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7.340 Under the Radar Screen: How Bugs Trick Our Immune Defenses (MIT) 7.340 Under the Radar Screen: How Bugs Trick Our Immune Defenses (MIT)

Description

In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about

Subjects

HIV | HIV | mycobacterium tuberculosis | mycobacterium tuberculosis | malaria | malaria | influenza | influenza | immune system | immune system | pathogens | pathogens | viruses | viruses | bacteria | bacteria | parasites | parasites | microbes | microbes | phagocytosis | phagocytosis | ubiquitin/proteasome pathway | ubiquitin/proteasome pathway | MHC I/II antigen presentation | MHC I/II antigen presentation | Salmonella | Salmonella | pathogen-associated molecular patterns | pathogen-associated molecular patterns | PAMP | PAMP | Toll-like receptors | Toll-like receptors | TLR | TLR | Vaccinia virus | Vaccinia virus | Proteasome | Proteasome | Ubiquitin; deubiquinating enzymes | Ubiquitin; deubiquinating enzymes | DUB | DUB | Herpes simplex virus | Herpes simplex virus | HSV | HSV | Yersinia | Yersinia | viral budding | viral budding | Human cytomegalovirus | Human cytomegalovirus | HCMV | HCMV | Histocompatiblity | Histocompatiblity | AIDS | AIDS | Kaposi Sarcoma-Associated Herpes virus | Kaposi Sarcoma-Associated Herpes virus | Mixoma virus | Mixoma virus | Epstein Barr virus | Epstein Barr virus | EBV | EBV | Burkitt?s B cell lymphoma | Burkitt?s B cell lymphoma

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.340 Nano-life: An Introduction to Virus Structure and Assembly (MIT) 7.340 Nano-life: An Introduction to Virus Structure and Assembly (MIT)

Description

Watson and Crick noted that the size of a viral genome was insufficient to encode a protein large enough to encapsidate it and reasoned, therefore that a virus shell must be composed of multiple, but identical subunits. Today, high resolution structures of virus capsids reveal the basis of this genetic economy as a highly symmetrical structure, much like a geodesic dome composed of protein subunits. Crystallographic structures and cryo-electron microscopy reconstructions combined with molecular data are beginning to reveal how these nano-structures are built. Topics covered in the course will include basic principles of virus structure and symmetry, capsid assembly, strategies for enclosing nucleic acid, proteins involved in entry and exit, and the life cycles of well understood pathogens Watson and Crick noted that the size of a viral genome was insufficient to encode a protein large enough to encapsidate it and reasoned, therefore that a virus shell must be composed of multiple, but identical subunits. Today, high resolution structures of virus capsids reveal the basis of this genetic economy as a highly symmetrical structure, much like a geodesic dome composed of protein subunits. Crystallographic structures and cryo-electron microscopy reconstructions combined with molecular data are beginning to reveal how these nano-structures are built. Topics covered in the course will include basic principles of virus structure and symmetry, capsid assembly, strategies for enclosing nucleic acid, proteins involved in entry and exit, and the life cycles of well understood pathogens

Subjects

viruses | viruses | virus structure | virus structure | virus assembly | virus assembly | virus shell | virus shell | virus genome | virus genome | capsids | capsids | capsid assembly | capsid assembly | TEM | TEM | transmission electron microscopy | transmission electron microscopy | nano-life | nano-life | nano-structures | nano-structures | virus symmetry | virus symmetry | icosahedral virus | icosahedral virus | electron cryotomography | electron cryotomography | nucleic acid packaging | nucleic acid packaging

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.340 Under the Radar Screen: How Bugs Trick Our Immune Defenses (MIT)

Description

In this course, we will explore the specific ways by which microbes defeat our immune system and the molecular mechanisms that are under attack (phagocytosis, the ubiquitin/proteasome pathway, MHC I/II antigen presentation). Through our discussion and dissection of the primary research literature, we will explore aspects of host-pathogen interactions. We will particularly emphasize the experimental techniques used in the field and how to read and understand research data. Technological advances in the fight against microbes will also be discussed, with specific examples. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about

Subjects

HIV | mycobacterium tuberculosis | malaria | influenza | immune system | pathogens | viruses | bacteria | parasites | microbes | phagocytosis | ubiquitin/proteasome pathway | MHC I/II antigen presentation | Salmonella | pathogen-associated molecular patterns | PAMP | Toll-like receptors | TLR | Vaccinia virus | Proteasome | Ubiquitin; deubiquinating enzymes | DUB | Herpes simplex virus | HSV | Yersinia | viral budding | Human cytomegalovirus | HCMV | Histocompatiblity | AIDS | Kaposi Sarcoma-Associated Herpes virus | Mixoma virus | Epstein Barr virus | EBV | Burkitt?s B cell lymphoma

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.340 Nano-life: An Introduction to Virus Structure and Assembly (MIT)

Description

Watson and Crick noted that the size of a viral genome was insufficient to encode a protein large enough to encapsidate it and reasoned, therefore that a virus shell must be composed of multiple, but identical subunits. Today, high resolution structures of virus capsids reveal the basis of this genetic economy as a highly symmetrical structure, much like a geodesic dome composed of protein subunits. Crystallographic structures and cryo-electron microscopy reconstructions combined with molecular data are beginning to reveal how these nano-structures are built. Topics covered in the course will include basic principles of virus structure and symmetry, capsid assembly, strategies for enclosing nucleic acid, proteins involved in entry and exit, and the life cycles of well understood pathogens

Subjects

viruses | virus structure | virus assembly | virus shell | virus genome | capsids | capsid assembly | TEM | transmission electron microscopy | nano-life | nano-structures | virus symmetry | icosahedral virus | electron cryotomography | nucleic acid packaging

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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7.346 Virus-host Interactions in Infectious Diseases (MIT) 7.346 Virus-host Interactions in Infectious Diseases (MIT)

Description

Co-evolution and adaptation between viruses and humans are often portrayed as a zero-sum biological arms race. Viruses enter host cells equipped with an array of mechanisms to evade the host defense responses and replicate. The rapid rate of mutation of viruses permits evolution of various methodologies for infection, which in turn drive development of non-specific but highly effective host mechanisms to restrict infection. This class will discuss the varied solutions each side has developed as a means for survival. We will use examples drawn from human disease-causing pathogens that contribute seriously to the global health burden, including HIV, influenza and dengue virus. Primary research papers will be discussed to help students learn to pose scientific questions and design and conduct Co-evolution and adaptation between viruses and humans are often portrayed as a zero-sum biological arms race. Viruses enter host cells equipped with an array of mechanisms to evade the host defense responses and replicate. The rapid rate of mutation of viruses permits evolution of various methodologies for infection, which in turn drive development of non-specific but highly effective host mechanisms to restrict infection. This class will discuss the varied solutions each side has developed as a means for survival. We will use examples drawn from human disease-causing pathogens that contribute seriously to the global health burden, including HIV, influenza and dengue virus. Primary research papers will be discussed to help students learn to pose scientific questions and design and conduct

Subjects

virus | virus | host | host | infection | infection | protein-protein interactions | protein-protein interactions | host mimicry | host mimicry | intra-cellular trafficking | intra-cellular trafficking | host-cell machinery | host-cell machinery | signaling pathways | signaling pathways | antiviral proteins | antiviral proteins | HIV | HIV | influenza | influenza | dengue virus | dengue virus | biotechnology | biotechnology | vaccine development | vaccine development | host sensors | host sensors | IFN production | IFN production | Secreted IFN | Secreted IFN | filoviruses | filoviruses | hCMV | hCMV | IFITM proteins | IFITM proteins

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Viruses, how to be the perfect host

Description

Professor Paul Klenerman talks about our relationship with persistent viruses, such as Hepatitis C. Prof. Paul Klenerman studies the evolutionary relationships between persistent viruses and their human hosts. He aims to understand the role of our immune responses in determining the outcome of Hepatitis C virus infection. Hepatitis C virus infects around 200 million people worldwide and is a major cause of liver disease. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

Hepatitis C virus | T cells | virus | hiv | liver and flow cytometry | Hepatitis C virus | T cells | virus | hiv | liver and flow cytometry

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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C0002P0039

Description

Cat Flu

Subjects

svmsvet | cats | fhv | fcv | cat | feline | felinecalicivirus | calicivirus | felineherpesvirus | felineherpes | herpesvirus | c0002

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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C0002P0039

Description

Cat Flu

Subjects

svmsvet | cats | fhv | fcv | cat | feline | felinecalicivirus | calicivirus | felineherpesvirus | felineherpes | herpesvirus | c0002

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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6.857 Network and Computer Security (MIT) 6.857 Network and Computer Security (MIT)

Description

6.857 is an upper-level undergraduate, first-year graduate course on network and computer security. It fits within the department's Computer Systems and Architecture Engineering concentration. Topics covered include (but are not limited to) the following: Techniques for achieving security in multi-user computer systems and distributed computer systems; Cryptography: secret-key, public-key, digital signatures; Authentication and identification schemes; Intrusion detection: viruses; Formal models of computer security; Secure operating systems; Software protection; Security of electronic mail and the World Wide Web; Electronic commerce: payment protocols, electronic cash; Firewalls; and Risk assessment. 6.857 is an upper-level undergraduate, first-year graduate course on network and computer security. It fits within the department's Computer Systems and Architecture Engineering concentration. Topics covered include (but are not limited to) the following: Techniques for achieving security in multi-user computer systems and distributed computer systems; Cryptography: secret-key, public-key, digital signatures; Authentication and identification schemes; Intrusion detection: viruses; Formal models of computer security; Secure operating systems; Software protection; Security of electronic mail and the World Wide Web; Electronic commerce: payment protocols, electronic cash; Firewalls; and Risk assessment.

Subjects

network | network | computer security | computer security | security | security | cryptography | cryptography | secret-key | secret-key | public-key | public-key | digital signature | digital signature | authentication | authentication | identification | identification | intrusion detection | intrusion detection | virus | virus | operating system | operating system | software | software | protection | protection | electronic mail | electronic mail | email | email | electronic commerce | electronic commerce | electronic cash | electronic cash | firewall | firewall | computer | computer | digital | digital | signature | signature | electronic | electronic | cash | cash | commerce | commerce | mail | mail | operating | operating | system | system | intrustion | intrustion | detection | detection | distributed | distributed | physical | physical | discretionary | discretionary | mandatory | mandatory | access | access | control | control | biometrics | biometrics | information | information | flow | flow | models | models | covert | covert | channels | channels | integrity | integrity | logic | logic | voting | voting | risk | risk | assessment | assessment | secure | secure | web | web | browsers | browsers | architecture | architecture | engineering | engineering | certificates | certificates | multi-user computer systems | multi-user computer systems | distributed computer systems | distributed computer systems | physical security | physical security | discretionary access control | discretionary access control | mandatory access control | mandatory access control | information-flow models | information-flow models | covert channels | covert channels | integrity models | integrity models | elementary cryptography | elementary cryptography | authentication logic;electronic cash | authentication logic;electronic cash | viruses | viruses | firewalls | firewalls | electronic voting | electronic voting | risk assessment | risk assessment | secure web browsers | secure web browsers | network security | network security | architecture engineering | architecture engineering | digital signatures | digital signatures | authentication schemes | authentication schemes | identification schemes | identification schemes | formal models | formal models | secure operating systems | secure operating systems | software protection | software protection | electronic mail security | electronic mail security | World Wide Web | World Wide Web | ecommerce | ecommerce | email security | email security | www | www | payment protocols | payment protocols | authentication logic | authentication logic

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Viruses, how to be the perfect host

Description

Professor Paul Klenerman talks about our relationship with persistent viruses, such as Hepatitis C. Prof. Paul Klenerman studies the evolutionary relationships between persistent viruses and their human hosts. He aims to understand the role of our immune responses in determining the outcome of Hepatitis C virus infection. Hepatitis C virus infects around 200 million people worldwide and is a major cause of liver disease. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

Hepatitis C virus | T cells | virus | hiv | liver and flow cytometry | Hepatitis C virus | T cells | virus | hiv | liver and flow cytometry

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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B0069P0001

Description

A collapsed cat with chronic cat flu

Subjects

svmsvet | cat | cats | feline | felines | flu | catflu | collapse | collapsed | collapsedcat | felinecollapse | emergency | felineemergency | catemergency | infectious | viral | felineinfectiousrhinitis | felinecalicivirus | calicivirus | nasaldischarge | felineherpesvirus | herpesvirus | chroniccatflu | b0069 | chronicrhinitis | dyspnoea | dyspnoeic | dyspnoeiccat

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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B0069P0002

Description

A collapsed cat with chronic cat flu

Subjects

svmsvet | cat | cats | feline | felines | flu | catflu | collapse | collapsed | collapsedcat | felinecollapse | emergency | felineemergency | catemergency | infectious | viral | felineinfectiousrhinitis | felinecalicivirus | calicivirus | nasaldischarge | felineherpesvirus | herpesvirus | chroniccatflu | b0069 | chronicrhinitis

License

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B0069P0003

Description

A collapsed cat with chronic cat flu

Subjects

svmsvet | cat | cats | feline | felines | flu | catflu | collapse | collapsed | collapsedcat | felinecollapse | emergency | felineemergency | catemergency | infectious | viral | felineinfectiousrhinitis | felinecalicivirus | calicivirus | nasaldischarge | felineherpesvirus | herpesvirus | chroniccatflu | b0069 | chronicrhinitis

License

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B0069P0004

Description

A collapsed cat with chronic cat flu

Subjects

svmsvet | cat | cats | feline | felines | flu | catflu | collapse | collapsed | collapsedcat | felinecollapse | emergency | felineemergency | catemergency | infectious | viral | felineinfectiousrhinitis | felinecalicivirus | calicivirus | nasaldischarge | felineherpesvirus | herpesvirus | chroniccatflu | b0069 | chronicrhinitis

License

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B0069P0001

Description

A collapsed cat with chronic cat flu

Subjects

svmsvet | cat | cats | feline | felines | flu | catflu | collapse | collapsed | collapsedcat | felinecollapse | emergency | felineemergency | catemergency | infectious | viral | felineinfectiousrhinitis | felinecalicivirus | calicivirus | nasaldischarge | felineherpesvirus | herpesvirus | chroniccatflu | b0069 | chronicrhinitis | dyspnoea | dyspnoeic | dyspnoeiccat

License

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B0069P0002

Description

A collapsed cat with chronic cat flu

Subjects

svmsvet | cat | cats | feline | felines | flu | catflu | collapse | collapsed | collapsedcat | felinecollapse | emergency | felineemergency | catemergency | infectious | viral | felineinfectiousrhinitis | felinecalicivirus | calicivirus | nasaldischarge | felineherpesvirus | herpesvirus | chroniccatflu | b0069 | chronicrhinitis

License

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B0069P0003

Description

A collapsed cat with chronic cat flu

Subjects

svmsvet | cat | cats | feline | felines | flu | catflu | collapse | collapsed | collapsedcat | felinecollapse | emergency | felineemergency | catemergency | infectious | viral | felineinfectiousrhinitis | felinecalicivirus | calicivirus | nasaldischarge | felineherpesvirus | herpesvirus | chroniccatflu | b0069 | chronicrhinitis

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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B0069P0004

Description

A collapsed cat with chronic cat flu

Subjects

svmsvet | cat | cats | feline | felines | flu | catflu | collapse | collapsed | collapsedcat | felinecollapse | emergency | felineemergency | catemergency | infectious | viral | felineinfectiousrhinitis | felinecalicivirus | calicivirus | nasaldischarge | felineherpesvirus | herpesvirus | chroniccatflu | b0069 | chronicrhinitis

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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B0054P0004

Description

A stray kitten with suspected cat flu

Subjects

svmsvet | cat | kitten | flu | nasal | discharge | cats | kittens | feline | felines | catflu | nasaldischarge | oculardischarge | felinecalicivirus | felineherpesvirus | herpesvirus | herpes | calici | calicivirus | respiratorydisease

License

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B0054P0003

Description

A stray kitten with suspected cat flu

Subjects

svmsvet | cat | kitten | flu | nasal | discharge | cats | kittens | feline | felines | catflu | nasaldischarge | oculardischarge | felinecalicivirus | felineherpesvirus | herpesvirus | herpes | calici | calicivirus | respiratorydisease

License

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B0054P0002

Description

A stray kitten with suspected cat flu

Subjects

svmsvet | cat | kitten | flu | nasal | discharge | cats | kittens | feline | felines | catflu | nasaldischarge | oculardischarge | felinecalicivirus | felineherpesvirus | herpesvirus | herpes | calici | calicivirus | respiratorydisease

License

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B0054P0001

Description

A stray kitten with suspected cat flu

Subjects

svmsvet | cat | kitten | flu | nasal | discharge | cats | kittens | feline | felines | catflu | nasaldischarge | oculardischarge | felinecalicivirus | felineherpesvirus | herpesvirus | herpes | calici | calicivirus | respiratorydisease

License

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B0054P0004

Description

A stray kitten with suspected cat flu

Subjects

svmsvet | cat | kitten | flu | nasal | discharge | cats | kittens | feline | felines | catflu | nasaldischarge | oculardischarge | felinecalicivirus | felineherpesvirus | herpesvirus | herpes | calici | calicivirus | respiratorydisease

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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B0054P0003

Description

A stray kitten with suspected cat flu

Subjects

svmsvet | cat | kitten | flu | nasal | discharge | cats | kittens | feline | felines | catflu | nasaldischarge | oculardischarge | felinecalicivirus | felineherpesvirus | herpesvirus | herpes | calici | calicivirus | respiratorydisease

License

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B0054P0002

Description

A stray kitten with suspected cat flu

Subjects

svmsvet | cat | kitten | flu | nasal | discharge | cats | kittens | feline | felines | catflu | nasaldischarge | oculardischarge | felinecalicivirus | felineherpesvirus | herpesvirus | herpes | calici | calicivirus | respiratorydisease

License

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