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7.342 G-Protein Coupled Receptors: Vision and Disease (MIT) 7.342 G-Protein Coupled Receptors: Vision and Disease (MIT)

Description

How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR

Subjects

allergies | allergies | hypertension | hypertension | depression | depression | obesity | obesity | central nervous system disorders | central nervous system disorders | G-protein coupled receptors | G-protein coupled receptors | GPCR | GPCR | cell-surface receptors | cell-surface receptors | George Wald | George Wald | vision | vision | chromophore | chromophore | transducin | transducin | metarhodopsin II | metarhodopsin II | homodimers | homodimers | heterodimers | heterodimers | retinitis pigmentosa | retinitis pigmentosa | night blindness | night blindness | Dopamine | Dopamine | antihistamines | antihistamines | Claviceps purpurea | Claviceps purpurea | Human chemokine receptor 5 | Human chemokine receptor 5 | CCR5 | CCR5 | HIV-1 | HIV-1 | CCR5-delta32 | CCR5-delta32 | Olfactory receptors | Olfactory receptors | Taste receptors | Taste receptors

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Blood pressure measurement resource stub

Description

A resource stub for the British Hypertension Society, British Medical Journal and the University of Aberdeen's "Blood pressure measurement" webpage. it contains BHS recommendations and tutorials.

Subjects

hypertension | disease prevention and control | diagnosis | sphygmomanometers | blood pressure | high | SAFETY | Medicine and Dentistry | Subjects allied to Medicine | Anatomy | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | UK EL07 = SCQF 7 | Higher Certificate | NICAT 4 | CQFW 4 | NVQ 4 | Advanced Higher | SVQ 4 | HN Certificate | Teaching | Learning | Students | dentistry | Subjects allied to medicine | A000 | B000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | G | P

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Heart attack resource stub

Description

Patient information on heart attacks provided by the American Heart Association. Includes guidance on risk factors, lifestyle, prevention, diagnostic tests, surgery and other treatments.

Subjects

coronary heart disease | aetiology | hypertension | myocardial infarction | Technology | Diseases | Medicine and Dentistry | SAFETY | Learning | Design and delivery of programmes | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | dentistry | A000 | HEALTH CARE / MEDICINE / HEALTH and SAFETY | INFORMATION TECHNOLOGY and INFORMATION | P | C

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Healthy heart resource stub

Description

A resource stub for the healthy heart website.

Subjects

heart diseases | prevention and control | epidemiology | hypertension | blood pressure | health promotion | Diseases | SAFETY | Subjects allied to Medicine | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | Teaching | Design and delivery of programmes | Educational research | Subjects allied to medicine | B000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | G | P

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Your guide to lowering blood pressure resource stub

Description

A resource stub from the National Heart, Lung, and Blood Institute entitled Your guide to lowering blood pressure.

Subjects

hypertension | epidemiology | aetiology | diagnosis | drug therapy | diet therapy | stress | ppevention and control | blood pressure | high | Technology | Diseases | SAFETY | Subjects allied to Medicine | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | UK EL07 = SCQF 7 | Higher Certificate | NICAT 4 | CQFW 4 | NVQ 4 | Advanced Higher | SVQ 4 | HN Certificate | Learning | Teaching | Students | Subjects allied to medicine | B000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | INFORMATION TECHNOLOGY and INFORMATION | G | P | C

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Heartinfo resource stub

Description

A resource stub for the "Heartinfo" website produced by the United States HealthCentral Network.

Subjects

heart diseases | myocardial infarction | aetiology | coronary disease | surgery | hypertension | heart failure | coronary arteriosclerosis | coronary artery disease | coronary heart disease | congestive heart failure | blood pressure | high | Technology | Diseases | SAFETY | Medicine and Dentistry | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | UK EL07 = SCQF 7 | Higher Certificate | NICAT 4 | CQFW 4 | NVQ 4 | Advanced Higher | SVQ 4 | HN Certificate | UK EL08 = SCQF 8 | Higher Diploma | NICAT 5 | CQFW 5 | HN Diploma | Diploma in HE | UK EL09 = SCQF 9 | Ordinary degree | NICAT 6 | CQFW 6 | NVQ 5 | SVQ 5 | Ordinary degree | Graduate certific | Teaching | Design and delivery of programmes | dentistry | A000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | INFORMATION TECHNOLOGY and INFORMATION | G | P | C

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Your guide to lowering blood pressure resource stub

Description

A resource stub for the 'Your guide to lowering blood pressure' Web page.

Subjects

hypertension | epidemiology | aetiology | disease prevention and control | blood pressure | Technology | Diseases | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | INFORMATION TECHNOLOGY and INFORMATION | C

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Heart and vascular disease resource stub

Description

A resource stub for the Heart and vascular disease webpage, which covers cholesterol, congenital heart defects, heart attack, high blood pressure, obesity and physical activity, and peripheral arterial diseases.

Subjects

coronary disease | disease prevention and control | hypertension | coronary heart disease | blood pressure | high | Technology | Diseases | Subjects allied to Medicine | SAFETY | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | UK EL07 = SCQF 7 | Higher Certificate | NICAT 4 | CQFW 4 | NVQ 4 | Advanced Higher | SVQ 4 | HN Certificate | Learning | Teaching | Students | Subjects allied to medicine | B000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | INFORMATION TECHNOLOGY and INFORMATION | G | P | C

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Heart attack resource stub

Description

A resource stub from the American Heart Association

Subjects

heart diseases | aetiology | epidemiology | prevention and control | diagnosis | hypertension | heart | blood pressure | high | Technology | Diseases | Medicine and Dentistry | SAFETY | Design and delivery of programmes | Teaching | Learning | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | dentistry | A000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | INFORMATION TECHNOLOGY and INFORMATION | G | P | C

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Cardiovascular physiology concepts resource stub

Description

A resource stub for the online edition of 'cardiovascular physiology concepts'. The resource covers arrhythmias, cardiac valve disease, coronary artery disease, edema, heart failure, hypertension, and peripheral artery disease.

Subjects

hypertension | aetiology | epidemiology | prevention and control | diagnosis | drug therapy | blood pressure | Diseases | Medicine and Dentistry | SAFETY | UK EL07 = SCQF 7 | Higher Certificate | NICAT 4 | CQFW 4 | NVQ 4 | Advanced Higher | SVQ 4 | HN Certificate | Institutions | Students | Teaching | dentistry | A000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | G | P

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Cardiac care resource stub

Description

A resource stub for the Cardiac care resource stub webpage, which provides a basic introduction to coronary heart disease (CHD). The resource covers the signs and symptoms of heart attacks; high blood pressure; rheumatic heart disease; and the risk factors, diagnostic tests, procedures and rehabilitation of CHD and stroke.

Subjects

heart | coronary disease | epidemiology | diagnosis | surgery | hypertension | coronary heart disease | blood pressure | cardiovascular disease | Anatomy | Diseases | Medicine and Dentistry | SAFETY | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | Teaching | Students | dentistry | A000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | G | P

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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'Lifeclinic: what is blood pressure?' resource stub

Description

A resource stub for the "Lifeclinic: what is blood pressure?" website, giving access to resources and information on blood pressure and disease.

Subjects

hypertension | aetiology | epidemiology | disease prevention and control | diagnosis | drug therapy | diet therapy | cerebrovascular accident | stroke | carotid endarterectomy | endarterectomy | carotid | blood pressure | high | Technology | Diseases | Analytical | Diagnostic and Therapeutic Techniques and Equipment | SAFETY | Medicine and Dentistry | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | UK EL07 = SCQF 7 | Higher Certificate | NICAT 4 | CQFW 4 | NVQ 4 | Advanced Higher | SVQ 4 | HN Certificate | UK EL08 = SCQF 8 | Higher Diploma | NICAT 5 | CQFW 5 | HN Diploma | Diploma in HE | UK EL09 = SCQF 9 | Ordinary degree | NICAT 6 | CQFW 6 | NVQ 5 | SVQ 5 | Ordinary degree | Graduate certific | Design and delivery of programmes | Teaching | dentistry | A000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | INFORMATION TECHNOLOGY and INFORMATION | G | P | C

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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7.342 G-Protein Coupled Receptors: Vision and Disease (MIT)

Description

How do we communicate with the outside world? How are our senses of vision, smell, taste and pain controlled at the cellular and molecular levels? What causes medical conditions like allergies, hypertension, depression, obesity and various central nervous system disorders? G-protein coupled receptors (GPCRs) provide a major part of the answer to all of these questions. GPCRs constitute the largest family of cell-surface receptors and in humans are encoded by more than 1,000 genes. GPCRs convert extracellular messages into intracellular responses and are involved in essentially all physiological processes. GPCR dysfunction results in numerous human disorders, and over 50% of all prescription drugs on the market today directly or indirectly target GPCRs. In this course, we will discuss GPCR

Subjects

allergies | hypertension | depression | obesity | central nervous system disorders | G-protein coupled receptors | GPCR | cell-surface receptors | George Wald | vision | chromophore | transducin | metarhodopsin II | homodimers | heterodimers | retinitis pigmentosa | night blindness | Dopamine | antihistamines | Claviceps purpurea | Human chemokine receptor 5 | CCR5 | HIV-1 | CCR5-delta32 | Olfactory receptors | Taste receptors

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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