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This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. The class focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); it also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation, and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems they control. This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. The class focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); it also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation, and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems they control.

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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http://ocw.mit.edu/rss/all/mit-allarchivedcourses.xml

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This subject is taught at MIT in an open format. The interactive discussion ranges widely and is designed to help entering graduate students understand the context of the specific papers, read empirical work critically, and make up their minds whether an argument is convincing. The aims of the subject therefore are both to inform students about economic history and to give them a taste of applied economic research. This subject is taught at MIT in an open format. The interactive discussion ranges widely and is designed to help entering graduate students understand the context of the specific papers, read empirical work critically, and make up their minds whether an argument is convincing. The aims of the subject therefore are both to inform students about economic history and to give them a taste of applied economic research.

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Professor Paul Harrison, Head of Translational Neurobiology Research Group, Oxford, gives the 2012 Monica Fooks memorial lecture on recent findings in bipolar disorder. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Professor Paul Harrison, Head of Translational Neurobiology Research Group, Oxford, gives the 2012 Monica Fooks memorial lecture on recent findings in bipolar disorder. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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http://ocw.mit.edu/rss/all/mit-allcourses-7.xml

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In this course we will discover how innovative technologies combined with profound hypotheses have given rise to our current understanding of neuroscience. We will study both new and classical primary research papers with a focus on the plasticity between synapses in a brain structure called the hippocampus, which is believed to underlie the ability to create and retrieve certain classes of memories. We will discuss the basic electrical properties of neurons and how they fire. We will see how firing properties can change with experience, and we will study the biochemical basis of these changes. We will learn how molecular biology can be used to specifically change the biochemical properties of brain circuits, and we will see how these circuits form a representation of space giving rise to In this course we will discover how innovative technologies combined with profound hypotheses have given rise to our current understanding of neuroscience. We will study both new and classical primary research papers with a focus on the plasticity between synapses in a brain structure called the hippocampus, which is believed to underlie the ability to create and retrieve certain classes of memories. We will discuss the basic electrical properties of neurons and how they fire. We will see how firing properties can change with experience, and we will study the biochemical basis of these changes. We will learn how molecular biology can be used to specifically change the biochemical properties of brain circuits, and we will see how these circuits form a representation of space giving rise to

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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http://ocw.mit.edu/rss/all/mit-allcourses-9.xml

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This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. We focus on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); we also examine amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. The involvement of particular neurotransmitters in human diseases is considered. This course considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. We focus on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); we also examine amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. The involvement of particular neurotransmitters in human diseases is considered.

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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This course gives a historical perspective on financial panics. Topics include the growth of the industrial world, the Great Depression and surrounding events, and more recent topics such as the first oil crisis, Japanese stagnation, and conditions following the financial crisis of 2008. This course gives a historical perspective on financial panics. Topics include the growth of the industrial world, the Great Depression and surrounding events, and more recent topics such as the first oil crisis, Japanese stagnation, and conditions following the financial crisis of 2008.

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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15.014 focuses on using case studies to investigate the macroenvironment in which firms operate. The course is divided in five parts: Basic tools of macroeconomic management Evaluation of different economic development strategies Crises in emerging markets: causes, solutions, and prevention Problems faced by transition economies Challenges of developed countries This course is a full-term version of Applied Macro- and International Economics (15.012), with additional topics. 15.014 focuses on using case studies to investigate the macroenvironment in which firms operate. The course is divided in five parts: Basic tools of macroeconomic management Evaluation of different economic development strategies Crises in emerging markets: causes, solutions, and prevention Problems faced by transition economies Challenges of developed countries This course is a full-term version of Applied Macro- and International Economics (15.012), with additional topics.

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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http://ocw.mit.edu/rss/all/mit-allcourses-21H.xml

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This course focuses on the Great Depression and World War II and how they led to a major reordering of American politics and society. We will examine how ordinary people experienced these crises and how those experiences changed their outlook on politics and the world around them. This course focuses on the Great Depression and World War II and how they led to a major reordering of American politics and society. We will examine how ordinary people experienced these crises and how those experiences changed their outlook on politics and the world around them.

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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This seminar aims to develop a teaching knowledge of the field through extensive reading and discussion of major works. The reading covers a broad range of topics - political, economic, social, and cultural - and represents a variety of historical methods. This seminar aims to develop a teaching knowledge of the field through extensive reading and discussion of major works. The reading covers a broad range of topics - political, economic, social, and cultural - and represents a variety of historical methods.

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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http://ocw.mit.edu/rss/all/mit-alltraditionalchinesecourses.xml

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This seminar aims to develop a teaching knowledge of the field through extensive reading and discussion of major works. The reading covers a broad range of topics - political, economic, social, and cultural - and represents a variety of historical methods. This seminar aims to develop a teaching knowledge of the field through extensive reading and discussion of major works. The reading covers a broad range of topics - political, economic, social, and cultural - and represents a variety of historical methods.

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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http://mediapub.it.ox.ac.uk/feeds/129165/video.xml

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Professor Jonathan Flint talks about his research on psychiatric genetics. It is now known that genetic variants can form the basis of psychiatric disorders, such as depression and anxiety. Professor Jonathan Flint is investigating the genetics behind psychiatric disorders, in particular the origins of stress-related conditions, such as anxiety and depression, for which we have relatively ineffective treatments. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Professor Mark Williams introduces Mindfulness in the first of four short videos in this series. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Professor Mark Williams examines the neuroscience of mindfulness in the second of four short videos. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Professor Mark Williams explains how you can support the work of the Oxford Mindfulness Centre in the third of four short videos. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Professor Mark Williams offers a brief guided meditation in the last of four short videos in this series. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Depression is expected to impose the second biggest health burden globally by 2020; greater even than heart disease, arthritis and many forms of cancer. Professor Mark Williams and Dr Danny Penman discuss the driving forces behind this startling trend. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Doctors and psychiatrists once believed that patterns of thinking played little or no role in depression, but this is now known to be wrong. Professor Williams and Dr Danny Penman discuss how the treatment of depression has evolved in recent years. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Depression tends to return even if it has been successfully treated. Scientists now understand why this happens and have developed therapies that reduce the risks of relapse and help lift the burden of depression should it return. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Mindfulness therapy is an extremely effective treatment preventing relapse in depression. But what does it entail and how does it work? Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Mindfulness-Based Cognitive Therapy (MBCT) is especially good for people who have suffered the most debilitating forms of depression. The evidence for its effectiveness is overwhelming and continues to grow. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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In this final episode Professor Mark Williams and Danny Penman discuss how imaging studies show that Mindfulness may have numerous profoundly positive effects on the brain. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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http://rss.oucs.ox.ac.uk/sedm/general-audio/rss20.xml

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In this fourth podcast Linda Yueh and Jonathan Michie discuss the G20 debates over co-ordinated fiscal expansion, global regulation, and the role of the IMF.

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