Searching for non-coding RNAs : 3 results found | RSS Feed for this search

7.347 Epigenetic Regulation of Stem Cells (MIT) 7.347 Epigenetic Regulation of Stem Cells (MIT)

Description

During development a single totipotent cell gives rise to the vast array of cell types present in the adult human body, yet each cell has essentially the same DNA sequence. As cells differentiate, distinct sets of genes must be coordinately activated and repressed, ultimately leading to a cell-type specific pattern of gene expression and a particular cell fate. In eukaryotic organisms, DNA is packaged in a complex protein super structure known as chromatin. Modification and reorganization of chromatin play a critical role in coordinating the cell-type specific gene expression programs that are required as a cell transitions from a pluripotent stem cell to a fully differentiated cell type. Epigenetics refers to such heritable changes that occur in chromatin without altering the primary DNA During development a single totipotent cell gives rise to the vast array of cell types present in the adult human body, yet each cell has essentially the same DNA sequence. As cells differentiate, distinct sets of genes must be coordinately activated and repressed, ultimately leading to a cell-type specific pattern of gene expression and a particular cell fate. In eukaryotic organisms, DNA is packaged in a complex protein super structure known as chromatin. Modification and reorganization of chromatin play a critical role in coordinating the cell-type specific gene expression programs that are required as a cell transitions from a pluripotent stem cell to a fully differentiated cell type. Epigenetics refers to such heritable changes that occur in chromatin without altering the primary DNA

Subjects

Stem cells | Stem cells | induced pluripotency | induced pluripotency | Epigenetics | Epigenetics | chromatin | chromatin | histone | histone | epigenome | epigenome | genome-wide analyses | genome-wide analyses | high-throughput sequencing technologies | high-throughput sequencing technologies | Chromatin Immunoprecipitation sequencing | Chromatin Immunoprecipitation sequencing | ncRNAs | ncRNAs | epigenetic regulation | epigenetic regulation | DNA methylation | DNA methylation | post-translational modification of histones | post-translational modification of histones | roles of chromatin-assembly modifying complexes | roles of chromatin-assembly modifying complexes | non-coding RNAs | non-coding RNAs | nuclear organization | nuclear organization | developmental fate | developmental fate | stem cell therapy | stem cell therapy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

Site sourced from

http://ocw.mit.edu/rss/all/mit-allcourses-7.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

7.347 Epigenetic Regulation of Stem Cells (MIT)

Description

During development a single totipotent cell gives rise to the vast array of cell types present in the adult human body, yet each cell has essentially the same DNA sequence. As cells differentiate, distinct sets of genes must be coordinately activated and repressed, ultimately leading to a cell-type specific pattern of gene expression and a particular cell fate. In eukaryotic organisms, DNA is packaged in a complex protein super structure known as chromatin. Modification and reorganization of chromatin play a critical role in coordinating the cell-type specific gene expression programs that are required as a cell transitions from a pluripotent stem cell to a fully differentiated cell type. Epigenetics refers to such heritable changes that occur in chromatin without altering the primary DNA

Subjects

Stem cells | induced pluripotency | Epigenetics | chromatin | histone | epigenome | genome-wide analyses | high-throughput sequencing technologies | Chromatin Immunoprecipitation sequencing | ncRNAs | epigenetic regulation | DNA methylation | post-translational modification of histones | roles of chromatin-assembly modifying complexes | non-coding RNAs | nuclear organization | developmental fate | stem cell therapy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-allcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata

7.342 The RNA Revolution: At the Frontiers of Cell Biology and Molecular Medicine (MIT)

Description

In this course, we will investigate the diverse types and functions of different RNA species, with a focus on "non-coding RNAs," i.e. those that do not directly encode proteins. The course will convey both the exciting discoveries in and frontiers of RNA research that are propelling our understanding of cell biology as well as the intellectual and experimental approaches responsible.The molecular biology revolution firmly established the role of DNA as the primary carrier of genetic information and proteins as the primary effector molecules of the cell. The intermediate between DNA and proteins is RNA, which initially was regarded as the "molecule in the middle" of the central dogma. This view has been transformed over the past two decades, as RNA has become recogn

Subjects

RNA | non-coding RNAs | ribosomal RNA | catalytic | circular RNA | long non-coding RNA | RNAi | RNA therapeutics | microRNAs | CRISPR/Cas9 | miRNAs | siRNA

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-allcourses.xml

Attribution

Click to get HTML | Click to get attribution | Click to get URL

All metadata

See all metadata