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7.88J Protein Folding Problem (MIT) 7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects. This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

amino acid sequence | amino acid sequence | polypeptide chains | polypeptide chains | sequence determinants | sequence determinants | folding | folding | synthesized polypeptide chains within cells | synthesized polypeptide chains within cells | unfolding and refolding of proteins in vitro | unfolding and refolding of proteins in vitro | folding intermediates aggregation | folding intermediates aggregation | competing off-pathway reactions | competing off-pathway reactions | chaperonins | chaperonins | isomerases | isomerases | helper proteins | helper proteins | protein recovery problems | protein recovery problems | biotechnology industry | biotechnology industry | protein folding defects | protein folding defects | 3-D conformation | 3-D conformation | globular proteins | globular proteins | fibrous proteins | fibrous proteins | kinetics | kinetics | in vitro refolding | in vitro refolding | pathways | pathways | in vivo folding | in vivo folding | synthesized proteins | synthesized proteins | aggregation | aggregation | protein misfolding | protein misfolding | human disease | human disease | protein folding | protein folding | genome sequences | genome sequences | 7.88 | 7.88 | 5.48 | 5.48 | 7.24 | 7.24 | 10.543 | 10.543

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Reynolds (LOC) Reynolds (LOC)

Description

Subjects

libraryofcongress | libraryofcongress | johnreynolds | johnreynolds | jackreynolds | jackreynolds | jammiereynolds | jammiereynolds | johnniereynolds | johnniereynolds | johnnyreynolds | johnnyreynolds | johnjammiereynolds | johnjammiereynolds | jnoreynolds | jnoreynolds | reynolds | reynolds | daredevils | daredevils | daredeviljack | daredeviljack | daredeviljohnny | daredeviljohnny | climbingwonder | climbingwonder | humanfly | humanfly | thehumanfly | thehumanfly | thelizard | thelizard

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Happy 8th Birthday, Flickr Commons ! 7 days to go (LOC) Happy 8th Birthday, Flickr Commons ! 7 days to go (LOC)

Description

Subjects

sf | sf | sanfrancisco | sanfrancisco | california | california | bridge | bridge | b | b | color | color | colour | colour | america | america | project | project | golden | golden | jon | jon | gate | gate | san | san | francisco | francisco | ellis | ellis | m | m | highway1 | highway1 | goldengatebridge | goldengatebridge | goldengate | goldengate | carol | carol | artdeco | artdeco | sanfranciscobay | sanfranciscobay | loc | loc | libraryofcongress | libraryofcongress | suspensionbridge | suspensionbridge | sfbay | sfbay | strauss | strauss | us101 | us101 | morrow | morrow | thegoldengate | thegoldengate | josephstrauss | josephstrauss | sr1 | sr1 | fransico | fransico | lovelace | lovelace | californiastateroute1 | californiastateroute1 | josephbstrauss | josephbstrauss | thegoldengatebridge | thegoldengatebridge | stateroute1 | stateroute1 | usroute101 | usroute101 | charlesellis | charlesellis | irvingfmorrow | irvingfmorrow | irvingmorrow | irvingmorrow | highsmiths | highsmiths | charlesaltonellis | charlesaltonellis | goldengatebridgeandhighwaydistrict | goldengatebridgeandhighwaydistrict | charlesaellis | charlesaellis | happybirthdayflickrcommons | happybirthdayflickrcommons

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7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

amino acid sequence | polypeptide chains | sequence determinants | folding | synthesized polypeptide chains within cells | unfolding and refolding of proteins in vitro | folding intermediates aggregation | competing off-pathway reactions | chaperonins | isomerases | helper proteins | protein recovery problems | biotechnology industry | protein folding defects | 3-D conformation | globular proteins | fibrous proteins | kinetics | in vitro refolding | pathways | in vivo folding | synthesized proteins | aggregation | protein misfolding | human disease | protein folding | genome sequences | 7.88 | 5.48 | 7.24 | 10.543

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.88J Protein Folding and Human Disease (MIT) 7.88J Protein Folding and Human Disease (MIT)

Description

This course covers amino acid sequence control of protein folding, misfolding, amyloid polymerization and aggregation. Readings and discussions address topics such as chaperone structure and function, folding and assembly of fibrous proteins, and pathologies associated with protein misfolding and aggregation in Alzheimer's, Parkinson's, Huntington's and other protein deposition diseases. Students are required to write and present a research paper. This course covers amino acid sequence control of protein folding, misfolding, amyloid polymerization and aggregation. Readings and discussions address topics such as chaperone structure and function, folding and assembly of fibrous proteins, and pathologies associated with protein misfolding and aggregation in Alzheimer's, Parkinson's, Huntington's and other protein deposition diseases. Students are required to write and present a research paper.

Subjects

protein folding | protein folding | misfolding | misfolding | aggregation | aggregation | protein structures | protein structures | folding intermediates | folding intermediates | off-pathway aggregation | off-pathway aggregation | amyloid formation | amyloid formation | Key chaperones | Key chaperones | chaperonins | chaperonins | human protein deposition diseases | human protein deposition diseases | Alzheimer’s disease | Alzheimer’s disease | Parkinson’s disease | Parkinson’s disease | Huntington’s disease | Huntington’s disease | amyloids | amyloids | prions | prions | amino acid sequence | amino acid sequence | amyloid polymerization | amyloid polymerization | chaperone structure and function | chaperone structure and function | folding and assembly of fibrous proteins | folding and assembly of fibrous proteins

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Scoops of a Friday Scoops of a Friday

Description

Subjects

ireland | ireland | dublin | dublin | pub | pub | courtyard | courtyard | brazenhead | brazenhead | publichouse | publichouse | milltown | milltown | leinster | leinster | twelfthcentury | twelfthcentury | granduncle | granduncle | codublin | codublin | colouth | colouth | unitedirishmen | unitedirishmen | nationallibraryofireland | nationallibraryofireland | michaelreynolds | michaelreynolds | castlebellingham | castlebellingham | thomasreynolds | thomasreynolds | brazenheadhotel | brazenheadhotel | drmadden | drmadden | elinorwiltshire | elinorwiltshire | wiltshirephotographiccollection | wiltshirephotographiccollection | reginaldwiltshire | reginaldwiltshire | thehorsetram | thehorsetram | june1872mustbestrictlysober | june1872mustbestrictlysober | missmkinahan | missmkinahan | missmarymchugh | missmarymchugh | oldestestablishedhotelinthecity | oldestestablishedhotelinthecity | monicamchughlrbridgest | monicamchughlrbridgest | brazenheadlandingwindow | brazenheadlandingwindow | johnlanganhaltedhere | johnlanganhaltedhere | 7thaugust1726 | 7thaugust1726 | dublinsoldestpub | dublinsoldestpub

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Comdr. H.C. Richardson (LOC) Comdr. H.C. Richardson (LOC)

Description

Subjects

libraryofcongress | libraryofcongress | aviator | aviator | navalaviator | navalaviator | unitedstatesnavy | unitedstatesnavy | usnavy | usnavy | usn | usn | navalaviation | navalaviation | holdenchesterrichardson | holdenchesterrichardson | holdencrichardson | holdencrichardson | hcrichardson | hcrichardson | holdenrichardson | holdenrichardson | richardson | richardson

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18.966 Geometry of Manifolds (MIT) 18.966 Geometry of Manifolds (MIT)

Description

This is a second-semester graduate course on the geometry of manifolds. The main emphasis is on the geometry of symplectic manifolds, but the material also includes long digressions into complex geometry and the geometry of 4-manifolds, with special emphasis on topological considerations. This is a second-semester graduate course on the geometry of manifolds. The main emphasis is on the geometry of symplectic manifolds, but the material also includes long digressions into complex geometry and the geometry of 4-manifolds, with special emphasis on topological considerations.

Subjects

Differential forms | Differential forms | Lie groups | Lie groups | DeRham | DeRham | Riemannian manifolds | Riemannian manifolds | curvature | curvature | Hodge | Hodge | Hodge theory | Hodge theory | manifolds | manifolds | Riemannian geometry | Riemannian geometry | holonomy | holonomy | symplectic geometry | symplectic geometry | complex geometry | complex geometry | Hodge-Kahler theory | Hodge-Kahler theory | smooth manifold topology | smooth manifold topology

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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18.117 Topics in Several Complex Variables (MIT) 18.117 Topics in Several Complex Variables (MIT)

Description

This course covers harmonic theory on complex manifolds, the Hodge decomposition theorem, the Hard Lefschetz theorem, and Vanishing theorems. Some results and tools on deformation and uniformization of complex manifolds are also discussed. This course covers harmonic theory on complex manifolds, the Hodge decomposition theorem, the Hard Lefschetz theorem, and Vanishing theorems. Some results and tools on deformation and uniformization of complex manifolds are also discussed.

Subjects

Harmonic theory | Harmonic theory | complex manifolds | complex manifolds | Hodge decomposition theorem | Hodge decomposition theorem | Hard Lefschetz theorem | Hard Lefschetz theorem | Vanishing theorems | Vanishing theorems | deformation of complex manifolds | deformation of complex manifolds | uniformization of complex manifolds | uniformization of complex manifolds

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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STS.436 Cold War Science (MIT) STS.436 Cold War Science (MIT)

Description

The history and legacy of the Cold War on science is examined in a seminar setting for this course, looking predominantly at examples in the United States. Topics range from exploring scientists' new political roles after World War II as elite policy-makers in the nuclear age to their victimization by domestic anti-Communism. The course next examines the changing institutions in which the physical, biological, and social sciences were conducted during the postwar decades, investigating the links between institutions and epistemology. The course closes by considering the place of science in the post-Cold-War era. The history and legacy of the Cold War on science is examined in a seminar setting for this course, looking predominantly at examples in the United States. Topics range from exploring scientists' new political roles after World War II as elite policy-makers in the nuclear age to their victimization by domestic anti-Communism. The course next examines the changing institutions in which the physical, biological, and social sciences were conducted during the postwar decades, investigating the links between institutions and epistemology. The course closes by considering the place of science in the post-Cold-War era.

Subjects

cold war | cold war | history of science | history of science | nuclear age | nuclear age | post-cold-war era | post-cold-war era | atomic bomb | atomic bomb | nuclear weapons | nuclear weapons | atom bomb | atom bomb | hydrogen bomb | hydrogen bomb | atomic energy | atomic energy | McCarthyism | McCarthyism | espionage | espionage | anti-communism | anti-communism | soviet union | soviet union | cold war america | cold war america | american science | american science

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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6.849 Geometric Folding Algorithms: Linkages, Origami, Polyhedra (MIT) 6.849 Geometric Folding Algorithms: Linkages, Origami, Polyhedra (MIT)

Description

Includes audio/video content: AV lectures. This course focuses on the algorithms for analyzing and designing geometric foldings. Topics include reconfiguration of foldable structures, linkages made from one-dimensional rods connected by hinges, folding two-dimensional paper (origami), and unfolding and folding three-dimensional polyhedra. Applications to architecture, robotics, manufacturing, and biology are also covered in this course. Acknowledgments Thanks to videographers Martin Demaine and Jayson Lynch. Includes audio/video content: AV lectures. This course focuses on the algorithms for analyzing and designing geometric foldings. Topics include reconfiguration of foldable structures, linkages made from one-dimensional rods connected by hinges, folding two-dimensional paper (origami), and unfolding and folding three-dimensional polyhedra. Applications to architecture, robotics, manufacturing, and biology are also covered in this course. Acknowledgments Thanks to videographers Martin Demaine and Jayson Lynch.

Subjects

origami | origami | geometry | geometry | algorithm | algorithm | folding | folding | linkage | linkage | polyhedra | polyhedra | seam | seam | crease pattern | crease pattern | universal molecule | universal molecule | box pleating | box pleating | triangulation | triangulation | vertex | vertex | edge | edge | curved crease | curved crease | rigidity | rigidity | tensegrity | tensegrity | hinged dissection | hinged dissection | unfolding | unfolding | gluing | gluing | platonic solid | platonic solid | refolding | refolding | sculpture | sculpture | paper | paper | 3D chain | 3D chain | design | design

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Czechoslovak armored train (LOC) Czechoslovak armored train (LOC)

Description

Subjects

libraryofcongress | libraryofcongress | signalcorps | signalcorps | soldier | soldier | soldiers | soldiers | machinegunner | machinegunner | machinegunners | machinegunners | machinegun | machinegun | armoredtrain | armoredtrain | armouredtrain | armouredtrain | czecharmy | czecharmy | czechoslovakarmy | czechoslovakarmy

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Lawrence Armstrong alias Hanby, soldier, arrested for theft Lawrence Armstrong alias Hanby, soldier, arrested for theft

Description

Subjects

eye | eye | face | face | hat | hat | shop | shop | emblem | emblem | soldier | soldier | army | army | nose | nose | head | head | mark | mark | military | military | coat | coat | grain | grain | property | property | criminal | criminal | crime | crime | button | button | mugshot | mugshot | fold | fold | unusual | unusual | ww1 | ww1 | pocket | pocket | cigarettes | cigarettes | striking | striking | shoulder | shoulder | theft | theft | policestation | policestation | crease | crease | wrinkle | wrinkle | firstworldwar | firstworldwar | youngman | youngman | attentive | attentive | accused | accused | arrested | arrested | arrest | arrest | stealing | stealing | prisoner | prisoner | homefront | homefront | distracted | distracted | fascinating | fascinating | committed | committed | charged | charged | £1 | £1 | 5s | 5s | northshields | northshields | transcription | transcription | imprisoned | imprisoned | tobacconist | tobacconist | socialhistory | socialhistory | newsreport | newsreport | militaryuniform | militaryuniform | blackframe | blackframe | blackandwhitephotograph | blackandwhitephotograph | criminalrecord | criminalrecord | publicrecords | publicrecords | savillestreet | savillestreet | northumberlandfusiliers | northumberlandfusiliers | neutralbackground | neutralbackground | dressring | dressring | pawnticket | pawnticket | 1stnorthumberlandfusiliers | 1stnorthumberlandfusiliers | northshieldspolicecourt | northshieldspolicecourt | henrynicholson | henrynicholson | 19021916 | 19021916 | northshieldspolicestation | northshieldspolicestation | northshieldslocalstudieslibrary | northshieldslocalstudieslibrary | shieldsdailynews | shieldsdailynews | criminalfacesofnorthshieldsfirstworldwar | criminalfacesofnorthshieldsfirstworldwar | aliashanby | aliashanby | microfilmcopies | microfilmcopies | lawrencearmstrong | lawrencearmstrong | valoneharrison | valoneharrison | 30september1915 | 30september1915 | pleadedguilty | pleadedguilty | detectivemason | detectivemason

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Happy 8th Birthday, Flickr Commons ! 6 days to go (LOC) Happy 8th Birthday, Flickr Commons ! 6 days to go (LOC)

Description

Subjects

boston | boston | bridges | bridges | trains | trains | amtrak | amtrak | fortpoint | fortpoint | libraryofcongress | libraryofcongress | bigdig | bigdig | 1904 | 1904 | boxcars | boxcars | channels | channels | southstation | southstation | railroads | railroads | fortpointchannel | fortpointchannel | streetscapes | streetscapes | thenandnow | thenandnow | thennow | thennow | railroadcars | railroadcars | suffolkcounty | suffolkcounty | bostonmassachusetts | bostonmassachusetts | newhavenrailroad | newhavenrailroad | grandtrunkrailway | grandtrunkrailway | liftbridges | liftbridges | bostonmainerailroad | bostonmainerailroad | massachusettsbaytransportationauthority | massachusettsbaytransportationauthority | oldcolonyrailroad | oldcolonyrailroad | detroitpublishingcompany | detroitpublishingcompany | towerbridges | towerbridges | rollingbridgepark | rollingbridgepark | newyorknewhavenhartfordrailroad | newyorknewhavenhartfordrailroad | oldcolonyrailroadbridge | oldcolonyrailroadbridge | pennsylvaniasteelcompany | pennsylvaniasteelcompany | fortpointchannelbridge | fortpointchannelbridge | bostonalbanyrailroad | bostonalbanyrailroad | 017090 | 017090 | newyorknewenglandrailroad | newyorknewenglandrailroad | rollingliftbridges | rollingliftbridges | bostonprovidencerailroad | bostonprovidencerailroad | bostonterminalcompany | bostonterminalcompany | happybirthdayflickrcommons | happybirthdayflickrcommons | fortpointchannelrollingliftbridge | fortpointchannelrollingliftbridge | scherzerrollingliftbridges | scherzerrollingliftbridges | thesixtrackscherzerrollingliftbridge | thesixtrackscherzerrollingliftbridge | williamscherzer | williamscherzer | suburbanloop | suburbanloop | newhavenrailroadsystem | newhavenrailroadsystem | southterminalstation | southterminalstation | holbrookcabotdaly | holbrookcabotdaly | southbaychannel | southbaychannel | maritimechannels | maritimechannels

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7.343 Protein Folding, Misfolding and Human Disease (MIT) 7.343 Protein Folding, Misfolding and Human Disease (MIT)

Description

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. The instructor for this course, Dr. Kosinski-Collins, is a member of the HHMI Education Group. Maintenance of the complex three-dimensional structure adopted by a protein in the cell is vital for function. Oftentimes, as a consequence of environmental stress, genetic mutation, and/or infection, the folded structure of a protein gets altered and multiple proteins stick and fall out of solution in a process known as aggregation. In many protein aggregation diseases, incorrectly folded proteins self-associate, for This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. The instructor for this course, Dr. Kosinski-Collins, is a member of the HHMI Education Group. Maintenance of the complex three-dimensional structure adopted by a protein in the cell is vital for function. Oftentimes, as a consequence of environmental stress, genetic mutation, and/or infection, the folded structure of a protein gets altered and multiple proteins stick and fall out of solution in a process known as aggregation. In many protein aggregation diseases, incorrectly folded proteins self-associate, for

Subjects

protein folding | protein folding | misfolded proteins | misfolded proteins | Mad Cow | Mad Cow | Creutzfedt-Jakob Disease | Creutzfedt-Jakob Disease | Alzheimer's Disease | Alzheimer's Disease | Huntington's Disease | Huntington's Disease | protein aggregation | protein aggregation | self-associate | self-associate | cell death | cell death | dementia | dementia | prions | prions | bovine spongiform encephalopathy | bovine spongiform encephalopathy | kuru | kuru | scrapie | scrapie | protein structure | protein structure | amyloid protein | amyloid protein | amyloidosis | amyloidosis | polyglutamine repeats | polyglutamine repeats | fibrils | fibrils

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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18.735 Double Affine Hecke Algebras in Representation Theory, Combinatorics, Geometry, and Mathematical Physics (MIT) 18.735 Double Affine Hecke Algebras in Representation Theory, Combinatorics, Geometry, and Mathematical Physics (MIT)

Description

Double affine Hecke algebras (DAHA), also called Cherednik algebras, and their representations appear in many contexts: integrable systems (Calogero-Moser and Ruijsenaars models), algebraic geometry (Hilbert schemes), orthogonal polynomials, Lie theory, quantum groups, etc. In this course we will review the basic theory of DAHA and their representations, emphasizing their connections with other subjects and open problems. Double affine Hecke algebras (DAHA), also called Cherednik algebras, and their representations appear in many contexts: integrable systems (Calogero-Moser and Ruijsenaars models), algebraic geometry (Hilbert schemes), orthogonal polynomials, Lie theory, quantum groups, etc. In this course we will review the basic theory of DAHA and their representations, emphasizing their connections with other subjects and open problems.

Subjects

dunkl operators | dunkl operators | cherednik | cherednik | affine algebra | affine algebra | representation theory | representation theory | hecke | hecke | knizknik-zamoldchikov | knizknik-zamoldchikov | orbifolds | orbifolds | calogero-moser space | calogero-moser space | hilbert scheme | hilbert scheme | algebra | algebra | macdonald-mehta integral | macdonald-mehta integral | integrable system | integrable system

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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3.37 Welding and Joining Processes (MIT) 3.37 Welding and Joining Processes (MIT)

Description

Discusses a wide variety of processes and materials from the viewpoint of their fundamental physical and chemical properties. Specific topics: cold welding, adhesive bonding, diffusion bonding, soldering, brazing, flames, arcs, high-energy density heat sources, solidification, cracking resistance, shielding methods, and electric contacts. Emphasis on underlying science of a given process rather than a detailed description of the technique or equipment. This course meets with the first half of 3.371J in the Fall Term. Discusses a wide variety of processes and materials from the viewpoint of their fundamental physical and chemical properties. Specific topics: cold welding, adhesive bonding, diffusion bonding, soldering, brazing, flames, arcs, high-energy density heat sources, solidification, cracking resistance, shielding methods, and electric contacts. Emphasis on underlying science of a given process rather than a detailed description of the technique or equipment. This course meets with the first half of 3.371J in the Fall Term.

Subjects

cold welding | cold welding | adhesive bonding | adhesive bonding | diffusion bonding | diffusion bonding | soldering | soldering | brazing | brazing | flames | flames | arcs | arcs | high-energy density heat sources | high-energy density heat sources | solidification | solidification | cracking resistance | cracking resistance | shielding methods | shielding methods | electric contacts | electric contacts

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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STS.436 Cold War Science (MIT) STS.436 Cold War Science (MIT)

Description

This seminar examines the history and legacy of the Cold War on American science. It explores scientist's new political roles after World War II, ranging from elite policy makers in the nuclear age to victims of domestic anti Communism. It also examines the changing institutions in which the physical sciences and social sciences were conducted during the postwar decades, investigating possible epistemic effects on forms of knowledge. The subject closes by considering the place of science in the post-Cold War era. This seminar examines the history and legacy of the Cold War on American science. It explores scientist's new political roles after World War II, ranging from elite policy makers in the nuclear age to victims of domestic anti Communism. It also examines the changing institutions in which the physical sciences and social sciences were conducted during the postwar decades, investigating possible epistemic effects on forms of knowledge. The subject closes by considering the place of science in the post-Cold War era.

Subjects

cold war | cold war | history of science | history of science | nuclear age | nuclear age | post-cold-war era | post-cold-war era | atomic bomb | atomic bomb | nuclear weapons | nuclear weapons | atom bomb | atom bomb | hydrogen bomb | hydrogen bomb | atomic energy | atomic energy | McCarthyism | McCarthyism | espionage | espionage | anti-communism | anti-communism | spying | spying | soviet union | soviet union | american science | american science | HUAC | HUAC | oppenheimer | oppenheimer | arms race | arms race | disarmament | disarmament | Sputnik | Sputnik | iron curtain | iron curtain | space race | space race | globalization | globalization | capitalism | capitalism | academic freedom | academic freedom | CIA | CIA | National Security Agency | National Security Agency | NSA | NSA | military-industrial complex | military-industrial complex | quantum physics | quantum physics | physics | physics

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Australian lighthorsemen snowballing on the slopes of Mt. Lebanon during the First World War Australian lighthorsemen snowballing on the slopes of Mt. Lebanon during the First World War

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Subjects

lighthorse | lighthorse | worldwar1 | worldwar1 | lebanon | lebanon | soldiers | soldiers | australiansoldiers | australiansoldiers | war | war | snow | snow | snowballs | snowballs

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No known copyright restrictions

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Soldiers of a Wellington Regiment in France, World War I Soldiers of a Wellington Regiment in France, World War I

Description

Subjects

world | world | newzealand | newzealand | war | war | worldwari | worldwari | soldiers | soldiers | 1917 | 1917 | soldados | soldados | primeraguerramundial | primeraguerramundial | wellingtonregiment | wellingtonregiment | henryarmytagesander | henryarmytagesander

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Mujeres Listas Para Recivia a Rabago Mujeres Listas Para Recivia a Rabago

Description

Subjects

sculpture | sculpture | texas | texas | soldiers | soldiers | monuments | monuments | troops | troops | memorials | memorials | mexicanrevolution | mexicanrevolution | militarypersonnel | militarypersonnel | rppc | rppc | usmexicoborder | usmexicoborder | soldaderas | soldaderas | gutierrezdelara | gutierrezdelara | 18701918 | 18701918

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7.88J Protein Folding and Human Disease (MIT)

Description

This course covers amino acid sequence control of protein folding, misfolding, amyloid polymerization and aggregation. Readings and discussions address topics such as chaperone structure and function, folding and assembly of fibrous proteins, and pathologies associated with protein misfolding and aggregation in Alzheimer's, Parkinson's, Huntington's and other protein deposition diseases. Students are required to write and present a research paper.

Subjects

protein folding | misfolding | aggregation | protein structures | folding intermediates | off-pathway aggregation | amyloid formation | Key chaperones | chaperonins | human protein deposition diseases | ?s disease | amyloids | prions | amino acid sequence | amyloid polymerization | chaperone structure and function | folding and assembly of fibrous proteins

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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1.223J Transportation Policy, Strategy, and Management (MIT) 1.223J Transportation Policy, Strategy, and Management (MIT)

Description

This class surveys the current concepts, theories, and issues in strategic management of transportation organizations. It provides transportation logistics and engineering systems students with an overview of the operating context, leadership challenges, strategies, and management tools that are used in today's public and private transportation organizations. The following concepts, tools, and issues are presented in both public and private sector cases: alternative models of decision-making, strategic planning (e.g., use of SWOT analysis and scenario development), stakeholder valuation and analysis, government-based regulation and cooperation within the transportation enterprise, disaster communications, systems safety, change management, and the impact of globalization. This class surveys the current concepts, theories, and issues in strategic management of transportation organizations. It provides transportation logistics and engineering systems students with an overview of the operating context, leadership challenges, strategies, and management tools that are used in today's public and private transportation organizations. The following concepts, tools, and issues are presented in both public and private sector cases: alternative models of decision-making, strategic planning (e.g., use of SWOT analysis and scenario development), stakeholder valuation and analysis, government-based regulation and cooperation within the transportation enterprise, disaster communications, systems safety, change management, and the impact of globalization.

Subjects

public transportation systems; pollution; infrastructure; government regulation; public policy; strategic planning management; labor relations; maintenance planning; administration; financing; marketing policy; fare policy; management information; decision support systems; transit industry; service provision; private sector; alternative models of decision-making; strategic planning; stakeholder valuation and analysis; government-based regulation and cooperation; transportation enterprise; disaster communications; systems safety; change management; and the impact of globalization; | public transportation systems; pollution; infrastructure; government regulation; public policy; strategic planning management; labor relations; maintenance planning; administration; financing; marketing policy; fare policy; management information; decision support systems; transit industry; service provision; private sector; alternative models of decision-making; strategic planning; stakeholder valuation and analysis; government-based regulation and cooperation; transportation enterprise; disaster communications; systems safety; change management; and the impact of globalization; | public transportation systems | public transportation systems | pollution | pollution | infrastructure | infrastructure | government regulation | government regulation | public policy | public policy | strategic planning management | strategic planning management | labor relations | labor relations | maintenance planning | maintenance planning | administration | administration | financing | financing | marketing policy | marketing policy | fare policy | fare policy | management information | management information | decision support systems | decision support systems | transit industry | transit industry | service provision | service provision | private sector | private sector | alternative models of decision-making | alternative models of decision-making | strategic planning | strategic planning | stakeholder valuation and analysis | stakeholder valuation and analysis | government-based regulation and cooperation | government-based regulation and cooperation | transportation enterprise | transportation enterprise | disaster communications | disaster communications | systems safety | systems safety | change management | change management | and the impact of globalization | and the impact of globalization | the impact of globalization | the impact of globalization | 1.223 | 1.223 | ESD.203 | ESD.203

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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TALAT Lecture 3706: Bending and Folding

Description

This lecture describes the fundamentals of bending and folding aluminium sheet; it also describes different methods in design of folding tools. Background in production engineering and sheet metal forming and familiarity with the subject matter covered in TALAT This lectures 3701- 3705 is assumed.

Subjects

aluminium | aluminum | european aluminium association | eaa | talat | training in aluminium application technologies | training | metallurgy | technology | lecture | machining | forming | forging | sheet | folding | fold geometries | drawn parts | bending | springback | bending line geometries | counter pressure | springback angle | yield stress | pre-straining | failure mechanism | tearing | pre-folding | pre-bending punches | bending forces | final folding | corematerials | ukoer | Engineering | H000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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German prisoners (LOC) German prisoners (LOC)

Description

Subjects

libraryofcongress | libraryofcongress | committeeonpublicinformation | committeeonpublicinformation | october171918 | october171918 | prisonerofwar | prisonerofwar | prisonersofwar | prisonersofwar | pow | pow | pows | pows | soldier | soldier | soldiers | soldiers | germanarmy | germanarmy | thegreatwar | thegreatwar | greatwar | greatwar | worldwarone | worldwarone | worldwari | worldwari | wwi | wwi | firstworldwar | firstworldwar | kaiserlichdeutschesheer | kaiserlichdeutschesheer | reichsheer | reichsheer | imperialgermanarmy | imperialgermanarmy | heer | heer

License

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