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7.347 Epigenetic Regulation of Stem Cells (MIT) 7.347 Epigenetic Regulation of Stem Cells (MIT)

Description

During development a single totipotent cell gives rise to the vast array of cell types present in the adult human body, yet each cell has essentially the same DNA sequence. As cells differentiate, distinct sets of genes must be coordinately activated and repressed, ultimately leading to a cell-type specific pattern of gene expression and a particular cell fate. In eukaryotic organisms, DNA is packaged in a complex protein super structure known as chromatin. Modification and reorganization of chromatin play a critical role in coordinating the cell-type specific gene expression programs that are required as a cell transitions from a pluripotent stem cell to a fully differentiated cell type. Epigenetics refers to such heritable changes that occur in chromatin without altering the primary DNA During development a single totipotent cell gives rise to the vast array of cell types present in the adult human body, yet each cell has essentially the same DNA sequence. As cells differentiate, distinct sets of genes must be coordinately activated and repressed, ultimately leading to a cell-type specific pattern of gene expression and a particular cell fate. In eukaryotic organisms, DNA is packaged in a complex protein super structure known as chromatin. Modification and reorganization of chromatin play a critical role in coordinating the cell-type specific gene expression programs that are required as a cell transitions from a pluripotent stem cell to a fully differentiated cell type. Epigenetics refers to such heritable changes that occur in chromatin without altering the primary DNA

Subjects

Stem cells | Stem cells | induced pluripotency | induced pluripotency | Epigenetics | Epigenetics | chromatin | chromatin | histone | histone | epigenome | epigenome | genome-wide analyses | genome-wide analyses | high-throughput sequencing technologies | high-throughput sequencing technologies | Chromatin Immunoprecipitation sequencing | Chromatin Immunoprecipitation sequencing | ncRNAs | ncRNAs | epigenetic regulation | epigenetic regulation | DNA methylation | DNA methylation | post-translational modification of histones | post-translational modification of histones | roles of chromatin-assembly modifying complexes | roles of chromatin-assembly modifying complexes | non-coding RNAs | non-coding RNAs | nuclear organization | nuclear organization | developmental fate | developmental fate | stem cell therapy | stem cell therapy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.344 The Fountain of Life: From Dolly to Customized Embryonic Stem Cells (MIT) 7.344 The Fountain of Life: From Dolly to Customized Embryonic Stem Cells (MIT)

Description

During development, the genetic content of each cell remains, with a few exceptions, identical to that of the zygote. Most differentiated cells therefore retain all of the genetic information necessary to generate an entire organism. It was through pioneering technology of somatic cell nuclear transfer (SCNT) that this concept was experimentally proven. Only 10 years ago the sheep Dolly was the first mammal to be cloned from an adult organism, demonstrating that the differentiated state of a mammalian cell can be fully reversible to a pluripotent embryonic state. A key conclusion from these experiments was that the difference between pluripotent cells such as embryonic stem (ES) cells and unipotent differentiated cells is solely a consequence of reversible changes. These changes, which hav During development, the genetic content of each cell remains, with a few exceptions, identical to that of the zygote. Most differentiated cells therefore retain all of the genetic information necessary to generate an entire organism. It was through pioneering technology of somatic cell nuclear transfer (SCNT) that this concept was experimentally proven. Only 10 years ago the sheep Dolly was the first mammal to be cloned from an adult organism, demonstrating that the differentiated state of a mammalian cell can be fully reversible to a pluripotent embryonic state. A key conclusion from these experiments was that the difference between pluripotent cells such as embryonic stem (ES) cells and unipotent differentiated cells is solely a consequence of reversible changes. These changes, which hav

Subjects

embryonic stem cells | embryonic stem cells | stem cells | stem cells | cells | cells | genetics | genetics | genome | genome | Dolly | Dolly | clone | clone | regenerative therapy | regenerative therapy | somatic | somatic | SCNT | SCNT | pluripotent | pluripotent | scientific literature | scientific literature | nuclear | nuclear | embryonic | embryonic | adult | adult | epigenetics | epigenetics | methylation | methylation | DNA | DNA | histone | histone | biomedical | biomedical | differentiation | differentiation | epigenome | epigenome | nuclear transfer | nuclear transfer | customized | customized | zygote | zygote | RNA | RNA | cancer | cancer | medicine | medicine

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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18.304 Undergraduate Seminar in Discrete Mathematics (MIT) 18.304 Undergraduate Seminar in Discrete Mathematics (MIT)

Description

This course is a student-presented seminar in combinatorics, graph theory, and discrete mathematics in general. Instruction and practice in written and oral communication is emphasized, with participants reading and presenting papers from recent mathematics literature and writing a final paper in a related topic. This course is a student-presented seminar in combinatorics, graph theory, and discrete mathematics in general. Instruction and practice in written and oral communication is emphasized, with participants reading and presenting papers from recent mathematics literature and writing a final paper in a related topic.

Subjects

discrete math; discrete mathematics; discrete; math; mathematics; seminar; presentations; student presentations; oral; communication; stable marriage; dych; emergency; response vehicles; ambulance; game theory; congruences; color theorem; four color; cake cutting; algorithm; RSA; encryption; numberical integration; sorting; post correspondence problem; PCP; ramsey; van der waals; fibonacci; recursion; domino; tiling; towers; hanoi; pigeonhole; principle; matrix; hamming; code; hat game; juggling; zero-knowledge; proof; repeated games; lewis carroll; determinants; infinitude of primes; bridges; konigsberg; koenigsberg; time series analysis; GARCH; rational; recurrence; relations; digital; image; compression; quantum computing | discrete math; discrete mathematics; discrete; math; mathematics; seminar; presentations; student presentations; oral; communication; stable marriage; dych; emergency; response vehicles; ambulance; game theory; congruences; color theorem; four color; cake cutting; algorithm; RSA; encryption; numberical integration; sorting; post correspondence problem; PCP; ramsey; van der waals; fibonacci; recursion; domino; tiling; towers; hanoi; pigeonhole; principle; matrix; hamming; code; hat game; juggling; zero-knowledge; proof; repeated games; lewis carroll; determinants; infinitude of primes; bridges; konigsberg; koenigsberg; time series analysis; GARCH; rational; recurrence; relations; digital; image; compression; quantum computing | discrete math | discrete math | discrete mathematics | discrete mathematics | discrete | discrete | math | math | mathematics | mathematics | seminar | seminar | presentations | presentations | student presentations | student presentations | oral | oral | communication | communication | stable marriage | stable marriage | dych | dych | emergency | emergency | response vehicles | response vehicles | ambulance | ambulance | game theory | game theory | congruences | congruences | color theorem | color theorem | four color | four color | cake cutting | cake cutting | algorithm | algorithm | RSA | RSA | encryption | encryption | numberical integration | numberical integration | sorting | sorting | post correspondence problem | post correspondence problem | PCP | PCP | ramsey | ramsey | van der waals | van der waals | fibonacci | fibonacci | recursion | recursion | domino | domino | tiling | tiling | towers | towers | hanoi | hanoi | pigeonhole | pigeonhole | principle | principle | matrix | matrix | hamming | hamming | code | code | hat game | hat game | juggling | juggling | zero-knowledge | zero-knowledge | proof | proof | repeated games | repeated games | lewis carroll | lewis carroll | determinants | determinants | infinitude of primes | infinitude of primes | bridges | bridges | konigsberg | konigsberg | koenigsberg | koenigsberg | time series analysis | time series analysis | GARCH | GARCH | rational | rational | recurrence | recurrence | relations | relations | digital | digital | image | image | compression | compression | quantum computing | quantum computing

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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C0001P0048

Description

Normal pig at water drinker

Subjects

svmsvet | pigs | pig | piglet | sow | sows | piglets | waterdrinker

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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C0001P0037

Description

Normal pigs

Subjects

svmsvet | pigs | pig | sow | piglet | piglets | sows

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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C0001P0048

Description

Normal pig at water drinker

Subjects

svmsvet | pigs | pig | piglet | sow | sows | piglets | waterdrinker

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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C0001P0037

Description

Normal pigs

Subjects

svmsvet | pigs | pig | sow | piglet | piglets | sows

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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18.304 Undergraduate Seminar in Discrete Mathematics (MIT) 18.304 Undergraduate Seminar in Discrete Mathematics (MIT)

Description

This course is a student-presented seminar in combinatorics, graph theory, and discrete mathematics in general. Instruction and practice in written and oral communication is emphasized, with participants reading and presenting papers from recent mathematics literature and writing a final paper in a related topic. This course is a student-presented seminar in combinatorics, graph theory, and discrete mathematics in general. Instruction and practice in written and oral communication is emphasized, with participants reading and presenting papers from recent mathematics literature and writing a final paper in a related topic.

Subjects

discrete math; discrete mathematics; discrete; math; mathematics; seminar; presentations; student presentations; oral; communication; stable marriage; dych; emergency; response vehicles; ambulance; game theory; congruences; color theorem; four color; cake cutting; algorithm; RSA; encryption; numberical integration; sorting; post correspondence problem; PCP; ramsey; van der waals; fibonacci; recursion; domino; tiling; towers; hanoi; pigeonhole; principle; matrix; hamming; code; hat game; juggling; zero-knowledge; proof; repeated games; lewis carroll; determinants; infinitude of primes; bridges; konigsberg; koenigsberg; time series analysis; GARCH; rational; recurrence; relations; digital; image; compression; quantum computing | discrete math; discrete mathematics; discrete; math; mathematics; seminar; presentations; student presentations; oral; communication; stable marriage; dych; emergency; response vehicles; ambulance; game theory; congruences; color theorem; four color; cake cutting; algorithm; RSA; encryption; numberical integration; sorting; post correspondence problem; PCP; ramsey; van der waals; fibonacci; recursion; domino; tiling; towers; hanoi; pigeonhole; principle; matrix; hamming; code; hat game; juggling; zero-knowledge; proof; repeated games; lewis carroll; determinants; infinitude of primes; bridges; konigsberg; koenigsberg; time series analysis; GARCH; rational; recurrence; relations; digital; image; compression; quantum computing | discrete math | discrete math | discrete mathematics | discrete mathematics | discrete | discrete | math | math | mathematics | mathematics | seminar | seminar | presentations | presentations | student presentations | student presentations | oral | oral | communication | communication | stable marriage | stable marriage | dych | dych | emergency | emergency | response vehicles | response vehicles | ambulance | ambulance | game theory | game theory | congruences | congruences | color theorem | color theorem | four color | four color | cake cutting | cake cutting | algorithm | algorithm | RSA | RSA | encryption | encryption | numberical integration | numberical integration | sorting | sorting | post correspondence problem | post correspondence problem | PCP | PCP | ramsey | ramsey | van der waals | van der waals | fibonacci | fibonacci | recursion | recursion | domino | domino | tiling | tiling | towers | towers | hanoi | hanoi | pigeonhole | pigeonhole | principle | principle | matrix | matrix | hamming | hamming | code | code | hat game | hat game | juggling | juggling | zero-knowledge | zero-knowledge | proof | proof | repeated games | repeated games | lewis carroll | lewis carroll | determinants | determinants | infinitude of primes | infinitude of primes | bridges | bridges | konigsberg | konigsberg | koenigsberg | koenigsberg | time series analysis | time series analysis | GARCH | GARCH | rational | rational | recurrence | recurrence | relations | relations | digital | digital | image | image | compression | compression | quantum computing | quantum computing

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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C0001P0003

Description

Normal abyssinian guinea pigs

Subjects

svmsvet | rodent | rodents | guineapig | guineapigs | abyssinian | abyssinianguineapigs | cavies | c0001

License

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C0001P0002

Description

Normal abyssinian guinea pigs

Subjects

svmsvet | rodent | rodents | guineapig | guineapigs | abyssinian | abyssinianguineapigs | cavies | c0001

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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C0001P0019

Description

Normal abyssinian guinea pigs

Subjects

svmsvet | rodent | rodents | guineapig | guineapigs | abyssinian | abyssinianguineapig | cavies | c0001

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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C0001P0003

Description

Normal abyssinian guinea pigs

Subjects

svmsvet | rodent | rodents | guineapig | guineapigs | abyssinian | abyssinianguineapigs | cavies | c0001

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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C0001P0002

Description

Normal abyssinian guinea pigs

Subjects

svmsvet | rodent | rodents | guineapig | guineapigs | abyssinian | abyssinianguineapigs | cavies | c0001

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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C0001P0019

Description

Normal abyssinian guinea pigs

Subjects

svmsvet | rodent | rodents | guineapig | guineapigs | abyssinian | abyssinianguineapig | cavies | c0001

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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1A1182101_283348III029

Description

Les pigeons voyageurs se sont révélés insensibles aux plus violents bombardements et pendant les grandes attaques, ils sont les meilleurs agents de liaisons, ils partagent la vie de tranchée des soldats ; l'officier de liaison d'un régiment fixe la dépêche au messager qui en quelques minutes sera rendu au P.C. de la division.

Subjects

thegreatwar | greatwar | worldwarone | worldwari | wwi | firstworldwar | grandeguerre | 1gm | premièreguerremondiale | pigeon | pigeonvoyageur | homingpigeon

License

No known copyright restrictions

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7.347 Epigenetic Regulation of Stem Cells (MIT)

Description

During development a single totipotent cell gives rise to the vast array of cell types present in the adult human body, yet each cell has essentially the same DNA sequence. As cells differentiate, distinct sets of genes must be coordinately activated and repressed, ultimately leading to a cell-type specific pattern of gene expression and a particular cell fate. In eukaryotic organisms, DNA is packaged in a complex protein super structure known as chromatin. Modification and reorganization of chromatin play a critical role in coordinating the cell-type specific gene expression programs that are required as a cell transitions from a pluripotent stem cell to a fully differentiated cell type. Epigenetics refers to such heritable changes that occur in chromatin without altering the primary DNA

Subjects

Stem cells | induced pluripotency | Epigenetics | chromatin | histone | epigenome | genome-wide analyses | high-throughput sequencing technologies | Chromatin Immunoprecipitation sequencing | ncRNAs | epigenetic regulation | DNA methylation | post-translational modification of histones | roles of chromatin-assembly modifying complexes | non-coding RNAs | nuclear organization | developmental fate | stem cell therapy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.349 Stem Cells: A Cure or Disease? (MIT) 7.349 Stem Cells: A Cure or Disease? (MIT)

Description

Have you ever considered going to a pharmacy to order some new cardiomyocytes (heart muscle cells) for your ailing heart? It might sound crazy, but recent developments in stem cell science have made this concept not so futuristic. In this course, we will explore the underlying biology behind the idea of using stem cells to treat disease, specifically analyzing the mechanisms that enable a single genome to encode multiple cell states ranging from neurons to fibroblasts to T cells. Overall, we hope to provide a comprehensive overview of this exciting new field of research and its clinical relevance. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literat Have you ever considered going to a pharmacy to order some new cardiomyocytes (heart muscle cells) for your ailing heart? It might sound crazy, but recent developments in stem cell science have made this concept not so futuristic. In this course, we will explore the underlying biology behind the idea of using stem cells to treat disease, specifically analyzing the mechanisms that enable a single genome to encode multiple cell states ranging from neurons to fibroblasts to T cells. Overall, we hope to provide a comprehensive overview of this exciting new field of research and its clinical relevance. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literat

Subjects

stem cells | stem cells | stem cell therapy | stem cell therapy | cellular reprogramming | cellular reprogramming | transdifferentiation | transdifferentiation | pluripotency | pluripotency | epigenetics | epigenetics | genome-wide sequencing | genome-wide sequencing | transcription-mediated reprogramming | transcription-mediated reprogramming | embryonic stem cell technology | embryonic stem cell technology | transcription factors | transcription factors | chromatin structure | chromatin structure | H3K4me3 | H3K4me3 | H3K27me3 | H3K27me3 | histone deacetylase 1 | histone deacetylase 1 | RNAi screens | RNAi screens | Oct4 | Oct4 | cloning | cloning | Dolly | Dolly | in vitro differentiation | in vitro differentiation | regenerative medicine | regenerative medicine

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.342 G-Protein Coupled Receptors: Vision and Disease (MIT) 7.342 G-Protein Coupled Receptors: Vision and Disease (MIT)

Description

How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR

Subjects

allergies | allergies | hypertension | hypertension | depression | depression | obesity | obesity | central nervous system disorders | central nervous system disorders | G-protein coupled receptors | G-protein coupled receptors | GPCR | GPCR | cell-surface receptors | cell-surface receptors | George Wald | George Wald | vision | vision | chromophore | chromophore | transducin | transducin | metarhodopsin II | metarhodopsin II | homodimers | homodimers | heterodimers | heterodimers | retinitis pigmentosa | retinitis pigmentosa | night blindness | night blindness | Dopamine | Dopamine | antihistamines | antihistamines | Claviceps purpurea | Claviceps purpurea | Human chemokine receptor 5 | Human chemokine receptor 5 | CCR5 | CCR5 | HIV-1 | HIV-1 | CCR5-delta32 | CCR5-delta32 | Olfactory receptors | Olfactory receptors | Taste receptors | Taste receptors

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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11.957 Frameworks of Urban Governance (MIT) 11.957 Frameworks of Urban Governance (MIT)

Description

Urban governance comprises the various forces, institutions, and movements that guide economic and physical development, the distribution of resources, social interactions, and other aspects of daily life in urban areas. This course examines governance from legal, political, social, and economic perspectives. In addition, we will discuss how these structures constrain collective decision making about particular urban issues (immigration, education…). Assignments will be nightly readings and a short paper relating an urban issue to the frameworks outlined in the class. Urban governance comprises the various forces, institutions, and movements that guide economic and physical development, the distribution of resources, social interactions, and other aspects of daily life in urban areas. This course examines governance from legal, political, social, and economic perspectives. In addition, we will discuss how these structures constrain collective decision making about particular urban issues (immigration, education…). Assignments will be nightly readings and a short paper relating an urban issue to the frameworks outlined in the class.

Subjects

physical development | physical development | urban sector | urban sector | urban politics | urban politics | immigration | immigration | education | education | economics | economics | environment | environment | public finance | public finance | environmental economics | environmental economics | research | research | causation | causation | pigovian taxes | pigovian taxes | coasian | coasian | bost-benefit analysis | bost-benefit analysis | public economics | public economics | hedonic method | hedonic method | valuation | valuation | housing | housing | health effects | health effects | dose-response | dose-response | avoidance | avoidance | household production function | household production function | locational equilibrium | locational equilibrium | policy | policy | regulations | regulations | double dividend | double dividend | climate change | climate change | development | development | markets | markets | labor | labor | workplace | workplace | safety | safety | advertising | advertising | traffic | traffic

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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14.475 Environmental Economics and Government Responses to Market Failure (MIT) 14.475 Environmental Economics and Government Responses to Market Failure (MIT)

Description

This course explores the theory behind and evidence on regulatory, tax, and other government responses to problems of market failure. Special emphasis is given to developing and implementing tools to evaluate environmental policies. Other topics include cost-benefit analysis, measurement of the benefits of non-market goods and costs of regulations, and the evaluation of the impact of regulations in areas such as financial markets, workplace health and safety, consumer product safety, and other contexts. This course explores the theory behind and evidence on regulatory, tax, and other government responses to problems of market failure. Special emphasis is given to developing and implementing tools to evaluate environmental policies. Other topics include cost-benefit analysis, measurement of the benefits of non-market goods and costs of regulations, and the evaluation of the impact of regulations in areas such as financial markets, workplace health and safety, consumer product safety, and other contexts.

Subjects

economics | economics | environment | environment | public finance | public finance | environmental economics | environmental economics | research | research | causation | causation | pigovian taxes | pigovian taxes | coasian | coasian | bost-benefit analysis | bost-benefit analysis | public economics | public economics | hedonic method | hedonic method | valuation | valuation | housing | housing | health effects | health effects | dose-response | dose-response | avoidance | avoidance | household production function | household production function | locational equilibrium | locational equilibrium | policy | policy | regulations | regulations | double dividend | double dividend | climate change | climate change | development | development | markets | markets | labor | labor | workplace | workplace | safety | safety | advertising | advertising | traffic | traffic

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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HST.161 Molecular Biology and Genetics in Modern Medicine (MIT) HST.161 Molecular Biology and Genetics in Modern Medicine (MIT)

Description

This course provides a foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. It develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics are reviewed. We translate clinical understanding into analysis at the level of the gene, chromosome and molecule; we cover the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. Material in the course extends beyond basic principles to current research activity in human genetics. This course provides a foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. It develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics are reviewed. We translate clinical understanding into analysis at the level of the gene, chromosome and molecule; we cover the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. Material in the course extends beyond basic principles to current research activity in human genetics.

Subjects

Genetics | Genetics | genes | genes | genetic disorders | genetic disorders | inborn error | inborn error | muscular dystrophy | muscular dystrophy | PKU | PKU | phenylketoneuria | phenylketoneuria | cancer | cancer | tumors | tumors | gene therapy | gene therapy | disease | disease | birth defects | birth defects | chromosomes | chromosomes | leukemia | leukemia | RNAi | RNAi | hemophilia | hemophilia | thalassemia | thalassemia | deafness | deafness | mutations | mutations | hypertrophic cardiomyopathy | hypertrophic cardiomyopathy | epigenetics | epigenetics | rett syndrome | rett syndrome | prenatal diagnosis | prenatal diagnosis | LOD scores | LOD scores | gene linkage | gene linkage | mitochondrial disorders | mitochondrial disorders | degenerative disorders | degenerative disorders | complex traits | complex traits | Mendelian inheritance | Mendelian inheritance

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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RJN0000PP0013

Description

Pyelonephritis in pig.

Subjects

kidney | pigs | pigkidney | pyelonephritis | abattoir | slaughterhouse | svmsvet | vph

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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RJN0000BR0002

Description

Subjects

pigs | breeds | pigbreeds | uk

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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Nottingham Vet School | FlickR

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RJN0000BR0001

Description

Subjects

pigs | breeds | pigbreeds | uk

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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Nottingham Vet School | FlickR

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RJN0000PP0001

Description

Pig lairage at abattoir.

Subjects

piglairage | pig | lairage | abattoir | svmsvet | vph

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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Nottingham Vet School | FlickR

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