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HST.035 Principle and Practice of Human Pathology (MIT) HST.035 Principle and Practice of Human Pathology (MIT)

Description

This course provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and diagnostic medicine. Topics include:Cellular Mechanisms of DiseaseMolecular PathologyPathology of Major Organ SystemsReview of Diagnostic Tools from Traditional Surgical Pathology to Diagnostic SpectroscopyFunctional and Molecular ImagingMolecular DiagnosticsIn addition to lectures, one of the two weekly sessions includes a 2-3 hour laboratory component. Periodically, time will also be devoted to minicases.LecturersProf. Jon AsterProf. Frederick BieberProf. Carlo BrugnaraProf. Robert B. ColvinProf. Christopher CrumProf. Douglas DockeryProf. Mel FeanyProf. Michael FeldProf. Jonathan FletcherProf. Michael GimbroneProf. Todd GolubProf. Frank B. HuProf. Donald IngberProf. Hart LidovProf. This course provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and diagnostic medicine. Topics include:Cellular Mechanisms of DiseaseMolecular PathologyPathology of Major Organ SystemsReview of Diagnostic Tools from Traditional Surgical Pathology to Diagnostic SpectroscopyFunctional and Molecular ImagingMolecular DiagnosticsIn addition to lectures, one of the two weekly sessions includes a 2-3 hour laboratory component. Periodically, time will also be devoted to minicases.LecturersProf. Jon AsterProf. Frederick BieberProf. Carlo BrugnaraProf. Robert B. ColvinProf. Christopher CrumProf. Douglas DockeryProf. Mel FeanyProf. Michael FeldProf. Jonathan FletcherProf. Michael GimbroneProf. Todd GolubProf. Frank B. HuProf. Donald IngberProf. Hart LidovProf.

Subjects

human pathology | human pathology | disease mechanisms | disease mechanisms | cellular pathology | cellular pathology | molecular pathology | molecular pathology | diagnostic tools | diagnostic tools | surgical pathology | surgical pathology | diagnostic spectroscopy | diagnostic spectroscopy | functional imaging | functional imaging | molecular imaging | molecular imaging | molecular diagnostics | molecular diagnostics | medicine | medicine | immune system | immune system | transplantation | transplantation | diagnosis | diagnosis | neoplasia | neoplasia | pathobiology | pathobiology | pathophysiology | pathophysiology

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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18.997 Topics in Combinatorial Optimization (MIT) 18.997 Topics in Combinatorial Optimization (MIT)

Description

In this graduate-level course, we will be covering advanced topics in combinatorial optimization. We will start with non-bipartite matchings and cover many results extending the fundamental results of matchings, flows and matroids. The emphasis is on the derivation of purely combinatorial results, including min-max relations, and not so much on the corresponding algorithmic questions of how to find such objects. The intended audience consists of Ph.D. students interested in optimization, combinatorics, or combinatorial algorithms. In this graduate-level course, we will be covering advanced topics in combinatorial optimization. We will start with non-bipartite matchings and cover many results extending the fundamental results of matchings, flows and matroids. The emphasis is on the derivation of purely combinatorial results, including min-max relations, and not so much on the corresponding algorithmic questions of how to find such objects. The intended audience consists of Ph.D. students interested in optimization, combinatorics, or combinatorial algorithms.

Subjects

combinatorial optimization | combinatorial optimization | Ear decompositions | Ear decompositions | Nonbipartite matching | Nonbipartite matching | Gallai-Milgram and Bessy-Thomasse theorems on partitioning/covering graphs by directed paths/cycles | Gallai-Milgram and Bessy-Thomasse theorems on partitioning/covering graphs by directed paths/cycles | Minimization of submodular functions | Minimization of submodular functions | Matroid intersection | Matroid intersection | Polymatroid intersection | Polymatroid intersection | Jump systems | Jump systems | Matroid union | Matroid union | Matroid matching | path matchings | Matroid matching | path matchings | Packing trees and arborescences | Packing trees and arborescences | Packing directed cuts and the Lucchesi-Younger theorem | Packing directed cuts and the Lucchesi-Younger theorem | Submodular flows and the Edmonds-Giles theorem | Submodular flows and the Edmonds-Giles theorem | Graph orientation | Graph orientation | Connectivity tree and connectivity augmentation | Connectivity tree and connectivity augmentation | Multicommodity flows | Multicommodity flows | Connectivity tree | Connectivity tree | connectivity augmentation | connectivity augmentation | Gallai-Milgram Theorem | Gallai-Milgram Theorem | Bessy-Thomasse Theorem | Bessy-Thomasse Theorem | paritioning graphs | paritioning graphs | covering graphs | covering graphs | directed paths | directed paths | directed cycles | directed cycles | matroid matching | matroid matching | path matching | path matching | packing directed cuts | packing directed cuts | Luchessi-Younger Theorem | Luchessi-Younger Theorem | packing trees | packing trees | arborescences | arborescences | submodular flows | submodular flows | Edmonds-Giles Theorem | Edmonds-Giles Theorem

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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HST.121 Gastroenterology (MIT) HST.121 Gastroenterology (MIT)

Description

The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, with emphasis on integrating the molecular, cellular and pathophysiological aspects of the disease processes to their related symptoms and signs. The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, with emphasis on integrating the molecular, cellular and pathophysiological aspects of the disease processes to their related symptoms and signs.

Subjects

gastroenterology | gastroenterology | anatomy | anatomy | physiology | physiology | biochemistry | biochemistry | biophysics | biophysics | bioengineering | bioengineering | gastrointestinal tract | gastrointestinal tract | pancreas | pancreas | liver | liver | biliary tract system | biliary tract system | gross pathology | gross pathology | microscopic pathology | microscopic pathology | clinical diseases | clinical diseases | molecular | molecular | cellular | cellular | pathophysiological processes | pathophysiological processes | symptoms | symptoms | medical | medical | health | health

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.340 Under the Radar Screen: How Bugs Trick Our Immune Defenses (MIT) 7.340 Under the Radar Screen: How Bugs Trick Our Immune Defenses (MIT)

Description

In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about

Subjects

HIV | HIV | mycobacterium tuberculosis | mycobacterium tuberculosis | malaria | malaria | influenza | influenza | immune system | immune system | pathogens | pathogens | viruses | viruses | bacteria | bacteria | parasites | parasites | microbes | microbes | phagocytosis | phagocytosis | ubiquitin/proteasome pathway | ubiquitin/proteasome pathway | MHC I/II antigen presentation | MHC I/II antigen presentation | Salmonella | Salmonella | pathogen-associated molecular patterns | pathogen-associated molecular patterns | PAMP | PAMP | Toll-like receptors | Toll-like receptors | TLR | TLR | Vaccinia virus | Vaccinia virus | Proteasome | Proteasome | Ubiquitin; deubiquinating enzymes | Ubiquitin; deubiquinating enzymes | DUB | DUB | Herpes simplex virus | Herpes simplex virus | HSV | HSV | Yersinia | Yersinia | viral budding | viral budding | Human cytomegalovirus | Human cytomegalovirus | HCMV | HCMV | Histocompatiblity | Histocompatiblity | AIDS | AIDS | Kaposi Sarcoma-Associated Herpes virus | Kaposi Sarcoma-Associated Herpes virus | Mixoma virus | Mixoma virus | Epstein Barr virus | Epstein Barr virus | EBV | EBV | Burkitt?s B cell lymphoma | Burkitt?s B cell lymphoma

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.340 Immune Evasion: How Sneaky Pathogens Avoid Host Surveillance (MIT) 7.340 Immune Evasion: How Sneaky Pathogens Avoid Host Surveillance (MIT)

Description

Every infection consists of a battle between the invading pathogen and the resisting host. To be successful, a pathogen must escape the many defenses of the host immune system until it can replicate and spread to another host. A pathogen must prevent one of three stages of immune function: detection, activation, or effector function. Examples of disease-specific immune evasion and the mechanisms used by pathogens to prevail over their hosts' immune systems are discussed. Also considered is what these host-pathogen interactions reveal about the normal function of the immune system and basic cell biological processes, such as protein maturation and degradation. Every infection consists of a battle between the invading pathogen and the resisting host. To be successful, a pathogen must escape the many defenses of the host immune system until it can replicate and spread to another host. A pathogen must prevent one of three stages of immune function: detection, activation, or effector function. Examples of disease-specific immune evasion and the mechanisms used by pathogens to prevail over their hosts' immune systems are discussed. Also considered is what these host-pathogen interactions reveal about the normal function of the immune system and basic cell biological processes, such as protein maturation and degradation.

Subjects

immunology | immunology | immune system | immune system | immune evasion | immune evasion | pathogen | pathogen | effector function | effector function | infections | infections | Human cytomegalovirus | Human cytomegalovirus | Human Immunodeficiency Virus | Human Immunodeficiency Virus | CD4 cells | CD4 cells | CD8 cells | CD8 cells | T cells | T cells | surace receptors | surace receptors | cell lysis | cell lysis | host-pathogen interactions | host-pathogen interactions | host surveillance | host surveillance | antibodies | antibodies | MHC class I | MHC class I | blood-borne pathogens | blood-borne pathogens | macrophages | macrophages | phagocytosis | phagocytosis | endocytosis | endocytosis | degradation | degradation | antigen | antigen | apoptosis | apoptosis | cytokines | cytokines | immune response | immune response

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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HST.035 Principle and Practice of Human Pathology (MIT)

Description

This course provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and diagnostic medicine. Topics include:Cellular Mechanisms of DiseaseMolecular PathologyPathology of Major Organ SystemsReview of Diagnostic Tools from Traditional Surgical Pathology to Diagnostic SpectroscopyFunctional and Molecular ImagingMolecular DiagnosticsIn addition to lectures, one of the two weekly sessions includes a 2-3 hour laboratory component. Periodically, time will also be devoted to minicases.LecturersProf. Jon AsterProf. Frederick BieberProf. Carlo BrugnaraProf. Robert B. ColvinProf. Christopher CrumProf. Douglas DockeryProf. Mel FeanyProf. Michael FeldProf. Jonathan FletcherProf. Michael GimbroneProf. Todd GolubProf. Frank B. HuProf. Donald IngberProf. Hart LidovProf.

Subjects

human pathology | disease mechanisms | cellular pathology | molecular pathology | diagnostic tools | surgical pathology | diagnostic spectroscopy | functional imaging | molecular imaging | molecular diagnostics | medicine | immune system | transplantation | diagnosis | neoplasia | pathobiology | pathophysiology

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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HST.035 Principle and Practice of Human Pathology (MIT)

Description

This course provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and diagnostic medicine. Topics include:Cellular Mechanisms of DiseaseMolecular PathologyPathology of Major Organ SystemsReview of Diagnostic Tools from Traditional Surgical Pathology to Diagnostic SpectroscopyFunctional and Molecular ImagingMolecular DiagnosticsIn addition to lectures, one of the two weekly sessions includes a 2-3 hour laboratory component. Periodically, time will also be devoted to minicases.LecturersProf. Jon AsterProf. Frederick BieberProf. Carlo BrugnaraProf. Robert B. ColvinProf. Christopher CrumProf. Douglas DockeryProf. Mel FeanyProf. Michael FeldProf. Jonathan FletcherProf. Michael GimbroneProf. Todd GolubProf. Frank B. HuProf. Donald IngberProf. Hart LidovProf.

Subjects

human pathology | disease mechanisms | cellular pathology | molecular pathology | diagnostic tools | surgical pathology | diagnostic spectroscopy | functional imaging | molecular imaging | molecular diagnostics | medicine | immune system | transplantation | diagnosis | neoplasia | pathobiology | pathophysiology

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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HST.121 Gastroenterology (MIT) HST.121 Gastroenterology (MIT)

Description

The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, with emphasis on integrating the molecular, cellular and pathophysiological aspects of the disease processes to their related symptoms and signs. The most recent knowledge of the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and the associated pancreatic, liver and biliary tract systems is presented and discussed. Gross and microscopic pathology and the clinical aspects of important gastroenterological diseases are then presented, with emphasis on integrating the molecular, cellular and pathophysiological aspects of the disease processes to their related symptoms and signs.

Subjects

gastroenterology | gastroenterology | anatomy | anatomy | physiology | physiology | biochemistry | biochemistry | biophysics | biophysics | bioengineering | bioengineering | gastrointestinal tract | gastrointestinal tract | pancreas | pancreas | liver | liver | biliary tract system | biliary tract system | gross pathology | gross pathology | microscopic pathology | microscopic pathology | clinical diseases | clinical diseases | molecular | molecular | cellular | cellular | pathophysiological processes | pathophysiological processes | symptoms | symptoms | medical | medical | health | health

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.343 Sophisticated Survival Skills of Simple Microorganisms (MIT) 7.343 Sophisticated Survival Skills of Simple Microorganisms (MIT)

Description

In this course, we will discuss the microbial physiology and genetics of stress responses in aquatic ecosystems, astrobiology, bacterial pathogenesis and other environments. We will learn about classical and novel methods utilized by researchers to uncover bacterial mechanisms induced under both general and environment-specific stresses. Finally, we will compare and contrast models for bacterial stress responses to gain an understanding of distinct mechanisms of survival and of why there are differences among bacterial genera. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly In this course, we will discuss the microbial physiology and genetics of stress responses in aquatic ecosystems, astrobiology, bacterial pathogenesis and other environments. We will learn about classical and novel methods utilized by researchers to uncover bacterial mechanisms induced under both general and environment-specific stresses. Finally, we will compare and contrast models for bacterial stress responses to gain an understanding of distinct mechanisms of survival and of why there are differences among bacterial genera. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly

Subjects

microbial physiology | microbial physiology | genetics | genetics | stress | stress | astrobiology | astrobiology | pathogenesis | pathogenesis | Escherichia coli | Escherichia coli | cyanobacteria | cyanobacteria | bleaching | bleaching | deprivation | deprivation | chlorosis | chlorosis | pollutants | pollutants | methylobacteria | methylobacteria | pathogen | pathogen | reactive oxygen species | reactive oxygen species | infection | infection | superoxides | superoxides | phage | phage | Deinococcus | Deinococcus | Raman spectroscopy | Raman spectroscopy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.343 The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Disease (MIT) 7.343 The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Disease (MIT)

Description

This course will start with a survey of basic oxygen radical biochemistry followed by a discussion of the mechanisms of action of cellular as well as dietary antioxidants. After considering the normal physiological roles of oxidants, we will examine the effects of elevated ROS and a failure of cellular redox capacity on the rate of organismal and cellular aging as well as on the onset and progression of several major diseases that are often age-related. Topics will include ROS-induced effects on stem cell regeneration, insulin resistance, heart disease, neurodegenerative disorders, and cancer. The role of antioxidants in potential therapeutic strategies for modulating ROS levels will also be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology D This course will start with a survey of basic oxygen radical biochemistry followed by a discussion of the mechanisms of action of cellular as well as dietary antioxidants. After considering the normal physiological roles of oxidants, we will examine the effects of elevated ROS and a failure of cellular redox capacity on the rate of organismal and cellular aging as well as on the onset and progression of several major diseases that are often age-related. Topics will include ROS-induced effects on stem cell regeneration, insulin resistance, heart disease, neurodegenerative disorders, and cancer. The role of antioxidants in potential therapeutic strategies for modulating ROS levels will also be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology D

Subjects

reactive oxygen species | reactive oxygen species | oxygen | oxygen | ROS | ROS | energy | energy | mitochondria | mitochondria | cell signaling | cell signaling | anti-pathogen | anti-pathogen | oxidative damage | oxidative damage | oncogene | oncogene | antioxidant | antioxidant | insulin resistance | insulin resistance | diabetes | diabetes | stem cell | stem cell | neurodegenerative | neurodegenerative | ischemic | ischemic | ATP | ATP | pathways | pathways | NADPH | NADPH | nox | nox | psd | psd | programmed cell death | programmed cell death | apoptosis | apoptosis | hsc | hsc | hematopoietic | hematopoietic

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.88J Protein Folding Problem (MIT) 7.88J Protein Folding Problem (MIT)

Description

This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects. This course focuses on the mechanisms by which the amino acid sequence of polypeptide chains (proteins), determine their three-dimensional conformation. Topics in this course include sequence determinants of secondary structure, the folding of newly synthesized polypeptide chains within cells, folding intermediates aggregation and competing off-pathway reactions, and the unfolding and refolding of proteins in vitro. Additional topics covered are the role of helper proteins such as chaperonins and isomerases, protein recovery problems in the biotechnology industry, and diseases found associated with protein folding defects.

Subjects

amino acid sequence | amino acid sequence | polypeptide chains | polypeptide chains | sequence determinants | sequence determinants | folding | folding | synthesized polypeptide chains within cells | synthesized polypeptide chains within cells | unfolding and refolding of proteins in vitro | unfolding and refolding of proteins in vitro | folding intermediates aggregation | folding intermediates aggregation | competing off-pathway reactions | competing off-pathway reactions | chaperonins | chaperonins | isomerases | isomerases | helper proteins | helper proteins | protein recovery problems | protein recovery problems | biotechnology industry | biotechnology industry | protein folding defects | protein folding defects | 3-D conformation | 3-D conformation | globular proteins | globular proteins | fibrous proteins | fibrous proteins | kinetics | kinetics | in vitro refolding | in vitro refolding | pathways | pathways | in vivo folding | in vivo folding | synthesized proteins | synthesized proteins | aggregation | aggregation | protein misfolding | protein misfolding | human disease | human disease | protein folding | protein folding | genome sequences | genome sequences | 7.88 | 7.88 | 5.48 | 5.48 | 7.24 | 7.24 | 10.543 | 10.543

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.342 Cancer Biology: From Basic Research to the Clinic (MIT) 7.342 Cancer Biology: From Basic Research to the Clinic (MIT)

Description

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. In 1971, President Nixon declared the "War on Cancer," but after three decades the war is still raging. How much progress have we made toward winning the war and what are we doing to improve the fight? Understanding the molecular and cellular events involved in tumor formation, progression, and metastasis is crucial to the development of innovative therapy for cancer patients. Insights into these processes have been gleaned through basic research using biochemical, molecular, and genetic ana This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. In 1971, President Nixon declared the "War on Cancer," but after three decades the war is still raging. How much progress have we made toward winning the war and what are we doing to improve the fight? Understanding the molecular and cellular events involved in tumor formation, progression, and metastasis is crucial to the development of innovative therapy for cancer patients. Insights into these processes have been gleaned through basic research using biochemical, molecular, and genetic ana

Subjects

cancer | cancer | tumor | tumor | metastasis | metastasis | genetic analysis | genetic analysis | cancer biology | cancer biology | model organisms | model organisms | genetic pathways | genetic pathways | uncontrolled growth | uncontrolled growth | tumor suppressor genes | tumor suppressor genes | oncogenes | oncogenes | tumor initiation | tumor initiation | cell cycle | cell cycle | chromosomal aberration | chromosomal aberration | apoptosis | apoptosis | cell death | cell death | signal transduction pathways | signal transduction pathways | proto-oncogene | proto-oncogene | mutation | mutation | DNA mismatch repair | DNA mismatch repair | telomeres | telomeres | mouse models | mouse models | tissue specificity | tissue specificity | malignancy | malignancy | stem cells | stem cells | therapeutic resistance | therapeutic resistance | differentiation | differentiation | caner research | caner research | cancer therapeutics | cancer therapeutics | chemotherapy | chemotherapy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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IV (MIT) IV (MIT)

Description

Includes audio/video content: AV selected lectures, AV faculty introductions, AV special element video. The basic objective of Unified Engineering is to give a solid understanding of the fundamental disciplines of aerospace engineering, as well as their interrelationships and applications. These disciplines are Materials and Structures (M); Computers and Programming (C); Fluid Mechanics (F); Thermodynamics (T); Propulsion (P); and Signals and Systems (S). In choosing to teach these subjects in a unified manner, the instructors seek to explain the common intellectual threads in these disciplines, as well as their combined application to solve engineering Systems Problems (SP). Throughout the year, the instructors emphasize the connections among the disciplines. Includes audio/video content: AV selected lectures, AV faculty introductions, AV special element video. The basic objective of Unified Engineering is to give a solid understanding of the fundamental disciplines of aerospace engineering, as well as their interrelationships and applications. These disciplines are Materials and Structures (M); Computers and Programming (C); Fluid Mechanics (F); Thermodynamics (T); Propulsion (P); and Signals and Systems (S). In choosing to teach these subjects in a unified manner, the instructors seek to explain the common intellectual threads in these disciplines, as well as their combined application to solve engineering Systems Problems (SP). Throughout the year, the instructors emphasize the connections among the disciplines.

Subjects

Unified | Unified | Unified Engineering | Unified Engineering | aerospace | aerospace | CDIO | CDIO | C-D-I-O | C-D-I-O | conceive | conceive | design | design | implement | implement | operate | operate | team | team | team-based | team-based | discipline | discipline | materials | materials | structures | structures | materials and structures | materials and structures | computers | computers | programming | programming | computers and programming | computers and programming | fluids | fluids | fluid mechanics | fluid mechanics | thermodynamics | thermodynamics | propulsion | propulsion | signals | signals | systems | systems | signals and systems | signals and systems | systems problems | systems problems | fundamentals | fundamentals | technical communication | technical communication | graphical communication | graphical communication | communication | communication | reading | reading | research | research | experimentation | experimentation | personal response system | personal response system | prs | prs | active learning | active learning | First law | First law | first law of thermodynamics | first law of thermodynamics | thermo-mechanical | thermo-mechanical | energy | energy | energy conversion | energy conversion | aerospace power systems | aerospace power systems | propulsion systems | propulsion systems | aerospace propulsion systems | aerospace propulsion systems | heat | heat | work | work | thermal efficiency | thermal efficiency | forms of energy | forms of energy | energy exchange | energy exchange | processes | processes | heat engines | heat engines | engines | engines | steady-flow energy equation | steady-flow energy equation | energy flow | energy flow | flows | flows | path-dependence | path-dependence | path-independence | path-independence | reversibility | reversibility | irreversibility | irreversibility | state | state | thermodynamic state | thermodynamic state | performance | performance | ideal cycle | ideal cycle | simple heat engine | simple heat engine | cycles | cycles | thermal pressures | thermal pressures | temperatures | temperatures | linear static networks | linear static networks | loop method | loop method | node method | node method | linear dynamic networks | linear dynamic networks | classical methods | classical methods | state methods | state methods | state concepts | state concepts | dynamic systems | dynamic systems | resistive circuits | resistive circuits | sources | sources | voltages | voltages | currents | currents | Thevinin | Thevinin | Norton | Norton | initial value problems | initial value problems | RLC networks | RLC networks | characteristic values | characteristic values | characteristic vectors | characteristic vectors | transfer function | transfer function | ada | ada | ada programming | ada programming | programming language | programming language | software systems | software systems | programming style | programming style | computer architecture | computer architecture | program language evolution | program language evolution | classification | classification | numerical computation | numerical computation | number representation systems | number representation systems | assembly | assembly | SimpleSIM | SimpleSIM | RISC | RISC | CISC | CISC | operating systems | operating systems | single user | single user | multitasking | multitasking | multiprocessing | multiprocessing | domain-specific classification | domain-specific classification | recursive | recursive | execution time | execution time | fluid dynamics | fluid dynamics | physical properties of a fluid | physical properties of a fluid | fluid flow | fluid flow | mach | mach | reynolds | reynolds | conservation | conservation | conservation principles | conservation principles | conservation of mass | conservation of mass | conservation of momentum | conservation of momentum | conservation of energy | conservation of energy | continuity | continuity | inviscid | inviscid | steady flow | steady flow | simple bodies | simple bodies | airfoils | airfoils | wings | wings | channels | channels | aerodynamics | aerodynamics | forces | forces | moments | moments | equilibrium | equilibrium | freebody diagram | freebody diagram | free-body | free-body | free body | free body | planar force systems | planar force systems | equipollent systems | equipollent systems | equipollence | equipollence | support reactions | support reactions | reactions | reactions | static determinance | static determinance | determinate systems | determinate systems | truss analysis | truss analysis | trusses | trusses | method of joints | method of joints | method of sections | method of sections | statically indeterminate | statically indeterminate | three great principles | three great principles | 3 great principles | 3 great principles | indicial notation | indicial notation | rotation of coordinates | rotation of coordinates | coordinate rotation | coordinate rotation | stress | stress | extensional stress | extensional stress | shear stress | shear stress | notation | notation | plane stress | plane stress | stress equilbrium | stress equilbrium | stress transformation | stress transformation | mohr | mohr | mohr's circle | mohr's circle | principal stress | principal stress | principal stresses | principal stresses | extreme shear stress | extreme shear stress | strain | strain | extensional strain | extensional strain | shear strain | shear strain | strain-displacement | strain-displacement | compatibility | compatibility | strain transformation | strain transformation | transformation of strain | transformation of strain | mohr's circle for strain | mohr's circle for strain | principal strain | principal strain | extreme shear strain | extreme shear strain | uniaxial stress-strain | uniaxial stress-strain | material properties | material properties | classes of materials | classes of materials | bulk material properties | bulk material properties | origin of elastic properties | origin of elastic properties | structures of materials | structures of materials | atomic bonding | atomic bonding | packing of atoms | packing of atoms | atomic packing | atomic packing | crystals | crystals | crystal structures | crystal structures | polymers | polymers | estimate of moduli | estimate of moduli | moduli | moduli | composites | composites | composite materials | composite materials | modulus limited design | modulus limited design | material selection | material selection | materials selection | materials selection | measurement of elastic properties | measurement of elastic properties | stress-strain | stress-strain | stress-strain relations | stress-strain relations | anisotropy | anisotropy | orthotropy | orthotropy | measurements | measurements | engineering notation | engineering notation | Hooke | Hooke | Hooke's law | Hooke's law | general hooke's law | general hooke's law | equations of elasticity | equations of elasticity | boundary conditions | boundary conditions | multi-disciplinary | multi-disciplinary | models | models | engineering systems | engineering systems | experiments | experiments | investigations | investigations | experimental error | experimental error | design evaluation | design evaluation | evaluation | evaluation | trade studies | trade studies | effects of engineering | effects of engineering | social context | social context | engineering drawings | engineering drawings

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24.120 Moral Psychology (MIT) 24.120 Moral Psychology (MIT)

Description

This course is an examination of philosophical theories of action and motivation in the light of empirical findings from social psychology, sociology, and neuroscience. Topics include belief, desire, and moral motivation; sympathy and empathy; intentions and other committing states; strength of will and weakness of will; free will; addiction and compulsion; guilt, shame and regret; evil; self-knowledge and self-deception; and, virtues and character traits. This course is a CI-M course. This course is an examination of philosophical theories of action and motivation in the light of empirical findings from social psychology, sociology, and neuroscience. Topics include belief, desire, and moral motivation; sympathy and empathy; intentions and other committing states; strength of will and weakness of will; free will; addiction and compulsion; guilt, shame and regret; evil; self-knowledge and self-deception; and, virtues and character traits. This course is a CI-M course.

Subjects

action | action | motivation | motivation | social psychology | social psychology | sociology | sociology | belief | belief | desire | desire | moral motivation | moral motivation | sympathy | sympathy | empathy | empathy | intention | intention | will | will | addiction | addiction | resolution | resolution | rationality | rationality | identification | identification | autonomy | autonomy | egoism | egoism | altruism | altruism | intentions | intentions | Humean theory of motivation | Humean theory of motivation | willing | willing | wanting | wanting | waiting | waiting | weakness | weakness | Akrasia | Akrasia | self-control | self-control | temptation | temptation | self-regulation | self-regulation | free will | free will | self-deception | self-deception | moral psychology | moral psychology | empirical work | empirical work | autism | autism | ethical judgment | ethical judgment | moral luck | moral luck | virtue | virtue

License

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24.120 Moral Psychology (MIT) 24.120 Moral Psychology (MIT)

Description

The course is an examination of philosophical theories of action and motivation in the light of empirical findings from social psychology, sociology and neuroscience. Topics include belief, desire, and moral motivation; sympathy and empathy; intentions and other committing states; strength of will and weakness of will; free will; addiction and compulsion; guilt, shame and regret; evil; self-knowledge and self-deception; virtues and character traits. The course is an examination of philosophical theories of action and motivation in the light of empirical findings from social psychology, sociology and neuroscience. Topics include belief, desire, and moral motivation; sympathy and empathy; intentions and other committing states; strength of will and weakness of will; free will; addiction and compulsion; guilt, shame and regret; evil; self-knowledge and self-deception; virtues and character traits.

Subjects

action | action | motivation | motivation | social psychology | social psychology | sociology | sociology | beleif | beleif | desire | desire | moral motivation | moral motivation | sympathy | sympathy | empathy | empathy | intention | intention | will | will | addiction | addiction | resolution | resolution | rationality | rationality | identification | identification | autonomy | autonomy

License

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9.01 Introduction to Neuroscience (MIT) 9.01 Introduction to Neuroscience (MIT)

Description

This course is an introduction to the mammalian nervous system, with emphasis on the structure and function of the human brain. Topics include the function of nerve cells, sensory systems, control of movement, learning and memory, and diseases of the brain. This course is an introduction to the mammalian nervous system, with emphasis on the structure and function of the human brain. Topics include the function of nerve cells, sensory systems, control of movement, learning and memory, and diseases of the brain.

Subjects

neuroscience | neuroscience | vision | vision | hearing | hearing | neuroanatomy | neuroanatomy | color vision | color vision | blind spot | blind spot | retinal phototransduction | retinal phototransduction | cortical maps | cortical maps | primary visual cortex | primary visual cortex | complex cells | complex cells | extrastriate cortex | extrastriate cortex | ear | ear | cochlea | cochlea | basilar membrane | basilar membrane | auditory transduction | auditory transduction | hair cells | hair cells | phase-locking | phase-locking | sound localization | sound localization | auditory cortex | auditory cortex | somatosensory system | somatosensory system | motor system | motor system | synaptic transmission | synaptic transmission | action potential | action potential | sympathetic neurons | sympathetic neurons | parasympathetic neurons | parasympathetic neurons | cellual neurophysiology | cellual neurophysiology | learning | learning | memory | memory

License

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IV (MIT) IV (MIT)

Description

The basic objective of Unified Engineering is to give a solid understanding of the fundamental disciplines of aerospace engineering, as well as their interrelationships and applications. These disciplines are Materials and Structures (M); Computers and Programming (C); Fluid Mechanics (F); Thermodynamics (T); Propulsion (P); and Signals and Systems (S). In choosing to teach these subjects in a unified manner, the instructors seek to explain the common intellectual threads in these disciplines, as well as their combined application to solve engineering Systems Problems (SP). Throughout the year, the instructors emphasize the connections among the disciplines.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files The basic objective of Unified Engineering is to give a solid understanding of the fundamental disciplines of aerospace engineering, as well as their interrelationships and applications. These disciplines are Materials and Structures (M); Computers and Programming (C); Fluid Mechanics (F); Thermodynamics (T); Propulsion (P); and Signals and Systems (S). In choosing to teach these subjects in a unified manner, the instructors seek to explain the common intellectual threads in these disciplines, as well as their combined application to solve engineering Systems Problems (SP). Throughout the year, the instructors emphasize the connections among the disciplines.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files

Subjects

Unified | Unified | Unified Engineering | Unified Engineering | aerospace | aerospace | CDIO | CDIO | C-D-I-O | C-D-I-O | conceive | conceive | design | design | implement | implement | operate | operate | team | team | team-based | team-based | discipline | discipline | materials | materials | structures | structures | materials and structures | materials and structures | computers | computers | programming | programming | computers and programming | computers and programming | fluids | fluids | fluid mechanics | fluid mechanics | thermodynamics | thermodynamics | propulsion | propulsion | signals | signals | systems | systems | signals and systems | signals and systems | systems problems | systems problems | fundamentals | fundamentals | technical communication | technical communication | graphical communication | graphical communication | communication | communication | reading | reading | research | research | experimentation | experimentation | personal response system | personal response system | prs | prs | active learning | active learning | First law | First law | first law of thermodynamics | first law of thermodynamics | thermo-mechanical | thermo-mechanical | energy | energy | energy conversion | energy conversion | aerospace power systems | aerospace power systems | propulsion systems | propulsion systems | aerospace propulsion systems | aerospace propulsion systems | heat | heat | work | work | thermal efficiency | thermal efficiency | forms of energy | forms of energy | energy exchange | energy exchange | processes | processes | heat engines | heat engines | engines | engines | steady-flow energy equation | steady-flow energy equation | energy flow | energy flow | flows | flows | path-dependence | path-dependence | path-independence | path-independence | reversibility | reversibility | irreversibility | irreversibility | state | state | thermodynamic state | thermodynamic state | performance | performance | ideal cycle | ideal cycle | simple heat engine | simple heat engine | cycles | cycles | thermal pressures | thermal pressures | temperatures | temperatures | linear static networks | linear static networks | loop method | loop method | node method | node method | linear dynamic networks | linear dynamic networks | classical methods | classical methods | state methods | state methods | state concepts | state concepts | dynamic systems | dynamic systems | resistive circuits | resistive circuits | sources | sources | voltages | voltages | currents | currents | Thevinin | Thevinin | Norton | Norton | initial value problems | initial value problems | RLC networks | RLC networks | characteristic values | characteristic values | characteristic vectors | characteristic vectors | transfer function | transfer function | ada | ada | ada programming | ada programming | programming language | programming language | software systems | software systems | programming style | programming style | computer architecture | computer architecture | program language evolution | program language evolution | classification | classification | numerical computation | numerical computation | number representation systems | number representation systems | assembly | assembly | SimpleSIM | SimpleSIM | RISC | RISC | CISC | CISC | operating systems | operating systems | single user | single user | multitasking | multitasking | multiprocessing | multiprocessing | domain-specific classification | domain-specific classification | recursive | recursive | execution time | execution time | fluid dynamics | fluid dynamics | physical properties of a fluid | physical properties of a fluid | fluid flow | fluid flow | mach | mach | reynolds | reynolds | conservation | conservation | conservation principles | conservation principles | conservation of mass | conservation of mass | conservation of momentum | conservation of momentum | conservation of energy | conservation of energy | continuity | continuity | inviscid | inviscid | steady flow | steady flow | simple bodies | simple bodies | airfoils | airfoils | wings | wings | channels | channels | aerodynamics | aerodynamics | forces | forces | moments | moments | equilibrium | equilibrium | freebody diagram | freebody diagram | free-body | free-body | free body | free body | planar force systems | planar force systems | equipollent systems | equipollent systems | equipollence | equipollence | support reactions | support reactions | reactions | reactions | static determinance | static determinance | determinate systems | determinate systems | truss analysis | truss analysis | trusses | trusses | method of joints | method of joints | method of sections | method of sections | statically indeterminate | statically indeterminate | three great principles | three great principles | 3 great principles | 3 great principles | indicial notation | indicial notation | rotation of coordinates | rotation of coordinates | coordinate rotation | coordinate rotation | stress | stress | extensional stress | extensional stress | shear stress | shear stress | notation | notation | plane stress | plane stress | stress equilbrium | stress equilbrium | stress transformation | stress transformation | mohr | mohr | mohr's circle | mohr's circle | principal stress | principal stress | principal stresses | principal stresses | extreme shear stress | extreme shear stress | strain | strain | extensional strain | extensional strain | shear strain | shear strain | strain-displacement | strain-displacement | compatibility | compatibility | strain transformation | strain transformation | transformation of strain | transformation of strain | mohr's circle for strain | mohr's circle for strain | principal strain | principal strain | extreme shear strain | extreme shear strain | uniaxial stress-strain | uniaxial stress-strain | material properties | material properties | classes of materials | classes of materials | bulk material properties | bulk material properties | origin of elastic properties | origin of elastic properties | structures of materials | structures of materials | atomic bonding | atomic bonding | packing of atoms | packing of atoms | atomic packing | atomic packing | crystals | crystals | crystal structures | crystal structures | polymers | polymers | estimate of moduli | estimate of moduli | moduli | moduli | composites | composites | composite materials | composite materials | modulus limited design | modulus limited design | material selection | material selection | materials selection | materials selection | measurement of elastic properties | measurement of elastic properties | stress-strain | stress-strain | stress-strain relations | stress-strain relations | anisotropy | anisotropy | orthotropy | orthotropy | measurements | measurements | engineering notation | engineering notation | Hooke | Hooke | Hooke's law | Hooke's law | general hooke's law | general hooke's law | equations of elasticity | equations of elasticity | boundary conditions | boundary conditions | multi-disciplinary | multi-disciplinary | models | models | engineering systems | engineering systems | experiments | experiments | investigations | investigations | experimental error | experimental error | design evaluation | design evaluation | evaluation | evaluation | trade studies | trade studies | effects of engineering | effects of engineering | social context | social context | engineering drawings | engineering drawings | 16.01 | 16.01 | 16.02 | 16.02 | 16.03 | 16.03 | 16.04 | 16.04

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18.997 Topics in Combinatorial Optimization (MIT)

Description

In this graduate-level course, we will be covering advanced topics in combinatorial optimization. We will start with non-bipartite matchings and cover many results extending the fundamental results of matchings, flows and matroids. The emphasis is on the derivation of purely combinatorial results, including min-max relations, and not so much on the corresponding algorithmic questions of how to find such objects. The intended audience consists of Ph.D. students interested in optimization, combinatorics, or combinatorial algorithms.

Subjects

combinatorial optimization | Ear decompositions | Nonbipartite matching | Gallai-Milgram and Bessy-Thomasse theorems on partitioning/covering graphs by directed paths/cycles | Minimization of submodular functions | Matroid intersection | Polymatroid intersection | Jump systems | Matroid union | Matroid matching | path matchings | Packing trees and arborescences | Packing directed cuts and the Lucchesi-Younger theorem | Submodular flows and the Edmonds-Giles theorem | Graph orientation | Connectivity tree and connectivity augmentation | Multicommodity flows | Connectivity tree | connectivity augmentation | Gallai-Milgram Theorem | Bessy-Thomasse Theorem | paritioning graphs | covering graphs | directed paths | directed cycles | matroid matching | path matching | packing directed cuts | Luchessi-Younger Theorem | packing trees | arborescences | submodular flows | Edmonds-Giles Theorem

License

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9.913-A Intensive Neuroanatomy (MIT) 9.913-A Intensive Neuroanatomy (MIT)

Description

The course will start with an overview of the central and peripheral nervous systems (CNS and PNS), the development of their structure and major divisions. The major functional components of the CNS will then be reviewed individually. Topography, functional distribution of nerve cell bodies, ascending and descending tracts in the spinal cord. Brainstem organization and functional components, including cranial nerve nuclei, ascending / descending pathways, amine-containing cells, structure and information flow in the cerebellar and vestibular systems. Distribution of the cranial nerves, resolution of their skeletal and branchial arch components. Functional divisions of the Diencephalon and Telencephalon. The course will then continue with how these various CNS pieces and parts work together The course will start with an overview of the central and peripheral nervous systems (CNS and PNS), the development of their structure and major divisions. The major functional components of the CNS will then be reviewed individually. Topography, functional distribution of nerve cell bodies, ascending and descending tracts in the spinal cord. Brainstem organization and functional components, including cranial nerve nuclei, ascending / descending pathways, amine-containing cells, structure and information flow in the cerebellar and vestibular systems. Distribution of the cranial nerves, resolution of their skeletal and branchial arch components. Functional divisions of the Diencephalon and Telencephalon. The course will then continue with how these various CNS pieces and parts work together

Subjects

peripheral nervous systems | peripheral nervous systems | CNS | CNS | PNS | PNS | structure | structure | nerve cell bodies | nerve cell bodies | ascending and descending tracts | ascending and descending tracts | spinal cord | spinal cord | brainstem | brainstem | cranial nerve nuclei | cranial nerve nuclei | ascending/descending pathways | ascending/descending pathways | amine-containing cells | amine-containing cells | cerebellar | cerebellar | vestibular systems | vestibular systems | cranial nerves | cranial nerves | skeletal and branchial arch | skeletal and branchial arch | diencephalon | diencephalon | Telencephalon | Telencephalon | Motor systems | Motor systems | motor neurons | motor neurons | motor units | motor units | medial | medial | lateral pathways | lateral pathways | sensory systems | sensory systems | visual | visual | auditory | auditory | somatosensory | somatosensory | olfaction | olfaction | limbic system | limbic system | autonomic control | autonomic control | Papez circuit | Papez circuit | neocortex | neocortex

License

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6.231 Dynamic Programming and Stochastic Control (MIT) 6.231 Dynamic Programming and Stochastic Control (MIT)

Description

This course covers the basic models and solution techniques for problems of sequential decision making under uncertainty (stochastic control). We will consider optimal control of a dynamical system over both a finite and an infinite number of stages (finite and infinite horizon). We will also discuss some approximation methods for problems involving large state spaces. Applications of dynamic programming in a variety of fields will be covered in recitations. This course covers the basic models and solution techniques for problems of sequential decision making under uncertainty (stochastic control). We will consider optimal control of a dynamical system over both a finite and an infinite number of stages (finite and infinite horizon). We will also discuss some approximation methods for problems involving large state spaces. Applications of dynamic programming in a variety of fields will be covered in recitations.

Subjects

dynamic programming | dynamic programming | stochastic control | stochastic control | decision making | decision making | uncertainty | uncertainty | sequential decision making | sequential decision making | finite horizon | finite horizon | infinite horizon | infinite horizon | approximation methods | approximation methods | state space | state space | large state space | large state space | optimal control | optimal control | dynamical system | dynamical system | dynamic programming and optimal control | dynamic programming and optimal control | deterministic systems | deterministic systems | shortest path | shortest path | state information | state information | rollout | rollout | stochastic shortest path | stochastic shortest path | approximate dynamic programming | approximate dynamic programming

License

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Special Veterinary Pathology (2014) Special Veterinary Pathology (2014)

Description

We study the morphological changes of the various organs that make up systems of domestic species and the proposed objectives, the student will recognize, explain and systematize the cadaverous alterations, development, circulatory, metabolic, inflammatory, parasitic and tumor of various organs and animal systems; will perform necropsies regulated in different domestic species and reports; and obtain and use bibliographic information on the subject. We study the morphological changes of the various organs that make up systems of domestic species and the proposed objectives, the student will recognize, explain and systematize the cadaverous alterations, development, circulatory, metabolic, inflammatory, parasitic and tumor of various organs and animal systems; will perform necropsies regulated in different domestic species and reports; and obtain and use bibliographic information on the subject.

Subjects

pig | pig | pathological anatomy | pathological anatomy | cattle | cattle | Veterinaria | Veterinaria | cat | cat | sheep | sheep | anatomic patology | anatomic patology | 駉s rumiantes | 駉s rumiantes | 韆 Patol骻ica | 韆 Patol骻ica | cabra | cabra | 韆 patol骻ica | 韆 patol骻ica | | | goat | goat | horse | horse | pathology small ruminant | pathology small ruminant | necropsia | necropsia | poultry | poultry | necropsy | necropsy | cow | cow | | | dog | dog | bird | bird

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11.332J Urban Design (MIT) 11.332J Urban Design (MIT)

Description

For many years, Cambridge, MA, as host to two major research universities, has been the scene of debates as to how best to meet the competing expectations of different stakeholders. Where there has been success, it has frequently been the result, at least in part, of inventive urban design proposals and the design and implementation of new institutional arrangements to accomplish those proposals. Where there has been failure it has often been explained by the inability - or unwillingness - of one stakeholder to accept and accommodate the expectations of another. The two most recent fall Urban Design Studios have examined these issues at a larger scale. In 2001 we looked at the possible patterns for growth and change in Cambridge, UK, as triggered by the plans of Cambridge University. And i For many years, Cambridge, MA, as host to two major research universities, has been the scene of debates as to how best to meet the competing expectations of different stakeholders. Where there has been success, it has frequently been the result, at least in part, of inventive urban design proposals and the design and implementation of new institutional arrangements to accomplish those proposals. Where there has been failure it has often been explained by the inability - or unwillingness - of one stakeholder to accept and accommodate the expectations of another. The two most recent fall Urban Design Studios have examined these issues at a larger scale. In 2001 we looked at the possible patterns for growth and change in Cambridge, UK, as triggered by the plans of Cambridge University. And i

Subjects

urban planning | urban planning | community | community | stakeholders | stakeholders | development | development | urban growth | urban growth | MIT | MIT | Cambridge | Cambridge | Cambridgeport | Cambridgeport | institutional mechanisms | institutional mechanisms | housing | housing | universities | universities | built form | built form | public space | public space | landscape | landscape | path and access systems | path and access systems | parking | parking | density | density | activity location and intensity | activity location and intensity | planning | planning | finance | finance | public/private partnerships | public/private partnerships | parcelization | parcelization | phasing | phasing | multi-disciplinary teams | multi-disciplinary teams | town and gown | town and gown | Massachusetts | Massachusetts | research universities | research universities | urban design | urban design | Fort Washington | Fort Washington | urban form | urban form | biotech research industry | biotech research industry | activity location | activity location | activity intensity | activity intensity | access systems | access systems | paths | paths | 11.332 | 11.332 | 4.163 | 4.163

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15.082J Network Optimization (MIT) 15.082J Network Optimization (MIT)

Description

15.082J/6.855J is an H-level graduate subject in the theory and practice of network flows and its extensions. Network flow problems form a subclass of linear programming problems with applications to transportation, logistics, manufacturing, computer science, project management, finance as well as a number of other domains. This subject will survey some of the applications of network flows and focus on key special cases of network flow problems including the following: the shortest path problem, the maximum flow problem, the minimum cost flow problem, and the multi-commodity flow problem. 15.082J/6.855J is an H-level graduate subject in the theory and practice of network flows and its extensions. Network flow problems form a subclass of linear programming problems with applications to transportation, logistics, manufacturing, computer science, project management, finance as well as a number of other domains. This subject will survey some of the applications of network flows and focus on key special cases of network flow problems including the following: the shortest path problem, the maximum flow problem, the minimum cost flow problem, and the multi-commodity flow problem.

Subjects

network flows | network flows | extensions | extensions | network flow problems | network flow problems | transportation | transportation | logistics | logistics | manufacturing | manufacturing | computer science | computer science | project management | project management | finance | finance | the shortest path problem | the shortest path problem | the maximum flow problem | the maximum flow problem | the minimum cost flow problem | the minimum cost flow problem | the multi-commodity flow problem | the multi-commodity flow problem | communication | communication | systems | systems | applications | applications | efficiency | efficiency | algorithms | algorithms | traffic | traffic | equilibrium | equilibrium | design | design | mplementation | mplementation | linear programming | linear programming | implementation | implementation | computer | computer | science | science | linear | linear | programming | programming | network | network | flow | flow | problems | problems | project | project | management | management | maximum | maximum | minimum | minimum | cost | cost | multi-commodity | multi-commodity | shortest | shortest | path | path | 15.082 | 15.082 | 6.855 | 6.855

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9.01 Introduction to Neuroscience (MIT) 9.01 Introduction to Neuroscience (MIT)

Description

This course begins with the study of nerve cells which includes their structure, the propagation of nerve impulses and transfer of information between nerve cells, the effect of drugs on this process, and the development of nerve cells into the brain and spinal cord. Next, sensory systems such as hearing, vision and touch are covered as well as a discussion on how physical energy such as light is converted into neural signals, where these signals travel in the brain and how they are processed. Other topics include the control of voluntary movement, the neurochemical bases of brain diseases, and those systems which control sleep and consciousness, learning and memory. This course begins with the study of nerve cells which includes their structure, the propagation of nerve impulses and transfer of information between nerve cells, the effect of drugs on this process, and the development of nerve cells into the brain and spinal cord. Next, sensory systems such as hearing, vision and touch are covered as well as a discussion on how physical energy such as light is converted into neural signals, where these signals travel in the brain and how they are processed. Other topics include the control of voluntary movement, the neurochemical bases of brain diseases, and those systems which control sleep and consciousness, learning and memory.

Subjects

neuroscience | neuroscience | vision | vision | hearing | hearing | neuroanatomy | neuroanatomy | color vision | color vision | blind spot | blind spot | retinal phototransduction | retinal phototransduction | center-surround receptive fields | center-surround receptive fields | corticalmaps | corticalmaps | primary visual cortex | primary visual cortex | simple cells | simple cells | complex cells | complex cells | extrastriate cortex | extrastriate cortex | ear | ear | cochlea | cochlea | basilar membrane | basilar membrane | auditory transduction | auditory transduction | hair cells | hair cells | phase-locking | phase-locking | tonotopy | tonotopy | sound localization | sound localization | auditory cortex | auditory cortex | somatosensory system | somatosensory system | motor system | motor system | synaptic transmission | synaptic transmission | action potential | action potential | sympathetic neurons | sympathetic neurons | parasympathetic neurons | parasympathetic neurons | cellual neurophysiology | cellual neurophysiology | learning | learning | memory | memory

License

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Immunology basics Immunology basics

Description

This is a module framework. It can be viewed online or downloaded as a zip file. As taught Autumn semester 2009 Infections are a major cause of morbidity and mortality worldwide. The body fights infection through the functions of the immune system, whose power has been harnessed by the development of vaccination (immunisation). Suitable for study at: Undergraduate levels 1 and 2. Dr Ian Todd, School of Molecular Medical Sciences Dr Ian Todd is Associate Professor & Reader in Cellular Immunopathology at The University of Nottingham. After reading Biochemistry at The University of Oxford, he carried out research for his PhD in Immunology at University College London. He then undertook post-doctoral research at The Oregon Health Sciences University and The Middlesex Hospital Medica This is a module framework. It can be viewed online or downloaded as a zip file. As taught Autumn semester 2009 Infections are a major cause of morbidity and mortality worldwide. The body fights infection through the functions of the immune system, whose power has been harnessed by the development of vaccination (immunisation). Suitable for study at: Undergraduate levels 1 and 2. Dr Ian Todd, School of Molecular Medical Sciences Dr Ian Todd is Associate Professor & Reader in Cellular Immunopathology at The University of Nottingham. After reading Biochemistry at The University of Oxford, he carried out research for his PhD in Immunology at University College London. He then undertook post-doctoral research at The Oregon Health Sciences University and The Middlesex Hospital Medica

Subjects

UNow | UNow | UKOER | UKOER | Immunology | Immunology | Introduction to immunology | Introduction to immunology | Recognition of extracellular pathogens | Recognition of extracellular pathogens | Defence against extracellular pathogens | Defence against extracellular pathogens | T cell-mediated immunity | T cell-mediated immunity | Helper T cells and cytokines | Helper T cells and cytokines | Immunity to viruses | Immunity to viruses

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Except for third party materials (materials owned by someone other than The University of Nottingham) and where otherwise indicated, the copyright in the content provided in this resource is owned by The University of Nottingham and licensed under a Creative Commons Attribution-NonCommercial-ShareAlike UK 2.0 Licence (BY-NC-SA) Except for third party materials (materials owned by someone other than The University of Nottingham) and where otherwise indicated, the copyright in the content provided in this resource is owned by The University of Nottingham and licensed under a Creative Commons Attribution-NonCommercial-ShareAlike UK 2.0 Licence (BY-NC-SA)

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