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21H.112 The American Revolution (MIT) 21H.112 The American Revolution (MIT)

Description

This course is concerned primarily with the revolutionary origins of American government. Topics covered include: English and American backgrounds of the Revolution; issues and arguments in the Anglo-American conflict; colonial resistance and the beginnings of republicanism; the Revolutionary War; constitution writing for the states and nation; and effects of the American Revolution. Readings emphasize documents from the period--pamphlets, correspondence, the minutes or resolutions of resistance organizations, constitutional documents and debates. This course is concerned primarily with the revolutionary origins of American government. Topics covered include: English and American backgrounds of the Revolution; issues and arguments in the Anglo-American conflict; colonial resistance and the beginnings of republicanism; the Revolutionary War; constitution writing for the states and nation; and effects of the American Revolution. Readings emphasize documents from the period--pamphlets, correspondence, the minutes or resolutions of resistance organizations, constitutional documents and debates.

Subjects

English and American backgrounds of the Revolution | English and American backgrounds of the Revolution | issues and arguments in the Anglo-American conflict | issues and arguments in the Anglo-American conflict | colonial resistance and the beginnings of republicanism | colonial resistance and the beginnings of republicanism | the Revolutionary War | the Revolutionary War | constitution writing for the states and nation | constitution writing for the states and nation | and effects of the American Revolution | and effects of the American Revolution | Concerned primarily with the revolutionary origins of American government | Concerned primarily with the revolutionary origins of American government | pamphlets | correspondence | the minutes or resolutions of resistance organizations | constitutional documents and debates | pamphlets | correspondence | the minutes or resolutions of resistance organizations | constitutional documents and debates | English background | English background | American Revolution effects | American Revolution effects | Anglo-American conflict | Anglo-American conflict | colonial resistance | republicanism | colonial resistance | republicanism | constitution writing | constitution writing | revolutionary origins of American government | revolutionary origins of American government | pamphlets | pamphlets | correspondence | correspondence | resistance organizations | resistance organizations | constitutional documents | constitutional documents | debates | debates | colonial resistance | colonial resistance | republicanism | republicanism

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Finding the best malaria treatments

Description

Dr Mehul Dhorda heads the Asia Regional Centre of the WorldWide Antimalarial Resistance Network (WWARN). Artemisinin resistance is firmly established in many parts of Southeast Asia and threatens the lives of millions of people. To improve regional intelligence and aid containment efforts, Dr Dhorda promotes the collection of high quality data on malaria drug resistance. His research aims to simplify and harmonise data, securely store results and analyse comparative or collective pooled analyses. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

malaria | antimalarial resistance | artemisinin resistance | artemisinin | drug resistance | data | malaria | antimalarial resistance | artemisinin resistance | artemisinin | drug resistance | data

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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21H.112 The American Revolution (MIT)

Description

This course is concerned primarily with the revolutionary origins of American government. Topics covered include: English and American backgrounds of the Revolution; issues and arguments in the Anglo-American conflict; colonial resistance and the beginnings of republicanism; the Revolutionary War; constitution writing for the states and nation; and effects of the American Revolution. Readings emphasize documents from the period--pamphlets, correspondence, the minutes or resolutions of resistance organizations, constitutional documents and debates.

Subjects

English and American backgrounds of the Revolution | issues and arguments in the Anglo-American conflict | colonial resistance and the beginnings of republicanism | the Revolutionary War | constitution writing for the states and nation | and effects of the American Revolution | Concerned primarily with the revolutionary origins of American government | pamphlets | correspondence | the minutes or resolutions of resistance organizations | constitutional documents and debates | English background | American Revolution effects | Anglo-American conflict | colonial resistance | republicanism | constitution writing | revolutionary origins of American government | pamphlets | correspondence | resistance organizations | constitutional documents | debates | colonial resistance | republicanism

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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21H.112 The American Revolution (MIT)

Description

This course is concerned primarily with the revolutionary origins of American government. Topics covered include: English and American backgrounds of the Revolution; issues and arguments in the Anglo-American conflict; colonial resistance and the beginnings of republicanism; the Revolutionary War; constitution writing for the states and nation; and effects of the American Revolution. Readings emphasize documents from the period--pamphlets, correspondence, the minutes or resolutions of resistance organizations, constitutional documents and debates.

Subjects

English and American backgrounds of the Revolution | issues and arguments in the Anglo-American conflict | colonial resistance and the beginnings of republicanism | the Revolutionary War | constitution writing for the states and nation | and effects of the American Revolution | Concerned primarily with the revolutionary origins of American government | pamphlets | correspondence | the minutes or resolutions of resistance organizations | constitutional documents and debates | English background | American Revolution effects | Anglo-American conflict | colonial resistance | republicanism | constitution writing | revolutionary origins of American government | pamphlets | correspondence | resistance organizations | constitutional documents | debates | colonial resistance | republicanism

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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TALAT Lecture 4500: Resistance Welding

Description

This lecture describes the spot welding characteristics of aluminium and its alloys, the spot welding process, the choice of process parameters, strength values, electrode life and ?requirements for quality assurance. General engineering background and knowledge in aluminium metallurgy and physical properties, and surface characteristics (e.g. TALAT lecture 5101) is assumed.

Subjects

aluminium | aluminum | european aluminium association | EAA | Training in Aluminium Application Technologies | training | metallurgy | technology | lecture | joining | fastening | mechanical | resistance welding | spot welding | physical properties | steel | resistance | oxide film | surface pretreatment | contact resistance | storage time | Peltier effect | spot welding machines | relative voltage drop | resistance welding machine | life of electrodes | machine design | current type | current-force diagram | welding parameters | weld spot diameter | direct current | shear strength | weld strengthrepeated tensile stress fatigue strength | fatigue tests | engineering parts | fatigue strength | 2024cl sheets | quality assurance | imperfections | aeronautical standards | metallography | x-ray analysis | corematerials | ukoer

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http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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TALAT Lecture 4500: Resistance Welding

Description

This lecture describes the spot welding characteristics of aluminium and its alloys, the spot welding process, the choice of process parameters, strength values, electrode life and ?requirements for quality assurance. General engineering background and knowledge in aluminium metallurgy and physical properties, and surface characteristics (e.g. TALAT lecture 5101) is assumed.

Subjects

aluminium | aluminum | european aluminium association | eaa | talat | training in aluminium application technologies | training | metallurgy | technology | lecture | joining | fastening | mechanical | resistance welding | spot welding | physical properties | steel | resistance | oxide film | surface pretreatment | contact resistance | storage time | peltier effect | spot welding machines | relative voltage drop | resistance welding machine | life of electrodes | machine design | current type | current-force diagram | welding parameters | weld spot diameter | direct current | shear strength | weld strengthrepeated tensile stress fatigue strength | fatigue tests | engineering parts | fatigue strength | 2024cl sheets | quality assurance | imperfections | aeronautical standards | metallography | x-ray analysis | corematerials | ukoer | Engineering | H000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Computation and genetics

Description

Resistance to drugs in bacteria can be aquired by swapping genes between individual bacteria. Computer programs developed by Dr Iqbal enable doctors to predict which antibiotics will be met with drug resistance, enabling the selection of the right drug. BIOINFORMATICS & PATHOGEN GENOMICS Dr Zamin Iqbal studies the DNA of bacteria and parasites, and compares the genomes of individual pathogens to track the spread of antibiotic resistance. Pathogens accumulate small genetic changes over time, and by tracking these changes, it is possible to map the spread of an infection. This enables better surveillance of pathogen evolution, within a host, within a hospital and across the world. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

computational | genetics | bioinformatics | pathogens | drug resistance | DNA | antibiotic resistance | computational | genetics | bioinformatics | pathogens | drug resistance | DNA | antibiotic resistance

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Intervention in Libya: A Humanitarian Success?

Description

Professor Alan Kuperman (Texas) gives a talk for the ELAC/CCW seminar series on 24th April 2012. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

revolution | libya | resistance | Arab Spring | gaddafi | politics | law | war | conflict | revolution | libya | resistance | Arab Spring | gaddafi | politics | law | war | conflict

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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2.019 Design of Ocean Systems (MIT) 2.019 Design of Ocean Systems (MIT)

Description

This course is the completion of the cycle of designing, implementing and testing an ocean system, including hardware and software implementation, that begins with 2.017J. Design lectures are given in hydrodynamics, power and thermal aspects of ocean vehicles, environment, materials and construction for ocean use, electronics, sensors, and actuators. Student teams work within schedule and budget, setting goals, reviewing progress, and making regular and final presentations. Instruction and practice occur in oral and written communication. This course is the completion of the cycle of designing, implementing and testing an ocean system, including hardware and software implementation, that begins with 2.017J. Design lectures are given in hydrodynamics, power and thermal aspects of ocean vehicles, environment, materials and construction for ocean use, electronics, sensors, and actuators. Student teams work within schedule and budget, setting goals, reviewing progress, and making regular and final presentations. Instruction and practice occur in oral and written communication.

Subjects

hydrodynamics | hydrodynamics | power and thermal aspects of ocean vehicles | power and thermal aspects of ocean vehicles | environment | environment | electronics | electronics | sensors | sensors | actuators | actuators | sea-keeping | sea-keeping | hull strength | hull strength | physics of acoustics | physics of acoustics | resistance | resistance | propulsion | propulsion | control surfaces | control surfaces | dynamics | dynamics | feedback control | feedback control | graphical information systems | graphical information systems | GIS | GIS

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Magnetic Materials and Devices (MIT) Magnetic Materials and Devices (MIT)

Description

This course explores the relationships which exist between the performance of electrical, optical, and magnetic devices and the microstructural characteristics of the materials from which they are constructed. It features a device-motivated approach which places strong emphasis on emerging technologies. Device applications of physical phenomena are considered, including electrical conductivity and doping, transistors, photodetectors and photovoltaics, luminescence, light emitting diodes, lasers, optical phenomena, photonics, ferromagnetism, and magnetoresistance. This course explores the relationships which exist between the performance of electrical, optical, and magnetic devices and the microstructural characteristics of the materials from which they are constructed. It features a device-motivated approach which places strong emphasis on emerging technologies. Device applications of physical phenomena are considered, including electrical conductivity and doping, transistors, photodetectors and photovoltaics, luminescence, light emitting diodes, lasers, optical phenomena, photonics, ferromagnetism, and magnetoresistance.

Subjects

electrical | optical | and magnetic devices | electrical | optical | and magnetic devices | microstructural characteristics of materials | microstructural characteristics of materials | device-motivated approach | device-motivated approach | emerging technologies | emerging technologies | physical phenomena | physical phenomena | electrical conductivity | electrical conductivity | doping | doping | transistors | transistors | photodectors | photodectors | photovoltaics | photovoltaics | luminescence | luminescence | light emitting diodes | light emitting diodes | lasers | lasers | optical phenomena | optical phenomena | photonics | photonics | ferromagnetism | ferromagnetism | magnetoresistance | magnetoresistance | electrical devices | electrical devices | optical devices | optical devices | magnetic devices | magnetic devices | materials | materials | device applications | device applications

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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13.400 Introduction to Naval Architecture (MIT) 13.400 Introduction to Naval Architecture (MIT)

Description

This course is an introduction to principles of naval architecture, ship geometry, hydrostatics, calculation and drawing of curves of form. It also explores concepts of  intact and damaged stability, hull structure strength calculations and ship resistance. Projects include analysis of ship lines drawings and ship model testing. This course is an introduction to principles of naval architecture, ship geometry, hydrostatics, calculation and drawing of curves of form. It also explores concepts of  intact and damaged stability, hull structure strength calculations and ship resistance. Projects include analysis of ship lines drawings and ship model testing.

Subjects

elementary principles of Naval Architecture | elementary principles of Naval Architecture | naval architecture tools | naval architecture tools | ship geometry | ship geometry | hydrostatics | hydrostatics | calculation | calculation | drawing | drawing | curves of form | curves of form | intact and damaged stability | intact and damaged stability | hull structure strength calculations | hull structure strength calculations | ship resistance | ship resistance | ship model testing | ship model testing | 2.701 | 2.701

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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17.462 Innovation in Military Organizations (MIT) 17.462 Innovation in Military Organizations (MIT)

Description

This seminar has three purposes. One, it inquires into the causes of military innovation by examining a number of the most outstanding historical cases. Two, it views military innovations through the lens of organization theory to develop generalizations about the innovation process within militaries. Three, it uses the empirical study of military innovations as a way to examine the strength and credibility of hypotheses that organization theorists have generated about innovation in non-military organizations. This seminar has three purposes. One, it inquires into the causes of military innovation by examining a number of the most outstanding historical cases. Two, it views military innovations through the lens of organization theory to develop generalizations about the innovation process within militaries. Three, it uses the empirical study of military innovations as a way to examine the strength and credibility of hypotheses that organization theorists have generated about innovation in non-military organizations.

Subjects

URIECA | URIECA | laboratory | laboratory | kinase | kinase | cancer cells | cancer cells | laboratory techniques | laboratory techniques | DNA | DNA | cultures | cultures | UV-Vis | UV-Vis | agarose gel | agarose gel | Abl-gleevec | Abl-gleevec | affinity tags | affinity tags | lyse | lyse | digest | digest | mutants | mutants | resistance | resistance | gel electrophoresis | gel electrophoresis | recombinant | recombinant | nickel affinity | nickel affinity | inhibitors | inhibitors | biochemistry | biochemistry | kinetics | kinetics | enzyme | enzyme | inhibition | inhibition | purification | purification | expression | expression | Political science | Political science | security studies | security studies | innovation | innovation | military organizations | military organizations | war | war | history | history | organization theory | organization theory | empirical study | empirical study | land warfare | land warfare | battleships | battleships | airpower | airpower | submarines | submarines | cruise | cruise | ballistic | ballistic | missiles | missiles | armor | armor | military affairs | military affairs | strategic | strategic | tactical | tactical | counterinsurgency | counterinsurgency | Vietnam | Vietnam | Revolution in Military Affairs | Revolution in Military Affairs | RMA | RMA

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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11.948 The Politics of Reconstructing Iraq (MIT) 11.948 The Politics of Reconstructing Iraq (MIT)

Description

This course is being offered in conjunction with the colloquium The Politics of Reconstructing Iraq, which is sponsored by MIT’s Center for International Studies and Department of Urban Studies and Planning. Fundamentally, the course focuses on contemporary post-conflict countries (or in-conflict countries) and the role of planning and reconstruction in building nations, mitigating conflicts, reshaping the social, spatial, geopolitical, and political life, and determining the country’s future. This course is being offered in conjunction with the colloquium The Politics of Reconstructing Iraq, which is sponsored by MIT’s Center for International Studies and Department of Urban Studies and Planning. Fundamentally, the course focuses on contemporary post-conflict countries (or in-conflict countries) and the role of planning and reconstruction in building nations, mitigating conflicts, reshaping the social, spatial, geopolitical, and political life, and determining the country’s future.

Subjects

planning | planning | politics | politics | post-conflict reconstruction | post-conflict reconstruction | Marshall Plan | Marshall Plan | reconstruction of Japan | reconstruction of Japan | Bosnia and Herzegovina | Bosnia and Herzegovina | September 11 reconstruction | September 11 reconstruction | Iraq politics and society | Iraq politics and society | post-war planning | post-war planning | building democracy | building democracy | international organizations | international organizations | Iraqi-Arab discourse | Iraqi-Arab discourse | vision | vision | stability | stability | resistance | resistance

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Magnetic Materials and Devices (MIT) Magnetic Materials and Devices (MIT)

Description

This course explores the relationships which exist between the performance of electrical, optical, and magnetic devices and the microstructural characteristics of the materials from which they are constructed. The class uses a device-motivated approach which emphasizes emerging technologies. Device applications of physical phenomena are considered, including electrical conductivity and doping, transistors, photodetectors and photovoltaics, luminescence, light emitting diodes, lasers, optical phenomena, photonics, ferromagnetism, and magnetoresistance. This course explores the relationships which exist between the performance of electrical, optical, and magnetic devices and the microstructural characteristics of the materials from which they are constructed. The class uses a device-motivated approach which emphasizes emerging technologies. Device applications of physical phenomena are considered, including electrical conductivity and doping, transistors, photodetectors and photovoltaics, luminescence, light emitting diodes, lasers, optical phenomena, photonics, ferromagnetism, and magnetoresistance.

Subjects

electrical | optical | and magnetic devices | electrical | optical | and magnetic devices | microstructural characteristics of materials | microstructural characteristics of materials | device-motivated approach | device-motivated approach | emerging technologies | emerging technologies | physical phenomena | physical phenomena | electrical conductivity | electrical conductivity | doping | doping | transistors | transistors | photodectors | photodectors | photovoltaics | photovoltaics | luminescence | luminescence | light emitting diodes | light emitting diodes | lasers | lasers | optical phenomena | optical phenomena | photonics | photonics | ferromagnetism | ferromagnetism | magnetoresistance | magnetoresistance

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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3.35 Fracture and Fatigue (MIT) 3.35 Fracture and Fatigue (MIT)

Description

Investigation of linear elastic and elastic-plastic fracture mechanics. Topics include microstructural effects on fracture in metals, ceramics, polymers, thin films, biological materials and composites, toughening mechanisms, crack growth resistance and creep fracture. Also covered: interface fracture mechanics, fatigue damage and dislocation substructures in single crystals, stress- and strain-life approach to fatigue, fatigue crack growth models and mechanisms, variable amplitude fatigue, corrosion fatigue and case studies of fracture and fatigue in structural, bioimplant, and microelectronic components. Investigation of linear elastic and elastic-plastic fracture mechanics. Topics include microstructural effects on fracture in metals, ceramics, polymers, thin films, biological materials and composites, toughening mechanisms, crack growth resistance and creep fracture. Also covered: interface fracture mechanics, fatigue damage and dislocation substructures in single crystals, stress- and strain-life approach to fatigue, fatigue crack growth models and mechanisms, variable amplitude fatigue, corrosion fatigue and case studies of fracture and fatigue in structural, bioimplant, and microelectronic components.

Subjects

Linear elastic | Linear elastic | elastic-plastic fracture mechanics | elastic-plastic fracture mechanics | Microstructural effects on fracture | Microstructural effects on fracture | Toughening mechanisms | Toughening mechanisms | Crack growth resistance | Crack growth resistance | creep fracture | creep fracture | Interface fracture mechanics | Interface fracture mechanics | Fatigue damage | Fatigue damage | dislocation substructures | dislocation substructures | Variable amplitude fatigue | Variable amplitude fatigue | Corrosion fatigue | Corrosion fatigue | experimental methods | experimental methods | microstructural effects | microstructural effects | metals | metals | ceramics | ceramics | polymers | polymers | thin films | thin films | biological materials | biological materials | composites | composites | single crystals | single crystals | stress-life | stress-life | strain-life | strain-life | structural components | structural components | bioimplant components | bioimplant components | microelectronic components | microelectronic components | case studies | case studies

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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3.37 Welding and Joining Processes (MIT) 3.37 Welding and Joining Processes (MIT)

Description

Discusses a wide variety of processes and materials from the viewpoint of their fundamental physical and chemical properties. Specific topics: cold welding, adhesive bonding, diffusion bonding, soldering, brazing, flames, arcs, high-energy density heat sources, solidification, cracking resistance, shielding methods, and electric contacts. Emphasis on underlying science of a given process rather than a detailed description of the technique or equipment. This course meets with the first half of 3.371J in the Fall Term. Discusses a wide variety of processes and materials from the viewpoint of their fundamental physical and chemical properties. Specific topics: cold welding, adhesive bonding, diffusion bonding, soldering, brazing, flames, arcs, high-energy density heat sources, solidification, cracking resistance, shielding methods, and electric contacts. Emphasis on underlying science of a given process rather than a detailed description of the technique or equipment. This course meets with the first half of 3.371J in the Fall Term.

Subjects

cold welding | cold welding | adhesive bonding | adhesive bonding | diffusion bonding | diffusion bonding | soldering | soldering | brazing | brazing | flames | flames | arcs | arcs | high-energy density heat sources | high-energy density heat sources | solidification | solidification | cracking resistance | cracking resistance | shielding methods | shielding methods | electric contacts | electric contacts

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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5.36 Biochemistry Laboratory (MIT) 5.36 Biochemistry Laboratory (MIT)

Description

The course, which spans two thirds of a semester, provides students with a research-inspired laboratory experience that introduces standard biochemical techniques in the context of investigating a current and exciting research topic, acquired resistance to the cancer drug Gleevec. Techniques include protein expression, purification, and gel analysis, PCR, site-directed mutagenesis, kinase activity assays, and protein structure viewing. This class is part of the new laboratory curriculum in the MIT Department of Chemistry. Undergraduate Research-Inspired Experimental Chemistry Alternatives (URIECA) introduces students to cutting edge research topics in a modular format. Acknowledgments Development of this course was funded through an HHMI Professors grant to Professor Catherine L. Drennan. The course, which spans two thirds of a semester, provides students with a research-inspired laboratory experience that introduces standard biochemical techniques in the context of investigating a current and exciting research topic, acquired resistance to the cancer drug Gleevec. Techniques include protein expression, purification, and gel analysis, PCR, site-directed mutagenesis, kinase activity assays, and protein structure viewing. This class is part of the new laboratory curriculum in the MIT Department of Chemistry. Undergraduate Research-Inspired Experimental Chemistry Alternatives (URIECA) introduces students to cutting edge research topics in a modular format. Acknowledgments Development of this course was funded through an HHMI Professors grant to Professor Catherine L. Drennan.

Subjects

URIECA | URIECA | laboratory | laboratory | kinase | kinase | cancer cells | cancer cells | laboratory techniques | laboratory techniques | DNA | DNA | cultures | cultures | UV-Vis | UV-Vis | agarose gel | agarose gel | Abl-gleevec | Abl-gleevec | affinity tags | affinity tags | lyse | lyse | digest | digest | mutants | mutants | resistance | resistance | gel electrophoresis | gel electrophoresis | recombinant | recombinant | nickel affinity | nickel affinity | inhibitors | inhibitors | biochemistry | biochemistry | kinetics | kinetics | enzyme | enzyme | inhibition | inhibition | purification | purification | expression | expression

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.343 The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Disease (MIT) 7.343 The Radical Consequences of Respiration: Reactive Oxygen Species in Aging and Disease (MIT)

Description

This course will start with a survey of basic oxygen radical biochemistry followed by a discussion of the mechanisms of action of cellular as well as dietary antioxidants. After considering the normal physiological roles of oxidants, we will examine the effects of elevated ROS and a failure of cellular redox capacity on the rate of organismal and cellular aging as well as on the onset and progression of several major diseases that are often age-related. Topics will include ROS-induced effects on stem cell regeneration, insulin resistance, heart disease, neurodegenerative disorders, and cancer. The role of antioxidants in potential therapeutic strategies for modulating ROS levels will also be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology D This course will start with a survey of basic oxygen radical biochemistry followed by a discussion of the mechanisms of action of cellular as well as dietary antioxidants. After considering the normal physiological roles of oxidants, we will examine the effects of elevated ROS and a failure of cellular redox capacity on the rate of organismal and cellular aging as well as on the onset and progression of several major diseases that are often age-related. Topics will include ROS-induced effects on stem cell regeneration, insulin resistance, heart disease, neurodegenerative disorders, and cancer. The role of antioxidants in potential therapeutic strategies for modulating ROS levels will also be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology D

Subjects

reactive oxygen species | reactive oxygen species | oxygen | oxygen | ROS | ROS | energy | energy | mitochondria | mitochondria | cell signaling | cell signaling | anti-pathogen | anti-pathogen | oxidative damage | oxidative damage | oncogene | oncogene | antioxidant | antioxidant | insulin resistance | insulin resistance | diabetes | diabetes | stem cell | stem cell | neurodegenerative | neurodegenerative | ischemic | ischemic | ATP | ATP | pathways | pathways | NADPH | NADPH | nox | nox | psd | psd | programmed cell death | programmed cell death | apoptosis | apoptosis | hsc | hsc | hematopoietic | hematopoietic

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.344 Antibiotics, Toxins, and Protein Engineering (MIT) 7.344 Antibiotics, Toxins, and Protein Engineering (MIT)

Description

The lethal poison Ricin (best known as a weapon of bioterrorism), Diphtheria toxin (the causative agent of a highly contagious bacterial disease), and the widely used antibiotic tetracycline have one thing in common: They specifically target the cell's translational apparatus and disrupt protein synthesis. In this course, we will explore the mechanisms of action of toxins and antibiotics, their roles in everyday medicine, and the emergence and spread of drug resistance. We will also discuss the identification of new drug targets and how we can manipulate the protein synthesis machinery to provide powerful tools for protein engineering and potential new treatments for patients with devastating diseases, such as cystic fibrosis and muscular dystrophy. This course is one of many Advanced Und The lethal poison Ricin (best known as a weapon of bioterrorism), Diphtheria toxin (the causative agent of a highly contagious bacterial disease), and the widely used antibiotic tetracycline have one thing in common: They specifically target the cell's translational apparatus and disrupt protein synthesis. In this course, we will explore the mechanisms of action of toxins and antibiotics, their roles in everyday medicine, and the emergence and spread of drug resistance. We will also discuss the identification of new drug targets and how we can manipulate the protein synthesis machinery to provide powerful tools for protein engineering and potential new treatments for patients with devastating diseases, such as cystic fibrosis and muscular dystrophy. This course is one of many Advanced Und

Subjects

lethal poison | lethal poison | Ricin | Ricin | Diphtheria | Diphtheria | contagious bacterial disease | contagious bacterial disease | tetracycline | tetracycline | protein synthesis | protein synthesis | drug resistance | drug resistance | protein engineering | protein engineering | cystic fibrosis | cystic fibrosis | muscular dystrophy | muscular dystrophy | ribosome | ribosome | ribosomal proteins | ribosomal proteins | rRNA | rRNA | mRNA | mRNA | tRNA | tRNA | translation factors | translation factors | genetic code | genetic code | E. coli ribosome | E. coli ribosome | prokaryotes | prokaryotes | eukaryotes | eukaryotes | Shiga | Shiga | Diphtheria toxin | Diphtheria toxin | Pseudomonas exotoxin A | Pseudomonas exotoxin A | Chloramphenicol | Chloramphenicol | Aminoglycoside | Aminoglycoside

License

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7.342 Cancer Biology: From Basic Research to the Clinic (MIT) 7.342 Cancer Biology: From Basic Research to the Clinic (MIT)

Description

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. In 1971, President Nixon declared the "War on Cancer," but after three decades the war is still raging. How much progress have we made toward winning the war and what are we doing to improve the fight? Understanding the molecular and cellular events involved in tumor formation, progression, and metastasis is crucial to the development of innovative therapy for cancer patients. Insights into these processes have been gleaned through basic research using biochemical, molecular, and genetic ana This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. In 1971, President Nixon declared the "War on Cancer," but after three decades the war is still raging. How much progress have we made toward winning the war and what are we doing to improve the fight? Understanding the molecular and cellular events involved in tumor formation, progression, and metastasis is crucial to the development of innovative therapy for cancer patients. Insights into these processes have been gleaned through basic research using biochemical, molecular, and genetic ana

Subjects

cancer | cancer | tumor | tumor | metastasis | metastasis | genetic analysis | genetic analysis | cancer biology | cancer biology | model organisms | model organisms | genetic pathways | genetic pathways | uncontrolled growth | uncontrolled growth | tumor suppressor genes | tumor suppressor genes | oncogenes | oncogenes | tumor initiation | tumor initiation | cell cycle | cell cycle | chromosomal aberration | chromosomal aberration | apoptosis | apoptosis | cell death | cell death | signal transduction pathways | signal transduction pathways | proto-oncogene | proto-oncogene | mutation | mutation | DNA mismatch repair | DNA mismatch repair | telomeres | telomeres | mouse models | mouse models | tissue specificity | tissue specificity | malignancy | malignancy | stem cells | stem cells | therapeutic resistance | therapeutic resistance | differentiation | differentiation | caner research | caner research | cancer therapeutics | cancer therapeutics | chemotherapy | chemotherapy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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21A.245J Power: Interpersonal, Organizational and Global Dimensions (MIT) 21A.245J Power: Interpersonal, Organizational and Global Dimensions (MIT)

Description

Using examples from anthropology and sociology alongside classical and contemporary social theory, this course explores the nature of dominant and subordinate relationships, types of legitimate authority, and practices of resistance. The course also examines how we are influenced in subtle ways by the people around us, who makes controlling decisions in the family, how people get ahead at work, and whether democracies, in fact, reflect the "will of the people." Using examples from anthropology and sociology alongside classical and contemporary social theory, this course explores the nature of dominant and subordinate relationships, types of legitimate authority, and practices of resistance. The course also examines how we are influenced in subtle ways by the people around us, who makes controlling decisions in the family, how people get ahead at work, and whether democracies, in fact, reflect the "will of the people."

Subjects

21A.245 | 21A.245 | 17.045 | 17.045 | Anthropology | Anthropology | power | power | interpersonal | interpersonal | organizational | organizational | global | global | dimensions | dimensions | sociology classical | sociology classical | contemporary | contemporary | social theory | social theory | dominant | dominant | subordinate | subordinate | relationships | relationships | legitimate authority | legitimate authority | resistance | resistance | control | control | decisions | decisions | family | family | work | work | democracies | democracies | will | will | people | people

License

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21L.715 Media in Cultural Context: Popular Readerships (MIT) 21L.715 Media in Cultural Context: Popular Readerships (MIT)

Description

What is the history of popular reading in the Western world? How does widespread access to print relate to distinctions between highbrow and lowbrow culture, between good taste and bad judgment, and between men and women readers? This course will introduce students to the broad history of popular reading and to controversies about taste and gender that have characterized its development. Our grounding in historical material will help make sense of our main focus: recent developments in the theory and practice of reading, including fan-fiction, Oprah's book club, comics, hypertext, mass-market romance fiction, mega-chain bookstores, and reader response theory. What is the history of popular reading in the Western world? How does widespread access to print relate to distinctions between highbrow and lowbrow culture, between good taste and bad judgment, and between men and women readers? This course will introduce students to the broad history of popular reading and to controversies about taste and gender that have characterized its development. Our grounding in historical material will help make sense of our main focus: recent developments in the theory and practice of reading, including fan-fiction, Oprah's book club, comics, hypertext, mass-market romance fiction, mega-chain bookstores, and reader response theory.

Subjects

popular reading | popular reading | highbrow culture | highbrow culture | lowbrow culture | lowbrow culture | gender | gender | taste | taste | theory and practice of reading | theory and practice of reading | fanfiction | fanfiction | fandom | fandom | Oprah | Oprah | comics | comics | hypertext | hypertext | mass-market romance fiction | mass-market romance fiction | mega-chain bookstore | mega-chain bookstore | reader response theory | reader response theory | Harry Potter | Harry Potter | sociology and history of reading | sociology and history of reading | resistance | resistance | rare books | rare books | fads | fads | social engineering | social engineering | bestseller | bestseller

License

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TALAT Lecture 2204: Design Philosophy

Description

This lecture outlines the requirements on load bearing structures with respect to safety against failure; it introduces the design analysis process with methods of verification and partial safety factors; it describes the characteristic of loads and load combinations on structures; it introduces the subject of load and resistance factors in the verification methods; it describes the basic structural design properties of aluminium alloys versus steel. Some background and experience in structural engineering and design calculations; basic understanding of the physical and mechanical properties of aluminium is assumed.

Subjects

aluminium | aluminum | european aluminium association | EAA | Training in Aluminium Application Technologies | training | metallurgy | technology | lecture | design | product | structural design | load carrying structure | safety | serviceability | limit states | economic considerations | verification | load and resistance design factor method | method of allowable stresses | characteristic loads | normal loads | long-term loads | load combinations | design value of the load | buildings | bridges | hydraulic structures | resistance | strength properties | corematerials | ukoer

License

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TALAT Lecture 2301: Design of Members

Description

This lecture gives background to calculation methods for aluminium members in order to understand the specific behavior of statically loaded aluminium alloy structures. Basic structural mechanic, design philosophy and structural aluminium alloys and product forms is assumed.

Subjects

aluminium | aluminum | european aluminium association | EAA | Training in Aluminium Application Technologies | training | metallurgy | technology | lecture | design | product | member | joint | static | safety | serviceability | geometrical imperfections | extruded profiles | welded profiles | residual stresses | mechanical properties | Bauschinger effect | heat affected zones | stress-strain relationship | strength | reduced strength | partial coefficients | resistance factors | gross section | net section | local buckling | cross section classes | slender plates | effective cross section | class 4 cross sections | deflections of beams | breathing | bending moment | yielding | slenderness parameter | element classification | effective thickness | welded section | section with holes | lateral torsional buckling | axial force | tensile force | compressive force | Euler load | squash load | flexural buckling | reduction factor | buckling length | splices | end connections | welded columns | columns with bolt holes | cut-outs | longitudinal welds | transverse welds | columns with unfilled bolt-holes | built-up members | intermediate stiffeners | edge stiffeners | single-sided rib | multi-stiffened plates | orthotropic plates | shear force | plate girder webs | shear buckling | shear resistance | webs with stiffeners | plate girders with intermediate stiffeners | corrugated webs | closely stiffened webs | concentrated loads | beam webs without stiffeners | beam webs with stiffeners | shear centre | closed sections | open sections | torsion without warping | torsion with warpin | bending and axial tension | bending and axial compression | strength of beam-column segments | rectangular section | strain hardening | plastic theory | I-section | H-section | thin walled cross sections | T-section | biaxial bending | linear stress distribution | shear lag | flange curling | lateral deflection | non-symmetrical flanges | corematerials | ukoer

License

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TALAT Lecture 2501: Fire Protection and Regulation

Description

This lecture helps to understand the characteristics of fire, the conditions for its occurrence and development; it introduces definition and terms of fire resistance and protection. General engineering or physics background is assumed.

Subjects

aluminium | aluminum | european aluminium association | EAA | Training in Aluminium Application Technologies | training | metallurgy | technology | lecture | design | fire resistance | fire technology | spread of fire | smoke gases | fire gases | fire resistance tests | fire protection | passive fire protection | active fire protection | building regulations | corematerials | ukoer

License

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