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7.343 Biological Bases of Learning and Memory (MIT) 7.343 Biological Bases of Learning and Memory (MIT)

Description

How does the brain come to learn whether a stimulus is annoying, rewarding or neutral? How does remembering how to ride a bicycle differ from remembering scenes from a movie? In this course, students will explore the concept that learning and memory have a physical basis that can be observed as biochemical, physiological and/or morphological changes to neural tissue. Our goal will be to understand the strategies and techniques biologists use to search for the memory trace: the "holy grail" of modern neuroscience. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interact How does the brain come to learn whether a stimulus is annoying, rewarding or neutral? How does remembering how to ride a bicycle differ from remembering scenes from a movie? In this course, students will explore the concept that learning and memory have a physical basis that can be observed as biochemical, physiological and/or morphological changes to neural tissue. Our goal will be to understand the strategies and techniques biologists use to search for the memory trace: the "holy grail" of modern neuroscience. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interact

Subjects

learning | learning | memory | memory | neural tissue | neural tissue | neuronal connections | neuronal connections | synapse formation | synapse formation | synapse stabilization | synapse stabilization | synaptic transmission | synaptic transmission | synaptic plasticity | synaptic plasticity | neuromodulation | neuromodulation | experience-dependent circuit remodeling | experience-dependent circuit remodeling | neuroscience | neuroscience | pre- and post-synaptic mechanisms | pre- and post-synaptic mechanisms | neurotransmitter release | neurotransmitter release | activity-regulated genes | activity-regulated genes | hippocampus | hippocampus | long-term potentiation | long-term potentiation | long-term depression | long-term depression | cerebellar plasticity | cerebellar plasticity | Non-Associative | Non-Associative | Associative | Associative | cpg15 | cpg15 | experience-dependent synaptic plasticity | experience-dependent synaptic plasticity | perceptual learning | perceptual learning | observational learning | observational learning

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7.346 Synaptic Plasticity and Memory, from Molecules to Behavior (MIT) 7.346 Synaptic Plasticity and Memory, from Molecules to Behavior (MIT)

Description

In this course we will discover how innovative technologies combined with profound hypotheses have given rise to our current understanding of neuroscience. We will study both new and classical primary research papers with a focus on the plasticity between synapses in a brain structure called the hippocampus, which is believed to underlie the ability to create and retrieve certain classes of memories. We will discuss the basic electrical properties of neurons and how they fire. We will see how firing properties can change with experience, and we will study the biochemical basis of these changes. We will learn how molecular biology can be used to specifically change the biochemical properties of brain circuits, and we will see how these circuits form a representation of space giving rise to In this course we will discover how innovative technologies combined with profound hypotheses have given rise to our current understanding of neuroscience. We will study both new and classical primary research papers with a focus on the plasticity between synapses in a brain structure called the hippocampus, which is believed to underlie the ability to create and retrieve certain classes of memories. We will discuss the basic electrical properties of neurons and how they fire. We will see how firing properties can change with experience, and we will study the biochemical basis of these changes. We will learn how molecular biology can be used to specifically change the biochemical properties of brain circuits, and we will see how these circuits form a representation of space giving rise to

Subjects

synapse | synapse | memory | memory | neuroscience | neuroscience | plasticity | plasticity | hippocampus | hippocampus | LTP | LTP | molecular mechanism | molecular mechanism | Morris water maze | Morris water maze | place cells | place cells | NMDA | NMDA | synaptic tagging | synaptic tagging | long term depression | long term depression | cortex | cortex | synaptic plasticity | synaptic plasticity | neuronal circuits | neuronal circuits | specificity | specificity | CA1 | CA1 | grid cells | grid cells | schema | schema | fear memory | fear memory | biochemistry | biochemistry

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3.032 Mechanical Behavior of Materials (MIT) 3.032 Mechanical Behavior of Materials (MIT)

Description

Here we will learn about the mechanical behavior of structures and materials, from the continuum description of properties to the atomistic and molecular mechanisms that confer those properties to all materials. We will cover elastic and plastic deformation, creep, and fracture of materials including crystalline and amorphous metals, ceramics, and (bio)polymers, and will focus on the design and processing of materials from the atomic to the macroscale to achieve desired mechanical behavior. Integrated laboratories provide the opportunity to explore these concepts through hands-on experiments including instrumentation of pressure vessels, visualization of atomistic deformation in bubble rafts, nanoindentation, and uniaxial mechanical testing, as well as writing assignments to communicate th Here we will learn about the mechanical behavior of structures and materials, from the continuum description of properties to the atomistic and molecular mechanisms that confer those properties to all materials. We will cover elastic and plastic deformation, creep, and fracture of materials including crystalline and amorphous metals, ceramics, and (bio)polymers, and will focus on the design and processing of materials from the atomic to the macroscale to achieve desired mechanical behavior. Integrated laboratories provide the opportunity to explore these concepts through hands-on experiments including instrumentation of pressure vessels, visualization of atomistic deformation in bubble rafts, nanoindentation, and uniaxial mechanical testing, as well as writing assignments to communicate th

Subjects

Basic concepts of solid mechanics and mechanical behavior of materials | Basic concepts of solid mechanics and mechanical behavior of materials | stress-strain relationships | stress-strain relationships | stress transformation | stress transformation | elasticity | elasticity | plasticity and fracture. Case studies include materials selection for bicycle frames | plasticity and fracture. Case studies include materials selection for bicycle frames | stress shielding in biomedical implants; residual stresses in thin films; and ancient materials. Lab experiments and demonstrations give hands-on experience of the physical concepts at a variety of length scales. Use of facilities for measuring mechanical properties including standard mechanical tests | stress shielding in biomedical implants; residual stresses in thin films; and ancient materials. Lab experiments and demonstrations give hands-on experience of the physical concepts at a variety of length scales. Use of facilities for measuring mechanical properties including standard mechanical tests | bubble raft models | bubble raft models | atomic force microscopy and nanoindentation. | atomic force microscopy and nanoindentation. | plasticity and fracture | plasticity and fracture | Case studies | Case studies | materials selection | materials selection | bicycle frames | bicycle frames | stress shielding in biomedical implants | stress shielding in biomedical implants | residual stresses in thin films | residual stresses in thin films | ancient materials | ancient materials | standard mechanical tests | standard mechanical tests | solid mechanics | solid mechanics | mechanical behavior of materials | mechanical behavior of materials

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7.343 Biological Bases of Learning and Memory (MIT)

Description

How does the brain come to learn whether a stimulus is annoying, rewarding or neutral? How does remembering how to ride a bicycle differ from remembering scenes from a movie? In this course, students will explore the concept that learning and memory have a physical basis that can be observed as biochemical, physiological and/or morphological changes to neural tissue. Our goal will be to understand the strategies and techniques biologists use to search for the memory trace: the "holy grail" of modern neuroscience. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interact

Subjects

learning | memory | neural tissue | neuronal connections | synapse formation | synapse stabilization | synaptic transmission | synaptic plasticity | neuromodulation | experience-dependent circuit remodeling | neuroscience | pre- and post-synaptic mechanisms | neurotransmitter release | activity-regulated genes | hippocampus | long-term potentiation | long-term depression | cerebellar plasticity | Non-Associative | Associative | cpg15 | experience-dependent synaptic plasticity | perceptual learning | observational learning

License

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2.002 Mechanics and Materials II (MIT) 2.002 Mechanics and Materials II (MIT)

Description

This course provides Mechanical Engineering students with an awareness of various responses exhibited by solid engineering materials when subjected to mechanical and thermal loadings; an introduction to the physical mechanisms associated with design-limiting behavior of engineering materials, especially stiffness, strength, toughness, and durability; an understanding of basic mechanical properties of engineering materials, testing procedures used to quantify these properties, and ways in which these properties characterize material response; quantitative skills to deal with materials-limiting problems in engineering design; and a basis for materials selection in mechanical design. This course provides Mechanical Engineering students with an awareness of various responses exhibited by solid engineering materials when subjected to mechanical and thermal loadings; an introduction to the physical mechanisms associated with design-limiting behavior of engineering materials, especially stiffness, strength, toughness, and durability; an understanding of basic mechanical properties of engineering materials, testing procedures used to quantify these properties, and ways in which these properties characterize material response; quantitative skills to deal with materials-limiting problems in engineering design; and a basis for materials selection in mechanical design.

Subjects

beam bending | beam bending | buckling | buckling | vibration | vibration | polymers | polymers | viscoelasticity | viscoelasticity | strength | strength | ductility | ductility | stress | stress | stress concentration | stress concentration | sheet bending | sheet bending | heat treatment | heat treatment | fracture | fracture | plasticity | plasticity | creep | creep | fatigue | fatigue | solid materials | solid materials | mechanical loading | mechanical loading | thermal loading | thermal loading | design-limiting behavior | design-limiting behavior | stiffness | stiffness | toughness | toughness | durability | durability | engineering materials | engineering materials | materials-limiting problem | materials-limiting problem | materials selection | materials selection

License

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16.225 Computational Mechanics of Materials (MIT) 16.225 Computational Mechanics of Materials (MIT)

Description

16.225 is a graduate level course on Computational Mechanics of Materials. The primary focus of this course is on the teaching of state-of-the-art numerical methods for the analysis of the nonlinear continuum response of materials. The range of material behavior considered in this course includes: linear and finite deformation elasticity, inelasticity and dynamics. Numerical formulation and algorithms include: variational formulation and variational constitutive updates, finite element discretization, error estimation, constrained problems, time integration algorithms and convergence analysis. There is a strong emphasis on the (parallel) computer implementation of algorithms in programming assignments. The application to real engineering applications and problems in engineering science is 16.225 is a graduate level course on Computational Mechanics of Materials. The primary focus of this course is on the teaching of state-of-the-art numerical methods for the analysis of the nonlinear continuum response of materials. The range of material behavior considered in this course includes: linear and finite deformation elasticity, inelasticity and dynamics. Numerical formulation and algorithms include: variational formulation and variational constitutive updates, finite element discretization, error estimation, constrained problems, time integration algorithms and convergence analysis. There is a strong emphasis on the (parallel) computer implementation of algorithms in programming assignments. The application to real engineering applications and problems in engineering science is

Subjects

Computational Mechanics | Computational Mechanics | Computation | Computation | Mechanics | Mechanics | Materials | Materials | Numerical Methods | Numerical Methods | Numerical | Numerical | Nonlinear Continuum Response | Nonlinear Continuum Response | Continuum | Continuum | Deformation | Deformation | Elasticity | Elasticity | Inelasticity | Inelasticity | Dynamics | Dynamics | Variational Formulation | Variational Formulation | Variational Constitutive Updates | Variational Constitutive Updates | Finite Element | Finite Element | Discretization | Discretization | Error Estimation | Error Estimation | Constrained Problems | Constrained Problems | Time Integration | Time Integration | Convergence Analysis | Convergence Analysis | Programming | Programming | Continuum Response | Continuum Response | Computational | Computational | state-of-the-art | state-of-the-art | methods | methods | modeling | modeling | simulation | simulation | mechanical | mechanical | response | response | engineering | engineering | aerospace | aerospace | civil | civil | material | material | science | science | biomechanics | biomechanics | behavior | behavior | finite | finite | deformation | deformation | elasticity | elasticity | inelasticity | inelasticity | contact | contact | friction | friction | coupled | coupled | numerical | numerical | formulation | formulation | algorithms | algorithms | Variational | Variational | constitutive | constitutive | updates | updates | element | element | discretization | discretization | mesh | mesh | generation | generation | error | error | estimation | estimation | constrained | constrained | problems | problems | time | time | convergence | convergence | analysis | analysis | parallel | parallel | computer | computer | implementation | implementation | programming | programming | assembly | assembly | equation-solving | equation-solving | formulating | formulating | implementing | implementing | complex | complex | approximations | approximations | equations | equations | motion | motion | dynamic | dynamic | deformations | deformations | continua | continua | plasticity | plasticity | rate-dependency | rate-dependency | integration | integration

License

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3.22 Mechanical Behavior of Materials (MIT) 3.22 Mechanical Behavior of Materials (MIT)

Description

Here we will learn about the mechanical behavior of structures and materials, from the continuum description of properties to the atomistic and molecular mechanisms that confer those properties to all materials. We will cover elastic and plastic deformation, creep, fracture and fatigue of materials including crystalline and amorphous metals, semiconductors, ceramics, and (bio)polymers, and will focus on the design and processing of materials from the atomic to the macroscale to achieve desired mechanical behavior. We will cover special topics in mechanical behavior for material systems of your choice, with reference to current research and publications. Here we will learn about the mechanical behavior of structures and materials, from the continuum description of properties to the atomistic and molecular mechanisms that confer those properties to all materials. We will cover elastic and plastic deformation, creep, fracture and fatigue of materials including crystalline and amorphous metals, semiconductors, ceramics, and (bio)polymers, and will focus on the design and processing of materials from the atomic to the macroscale to achieve desired mechanical behavior. We will cover special topics in mechanical behavior for material systems of your choice, with reference to current research and publications.

Subjects

Phenomenology | Phenomenology | mechanical behavior | mechanical behavior | material structure | material structure | deformation | deformation | failure | failure | elasticity | elasticity | viscoelasticity | viscoelasticity | plasticity | plasticity | creep | creep | fracture | fracture | fatigue | fatigue | metals | metals | semiconductors | semiconductors | ceramics | ceramics | polymers | polymers | microstructure | microstructure | composition | composition | semiconductor diodes | semiconductor diodes | thin films | thin films | carbon nanotubes | carbon nanotubes | battery materials | battery materials | superelastic alloys | superelastic alloys | defect nucleation | defect nucleation | student projects | student projects | viral capsides | viral capsides

License

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3.225 Electronic and Mechanical Properties of Materials (MIT) 3.225 Electronic and Mechanical Properties of Materials (MIT)

Description

This course covers the fundamental concepts that determine the electrical, optical, magnetic and mechanical properties of metals, semiconductors, ceramics and polymers. The roles of bonding, structure (crystalline, defect, energy band and microstructure) and composition in influencing and controlling physical properties are discussed. Also included are case studies drawn from a variety of applications: semiconductor diodes and optical detectors, sensors, thin films, biomaterials, composites and cellular materials, and others. This course covers the fundamental concepts that determine the electrical, optical, magnetic and mechanical properties of metals, semiconductors, ceramics and polymers. The roles of bonding, structure (crystalline, defect, energy band and microstructure) and composition in influencing and controlling physical properties are discussed. Also included are case studies drawn from a variety of applications: semiconductor diodes and optical detectors, sensors, thin films, biomaterials, composites and cellular materials, and others.

Subjects

metals | metals | semiconductors | semiconductors | ceramics | ceramics | polymers | polymers | bonding | bonding | structure | structure | energy band | energy band | microstructure | microstructure | composition | composition | semiconductor diodes | semiconductor diodes | optical detectors | optical detectors | sensors | sensors | thin films | thin films | biomaterials | biomaterials | cellular materials | cellular materials | magnetism | magnetism | polarity | polarity | viscoelasticity | viscoelasticity | plasticity | plasticity | fracture | fracture | materials selection | materials selection

License

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HST.723 Neural Coding and Perception of Sound (MIT) HST.723 Neural Coding and Perception of Sound (MIT)

Description

Neural structures and mechanisms mediating the detection, localization and recognition of sounds. We will discuss how acoustic signals are coded by auditory neurons, the impact of these codes on behavioral performance, and the circuitry and cellular mechanisms underlying signal transformations. Topics include temporal coding, neural maps and feature detectors, learning and plasticity, and feedback control. General principles are conveyed by theme discussions of auditory masking, sound localization, musical pitch, speech coding, and cochlear implants. Neural structures and mechanisms mediating the detection, localization and recognition of sounds. We will discuss how acoustic signals are coded by auditory neurons, the impact of these codes on behavioral performance, and the circuitry and cellular mechanisms underlying signal transformations. Topics include temporal coding, neural maps and feature detectors, learning and plasticity, and feedback control. General principles are conveyed by theme discussions of auditory masking, sound localization, musical pitch, speech coding, and cochlear implants.

Subjects

hearing | hearing | neural structures | neural structures | auditory masking | auditory masking | acoustics | acoustics | signal transformations | signal transformations | temporal coding | temporal coding | neural maps | neural maps | feature detectors | feature detectors | learning | learning | plasticity | plasticity | feedback control | feedback control | sound localization | sound localization | musical pitch | musical pitch | speech coding | speech coding | cochlear implants | cochlear implants

License

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9.14 Brain Structure and its Origins (MIT) 9.14 Brain Structure and its Origins (MIT)

Description

This course covers major CNS structures with emphasis on systems being used as models for experimental studies of development and plasticity. Topics include basic patterns of connections in CNS, embryogenesis, PNS anatomy and development, process outgrowth and synaptogenesis, growth factors and cell survival, spinal and hindbrain anatomy, and development of regional specificity with an introduction to comparative anatomy and CNS evolution. A review of lab techniques (anatomy, tissue culture) is also covered as well as the trigeminal system, retinotectal system development, plasticity, regeneration, neocortex anatomy and development, the olfactory system, corpus striatum, brain transplants, the limbic system and hippocampal anatomy and plasticity. This course covers major CNS structures with emphasis on systems being used as models for experimental studies of development and plasticity. Topics include basic patterns of connections in CNS, embryogenesis, PNS anatomy and development, process outgrowth and synaptogenesis, growth factors and cell survival, spinal and hindbrain anatomy, and development of regional specificity with an introduction to comparative anatomy and CNS evolution. A review of lab techniques (anatomy, tissue culture) is also covered as well as the trigeminal system, retinotectal system development, plasticity, regeneration, neocortex anatomy and development, the olfactory system, corpus striatum, brain transplants, the limbic system and hippocampal anatomy and plasticity.

Subjects

CNS structures | CNS structures | development | development | plasticity | plasticity | anatomy | anatomy | tissue culture | tissue culture | embryogenesis | embryogenesis | PNS anatomy and development | PNS anatomy and development | process outgrowth | process outgrowth | synaptogenesis | synaptogenesis | growth factors | growth factors | cell survival | cell survival | spinal and hindbrain anatomy | spinal and hindbrain anatomy | comparative anatomy | comparative anatomy | CNS evolution | CNS evolution | trigeminal system | trigeminal system | retinotectal system | retinotectal system | regeneration | regeneration | neocortex anatomy | neocortex anatomy | olfactory system | olfactory system | corpus striatum | corpus striatum | brain transplants | brain transplants | limbic system | limbic system | Development | Development

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9.03 Neural Basis of Learning and Memory (MIT) 9.03 Neural Basis of Learning and Memory (MIT)

Description

Topics in mammalian learning and memory including cellular mechanisms of neural plasticity, electrophysiology, and behavior. Emphasis on human and animal models of hippocampal mechanisms and function. Lectures and discussion of papers. An additional project is required for graduate credit. This course is offered alternate years. Topics in mammalian learning and memory including cellular mechanisms of neural plasticity, electrophysiology, and behavior. Emphasis on human and animal models of hippocampal mechanisms and function. Lectures and discussion of papers. An additional project is required for graduate credit. This course is offered alternate years.

Subjects

learning | learning | memory | memory | neural plasticity | neural plasticity | electrophysiology | electrophysiology | hippocampus | hippocampus

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9.S915 Developmental Cognitive Neuroscience (MIT) 9.S915 Developmental Cognitive Neuroscience (MIT)

Description

This course uses neuroscience methods to study the cognitive development of human infants and children. Case studies draw from research on face recognition, language, executive function, representations of objects, number and theory of mind. This course uses neuroscience methods to study the cognitive development of human infants and children. Case studies draw from research on face recognition, language, executive function, representations of objects, number and theory of mind.

Subjects

development | development | cognition | cognition | theory of mind | theory of mind | neuroscience | neuroscience | childhood | childhood | learning | learning | plasticity | plasticity | executive function | executive function | perception | perception

License

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Development of the Mammalian Brain (MIT) Development of the Mammalian Brain (MIT)

Description

Lectures plus guided readings and discussion with project reports, covering major CNS structures, with emphasis on systems being used as models for experimental studies of development and plasticity. Topics include: basic patterns of connections in CNS; review of lab techniques (anatomy, tissue culture); embryogenesis; PNS anatomy and development; process outgrowth and synaptogenesis; growth factors and cell survival; spinal and hindbrain anatomy; development of regional specificity with introduction to comparative anatomy and CNS evolution; trigeminal system; retinotectal system development, plasticity, regeneration; neocortex anatomy and development; olfactory system; corpus striatum; brain transplants; limbic system and hippocampal anatomy and plasticity.Technical RequirementsMedia play Lectures plus guided readings and discussion with project reports, covering major CNS structures, with emphasis on systems being used as models for experimental studies of development and plasticity. Topics include: basic patterns of connections in CNS; review of lab techniques (anatomy, tissue culture); embryogenesis; PNS anatomy and development; process outgrowth and synaptogenesis; growth factors and cell survival; spinal and hindbrain anatomy; development of regional specificity with introduction to comparative anatomy and CNS evolution; trigeminal system; retinotectal system development, plasticity, regeneration; neocortex anatomy and development; olfactory system; corpus striatum; brain transplants; limbic system and hippocampal anatomy and plasticity.Technical RequirementsMedia play

Subjects

CNS structures | CNS structures | development | development | plasticity | plasticity | anatomy | anatomy | tissue culture | tissue culture | embryogenesis | embryogenesis | PNS anatomy and development | PNS anatomy and development | process outgrowth | process outgrowth | synaptogenesis | synaptogenesis | growth factors | growth factors | cell survival | cell survival | spinal and hindbrain anatomy | spinal and hindbrain anatomy | comparative anatomy | comparative anatomy | CNS evolution | CNS evolution | trigeminal system | trigeminal system | retinotectal system | retinotectal system | regeneration | regeneration | neocortex anatomy | neocortex anatomy | olfactory system | olfactory system | corpus striatum | corpus striatum | brain transplants | brain transplants | limbic system | limbic system | Mammals -- Physiology | Mammals -- Physiology

License

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9.013J Cell and Molecular Neurobiology (MIT) 9.013J Cell and Molecular Neurobiology (MIT)

Description

This course explores the major areas of cellular and molecular neurobiology, including excitable cells and membranes, ion channels and receptors, synaptic transmission, cell-type determination, axon guidance, neuronal cell biology, neurotrophin signaling and cell survival, synapse formation and neural plasticity. Material includes lectures and exams, and involves presentation and discussion of primary literature. It focuses on major concepts and recent advances in experimental neuroscience. This course explores the major areas of cellular and molecular neurobiology, including excitable cells and membranes, ion channels and receptors, synaptic transmission, cell-type determination, axon guidance, neuronal cell biology, neurotrophin signaling and cell survival, synapse formation and neural plasticity. Material includes lectures and exams, and involves presentation and discussion of primary literature. It focuses on major concepts and recent advances in experimental neuroscience.

Subjects

cellular | cellular | molecular neurobiology | molecular neurobiology | cells | cells | membranes | membranes | ion channels | ion channels | receptors | receptors | synaptic transmission | synaptic transmission | axon guidance | axon guidance | targeting | targeting | neuronal cell biology | neuronal cell biology | synapse formation | synapse formation | plasticity | plasticity

License

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9.03 Neural Basis of Learning and Memory (MIT) 9.03 Neural Basis of Learning and Memory (MIT)

Description

This course highlights the interplay between cellular and molecular storage mechanisms and the cognitive neuroscience of memory, with an emphasis on human and animal models of hippocampal mechanisms and function. Class sessions include lectures and discussion of papers. This course highlights the interplay between cellular and molecular storage mechanisms and the cognitive neuroscience of memory, with an emphasis on human and animal models of hippocampal mechanisms and function. Class sessions include lectures and discussion of papers.

Subjects

learning | learning | memory | memory | neural plasticity | neural plasticity | electrophysiology | electrophysiology | hippocampus | hippocampus | synapse | synapse | aplysia | aplysia | drosophlia | drosophlia | NMDA | NMDA | semantic memory | semantic memory | working memory | working memory | short-term memory | short-term memory | alzheimer's disease | alzheimer's disease | skill learning | skill learning | mirror neurons | mirror neurons | short-term | short-term | long-term | long-term

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9.22J A Clinical Approach to the Human Brain (MIT) 9.22J A Clinical Approach to the Human Brain (MIT)

Description

This course is designed to provide an understanding of how the human brain works in health and disease, and is intended for both the Brain and Cognitive Sciences major and the non-Brain and Cognitive Sciences major. Knowledge of how the human brain works is important for all citizens, and the lessons to be learned have enormous implications for public policy makers and educators. The course will cover the regional anatomy of the brain and provide an introduction to the cellular function of neurons, synapses and neurotransmitters. Commonly used drugs that alter brain function can be understood through a knowledge of neurotransmitters. Along similar lines, common diseases that illustrate normal brain function will be discussed. Experimental animal studies that reveal how the brain works wil This course is designed to provide an understanding of how the human brain works in health and disease, and is intended for both the Brain and Cognitive Sciences major and the non-Brain and Cognitive Sciences major. Knowledge of how the human brain works is important for all citizens, and the lessons to be learned have enormous implications for public policy makers and educators. The course will cover the regional anatomy of the brain and provide an introduction to the cellular function of neurons, synapses and neurotransmitters. Commonly used drugs that alter brain function can be understood through a knowledge of neurotransmitters. Along similar lines, common diseases that illustrate normal brain function will be discussed. Experimental animal studies that reveal how the brain works wil

Subjects

9.22 | 9.22 | HST.422 | HST.422 | brain | brain | fMRI | fMRI | visual | visual | spatial | spatial | dyslexia | dyslexia | development | development | motor activities | motor activities | anatomy | anatomy | cellular function | cellular function | neurons | neurons | synapes | synapes | neurotransmitters | neurotransmitters | diseases | diseases | animal studies | animal studies | clinical cases | clinical cases | activity-dependent development | activity-dependent development | critical periods | critical periods | plasticity | plasticity | learning | learning | emotional disorders | emotional disorders | vision | vision | language | language | motor function | motor function | pain | pain | placebo effects | placebo effects | emotional states | emotional states | education | education | dementia | dementia

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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9.373 Somatosensory and Motor Systems (MIT) 9.373 Somatosensory and Motor Systems (MIT)

Description

General principles of motor control in biological systems. Structure and function of sensory receptors. Muscle structure and reflex arcs. Spinal cord. Locomotion. Oculomotor control. Cerebellar structure and function. Motor thalamus. Basal ganglia. Somatosensory cortex: maps and neuronal properties. Cortical plasticity. Motor psychophysics and computational approaches to motor control, and motor planning. General principles of motor control in biological systems. Structure and function of sensory receptors. Muscle structure and reflex arcs. Spinal cord. Locomotion. Oculomotor control. Cerebellar structure and function. Motor thalamus. Basal ganglia. Somatosensory cortex: maps and neuronal properties. Cortical plasticity. Motor psychophysics and computational approaches to motor control, and motor planning.

Subjects

locomotion | locomotion | motor control | motor control | biological systems | biological systems | Structure | Structure | function | function | Muscle structure | Muscle structure | reflex | reflex | Spinal cord | Spinal cord | Oculomotor control | Oculomotor control | Cerebellar structure | Cerebellar structure | Motor thalamus | Motor thalamus | Basal ganglia | Basal ganglia | Somatosensory cortex | Somatosensory cortex | Cortical plasticity | Cortical plasticity | Motor psychophysics | Motor psychophysics | motor planning | motor planning | Locomotion | Locomotion

License

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9.05 Neural Basis of Movement (MIT) 9.05 Neural Basis of Movement (MIT)

Description

Surveys general principles and specific examples of motor control in biological systems. Emphasizes the neural mechanisms underlying different aspects of movement and movement planning. Covers sensory reception, reflex arcs, spinal cord organization, pattern generators, muscle function, locomotion, eye movement, and cognitive aspects of motor control. Functions of central motor structures including cerebellum, basal ganglia, and cerebral cortex considered. Cortical plasticity, motor learning and computational approaches to motor control, and motor disorders are discussed. Surveys general principles and specific examples of motor control in biological systems. Emphasizes the neural mechanisms underlying different aspects of movement and movement planning. Covers sensory reception, reflex arcs, spinal cord organization, pattern generators, muscle function, locomotion, eye movement, and cognitive aspects of motor control. Functions of central motor structures including cerebellum, basal ganglia, and cerebral cortex considered. Cortical plasticity, motor learning and computational approaches to motor control, and motor disorders are discussed.

Subjects

motor control | motor control | neural mechanisms | neural mechanisms | movement | movement | movement planning | movement planning | sensory reception | sensory reception | reflex arcs | reflex arcs | spinal cord organization | spinal cord organization | pattern generators | pattern generators | muscle function | muscle function | locomotion | locomotion | eye movement | eye movement | cognitive aspects of motor control | cognitive aspects of motor control | central motor structures | central motor structures | cerebellum | cerebellum | basal ganglia | basal ganglia | cerebral cortex | cerebral cortex | Cortical plasticity | Cortical plasticity | motor learning | motor learning | computation | computation | motor disorders | motor disorders

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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9.916 Modularity, Domain-specificity, and the Organization of Knowledge (MIT) 9.916 Modularity, Domain-specificity, and the Organization of Knowledge (MIT)

Description

This course will consider the degree and nature of the modular organization of the mind and brain. We will focus in detail on the domains of objects, number, places, and people, drawing on evidence from behavioral studies in human infants, children, normal adults, neurological patients, and animals, as well as from studies using neural measures such as functional brain imaging and ERPs. With these domains as examples, we will address broader questions about the role of domain-general and domain-specific processing systems in mature human performance, the innateness vs. plasticity of encapsulated cognitive systems, the nature of the evidence for such systems, and the processes by which people link information flexibly across domains. This course will consider the degree and nature of the modular organization of the mind and brain. We will focus in detail on the domains of objects, number, places, and people, drawing on evidence from behavioral studies in human infants, children, normal adults, neurological patients, and animals, as well as from studies using neural measures such as functional brain imaging and ERPs. With these domains as examples, we will address broader questions about the role of domain-general and domain-specific processing systems in mature human performance, the innateness vs. plasticity of encapsulated cognitive systems, the nature of the evidence for such systems, and the processes by which people link information flexibly across domains.

Subjects

organization | organization | mind | mind | brain | brain | domains | domains | objects | objects | number | number | places | places | people | people | behavior | behavior | infants | infants | children | children | normal adults | normal adults | neurological patients | neurological patients | animals | animals | functional brain imaging | functional brain imaging | ERPs | ERPs | innateness | innateness | plasticity | plasticity | cognitive systems | cognitive systems

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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9.301J Neural Plasticity in Learning and Development (MIT) 9.301J Neural Plasticity in Learning and Development (MIT)

Description

Roles of neural plasticity in learning and memory and in development of invertebrates and mammals. An in-depth critical analysis of current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Discussion of original papers supplemented by introductory lectures. Roles of neural plasticity in learning and memory and in development of invertebrates and mammals. An in-depth critical analysis of current literature of molecular, cellular, genetic, electrophysiological, and behavioral studies. Discussion of original papers supplemented by introductory lectures.

Subjects

plasticity | plasticity | learning | learning | memory | memory | invertebrates | invertebrates | mammals | mammals | molecular | molecular | cellular | cellular | genetic | genetic | electrophysiological | electrophysiological | behavior | behavior | 9.301 | 9.301 | 7.98 | 7.98

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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3.032 Mechanical Behavior of Materials (MIT)

Description

Here we will learn about the mechanical behavior of structures and materials, from the continuum description of properties to the atomistic and molecular mechanisms that confer those properties to all materials. We will cover elastic and plastic deformation, creep, and fracture of materials including crystalline and amorphous metals, ceramics, and (bio)polymers, and will focus on the design and processing of materials from the atomic to the macroscale to achieve desired mechanical behavior. Integrated laboratories provide the opportunity to explore these concepts through hands-on experiments including instrumentation of pressure vessels, visualization of atomistic deformation in bubble rafts, nanoindentation, and uniaxial mechanical testing, as well as writing assignments to communicate th

Subjects

Basic concepts of solid mechanics and mechanical behavior of materials | stress-strain relationships | stress transformation | elasticity | plasticity and fracture. Case studies include materials selection for bicycle frames | stress shielding in biomedical implants; residual stresses in thin films; and ancient materials. Lab experiments and demonstrations give hands-on experience of the physical concepts at a variety of length scales. Use of facilities for measuring mechanical properties including standard mechanical tests | bubble raft models | atomic force microscopy and nanoindentation. | plasticity and fracture | Case studies | materials selection | bicycle frames | stress shielding in biomedical implants | residual stresses in thin films | ancient materials | standard mechanical tests | solid mechanics | mechanical behavior of materials

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.346 Synaptic Plasticity and Memory, from Molecules to Behavior (MIT)

Description

In this course we will discover how innovative technologies combined with profound hypotheses have given rise to our current understanding of neuroscience. We will study both new and classical primary research papers with a focus on the plasticity between synapses in a brain structure called the hippocampus, which is believed to underlie the ability to create and retrieve certain classes of memories. We will discuss the basic electrical properties of neurons and how they fire. We will see how firing properties can change with experience, and we will study the biochemical basis of these changes. We will learn how molecular biology can be used to specifically change the biochemical properties of brain circuits, and we will see how these circuits form a representation of space giving rise to

Subjects

synapse | memory | neuroscience | plasticity | hippocampus | LTP | molecular mechanism | Morris water maze | place cells | NMDA | synaptic tagging | long term depression | cortex | synaptic plasticity | neuronal circuits | specificity | CA1 | grid cells | schema | fear memory | biochemistry

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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9.05 Neural Basis of Movement (MIT) 9.05 Neural Basis of Movement (MIT)

Description

Surveys general principles and specific examples of motor control in biological systems. Emphasizes the neural mechanisms underlying different aspects of movement and movement planning. Covers sensory reception, reflex arcs, spinal cord organization, pattern generators, muscle function, locomotion, eye movement, and cognitive aspects of motor control. Functions of central motor structures including cerebellum, basal ganglia, and cerebral cortex considered. Cortical plasticity, motor learning and computational approaches to motor control, and motor disorders are discussed. Surveys general principles and specific examples of motor control in biological systems. Emphasizes the neural mechanisms underlying different aspects of movement and movement planning. Covers sensory reception, reflex arcs, spinal cord organization, pattern generators, muscle function, locomotion, eye movement, and cognitive aspects of motor control. Functions of central motor structures including cerebellum, basal ganglia, and cerebral cortex considered. Cortical plasticity, motor learning and computational approaches to motor control, and motor disorders are discussed.

Subjects

motor control | motor control | neural mechanisms | neural mechanisms | movement | movement | movement planning | movement planning | sensory reception | sensory reception | reflex arcs | reflex arcs | spinal cord organization | spinal cord organization | pattern generators | pattern generators | muscle function | muscle function | locomotion | locomotion | eye movement | eye movement | cognitive aspects of motor control | cognitive aspects of motor control | central motor structures | central motor structures | cerebellum | cerebellum | basal ganglia | basal ganglia | cerebral cortex | cerebral cortex | Cortical plasticity | Cortical plasticity | motor learning | motor learning | computation | computation | motor disorders | motor disorders

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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9.14 Brain Structure and Its Origins (MIT) 9.14 Brain Structure and Its Origins (MIT)

Description

Outline of mammalian functional neuroanatomy, aided by studies of comparative neuroanatomy and evolution, and of brain development. Topics include early steps to a central nervous system, basic patterns of brain and spinal cord connections, regional development and differentiation, regeneration, motor and sensory pathways and structures, systems underlying motivations, innate action patterns, formation of habits, and various cognitive functions. Lab techniques reviewed. Optional brain dissections. Outline of mammalian functional neuroanatomy, aided by studies of comparative neuroanatomy and evolution, and of brain development. Topics include early steps to a central nervous system, basic patterns of brain and spinal cord connections, regional development and differentiation, regeneration, motor and sensory pathways and structures, systems underlying motivations, innate action patterns, formation of habits, and various cognitive functions. Lab techniques reviewed. Optional brain dissections.

Subjects

CNS structures | CNS structures | development | development | plasticity | plasticity | anatomy | anatomy | tissue culture | tissue culture | embryogenesis | embryogenesis | PNS anatomy and development | PNS anatomy and development | process outgrowth | process outgrowth | synaptogenesis | synaptogenesis | growth factors | growth factors | cell survival | cell survival | spinal and hindbrain anatomy | spinal and hindbrain anatomy | comparative anatomy | comparative anatomy | CNS evolution | CNS evolution | trigeminal system | trigeminal system | retinotectal system | retinotectal system | regeneration | regeneration | neocortex anatomy | neocortex anatomy | olfactory system | olfactory system | corpus striatum | corpus striatum | brain transplants | brain transplants | limbic system | limbic system

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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9.916 Modularity, Domain-specificity, and the Organization of Knowledge (MIT) 9.916 Modularity, Domain-specificity, and the Organization of Knowledge (MIT)

Description

This course will consider the degree and nature of the modular organization of the mind and brain. We will focus in detail on the domains of objects, number, places, and people, drawing on evidence from behavioral studies in human infants, children, normal adults, neurological patients, and animals, as well as from studies using neural measures such as functional brain imaging and ERPs. With these domains as examples, we will address broader questions about the role of domain-general and domain-specific processing systems in mature human performance, the innateness vs. plasticity of encapsulated cognitive systems, the nature of the evidence for such systems, and the processes by which people link information flexibly across domains. This course will consider the degree and nature of the modular organization of the mind and brain. We will focus in detail on the domains of objects, number, places, and people, drawing on evidence from behavioral studies in human infants, children, normal adults, neurological patients, and animals, as well as from studies using neural measures such as functional brain imaging and ERPs. With these domains as examples, we will address broader questions about the role of domain-general and domain-specific processing systems in mature human performance, the innateness vs. plasticity of encapsulated cognitive systems, the nature of the evidence for such systems, and the processes by which people link information flexibly across domains.

Subjects

organization | organization | mind | mind | brain | brain | domains | domains | objects | objects | number | number | places | places | people | people | behavior | behavior | infants | infants | children | children | normal adults | normal adults | neurological patients | neurological patients | animals | animals | functional brain imaging | functional brain imaging | ERPs | ERPs | innateness | innateness | plasticity | plasticity | cognitive systems | cognitive systems

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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