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7.340 Under the Radar Screen: How Bugs Trick Our Immune Defenses (MIT) 7.340 Under the Radar Screen: How Bugs Trick Our Immune Defenses (MIT)

Description

In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about

Subjects

HIV | HIV | mycobacterium tuberculosis | mycobacterium tuberculosis | malaria | malaria | influenza | influenza | immune system | immune system | pathogens | pathogens | viruses | viruses | bacteria | bacteria | parasites | parasites | microbes | microbes | phagocytosis | phagocytosis | ubiquitin/proteasome pathway | ubiquitin/proteasome pathway | MHC I/II antigen presentation | MHC I/II antigen presentation | Salmonella | Salmonella | pathogen-associated molecular patterns | pathogen-associated molecular patterns | PAMP | PAMP | Toll-like receptors | Toll-like receptors | TLR | TLR | Vaccinia virus | Vaccinia virus | Proteasome | Proteasome | Ubiquitin; deubiquinating enzymes | Ubiquitin; deubiquinating enzymes | DUB | DUB | Herpes simplex virus | Herpes simplex virus | HSV | HSV | Yersinia | Yersinia | viral budding | viral budding | Human cytomegalovirus | Human cytomegalovirus | HCMV | HCMV | Histocompatiblity | Histocompatiblity | AIDS | AIDS | Kaposi Sarcoma-Associated Herpes virus | Kaposi Sarcoma-Associated Herpes virus | Mixoma virus | Mixoma virus | Epstein Barr virus | Epstein Barr virus | EBV | EBV | Burkitt?s B cell lymphoma | Burkitt?s B cell lymphoma

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Tuberculosis

Description

Dr Helen McShane has been working on a new TB vaccine for 10 years. She explains why developing countries are especially in need of a new vaccine since HIV and TB epidemics overlap and show a devastating synergy. There are about 9 million new cases and 1.7 million deaths every year from tuberculosis. Dr Helen McShane developed MVA85A, a vaccine with the aim to boost the cellular immune response induced by BCG. BCG, now over 100 years old, remains the only licensed vaccine against Tuberculosis. It confers good protection against severe disease and meningitis but doesn't protect against lung disease. MVA85A was the first vaccine of the new generation to enter into efficacy testing. It is currently being tested in The Gambia, Senegal and South Africa. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

jenner | developing world | immunisation | tuberculosis | Medicine | clinical trial | vaccine | jenner | developing world | immunisation | tuberculosis | Medicine | clinical trial | vaccine

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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http://mediapub.it.ox.ac.uk/feeds/129165/video.xml

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STS.005 Disease and Society in America (MIT) STS.005 Disease and Society in America (MIT)

Description

This course examines the growing importance of medicine in culture, economics and politics. It uses an historical approach to examine the changing patterns of disease, the causes of morbidity and mortality, the evolution of medical theory and practice, the development of hospitals and the medical profession, the rise of the biomedical research industry, and the ethics of health care in America. This course examines the growing importance of medicine in culture, economics and politics. It uses an historical approach to examine the changing patterns of disease, the causes of morbidity and mortality, the evolution of medical theory and practice, the development of hospitals and the medical profession, the rise of the biomedical research industry, and the ethics of health care in America.

Subjects

Science | Science | technology | technology | society | society | disease | disease | America | America | health | health | life | life | smallpox | smallpox | tuberculosis | tuberculosis | obesity | obesity | heart disease | heart disease | mental illness | mental illness | medicine | medicine | culture | culture | economics | economics | politics | politics | Health care | Health care | historical approach | historical approach | morbidity | morbidity | mortality | mortality | medical theory | medical theory | practice | practice | hospitals | hospitals | biomedical | biomedical | research | research | industry | industry | ethics | ethics

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Developing an improved TB vaccine

Description

Dr McShane talks about the University's work in creating an improved vaccine against tuberculosis and she also talks about the urgency of this research. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

tb | alumni | tuberculosis | vaccinology | tb | alumni | tuberculosis | vaccinology

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129169/audio.xml

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Fighting to end Tuberculosis

Description

Helen McShane and Dr Helen Fletcher talk about a new TB vaccine currently being developed at Oxford's Wellcome Trust Centre that could become a more effective vaccine against Tuberculosis. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

bcg | tb | tuberculosis | vaccine | bcg | tb | tuberculosis | vaccine

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129109/video.xml

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Fighting to end Tuberculosis

Description

Helen McShane and Dr Helen Fletcher talk about a new TB vaccine currently being developed at Oxford's Wellcome Trust Centre that could become a more effective vaccine against Tuberculosis. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

bcg | tb | tuberculosis | vaccine | bcg | tb | tuberculosis | vaccine

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129109/audio.xml

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Fighting to end Tuberculosis

Description

Helen McShane and Dr Helen Fletcher talk about a new TB vaccine currently being developed at Oxford's Wellcome Trust Centre that could become a more effective vaccine against Tuberculosis.

Subjects

bcg | tb | tuberculosis | vaccine | bcg | tb | tuberculosis | vaccine

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://rss.oucs.ox.ac.uk/medsci/vaccination-audio/rss20.xml

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Developing an improved TB vaccine

Description

Dr McShane talks about the University's work in creating an improved vaccine against tuberculosis and she also talks about the urgency of this research.

Subjects

vaccination | bcg | alumni | vaccine | tb. tuberculosis | vaccination | bcg | alumni | vaccine | tb. tuberculosis | 2009-09-25

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://rss.oucs.ox.ac.uk/medsci/vaccination-audio/rss20.xml

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Viral vectored vaccine development

Description

Professor Sarah Gilbert talks about her work on viral vectored vaccines. Professor Sarah Gilbert has been making and testing vaccines designed to induce T cell responses for ten years, chiefly using antigens from malaria and influenza. Based at the Jenner Institute, several of the vaccines developed in Professor Gilberts laboratory have progressed into Clinical Trials. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

immunology | tuberculosis and influenza | malaria | T cell | immune response | vaccine | clinical trials | immunology | tuberculosis and influenza | malaria | T cell | immune response | vaccine | clinical trials

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/audio.xml

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Can we eradicate Tuberculosis?

Description

Dr Helen Fletcher talks about progress in the development of a vaccine against tuberculosis. Dr Helen Fletcher works on multi-partner projects to discover biomarkers of protection from TB disease, develop clinical trials capacity in Africa, and develop new vaccines for TB. Dr Fletcher has also developed her own research programme on transcriptional profiling of immune responses following both TB and malaria vaccination. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

jenner | developing world | immunisation | tuberculosis | clinical trial | vaccine | jenner | developing world | immunisation | tuberculosis | clinical trial | vaccine

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/audio.xml

Attribution

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Tuberculosis

Description

Dr Helen McShane has been working on a new TB vaccine for 10 years. She explains why developing countries are especially in need of a new vaccine since HIV and TB epidemics overlap and show a devastating synergy. There are about 9 million new cases and 1.7 million deaths every year from tuberculosis. Dr Helen McShane developed MVA85A, a vaccine with the aim to boost the cellular immune response induced by BCG. BCG, now over 100 years old, remains the only licensed vaccine against Tuberculosis. It confers good protection against severe disease and meningitis but doesn't protect against lung disease. MVA85A was the first vaccine of the new generation to enter into efficacy testing. It is currently being tested in The Gambia, Senegal and South Africa. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

jenner | developing world | immunisation | tuberculosis | Medicine | clinical trial | vaccine | jenner | developing world | immunisation | tuberculosis | Medicine | clinical trial | vaccine

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/audio.xml

Attribution

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Tracking infections

Description

Professor Derrick Crook from our Experimental Medicine division tells us about his research on tracking infections Professor Derrick Crook's research consortium focusses on translating new molecular technologies and advances in informatics into the investigation of microbial transmission, diagnosis of infectious disease and identifying outbreaks of communicable disease. This research aims to translate deep sequencing of pathogens on an epidemiological scale for tracking infections, and is focussed on four different major pathogens: Staphylococcus aureus (including MRSA), Clostridium difficile, Norovirus and Mycobacterium tuberculosis. Understanding how an infection spreads is vitally important for prevention. Whole genome sequencing of microorganisms allows us to construct family trees of Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

translational medicine | infections | tuberculosis | genetics | viruses | translational medicine | infections | tuberculosis | genetics | viruses

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/video.xml

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Viral vectored vaccine development

Description

Professor Sarah Gilbert talks about her work on viral vectored vaccines. Professor Sarah Gilbert has been making and testing vaccines designed to induce T cell responses for ten years, chiefly using antigens from malaria and influenza. Based at the Jenner Institute, several of the vaccines developed in Professor Gilberts laboratory have progressed into Clinical Trials. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

immunology | tuberculosis and influenza | malaria | T cell | immune response | vaccine | clinical trials | immunology | tuberculosis and influenza | malaria | T cell | immune response | vaccine | clinical trials

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/video.xml

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Vaccine Research at Oxford

Description

Podcasts from the University of Oxford's vaccination research programmes, looking at innovative ways to vaccinate people against the world's most dangerous diseases.

Subjects

simple-podcasting | tpi3 | vaccine | hiv | aids | alumni | checked1 | 2009-09-25 | 1 | tb. tuberculosis | vaccination | bcg | tb | tuberculosis | malaria | immunology | he - medicine and dentistry | c540 | c550 | b210 | jenner institute | dentistry | A000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Can we eradicate Tuberculosis?

Description

Dr Helen Fletcher talks about progress in the development of a vaccine against tuberculosis. Dr Helen Fletcher works on multi-partner projects to discover biomarkers of protection from TB disease, develop clinical trials capacity in Africa, and develop new vaccines for TB. Dr Fletcher has also developed her own research programme on transcriptional profiling of immune responses following both TB and malaria vaccination. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

jenner | developing world | immunisation | tuberculosis | clinical trial | vaccine | jenner | developing world | immunisation | tuberculosis | clinical trial | vaccine

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/video.xml

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RJN0001PM0032

Description

Pig lymph node with granulomatous lesion.

Subjects

pig | lymphnode | tuberculosis | svmsvet | vph

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

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RJN0001PM0031

Description

Pig lymph node with granulomatous lesion.

Subjects

pig | lymphnode | tuberculosis | svmsvet | vph

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

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STS.005 Disease and Society in America (MIT)

Description

This course examines the growing importance of medicine in culture, economics and politics. It uses an historical approach to examine the changing patterns of disease, the causes of morbidity and mortality, the evolution of medical theory and practice, the development of hospitals and the medical profession, the rise of the biomedical research industry, and the ethics of health care in America.

Subjects

Science | technology | society | disease | America | health | life | smallpox | tuberculosis | obesity | heart disease | mental illness | medicine | culture | economics | politics | Health care | historical approach | morbidity | mortality | medical theory | practice | hospitals | biomedical | research | industry | ethics

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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Oga

Description

This is the story of a Virtual Patient called Oga. She is a 3 year girl originally from Turkey who presents with a history of chronic cough to your respiratory clinic. As you proceed through the case you are able to evaluate the important aspects of the history and clinical examination. By interpreting specialist investigations you are able to make a diagnosis and formulate a management plan as well as managing some complications.

Subjects

paediatric | chronic cough | tuberculosis | respiratory | ukoer | dentistry | A000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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A nasty cough

Description

This tutorial provides a walk-through scenario. The student is a dental practitioner who treats a patient who subsequently develops tuberculosis. The walk-through leads the student through the measures needed to contain the spread of infection, and indicates what measures should be taken, which authorities should be informed, and future precautions that should be taken. This is a Questionmark Perception file. The QTIXML file needs to be opened in QP Authoring Manager, converted to an assessment and exported into your own VLE.

Subjects

tuberculosis | tutorial | dental treatment | walk-through | cough | occupational health | bioukoer | ukoer | Biological sciences | C000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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7.340 Under the Radar Screen: How Bugs Trick Our Immune Defenses (MIT)

Description

In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about

Subjects

HIV | mycobacterium tuberculosis | malaria | influenza | immune system | pathogens | viruses | bacteria | parasites | microbes | phagocytosis | ubiquitin/proteasome pathway | MHC I/II antigen presentation | Salmonella | pathogen-associated molecular patterns | PAMP | Toll-like receptors | TLR | Vaccinia virus | Proteasome | Ubiquitin; deubiquinating enzymes | DUB | Herpes simplex virus | HSV | Yersinia | viral budding | Human cytomegalovirus | HCMV | Histocompatiblity | AIDS | Kaposi Sarcoma-Associated Herpes virus | Mixoma virus | Epstein Barr virus | EBV | Burkitt?s B cell lymphoma

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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Öga (eViP Virtual Patient)

Description

This is the story of a Virtual Patient called Öga. She is a 3 year girl originally from Turkey who presents with a history of chronic cough to your respiratory clinic. As you proceed through the case you are able to evaluate the important aspects of the history and clinical examination. By interpreting specialist investigations you are able to make a diagnosis and formulate a management plan as well as managing some complications.

Subjects

paediatric | chronic cough | tuberculosis | respiratory | Medicine and Dentistry | Subjects allied to Medicine | dentistry | Subjects allied to medicine | A000 | B000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Respiratory Infections

Description

A unit containing a series of case studies in which clinical presentations of various respiratory infections are described. The reader is required to diagnose the infection and the treatment required. A full explanation of the correct answers is provided. This is a Questionmark Perception file. The QTIXML file needs to be opened in QP Authoring Manager, converted to an assessment and exported into your own VLE.

Subjects

microbiology | ukoer | bioukoer | respiratory infections | cough | bronchitis | earache | pneumonia | influenza | tuberculosis | Biological sciences | C000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Cross Infection

Description

A Questionmark Perception file containing clinical based scenarios. The reader is expected to ellucidate the cause of infection from information supplied, and also their risk to others with respect to cross infection. The QTIXML file supplied needs to be opened in QP Authoring Manager, converted to an assessment and exported into your own VLE.

Subjects

jaundice | hepatitis | cross infection | healthcare | medical microbiology | microbiology | tuberculosis | bioukoer | Biological sciences | C000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Fighting to end Tuberculosis

Description

Dr Helen McShane and Dr Helen Fletcher talk about a new TB vaccine currently being developed at Oxford's Wellcome Trust Centre that could become a more effective vaccine against Tuberculosis

Subjects

vaccine | tb | tuberculosis | bcg | c550 | ukoer | dentistry | A000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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