscopy | symmetry elements | symmetry elements | mathematical groups | mathematical groups | character tables | character tables | molecular point groups | molecular point groups | Huckel Theory | Huckel Theory | N-Dimensional cyclic systems | N-Dimensional cyclic systems | solid state theory | solid state theory | band theory | band theory | frontier molecular orbitals | frontier molecular orbitals | similarity transformations | similarity transformations | complexes | complexes | organometallic complexes | organometallic complexes | two electron bond | two electron bond | vibrational spectroscopy | vibrational spectroscopy | symmetry | symmetry | overtones | overtones | normal coordinat analysis | normal coordinat analysis | AOM | AOM | single electron CFT | single electron CFT | tanabe-sugano diagram | tanabe-sugano diagram | ligand | ligand | crystal field theory | crystal field theory | LCAO | LCAO

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5.13 Organic Chemistry II (MIT) 5.13 Organic Chemistry II (MIT)

Description

This intermediate organic chemistry course focuses on the methods used to identify the structure of organic molecules, advanced principles of organic stereochemistry, organic reaction mechanisms, and methods used for the synthesis of organic compounds. Additional special topics include illustrating the role of organic chemistry in biology, medicine, and industry. This intermediate organic chemistry course focuses on the methods used to identify the structure of organic molecules, advanced principles of organic stereochemistry, organic reaction mechanisms, and methods used for the synthesis of organic compounds. Additional special topics include illustrating the role of organic chemistry in biology, medicine, and industry.

Subjects

intermediate organic chemistry | intermediate organic chemistry | organic molecules | organic molecules | stereochemistry | stereochemistry | reaction | reaction

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5.12 Organic Chemistry I (MIT) 5.12 Organic Chemistry I (MIT)

Description

This subject deals primarily with the basic principles to understand the structure and reactivity of organic molecules. Emphasis is on substitution and elimination reactions and chemistry of the carbonyl group. The course also provides an introduction to the chemistry of aromatic compounds. This subject deals primarily with the basic principles to understand the structure and reactivity of organic molecules. Emphasis is on substitution and elimination reactions and chemistry of the carbonyl group. The course also provides an introduction to the chemistry of aromatic compounds.

Subjects

organic chemistry | organic chemistry | molecular structure | molecular structure | reactivity | reactivity | organic molecules | organic molecules | substitution reactions | substitution reactions | elimination reactions | elimination reactions | carbonyl group | carbonyl group | aromatic compounds | aromatic compounds

License

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5.512 Synthetic Organic Chemistry II (MIT) 5.512 Synthetic Organic Chemistry II (MIT)

Description

This course focuses on general methods and strategies for the synthesis of complex organic molecules. Emphasis is on strategies for stereoselective synthesis, including stereocontrolled synthesis of complex acyclic compounds. This course focuses on general methods and strategies for the synthesis of complex organic molecules. Emphasis is on strategies for stereoselective synthesis, including stereocontrolled synthesis of complex acyclic compounds.

Subjects

synthetic organic chemistry | synthetic organic chemistry | synthesis | synthesis | complex organic molecules | complex organic molecules | stereoselective synthesis | stereoselective synthesis | acyclic compounds | acyclic compounds | stereocontrolled synthesis | stereocontrolled synthesis | stereocontrolled alkylation | stereocontrolled alkylation | stereocontrolled conjugate addition | stereocontrolled conjugate addition | carbonyls | carbonyls | aldol reactions | aldol reactions | carbonyl reduction | carbonyl reduction | alkene reduction | alkene reduction | hydroboration | hydroboration | dihydroxylation | dihydroxylation | epoxidation | epoxidation

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5.13 Organic Chemistry II (MIT) 5.13 Organic Chemistry II (MIT)

Description

This intermediate organic chemistry course focuses on the methods used to identify the structure of organic molecules, advanced principles of organic stereochemistry, organic reaction mechanisms, and methods used for the synthesis of organic compounds. Additional special topics include illustrating the role of organic chemistry in biology, medicine, and industry. This intermediate organic chemistry course focuses on the methods used to identify the structure of organic molecules, advanced principles of organic stereochemistry, organic reaction mechanisms, and methods used for the synthesis of organic compounds. Additional special topics include illustrating the role of organic chemistry in biology, medicine, and industry.

Subjects

intermediate organic chemistry | intermediate organic chemistry | organic molecules | organic molecules | stereochemistry | stereochemistry | reaction mechanisms | reaction mechanisms | synthesis of organic compounds | synthesis of organic compounds | synthesis | synthesis | structure determination | structure determination | mechanism | mechanism | reactivity | reactivity | functional groups | functional groups | NMR | NMR | spectroscopy | spectroscopy | spectrometry | spectrometry | structure elucidation | structure elucidation | infrared spectroscopy | infrared spectroscopy | nuclear magnetic resonance spectroscopy | nuclear magnetic resonance spectroscopy | reactive intermediates | reactive intermediates | carbocations | carbocations | radicals | radicals | aromaticity | aromaticity | conjugated systems | conjugated systems | molecular orbital theory | molecular orbital theory | pericyclic reactions | pericyclic reactions

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5.12 Organic Chemistry I (MIT) 5.12 Organic Chemistry I (MIT)

Description

5.12 is an introduction to organic chemistry, focusing primarily on the basic principles to understand the structure and reactivity of organic molecules. Emphasis is on substitution and elimination reactions and chemistry of the carbonyl group. The course also provides an introduction to the chemistry of aromatic compounds. 5.12 is an introduction to organic chemistry, focusing primarily on the basic principles to understand the structure and reactivity of organic molecules. Emphasis is on substitution and elimination reactions and chemistry of the carbonyl group. The course also provides an introduction to the chemistry of aromatic compounds.

Subjects

organic chemistry | organic chemistry | structure | structure | reactivity | reactivity | organic molecules | organic molecules | substitution | substitution | carbonyl group | carbonyl group | elimination | elimination

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6.701 Introduction to Nanoelectronics (MIT) 6.701 Introduction to Nanoelectronics (MIT)

Description

Traditionally, progress in electronics has been driven by miniaturization. But as electronic devices approach the molecular scale, classical models for device behavior must be abandoned. To prepare for the next generation of electronic devices, this class teaches the theory of current, voltage and resistance from atoms up. To describe electrons at the nanoscale, we will begin with an introduction to the principles of quantum mechanics, including quantization, the wave-particle duality, wavefunctions and Schrödinger's equation. Then we will consider the electronic properties of molecules, carbon nanotubes and crystals, including energy band formation and the origin of metals, insulators and semiconductors. Electron conduction will be taught beginning with ballistic transport and concludin Traditionally, progress in electronics has been driven by miniaturization. But as electronic devices approach the molecular scale, classical models for device behavior must be abandoned. To prepare for the next generation of electronic devices, this class teaches the theory of current, voltage and resistance from atoms up. To describe electrons at the nanoscale, we will begin with an introduction to the principles of quantum mechanics, including quantization, the wave-particle duality, wavefunctions and Schrödinger's equation. Then we will consider the electronic properties of molecules, carbon nanotubes and crystals, including energy band formation and the origin of metals, insulators and semiconductors. Electron conduction will be taught beginning with ballistic transport and concludin

Subjects

nanoelectronics | nanoelectronics | quantum mechanics | quantum mechanics | wave-particle duality | wave-particle duality | Schrodinger's equation | Schrodinger's equation | electronic properties of molecules | electronic properties of molecules | energy band formation | energy band formation | electron conduction | electron conduction | ballistic transport | ballistic transport | Ohm's law | Ohm's law | fundamental limits to computation | fundamental limits to computation

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7.341 Harnessing the Biosphere: Natural Products and Biotechnology (MIT) 7.341 Harnessing the Biosphere: Natural Products and Biotechnology (MIT)

Description

What do the organisms of the biosphere, specifically microorganisms, have to offer to biotechnological endeavors? In this course we will focus on the production of biomolecules using microbial systems. We will discuss potential growth substrates (such as agricultural waste and carbon dioxide) that can be used and learn about both established and cutting-edge manipulation techniques in the field of synthetic biology. We will also cover the production of biofuels, bioplastics, amino acids (e.g. lysine), food additives (e.g. monosodium glutamate, MSG), specialty chemicals (e.g. succinate), and biopharmaceuticals (e.g. plasmids for gene therapy). This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an What do the organisms of the biosphere, specifically microorganisms, have to offer to biotechnological endeavors? In this course we will focus on the production of biomolecules using microbial systems. We will discuss potential growth substrates (such as agricultural waste and carbon dioxide) that can be used and learn about both established and cutting-edge manipulation techniques in the field of synthetic biology. We will also cover the production of biofuels, bioplastics, amino acids (e.g. lysine), food additives (e.g. monosodium glutamate, MSG), specialty chemicals (e.g. succinate), and biopharmaceuticals (e.g. plasmids for gene therapy). This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an

Subjects

microorganisms | microorganisms | biomolecules | biomolecules | microbial systems | microbial systems | synthetic biology | synthetic biology | biofuels | biofuels | bioplastics | bioplastics | amino acids | amino acids | lysine | lysine | food additives | food additives | monosodium glutamate (MSG) | monosodium glutamate (MSG) | specialty chemicals | specialty chemicals | succinate | succinate | biopharmaceuticals | biopharmaceuticals | enzymes | enzymes | antibiotics and biocompatible materials | antibiotics and biocompatible materials | microbial biotechnology | microbial biotechnology | genetic engineering | genetic engineering

License

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7.345 Survival in Extreme Conditions: The Bacterial Stress Response (MIT) 7.345 Survival in Extreme Conditions: The Bacterial Stress Response (MIT)

Description

Bacteria survive in almost all environments on Earth, including some considered extremely harsh. From the steaming hot springs of Yellowstone to the frozen tundra of the arctic to the barren deserts of Chile, microbes have been found thriving. Their tenacity to survive in such extreme and varied conditions allows them to play fundamental roles in global nutrient cycling. Microbes also cause a wide range of human diseases and can survive inhospitable conditions found in the human body. In this course, we will examine the molecular systems that bacteria use to adapt to changes in their environment. We will consider stresses commonly encountered, such as starvation, oxidative stress and heat shock, and also discuss how the adaptive responses affect the evolution of the bacteria. This course Bacteria survive in almost all environments on Earth, including some considered extremely harsh. From the steaming hot springs of Yellowstone to the frozen tundra of the arctic to the barren deserts of Chile, microbes have been found thriving. Their tenacity to survive in such extreme and varied conditions allows them to play fundamental roles in global nutrient cycling. Microbes also cause a wide range of human diseases and can survive inhospitable conditions found in the human body. In this course, we will examine the molecular systems that bacteria use to adapt to changes in their environment. We will consider stresses commonly encountered, such as starvation, oxidative stress and heat shock, and also discuss how the adaptive responses affect the evolution of the bacteria. This course

Subjects

bacteria | bacteria | microbes | microbes | signal transduction pathways | signal transduction pathways | cellular response | cellular response | model systems | model systems | Escherichia coli | Escherichia coli | Bacillus subtilis | Bacillus subtilis | oxidative stress | oxidative stress | starvation | starvation | heat shock | heat shock | dormant state | dormant state | microbial stress response | microbial stress response | bacterial genetics | bacterial genetics | microbiology | microbiology | sporulation | sporulation | sRNAs | sRNAs | histidine kinases | histidine kinases | response regulators | response regulators | mRNAs | mRNAs | RpoS | RpoS | small molecules | small molecules | efflux pumps | efflux pumps | Pseudomonas aeruginosa | Pseudomonas aeruginosa

License

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7.341 Brightening up Life: Harnessing the Power of Fluorescence Imaging to Observe Biology in Action (MIT) 7.341 Brightening up Life: Harnessing the Power of Fluorescence Imaging to Observe Biology in Action (MIT)

Description

One summer in the 1960s a young Japanese researcher, with the help of a few high school students, chopped up ten thousand jellyfish. As a by-product of this harvest, they isolated a green fluorescent protein (GFP). Since then, GFP has triggered a revolution in our understanding of gene expression and signaling in live cells. In this seminar, we will examine how this small protein generates fluorescence, i.e. absorbs light of one wavelength and emits light of a longer wavelength. We will discuss how the color palette has been extended from green to blue, red and many other colors, based on protein engineering of GFP and the study of vividly colorful coral reefs. We will then investigate how these fluorescent proteins can be used to track the motion of DNA, RNA and protein in living cells, a One summer in the 1960s a young Japanese researcher, with the help of a few high school students, chopped up ten thousand jellyfish. As a by-product of this harvest, they isolated a green fluorescent protein (GFP). Since then, GFP has triggered a revolution in our understanding of gene expression and signaling in live cells. In this seminar, we will examine how this small protein generates fluorescence, i.e. absorbs light of one wavelength and emits light of a longer wavelength. We will discuss how the color palette has been extended from green to blue, red and many other colors, based on protein engineering of GFP and the study of vividly colorful coral reefs. We will then investigate how these fluorescent proteins can be used to track the motion of DNA, RNA and protein in living cells, a

Subjects

Green Fluorescent Protein | Green Fluorescent Protein | Fluorescent protein engineering | Fluorescent protein engineering | Photoconversion | Photoconversion | fluorescent protein variants | fluorescent protein variants | fluorescent microscopy facility | fluorescent microscopy facility | Quantitative fluorescent imaging | Quantitative fluorescent imaging | ultra-sensitive fluorescent imaging | ultra-sensitive fluorescent imaging | high-throughput analysis | high-throughput analysis | Fluorescent imaging in living organisms | Fluorescent imaging in living organisms | phycoerythrin | phycoerythrin | phytochrome | phytochrome | jellyfish | jellyfish | red fluorescent protein | red fluorescent protein | photoactivation | photoactivation | chromophore | chromophore | protonation | protonation | lysosomes | lysosomes | recombinant protein molecules | recombinant protein molecules

License

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20.011J Statistical Thermodynamics of Biomolecular Systems (BE.011J) (MIT) 20.011J Statistical Thermodynamics of Biomolecular Systems (BE.011J) (MIT)

Description

This course provides an introduction to the physical chemistry of biological systems. Topics include: connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics, chemical potentials, equilibrium states, binding cooperativity, behavior of macromolecules in solution and at interfaces, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials. This course provides an introduction to the physical chemistry of biological systems. Topics include: connection of macroscopic thermodynamic properties to microscopic molecular properties using statistical mechanics, chemical potentials, equilibrium states, binding cooperativity, behavior of macromolecules in solution and at interfaces, and solvation. Example problems include protein structure, genomic analysis, single molecule biomechanics, and biomaterials.

Subjects

physical chemistry of biological systems | physical chemistry of biological systems | macroscopic thermodynamic properties | macroscopic thermodynamic properties | microscopic molecular properties | microscopic molecular properties | statistical mechanics | statistical mechanics | chemical potentials | chemical potentials | equilibrium states | equilibrium states | binding cooperativity | binding cooperativity | behavior of macromolecules in solution and at interfaces | behavior of macromolecules in solution and at interfaces | solvation | solvation | protein structure | protein structure | genomic analysis | genomic analysis | single molecule biomechanics | single molecule biomechanics | biomaterials | biomaterials | BE.011J | BE.011J | BE.011 | BE.011 | 2.772 | 2.772

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7.343 An RNA Safari: Exploring the Surprising Diversity of Mammalian Transcriptomes (MIT) 7.343 An RNA Safari: Exploring the Surprising Diversity of Mammalian Transcriptomes (MIT)

Description

The aim of this class is to introduce the exciting and often under appreciated discoveries in RNA biology by exploring the diversity of RNAs—encompassing classical molecules such as ribosomal RNAs (rRNAs), transfer RNAs (tRNAs) and messenger RNAs (mRNAs) as well as newer species, such as microRNAs (miRNAs), long-noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). For each new class of RNA, we will evaluate the evidence for its existence as well as for its proposed function. Students will develop both a deep understanding of the field of RNA biology and the ability to critically assess new papers in this fast-paced field.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in The aim of this class is to introduce the exciting and often under appreciated discoveries in RNA biology by exploring the diversity of RNAs—encompassing classical molecules such as ribosomal RNAs (rRNAs), transfer RNAs (tRNAs) and messenger RNAs (mRNAs) as well as newer species, such as microRNAs (miRNAs), long-noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). For each new class of RNA, we will evaluate the evidence for its existence as well as for its proposed function. Students will develop both a deep understanding of the field of RNA biology and the ability to critically assess new papers in this fast-paced field.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in

Subjects

RNA | RNA | ribosomal RNAs (rRNAs) | ribosomal RNAs (rRNAs) | transfer RNAs (tRNAs) | transfer RNAs (tRNAs) | messenger RNAs (mRNAs) | messenger RNAs (mRNAs) | microRNAs (miRNAs) | microRNAs (miRNAs) | long-noncoding RNAs (lncRNAs) | long-noncoding RNAs (lncRNAs) | circular RNAs (circRNAs) | circular RNAs (circRNAs) | high-throughput sequencing | high-throughput sequencing | snRNAs | snRNAs | pre-mRNA splicing | pre-mRNA splicing | snoRNAs | snoRNAs | regulatory molecules | regulatory molecules | siRNA | siRNA | piRNAs | piRNAs | CRISPR-associated RNAs | CRISPR-associated RNAs

License

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7.347 Peptides as Biological Signaling Molecules and Novel Drugs (MIT) 7.347 Peptides as Biological Signaling Molecules and Novel Drugs (MIT)

Description

How do we sense hunger? How do we sense pain? What causes growth in our bodies? How are we protected from pathogens? The answer to many of these questions involves small polymers of amino acids known as peptides. Peptides are broadly used as signal molecules for intercellular communication in prokaryotes, plants, fungi, and animals. Peptide signals in animals include vast numbers of peptide hormones, growth factors and neuropeptides. In this course, we will learn about molecular bases of peptide signaling. In addition, peptides potentially can be used as potent broad-spectrum antibiotics and hence might define novel therapeutic agents. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an intere How do we sense hunger? How do we sense pain? What causes growth in our bodies? How are we protected from pathogens? The answer to many of these questions involves small polymers of amino acids known as peptides. Peptides are broadly used as signal molecules for intercellular communication in prokaryotes, plants, fungi, and animals. Peptide signals in animals include vast numbers of peptide hormones, growth factors and neuropeptides. In this course, we will learn about molecular bases of peptide signaling. In addition, peptides potentially can be used as potent broad-spectrum antibiotics and hence might define novel therapeutic agents. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an intere

Subjects

peptides | peptides | signal molecules | signal molecules | intercellular communication | intercellular communication | peptide hormones | peptide hormones | growth factors | growth factors | neuropeptides | neuropeptides | antimicrobial peptides (AMPs) | antimicrobial peptides (AMPs) | defensins | defensins | biotic interactions | biotic interactions | Peptide transporters | Peptide transporters | epidermal growth factors (EGFs) | epidermal growth factors (EGFs)

License

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