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20.320 Biomolecular Kinetics and Cell Dynamics (MIT) 20.320 Biomolecular Kinetics and Cell Dynamics (MIT)

Description

This class covers analysis of kinetics and dynamics of molecular and cellular processes across a hierarchy of scales, including intracellular, extracellular, and cell population levels; a spectrum of biotechnology applications are also taken into consideration. Topics include gene regulation networks; nucleic acid hybridization; signal transduction pathways; and cell populations in tissues and bioreactors. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling. This class covers analysis of kinetics and dynamics of molecular and cellular processes across a hierarchy of scales, including intracellular, extracellular, and cell population levels; a spectrum of biotechnology applications are also taken into consideration. Topics include gene regulation networks; nucleic acid hybridization; signal transduction pathways; and cell populations in tissues and bioreactors. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

Subjects

kinetics of molecular processes | kinetics of molecular processes | dynamics of molecular processes | dynamics of molecular processes | kinetics of cellular processes | kinetics of cellular processes | dynamics of cellular processes | dynamics of cellular processes | intracellular scale | intracellular scale | extracellular scale | extracellular scale | and cell population scale | and cell population scale | biotechnology applications | biotechnology applications | gene regulation networks | gene regulation networks | nucleic acid hybridization | nucleic acid hybridization | signal transduction pathways | signal transduction pathways | cell populations in tissues | cell populations in tissues | cell populations in bioreactors | cell populations in bioreactors | experimental methods | experimental methods | quantitative analysis | quantitative analysis | computational modeling | computational modeling | cell population scale | cell population scale

License

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20.320 Analysis of Biomolecular and Cellular Systems (MIT) 20.320 Analysis of Biomolecular and Cellular Systems (MIT)

Description

This course focuses on computational and experimental analysis of biological systems across a hierarchy of scales, including genetic, molecular, cellular, and cell population levels. The two central themes of the course are modeling of complex dynamic systems and protein design and engineering. Topics include gene sequence analysis, molecular modeling, metabolic and gene regulation networks, signal transduction pathways and cell populations in tissues. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling. This course focuses on computational and experimental analysis of biological systems across a hierarchy of scales, including genetic, molecular, cellular, and cell population levels. The two central themes of the course are modeling of complex dynamic systems and protein design and engineering. Topics include gene sequence analysis, molecular modeling, metabolic and gene regulation networks, signal transduction pathways and cell populations in tissues. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

Subjects

biological engineering | biological engineering | kinase | kinase | PyMOL | PyMOL | PyRosetta | PyRosetta | MATLAB | MATLAB | Michaelis-Menten | Michaelis-Menten | bioreactor | bioreactor | bromodomain | bromodomain | protein-ligand interactions | protein-ligand interactions | titration analysis | titration analysis | fractional separation | fractional separation | isothermal titration calorimetry | isothermal titration calorimetry | ITC | ITC | mass spectrometry | mass spectrometry | MS | MS | co-immunoprecipitation | co-immunoprecipitation | Co-IP | Co-IP | Forster resonance energy transfer | Forster resonance energy transfer | FRET | FRET | primary ligation assay | primary ligation assay | PLA | PLA | surface plasmon resonance | surface plasmon resonance | SPR | SPR | enzyme kinetics | enzyme kinetics | kinase engineering | kinase engineering | competitive inhibition | competitive inhibition | epidermal growth factor receptor | epidermal growth factor receptor | mitogen-activated protein kinase | mitogen-activated protein kinase | MAPK | MAPK | genome editing | genome editing | Imatinib | Imatinib | Gleevec | Gleevec | Glivec | Glivec | drug delivery | drug delivery | kinetics of molecular processes | kinetics of molecular processes | dynamics of molecular processes | dynamics of molecular processes | kinetics of cellular processes | kinetics of cellular processes | dynamics of cellular processes | dynamics of cellular processes | intracellular scale | intracellular scale | extracellular scale | extracellular scale | and cell population scale | and cell population scale | biotechnology applications | biotechnology applications | gene regulation networks | gene regulation networks | nucleic acid hybridization | nucleic acid hybridization | signal transduction pathways | signal transduction pathways | cell populations in tissues | cell populations in tissues | cell populations in bioreactors | cell populations in bioreactors | experimental methods | experimental methods | quantitative analysis | quantitative analysis | computational modeling | computational modeling

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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11.701 Introduction to Planning and Institutional Processes in Developing Countries (MIT) 11.701 Introduction to Planning and Institutional Processes in Developing Countries (MIT)

Description

This introductory course is structured to cultivate the key sensibilities necessary for effective planning practice in newly industrializing countries. The word "sensibility" refers to an awareness of key developmental issues, interdependent causalities, and anticipated as well as unanticipated consequences of social action which mark most planning efforts. In cultivating such sensibilities, this course will use examples from varying institutional settings, ranging from the local to the international levels, and probe how the particularities of each setting call for an awareness of particular institutional opportunities and constraints that planners need to account for when devising planning strategies. This introductory course is structured to cultivate the key sensibilities necessary for effective planning practice in newly industrializing countries. The word "sensibility" refers to an awareness of key developmental issues, interdependent causalities, and anticipated as well as unanticipated consequences of social action which mark most planning efforts. In cultivating such sensibilities, this course will use examples from varying institutional settings, ranging from the local to the international levels, and probe how the particularities of each setting call for an awareness of particular institutional opportunities and constraints that planners need to account for when devising planning strategies.

Subjects

developing-country governments | developing-country governments | international organizations | international organizations | NGOs | NGOs | economies of scale | economies of scale | diseconomies of scale | diseconomies of scale | international development planning | international development planning | externality | externality | historical advances in developing and developing countries | historical advances in developing and developing countries | interaction between planners and institutions | interaction between planners and institutions | decentralization | decentralization | provision of low-cost housing | provision of low-cost housing | new-town development | new-town development | progress | progress | anti-planning arguments | anti-planning arguments | state-centered planning | state-centered planning | social control | social control | bureaucracies | bureaucracies | good governance | good governance | market institutions | market institutions | collective action | collective action | decision making | decision making | political savvy | political savvy | legal sensibility | legal sensibility

License

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11.701 Introduction to Planning and Institutional Processes in Developing Countries (MIT) 11.701 Introduction to Planning and Institutional Processes in Developing Countries (MIT)

Description

This introductory course is structured to cultivate the key sensibilities necessary for effective planning practice in newly industrializing countries. The word "sensibility" refers to an awareness of key developmental issues, interdependent causalities, and anticipated as well as unanticipated consequences of social action which mark most planning efforts. In cultivating such sensibilities, this course will use examples from varying institutional settings, ranging from the local to the international levels, and probe how the particularities of each setting call for an awareness of particular institutional opportunities and constraints that planners need to account for when devising planning strategies. This introductory course is structured to cultivate the key sensibilities necessary for effective planning practice in newly industrializing countries. The word "sensibility" refers to an awareness of key developmental issues, interdependent causalities, and anticipated as well as unanticipated consequences of social action which mark most planning efforts. In cultivating such sensibilities, this course will use examples from varying institutional settings, ranging from the local to the international levels, and probe how the particularities of each setting call for an awareness of particular institutional opportunities and constraints that planners need to account for when devising planning strategies.

Subjects

developing-country governments | developing-country governments | international organizations | international organizations | NGOs | NGOs | economies of scale | economies of scale | diseconomies of scale | diseconomies of scale | international development planning | international development planning | externality | externality | historical advances in developing and developing countries | historical advances in developing and developing countries | interaction between planners and institutions | interaction between planners and institutions | decentralization | provision of low-cost housing | new-town development | decentralization | provision of low-cost housing | new-town development | progress | progress | anti-planning arguments | anti-planning arguments | state-centered planning | state-centered planning | social control | social control | bureaucracies | bureaucracies | good governance | good governance | market institutions | market institutions | collective action | collective action | decision making | decision making | political savvy | political savvy | legal sensibility | legal sensibility

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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1.978 From Nano to Macro: Introduction to Atomistic Modeling Techniques (MIT) 1.978 From Nano to Macro: Introduction to Atomistic Modeling Techniques (MIT)

Description

The objective of this course is to introduce large-scale atomistic modeling techniques and highlight its importance for solving problems in modern engineering sciences. We demonstrate how atomistic modeling can be used to understand how materials fail under extreme loading, involving unfolding of proteins and propagation of cracks. This course was featured in an MIT Tech Talk article. The objective of this course is to introduce large-scale atomistic modeling techniques and highlight its importance for solving problems in modern engineering sciences. We demonstrate how atomistic modeling can be used to understand how materials fail under extreme loading, involving unfolding of proteins and propagation of cracks. This course was featured in an MIT Tech Talk article.

Subjects

large-scale atomistic | large-scale atomistic | large-scale atomistic modeling techniques | large-scale atomistic modeling techniques | modern engineering sciences | modern engineering sciences | atomistic modeling | atomistic modeling | extreme loading | extreme loading | ductile and brittle materials failure | ductile and brittle materials failure | molecular dynamics | molecular dynamics | simulations | simulations | Cauchy-Born rule | Cauchy-Born rule | biomechanics | biomechanics | biomaterials | biomaterials | copper nanocrystal | copper nanocrystal | nanomechanics | nanomechanics | material mechanics | material mechanics

License

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2.76 Multi-Scale System Design (MIT) 2.76 Multi-Scale System Design (MIT)

Description

Multi-scale systems (MuSS) consist of components from two or more length scales (nano, micro, meso, or macro-scales). In MuSS, the engineering modeling, design principles, and fabrication processes of the components are fundamentally different. The challenge is to make these components so they are conceptually and model-wise compatible with other-scale components with which they interface. This course covers the fundamental properties of scales, design theories, modeling methods and manufacturing issues which must be addressed in these systems. Examples of MuSS include precision instruments, nanomanipulators, fiber optics, micro/nano-photonics, nanorobotics, MEMS (piezoelectric driven manipulators and optics), X-Ray telescopes and carbon nano-tube assemblies. Students master the materials Multi-scale systems (MuSS) consist of components from two or more length scales (nano, micro, meso, or macro-scales). In MuSS, the engineering modeling, design principles, and fabrication processes of the components are fundamentally different. The challenge is to make these components so they are conceptually and model-wise compatible with other-scale components with which they interface. This course covers the fundamental properties of scales, design theories, modeling methods and manufacturing issues which must be addressed in these systems. Examples of MuSS include precision instruments, nanomanipulators, fiber optics, micro/nano-photonics, nanorobotics, MEMS (piezoelectric driven manipulators and optics), X-Ray telescopes and carbon nano-tube assemblies. Students master the materials

Subjects

scale | scale | complexity | complexity | nano | micro | meso | or macro-scale | nano | micro | meso | or macro-scale | kinematics | kinematics | metrology | metrology | engineering modeling | motion | engineering modeling | motion | modeling | modeling | design | design | manufacture | manufacture | design principles | design principles | fabrication process | fabrication process | functional requirements | functional requirements | precision instruments | precision instruments | nanomanipulators | fiber optics | micro- photonics | nano-photonics | nanorobotics | MEMS | nanomanipulators | fiber optics | micro- photonics | nano-photonics | nanorobotics | MEMS | piezoelectric | transducer | actuator | sensor | piezoelectric | transducer | actuator | sensor | constraint | rigid constraint | flexible constraint | ride-flexible constraint | constraint | rigid constraint | flexible constraint | ride-flexible constraint | constaint-based design | constaint-based design | carbon nanotube | carbon nanotube | nanowire | nanowire | scanning tunneling microscope | scanning tunneling microscope | flexure | flexure | protein structure | protein structure | polymer structure | polymer structure | nanopelleting | nanopipette | nanowire | nanopelleting | nanopipette | nanowire | TMA pixel array | TMA pixel array | error modeling | error modeling | repeatability | repeatability

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Institutional Processes in Developing Countries (MIT) Institutional Processes in Developing Countries (MIT)

Description

This introductory course helps students learn to pose questions and analyze problems in the field of planning in developing countries. Not arguing for one "right" approach, the course draws on grounded empirical experiences - historical and recent - to help students navigate the way they approach their future work in developing-country governments, NGOs and international organizations. This introductory course helps students learn to pose questions and analyze problems in the field of planning in developing countries. Not arguing for one "right" approach, the course draws on grounded empirical experiences - historical and recent - to help students navigate the way they approach their future work in developing-country governments, NGOs and international organizations.

Subjects

developing--country governments | developing--country governments | international | international | international organizations | international organizations | NGOs | NGOs | economies of scale | economies of scale | diseconomies of scale | diseconomies of scale | international development planning | international development planning | externality | externality | historical advances in developing and developing countries | historical advances in developing and developing countries | interaction between planners and institutions | interaction between planners and institutions | ecentralization | provision of low-cost housing | ecentralization | provision of low-cost housing | new--town development | new--town development | decentralization | decentralization | provision of low--cost housing | provision of low--cost housing | developing countries | developing countries | national planning | national planning | planners | planners | government institutions | government institutions | national government | national government | local government | local government | low-cost housing | low-cost housing | new-town development | new-town development | reform | reform | politics | politics | patronage | patronage | clientelism | clientelism | corruption | corruption | civil servants | civil servants | service-delivery organizations | service-delivery organizations | public vs. private | public vs. private

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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12.333 Atmospheric and Ocean Circulations (MIT) 12.333 Atmospheric and Ocean Circulations (MIT)

Description

In this course, we will look at many important aspects of the circulation of the atmosphere and ocean, from length scales of meters to thousands of km and time scales ranging from seconds to years. We will assume familiarity with concepts covered in course 12.003 (Physics of the Fluid Earth). In the early stages of the present course, we will make somewhat greater use of math than did 12.003, but the math we will use is no more than that encountered in elementary electromagnetic field theory, for example. The focus of the course is on the physics of the phenomena which we will discuss. In this course, we will look at many important aspects of the circulation of the atmosphere and ocean, from length scales of meters to thousands of km and time scales ranging from seconds to years. We will assume familiarity with concepts covered in course 12.003 (Physics of the Fluid Earth). In the early stages of the present course, we will make somewhat greater use of math than did 12.003, but the math we will use is no more than that encountered in elementary electromagnetic field theory, for example. The focus of the course is on the physics of the phenomena which we will discuss.

Subjects

atmospheric and oceanic phenomena | atmospheric and oceanic phenomena | observations | observations | theoretical interpretations | theoretical interpretations | monsoons | monsoons | El Ni?o | El Ni?o | planetary waves | planetary waves | atmospheric synoptic eddies and fronts | atmospheric synoptic eddies and fronts | gulf stream rings | gulf stream rings | hurricanes | hurricanes | surface and internal gravity waves | surface and internal gravity waves | tides | tides | shallow water gravity waves | shallow water gravity waves | deep water gravity waves | deep water gravity waves | internal gravity waves | internal gravity waves | large-scale motions | large-scale motions | rotating earth | rotating earth | Rossby waves | Rossby waves | planetary scale motions | planetary scale motions | baroclinic instability | baroclinic instability | midlatitude storms | midlatitude storms | equatorial atmosphere | equatorial atmosphere | equatorial ocean | equatorial ocean | southern oscillation | southern oscillation | tropical cyclones | tropical cyclones | typhoons | typhoons

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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14.01 Principles of Microeconomics (MIT) 14.01 Principles of Microeconomics (MIT)

Description

This introductory course teaches the fundamentals of microeconomics. Topics include consumer theory, producer theory, the behavior of firms, market equilibrium, monopoly, and the role of the government in the economy. 14.01 is a Humanities, Arts, and Social Sciences (HASS) elective and is offered both terms. This course is a core subject in MIT's undergraduate Energy Studies Minor. This Institute-wide program complements the deep expertise obtained in any major with a broad understanding of the interlinked realms of science, technology, and social sciences as they relate to energy and associated environmental challenges. This introductory course teaches the fundamentals of microeconomics. Topics include consumer theory, producer theory, the behavior of firms, market equilibrium, monopoly, and the role of the government in the economy. 14.01 is a Humanities, Arts, and Social Sciences (HASS) elective and is offered both terms. This course is a core subject in MIT's undergraduate Energy Studies Minor. This Institute-wide program complements the deep expertise obtained in any major with a broad understanding of the interlinked realms of science, technology, and social sciences as they relate to energy and associated environmental challenges.

Subjects

market | market | optimization | optimization | allocation | allocation | economic measurement | economic measurement | analysis | analysis | microeconomics | microeconomics | demand | demand | supply | supply | equilibrium | equilibrium | general equilibrium | general equilibrium | government interventions | government interventions | price elasticity of demand | price elasticity of demand | income elasticity of demand | income elasticity of demand | cross price elasticity of demand | cross price elasticity of demand | price elasticity of supply | price elasticity of supply | consumer behavior | consumer behavior | consumer preference | consumer preference | utility functions | utility functions | marginal rate of substitution | marginal rate of substitution | budget constraints | budget constraints | interior solutions | interior solutions | corner solutions | corner solutions | Engle curves | Engle curves | individual demand | individual demand | market demand | market demand | revealed preferences | revealed preferences | substitution effect | substitution effect | income effect | income effect | Giffen goods | Giffen goods | consumer surplus | consumer surplus | Irish potato famine | Irish potato famine | network externalities | network externalities | uncertainty | uncertainty | preference toward risk | preference toward risk | risk premium | risk premium | indifference curves | indifference curves | diversification | diversification | insurance | insurance | producer theory | producer theory | production functions | production functions | short run | short run | long run | long run | returns to scale | returns to scale | cost functions | cost functions | economies of scale | economies of scale | economies of scope | economies of scope | learning | learning | profit maximization | profit maximization | producer surplus | producer surplus | agricultural price support | agricultural price support | tax | tax | subsidy | subsidy | exchange economy | exchange economy | contract curves | contract curves | utility possibilities frontier | utility possibilities frontier | Edgeworth Box | Edgeworth Box | production possibilities frontier | production possibilities frontier | efficiency | efficiency | monopoly | monopoly | multiplant firm | multiplant firm | social cost | social cost | price regulation | price regulation | monopsony | monopsony | price discrimination | price discrimination | peak-load pricing | peak-load pricing | two-part tariffs | two-part tariffs | bundling | bundling | monopolistic competition | monopolistic competition | game theory | game theory | oligopoly | oligopoly | Cournot | Cournot | Stackelberg | Stackelberg | Bertrand | Bertrand | Prisoner's Dilemma | Prisoner's Dilemma

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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20.320 Biomolecular Kinetics and Cell Dynamics (MIT)

Description

This class covers analysis of kinetics and dynamics of molecular and cellular processes across a hierarchy of scales, including intracellular, extracellular, and cell population levels; a spectrum of biotechnology applications are also taken into consideration. Topics include gene regulation networks; nucleic acid hybridization; signal transduction pathways; and cell populations in tissues and bioreactors. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

Subjects

kinetics of molecular processes | dynamics of molecular processes | kinetics of cellular processes | dynamics of cellular processes | intracellular scale | extracellular scale | and cell population scale | biotechnology applications | gene regulation networks | nucleic acid hybridization | signal transduction pathways | cell populations in tissues | cell populations in bioreactors | experimental methods | quantitative analysis | computational modeling | cell population scale

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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21H.560 Smashing the Iron Rice Bowl: Chinese East Asia (MIT) 21H.560 Smashing the Iron Rice Bowl: Chinese East Asia (MIT)

Description

This subject examines the experiences of ordinary Chinese people as they lived through the tumultuous changes of the nineteenth and twentieth centuries. We look at personal narratives, primary sources, films alongside a textbook to think about how individual and family lives connect with the broader processes of change in modern China. In the readings and discussions, you should focus on how major political events have an impact on the characters' daily lives, and how the decisions they make cause large-scale social transformation. This subject examines the experiences of ordinary Chinese people as they lived through the tumultuous changes of the nineteenth and twentieth centuries. We look at personal narratives, primary sources, films alongside a textbook to think about how individual and family lives connect with the broader processes of change in modern China. In the readings and discussions, you should focus on how major political events have an impact on the characters' daily lives, and how the decisions they make cause large-scale social transformation.

Subjects

China; rice; bowl; Chinese; East Asia; ordinary people; nineteenth century; twentieth century; personal narratives; primary sources; films; textbook; individual; family; lives; change; modern; readings; discussions; political events; daily; decisions; large-scale; social; transformation. | China; rice; bowl; Chinese; East Asia; ordinary people; nineteenth century; twentieth century; personal narratives; primary sources; films; textbook; individual; family; lives; change; modern; readings; discussions; political events; daily; decisions; large-scale; social; transformation. | China | China | rice | rice | bowl | bowl | Chinese | Chinese | East Asia | East Asia | ordinary people | ordinary people | nineteenth century | nineteenth century | twentieth century | twentieth century | personal narratives | personal narratives | primary sources | primary sources | films | films | textbook | textbook | individual | individual | family | family | lives | lives | change | change | modern | modern | readings | readings | discussions | discussions | political events | political events | daily | daily | decisions | decisions | large-scale | large-scale | social | social | transformation | transformation | 21F.191 | 21F.191 | 21F.991 | 21F.991

License

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11.701 Introduction to International Development Planning (MIT) 11.701 Introduction to International Development Planning (MIT)

Description

This introductory survey course is intended to develop an understanding of key issues and dilemmas of planning in non-western countries. The topics covered in this course will include state intervention, governance, law and institutions in development, privatization, participatory planning, decentralization, poverty, urban-rural linkages, corruption and civil service reform, trade and outsourcing, labor standards, post-conflict development, and the role of aid in development. The course will illuminate current development challenges through published research in the field. The literature is rich, and across many disciplines in the social sciences. Case studies and real world examples through interaction with planning practitioners are drawn from around the world. This introductory survey course is intended to develop an understanding of key issues and dilemmas of planning in non-western countries. The topics covered in this course will include state intervention, governance, law and institutions in development, privatization, participatory planning, decentralization, poverty, urban-rural linkages, corruption and civil service reform, trade and outsourcing, labor standards, post-conflict development, and the role of aid in development. The course will illuminate current development challenges through published research in the field. The literature is rich, and across many disciplines in the social sciences. Case studies and real world examples through interaction with planning practitioners are drawn from around the world.

Subjects

developing-country governments | developing-country governments | international organizations | international organizations | NGOs | NGOs | economies of scale | economies of scale | diseconomies of scale | diseconomies of scale | international development planning | international development planning | externality | externality | historical advances in developing and developing countries | historical advances in developing and developing countries | interaction between planners and institutions | interaction between planners and institutions | decentralization | provision of low-cost housing | new-town development | decentralization | provision of low-cost housing | new-town development | progress | progress | anti-planning arguments | anti-planning arguments | state-centered planning | state-centered planning | social control | social control | bureaucracies | bureaucracies | good governance | good governance | market institutions | market institutions | collective action | collective action | decision making | decision making | political savvy | political savvy | legal sensibility | legal sensibility

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Town scales, in the market square, Donegal town Town scales, in the market square, Donegal town

Description

Subjects

ireland | ireland | scales | scales | posters | posters | lantern | lantern | slides | slides | donegal | donegal | ulster | ulster | marketsquare | marketsquare | countydonegal | countydonegal | hargrave | hargrave | thediamond | thediamond | markethall | markethall | nationallibraryofireland | nationallibraryofireland | limerickbybeachcomber | limerickbybeachcomber | joshuahhargravecollection | joshuahhargravecollection | joshuahhargrave | joshuahhargrave | joshuaharrisonhargrave | joshuaharrisonhargrave | diamondisatriangle | diamondisatriangle | townscales | townscales | excursionlondonderry | excursionlondonderry | lcraig | lcraig | bakerandconfectioner | bakerandconfectioner | lcraigbakerandconfectioner | lcraigbakerandconfectioner

License

No known copyright restrictions

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20.320 Biomolecular Kinetics and Cell Dynamics (MIT)

Description

This class covers analysis of kinetics and dynamics of molecular and cellular processes across a hierarchy of scales, including intracellular, extracellular, and cell population levels; a spectrum of biotechnology applications are also taken into consideration. Topics include gene regulation networks; nucleic acid hybridization; signal transduction pathways; and cell populations in tissues and bioreactors. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

Subjects

kinetics of molecular processes | dynamics of molecular processes | kinetics of cellular processes | dynamics of cellular processes | intracellular scale | extracellular scale | and cell population scale | biotechnology applications | gene regulation networks | nucleic acid hybridization | signal transduction pathways | cell populations in tissues | cell populations in bioreactors | experimental methods | quantitative analysis | computational modeling | cell population scale

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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20.320 Analysis of Biomolecular and Cellular Systems (MIT)

Description

This course focuses on computational and experimental analysis of biological systems across a hierarchy of scales, including genetic, molecular, cellular, and cell population levels. The two central themes of the course are modeling of complex dynamic systems and protein design and engineering. Topics include gene sequence analysis, molecular modeling, metabolic and gene regulation networks, signal transduction pathways and cell populations in tissues. Emphasis is placed on experimental methods, quantitative analysis, and computational modeling.

Subjects

biological engineering | kinase | PyMOL | PyRosetta | MATLAB | Michaelis-Menten | bioreactor | bromodomain | protein-ligand interactions | titration analysis | fractional separation | isothermal titration calorimetry | ITC | mass spectrometry | MS | co-immunoprecipitation | Co-IP | Forster resonance energy transfer | FRET | primary ligation assay | PLA | surface plasmon resonance | SPR | enzyme kinetics | kinase engineering | competitive inhibition | epidermal growth factor receptor | mitogen-activated protein kinase | MAPK | genome editing | Imatinib | Gleevec | Glivec | drug delivery | kinetics of molecular processes | dynamics of molecular processes | kinetics of cellular processes | dynamics of cellular processes | intracellular scale | extracellular scale | and cell population scale | biotechnology applications | gene regulation networks | nucleic acid hybridization | signal transduction pathways | cell populations in tissues | cell populations in bioreactors | experimental methods | quantitative analysis | computational modeling

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2.57 Nano-to-Macro Transport Processes (MIT) 2.57 Nano-to-Macro Transport Processes (MIT)

Description

This course provides parallel treatments of photons, electrons, phonons, and molecules as energy carriers, aiming at fundamental understanding and descriptive tools for energy and heat transport processes from nanoscale continuously to macroscale. Topics include the energy levels, the statistical behavior and internal energy, energy transport in the forms of waves and particles, scattering and heat generation processes, Boltzmann equation and derivation of classical laws, deviation from classical laws at nanoscale and their appropriate descriptions, with applications in nano- and microtechnology. This course provides parallel treatments of photons, electrons, phonons, and molecules as energy carriers, aiming at fundamental understanding and descriptive tools for energy and heat transport processes from nanoscale continuously to macroscale. Topics include the energy levels, the statistical behavior and internal energy, energy transport in the forms of waves and particles, scattering and heat generation processes, Boltzmann equation and derivation of classical laws, deviation from classical laws at nanoscale and their appropriate descriptions, with applications in nano- and microtechnology.

Subjects

nanotechnology | nanotechnology | nanoscale | nanoscale | transport phenomena | transport phenomena | photons | photons | electrons | electrons | phonons | phonons | energy carriers | energy carriers | energy transport | energy transport | heat transport | heat transport | energy levels | energy levels | statistical behavior | statistical behavior | internal energy | internal energy | waves and particles | waves and particles | scattering | scattering | heat generation | heat generation | Boltzmann equation | Boltzmann equation | classical laws | classical laws | microtechnology | microtechnology | crystal | crystal | lattice | lattice | quantum oscillator | quantum oscillator | laudaurer | laudaurer | nanotube | nanotube | Louiville equation | Louiville equation | X-ray | X-ray | blackbody | blackbody | quantum well | quantum well | Fourier | Fourier | Newton | Newton | Ohm | Ohm | thermoelectric effect | thermoelectric effect | Brownian motion | Brownian motion | surface tension | surface tension | van der Waals potential. | van der Waals potential. | van der Waals potential | van der Waals potential

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ESD.83 Doctoral Seminar in Engineering Systems (MIT) ESD.83 Doctoral Seminar in Engineering Systems (MIT)

Description

In establishing the Engineering Systems Division, MIT has embarked on a bold experiment – bringing together diverse areas of expertise into what is designed to be a new field of study. In many respects, the full scale and scope of Engineering Systems as a field is still emerging. This seminar is simultaneously designed to codify what we presently know and to give direction for future development. In establishing the Engineering Systems Division, MIT has embarked on a bold experiment – bringing together diverse areas of expertise into what is designed to be a new field of study. In many respects, the full scale and scope of Engineering Systems as a field is still emerging. This seminar is simultaneously designed to codify what we presently know and to give direction for future development.

Subjects

engineering systems | engineering systems | complexity | complexity | uncertainty | uncertainty | fragility | fragility | robustness | robustness | systems engineering | systems engineering | systems dynamics | systems dynamics | agent modeling | agent modeling | systems simulations | systems simulations | large-scale systems change | large-scale systems change | modeling paradigms | modeling paradigms | cumulative knowledge | cumulative knowledge | empirical data generation | empirical data generation | boundary setting | boundary setting | network models | network models | policy evaluation | policy evaluation

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1.011 Project Evaluation (MIT) 1.011 Project Evaluation (MIT)

Description

1.011 examines methodologies for evaluating civil engineering projects, which typically are large-scale, long-lived projects involving many economic, financial, social, and environmental factors. Topics covered include: basic techniques of engineering economics including net present value analysis, life-cycle costing, benefit-cost analysis, and other approaches to project evaluation; resource and cost estimation procedures appropriate for large-scale infrastructure systems; and incorporating service quality, risk, environmental impacts, and other factors within the evaluation process. Examples are drawn from building design and construction, transportation systems, urban development, environmental projects, water resource management, and other elements of both the public and private infras 1.011 examines methodologies for evaluating civil engineering projects, which typically are large-scale, long-lived projects involving many economic, financial, social, and environmental factors. Topics covered include: basic techniques of engineering economics including net present value analysis, life-cycle costing, benefit-cost analysis, and other approaches to project evaluation; resource and cost estimation procedures appropriate for large-scale infrastructure systems; and incorporating service quality, risk, environmental impacts, and other factors within the evaluation process. Examples are drawn from building design and construction, transportation systems, urban development, environmental projects, water resource management, and other elements of both the public and private infras

Subjects

civil engineering project | civil engineering project | engineering economics | engineering economics | net present value | net present value | life-cycle costing | life-cycle costing | benefit-cost analysis | benefit-cost analysis | project evaluation | project evaluation | cost estimation | cost estimation | large-scale infrastructure | large-scale infrastructure | building design | building design | construction | construction | transportation systems | transportation systems | urban development | urban development | environmental projects | environmental projects | water resource management | water resource management

License

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3.021J Introduction to Modeling and Simulation (MIT) 3.021J Introduction to Modeling and Simulation (MIT)

Description

This course explores the basic concepts of computer modeling and simulation in science and engineering. We'll use techniques and software for simulation, data analysis and visualization. Continuum, mesoscale, atomistic and quantum methods are used to study fundamental and applied problems in physics, chemistry, materials science, mechanics, engineering, and biology. Examples drawn from the disciplines above are used to understand or characterize complex structures and materials, and complement experimental observations. This course explores the basic concepts of computer modeling and simulation in science and engineering. We'll use techniques and software for simulation, data analysis and visualization. Continuum, mesoscale, atomistic and quantum methods are used to study fundamental and applied problems in physics, chemistry, materials science, mechanics, engineering, and biology. Examples drawn from the disciplines above are used to understand or characterize complex structures and materials, and complement experimental observations.

Subjects

computer modeling | computer modeling | discrete particle system | discrete particle system | continuum | continuum | continuum field | continuum field | statistical sampling | statistical sampling | data analysis | data analysis | visualization | visualization | quantum | quantum | quantum method | quantum method | chemical | chemical | molecular dynamics | molecular dynamics | Monte Carlo | Monte Carlo | mesoscale | mesoscale | continuum method | continuum method | computational physics | computational physics | chemistry | chemistry | mechanics | mechanics | materials science | materials science | biology | biology | applied mathematics | applied mathematics | fluid dynamics | fluid dynamics | heat | heat | fractal | fractal | evolution | evolution | melting | melting | gas | gas | structural mechanics | structural mechanics | FEM | FEM | finite element | finite element

License

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14.581 International Economics I (MIT) 14.581 International Economics I (MIT)

Description

This course provides a graduate-level introduction to the field of international trade. It examines the theory of international trade and foreign investment with applications in commercial policy. Topics include gains from trade, Ricardian models of technological differences, Heckscher-Ohlin models of factor endowment differences, intermediate input trade, wage inequality, imperfect competition, firm heterogeneity, multinational firms, international organization of production, dynamics, trade policy, trade and institutions, sorting in trade and FDI, and effects of geography on trade. This course is targeted to second-year PhD students in economics. This course provides a graduate-level introduction to the field of international trade. It examines the theory of international trade and foreign investment with applications in commercial policy. Topics include gains from trade, Ricardian models of technological differences, Heckscher-Ohlin models of factor endowment differences, intermediate input trade, wage inequality, imperfect competition, firm heterogeneity, multinational firms, international organization of production, dynamics, trade policy, trade and institutions, sorting in trade and FDI, and effects of geography on trade. This course is targeted to second-year PhD students in economics.

Subjects

international economics | international economics | nternational trade | nternational trade | foreign investment | foreign investment | commercial policy | commercial policy | Ricardian models | Ricardian models | Eaton and Kortum's Ricardian Model | Eaton and Kortum's Ricardian Model | Heckscher-Ohlin Model | Heckscher-Ohlin Model | Generalized Heckscher-Ohlin Model | Generalized Heckscher-Ohlin Model | empirical tests | empirical tests | intermediate input trade | intermediate input trade | wage inequality | wage inequality | external scale economics | external scale economics | oligopoly | oligopoly | monopolistic competition | monopolistic competition | intraindustry heterogeneity | intraindustry heterogeneity | technological theories of FDI | technological theories of FDI | transaction-cost approach | transaction-cost approach | property-rights approach | property-rights approach | dynamic trade theory | dynamic trade theory | neoclassical growth | neoclassical growth | technology and growth | technology and growth | innovation | innovation | technology transfer | technology transfer | product cycles | product cycles | tariff retaliation | tariff retaliation | WTO | WTO | regionalism | regionalism | multilateralism | multilateralism

License

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22.106 Neutron Interactions and Applications (MIT) 22.106 Neutron Interactions and Applications (MIT)

Description

This course is a foundational study of the effects of single and multiple interactions on neutron distributions and their applications to problems across the Nuclear Engineering department - fission, fusion, and RST. Particle simulation methods are introduced to deal with complex processes that cannot be studied only experimentally or by numerical solutions of equations. Treatment will emphasize basic concepts and understanding, as well as showing the underlying scientific connections with current research areas. This course is a foundational study of the effects of single and multiple interactions on neutron distributions and their applications to problems across the Nuclear Engineering department - fission, fusion, and RST. Particle simulation methods are introduced to deal with complex processes that cannot be studied only experimentally or by numerical solutions of equations. Treatment will emphasize basic concepts and understanding, as well as showing the underlying scientific connections with current research areas.

Subjects

Neutron Interaction | Neutron Interaction | Neutron Elastic Scattering: Thermal Motion | Neutron Elastic Scattering: Thermal Motion | Chemical Binding Effects | Chemical Binding Effects | Particle Simulations I | Particle Simulations I | Monte Carlo Basics Monte Carlo in Statistical Physics and Radiation Transport | Monte Carlo Basics Monte Carlo in Statistical Physics and Radiation Transport | The Neutron Transport Equation | The Neutron Transport Equation | Neutron Slowing Down | Neutron Slowing Down | Neutron Diffusion | Neutron Diffusion | Particle Simulation Methods | Particle Simulation Methods | Basic Molecular Dynamics | Basic Molecular Dynamics | Direct Simulation of Melting | Direct Simulation of Melting | Multiscale Materials Modeling | Multiscale Materials Modeling | Thermal Neutron Scattering | Thermal Neutron Scattering | Dynamic Structure Factor in Neutron Inelastic Scattering | Dynamic Structure Factor in Neutron Inelastic Scattering

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HST.921 Information Technology in the Health Care System of the Future (MIT) HST.921 Information Technology in the Health Care System of the Future (MIT)

Description

This course will show how information technologies (IT) shape and redefine the health care marketplace. Students will learn how IT enhances medical care through: 1) improved economies of scale, 2) greater technical efficiencies in the delivery of care, 3) advanced tools for patient education and self-care, 4) network-integrated decision support tools for clinicians, and 5) opportunities for e-health delivery over the internet. Students will work in interdisciplinary teams to design an innovative solution to a current or future health care problem. Students' proposed solutions will draw upon understanding of tools and principles acquired and will be presented as an application design during the final days of the course. Adjunct Faculty Mirena Bagur Sherri Dorfman Paul Heinzelman Gary H This course will show how information technologies (IT) shape and redefine the health care marketplace. Students will learn how IT enhances medical care through: 1) improved economies of scale, 2) greater technical efficiencies in the delivery of care, 3) advanced tools for patient education and self-care, 4) network-integrated decision support tools for clinicians, and 5) opportunities for e-health delivery over the internet. Students will work in interdisciplinary teams to design an innovative solution to a current or future health care problem. Students' proposed solutions will draw upon understanding of tools and principles acquired and will be presented as an application design during the final days of the course. Adjunct Faculty Mirena Bagur Sherri Dorfman Paul Heinzelman Gary H

Subjects

information technology | information technology | health care system | health care system | economy of scale | economy of scale | technical efficiency | technical efficiency | patient education | patient education | self-care | self-care | network integration | network integration | decision support tool | decision support tool | internet | internet | web | web | disease managment | disease managment | health economics | health economics | clinical effectiveness | clinical effectiveness | trials design | trials design | software | software

License

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ESD.84 Engineering Systems Doctoral Seminar (MIT) ESD.84 Engineering Systems Doctoral Seminar (MIT)

Description

Examines core theory and contextual applications of the emerging field of Engineering Systems. The focus is on doctoral-level analysis of scholarship on key concepts such as complexity, uncertainty, fragility, and robustness, as well as a critical look at the historical roots of the field and related areas such as systems engineering, systems dynamics, agent modeling, and systems simulations. Contextual applications range from aerospace to technology implementation to regulatory systems to large-scale systems change. Special attention is given to the interdependence of social and technical dimensions of engineering systems. Examines core theory and contextual applications of the emerging field of Engineering Systems. The focus is on doctoral-level analysis of scholarship on key concepts such as complexity, uncertainty, fragility, and robustness, as well as a critical look at the historical roots of the field and related areas such as systems engineering, systems dynamics, agent modeling, and systems simulations. Contextual applications range from aerospace to technology implementation to regulatory systems to large-scale systems change. Special attention is given to the interdependence of social and technical dimensions of engineering systems.

Subjects

engineering systems | engineering systems | complexity | complexity | fragility | fragility | robustness | robustness | systems engineering | systems engineering | systems dynamics | systems dynamics | agent modeling | agent modeling | systems simulations | systems simulations | large-scale systems change | large-scale systems change | uncertainty | uncertainty

License

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6.895 Computational Biology: Genomes, Networks, Evolution (MIT) 6.895 Computational Biology: Genomes, Networks, Evolution (MIT)

Description

This course focuses on the algorithmic and machine learning foundations of computational biology, combining theory with practice. We study the principles of algorithm design for biological datasets, and analyze influential problems and techniques. We use these to analyze real datasets from large-scale studies in genomics and proteomics. The topics covered include:Genomes: Biological Sequence Analysis, Hidden Markov Models, Gene Finding, RNA Folding, Sequence Alignment, Genome Assembly.Networks: Gene Expression Analysis, Regulatory Motifs, Graph Algorithms, Scale-free Networks, Network Motifs, Network Evolution.Evolution: Comparative Genomics, Phylogenetics, Genome Duplication, Genome Rearrangements, Evolutionary Theory, Rapid Evolution. This course focuses on the algorithmic and machine learning foundations of computational biology, combining theory with practice. We study the principles of algorithm design for biological datasets, and analyze influential problems and techniques. We use these to analyze real datasets from large-scale studies in genomics and proteomics. The topics covered include:Genomes: Biological Sequence Analysis, Hidden Markov Models, Gene Finding, RNA Folding, Sequence Alignment, Genome Assembly.Networks: Gene Expression Analysis, Regulatory Motifs, Graph Algorithms, Scale-free Networks, Network Motifs, Network Evolution.Evolution: Comparative Genomics, Phylogenetics, Genome Duplication, Genome Rearrangements, Evolutionary Theory, Rapid Evolution.

Subjects

Genomes: Biological sequence analysis | Genomes: Biological sequence analysis | hidden Markov models | hidden Markov models | gene finding | gene finding | RNA folding | RNA folding | sequence alignment | sequence alignment | genome assembly | genome assembly | Networks: Gene expression analysis | Networks: Gene expression analysis | regulatory motifs | regulatory motifs | graph algorithms | graph algorithms | scale-free networks | scale-free networks | network motifs | network motifs | network evolution | network evolution | Evolution: Comparative genomics | Evolution: Comparative genomics | phylogenetics | phylogenetics | genome duplication | genome duplication | genome rearrangements | genome rearrangements | evolutionary theory | evolutionary theory | rapid evolution | rapid evolution

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22.00J Introduction to Modeling and Simulation (MIT) 22.00J Introduction to Modeling and Simulation (MIT)

Description

This course surveys the basic concepts of computer modeling in science and engineering using discrete particle systems and continuum fields. It covers techniques and software for statistical sampling, simulation, data analysis and visualization, and uses statistical, quantum chemical, molecular dynamics, Monte Carlo, mesoscale and continuum methods to study fundamental physical phenomena encountered in the fields of computational physics, chemistry, mechanics, materials science, biology, and applied mathematics. Applications are drawn from a range of disciplines to build a broad-based understanding of complex structures and interactions in problems where simulation is on equal footing with theory and experiment. A term project allows development of individual interests. Students are mentor This course surveys the basic concepts of computer modeling in science and engineering using discrete particle systems and continuum fields. It covers techniques and software for statistical sampling, simulation, data analysis and visualization, and uses statistical, quantum chemical, molecular dynamics, Monte Carlo, mesoscale and continuum methods to study fundamental physical phenomena encountered in the fields of computational physics, chemistry, mechanics, materials science, biology, and applied mathematics. Applications are drawn from a range of disciplines to build a broad-based understanding of complex structures and interactions in problems where simulation is on equal footing with theory and experiment. A term project allows development of individual interests. Students are mentor

Subjects

computer modeling | computer modeling | discrete particle system | discrete particle system | continuum | continuum | continuum field | continuum field | statistical sampling | statistical sampling | data analysis | data analysis | visualization | visualization | quantum | quantum | quantum method | quantum method | chemical | chemical | molecular dynamics | molecular dynamics | Monte Carlo | Monte Carlo | mesoscale | mesoscale | continuum method | continuum method | computational physics | computational physics | chemistry | chemistry | mechanics | mechanics | materials science | materials science | biology; applied mathematics | biology; applied mathematics | fluid dynamics | fluid dynamics | heat | heat | fractal | fractal | evolution | evolution | melting | melting | gas | gas | structural mechanics | structural mechanics | FEM | FEM | finite element | finite element | biology | biology | applied mathematics | applied mathematics | 1.021 | 1.021 | 2.030 | 2.030 | 3.021 | 3.021 | 10.333 | 10.333 | 18.361 | 18.361 | HST.588 | HST.588 | 22.00 | 22.00

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