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2.18 Biomolecular Feedback Systems (MIT) 2.18 Biomolecular Feedback Systems (MIT)

Description

This course focuses on feedback control mechanisms that living organisms implement at the molecular level to execute their functions, with emphasis on techniques to design novel systems with prescribed behaviors. Students will learn how biological functions can be understood and designed using notions from feedback control. This course focuses on feedback control mechanisms that living organisms implement at the molecular level to execute their functions, with emphasis on techniques to design novel systems with prescribed behaviors. Students will learn how biological functions can be understood and designed using notions from feedback control.

Subjects

biomolecular feedback systems | biomolecular feedback systems | systems biology | systems biology | modeling | modeling | feedback | feedback | cell | cell | system | system | control | control | dynamical | dynamical | input/output | input/output | synthetic biology | synthetic biology | techniques | techniques | transcription | transcription | translation | translation | transcriptional regulation | transcriptional regulation | post-transcriptional regulation | post-transcriptional regulation | cellular subsystems | cellular subsystems | dynamic behavior | dynamic behavior | analysis | analysis | equilibrium | equilibrium | robustness | robustness | oscillatory behavior | oscillatory behavior | bifurcations | bifurcations | model reduction | model reduction | stochastic | stochastic | biochemical | biochemical | simulation | simulation | linear | linear | circuit | circuit | design | design | biological circuit design | biological circuit design | negative autoregulation | negative autoregulation | toggle switch | toggle switch | repressilator | repressilator | activator-repressor clock | activator-repressor clock | IFFL | IFFL | incoherent feedforward loop | incoherent feedforward loop | bacterial chemotaxis | bacterial chemotaxis | interconnecting components | interconnecting components | modularity | modularity | retroactivity | retroactivity | gene circuit | gene circuit

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.60 Cell Biology: Structure and Functions of the Nucleus (MIT) 7.60 Cell Biology: Structure and Functions of the Nucleus (MIT)

Description

The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology. The assigned readings will provide concrete examples of the experimental approaches and logic used to establish these findings. Some examples of topics include genome and systems biology, transcription, and gene expression. The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology. The assigned readings will provide concrete examples of the experimental approaches and logic used to establish these findings. Some examples of topics include genome and systems biology, transcription, and gene expression.

Subjects

cell biology | cell biology | nucleus | nucleus | biology | biology | nuclear cell biology | nuclear cell biology | DNA replication | DNA replication | DNA repair | DNA repair | DNA | DNA | genome | genome | cell cycle control | cell cycle control | transcriptional regulation | transcriptional regulation | gene expression | gene expression | chromatin | chromatin | chromosomes | chromosomes | replication | replication | transcription | transcription | RNA | RNA | RNA interference | RNA interference | mRNA | mRNA | microRNA | microRNA | RNAi | RNAi

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT) 7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT)

Description

In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at

Subjects

blueprint of life | blueprint of life | transcription | transcription | stem cells | stem cells | differentiation | differentiation | human tissues | human tissues | tissue regeneration | tissue regeneration | human disease | human disease | RNA and protein expression patterns | RNA and protein expression patterns | transcriptional regulation | transcriptional regulation | specialized gene expression programs | specialized gene expression programs | genome | genome | multipotent | multipotent | terminally differentiated | terminally differentiated | pluripotency | pluripotency | master regulators | master regulators | chromatin regulators | chromatin regulators | developmental defects | developmental defects | cancer | cancer

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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2.18 Biomolecular Feedback Systems (MIT)

Description

This course focuses on feedback control mechanisms that living organisms implement at the molecular level to execute their functions, with emphasis on techniques to design novel systems with prescribed behaviors. Students will learn how biological functions can be understood and designed using notions from feedback control.

Subjects

biomolecular feedback systems | systems biology | modeling | feedback | cell | system | control | dynamical | input/output | synthetic biology | techniques | transcription | translation | transcriptional regulation | post-transcriptional regulation | cellular subsystems | dynamic behavior | analysis | equilibrium | robustness | oscillatory behavior | bifurcations | model reduction | stochastic | biochemical | simulation | linear | circuit | design | biological circuit design | negative autoregulation | toggle switch | repressilator | activator-repressor clock | IFFL | incoherent feedforward loop | bacterial chemotaxis | interconnecting components | modularity | retroactivity | gene circuit

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT)

Description

In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at

Subjects

blueprint of life | transcription | stem cells | differentiation | human tissues | tissue regeneration | human disease | RNA and protein expression patterns | transcriptional regulation | specialized gene expression programs | genome | multipotent | terminally differentiated | pluripotency | master regulators | chromatin regulators | developmental defects | cancer

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.60 Cell Biology: Structure and Functions of the Nucleus (MIT)

Description

The goal of this course is to teach both the fundamentals of nuclear cell biology as well as the methodological and experimental approaches upon which they are based. Lectures and class discussions will cover the background and fundamental findings in a particular area of nuclear cell biology. The assigned readings will provide concrete examples of the experimental approaches and logic used to establish these findings. Some examples of topics include genome and systems biology, transcription, and gene expression.

Subjects

cell biology | nucleus | biology | nuclear cell biology | DNA replication | DNA repair | DNA | genome | cell cycle control | transcriptional regulation | gene expression | chromatin | chromosomes | replication | transcription | RNA | RNA interference | mRNA | microRNA | RNAi

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT)

Description

In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at

Subjects

blueprint of life | transcription | stem cells | differentiation | human tissues | tissue regeneration | human disease | RNA and protein expression patterns | transcriptional regulation | specialized gene expression programs | genome | multipotent | terminally differentiated | pluripotency | master regulators | chromatin regulators | developmental defects | cancer

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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https://ocw.mit.edu/rss/all/mit-alllifesciencescourses.xml

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