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7.342 Personal Genomics and Medicine: What's in Your Genome? (MIT) 7.342 Personal Genomics and Medicine: What's in Your Genome? (MIT)

Description

Human genome sequencing has revolutionized our understanding of disease susceptibility, drug metabolism and human ancestry. This course will explore how these advances have been made possible by revolutionary new sequencing methodologies that have decreased costs and increased throughput of genome analysis, making it possible to examine genetic correlates for a variety of biological processes and disorders. The course will combine discussions of primary scientific research papers with hands-on data analysis and small group presentations. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a Human genome sequencing has revolutionized our understanding of disease susceptibility, drug metabolism and human ancestry. This course will explore how these advances have been made possible by revolutionary new sequencing methodologies that have decreased costs and increased throughput of genome analysis, making it possible to examine genetic correlates for a variety of biological processes and disorders. The course will combine discussions of primary scientific research papers with hands-on data analysis and small group presentations. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a

Subjects

genome sequencing | genome sequencing | genome analysis | genome analysis | disease susceptibility | disease susceptibility | drug metabolism | drug metabolism | human ancestry | human ancestry | mitochondrial DNA | mitochondrial DNA | tyrosine kinase inhibitors | tyrosine kinase inhibitors | BCR-ABL gene fusion | BCR-ABL gene fusion | PCSK9 inhibitors | PCSK9 inhibitors | hypercholesterolemia | hypercholesterolemia | genetic testing | genetic testing | next generation sequencing | next generation sequencing | Single-nucleotide polymorphisms (SNPs) | Single-nucleotide polymorphisms (SNPs) | copy number variations (CNVs) | copy number variations (CNVs) | genome-wide association studies (GWAS) | genome-wide association studies (GWAS) | Chronic myelogenous leukemia (CML) | Chronic myelogenous leukemia (CML) | mosaics | mosaics | chimeras | chimeras | bioinformatics | bioinformatics

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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17.462 Innovation in Military Organizations (MIT) 17.462 Innovation in Military Organizations (MIT)

Description

This seminar has three purposes. One, it inquires into the causes of military innovation by examining a number of the most outstanding historical cases. Two, it views military innovations through the lens of organization theory to develop generalizations about the innovation process within militaries. Three, it uses the empirical study of military innovations as a way to examine the strength and credibility of hypotheses that organization theorists have generated about innovation in non-military organizations. This seminar has three purposes. One, it inquires into the causes of military innovation by examining a number of the most outstanding historical cases. Two, it views military innovations through the lens of organization theory to develop generalizations about the innovation process within militaries. Three, it uses the empirical study of military innovations as a way to examine the strength and credibility of hypotheses that organization theorists have generated about innovation in non-military organizations.

Subjects

URIECA | URIECA | laboratory | laboratory | kinase | kinase | cancer cells | cancer cells | laboratory techniques | laboratory techniques | DNA | DNA | cultures | cultures | UV-Vis | UV-Vis | agarose gel | agarose gel | Abl-gleevec | Abl-gleevec | affinity tags | affinity tags | lyse | lyse | digest | digest | mutants | mutants | resistance | resistance | gel electrophoresis | gel electrophoresis | recombinant | recombinant | nickel affinity | nickel affinity | inhibitors | inhibitors | biochemistry | biochemistry | kinetics | kinetics | enzyme | enzyme | inhibition | inhibition | purification | purification | expression | expression | Political science | Political science | security studies | security studies | innovation | innovation | military organizations | military organizations | war | war | history | history | organization theory | organization theory | empirical study | empirical study | land warfare | land warfare | battleships | battleships | airpower | airpower | submarines | submarines | cruise | cruise | ballistic | ballistic | missiles | missiles | armor | armor | military affairs | military affairs | strategic | strategic | tactical | tactical | counterinsurgency | counterinsurgency | Vietnam | Vietnam | Revolution in Military Affairs | Revolution in Military Affairs | RMA | RMA

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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5.36 Biochemistry Laboratory (MIT) 5.36 Biochemistry Laboratory (MIT)

Description

The course, which spans two thirds of a semester, provides students with a research-inspired laboratory experience that introduces standard biochemical techniques in the context of investigating a current and exciting research topic, acquired resistance to the cancer drug Gleevec. Techniques include protein expression, purification, and gel analysis, PCR, site-directed mutagenesis, kinase activity assays, and protein structure viewing. This class is part of the new laboratory curriculum in the MIT Department of Chemistry. Undergraduate Research-Inspired Experimental Chemistry Alternatives (URIECA) introduces students to cutting edge research topics in a modular format. Acknowledgments Development of this course was funded through an HHMI Professors grant to Professor Catherine L. Drennan. The course, which spans two thirds of a semester, provides students with a research-inspired laboratory experience that introduces standard biochemical techniques in the context of investigating a current and exciting research topic, acquired resistance to the cancer drug Gleevec. Techniques include protein expression, purification, and gel analysis, PCR, site-directed mutagenesis, kinase activity assays, and protein structure viewing. This class is part of the new laboratory curriculum in the MIT Department of Chemistry. Undergraduate Research-Inspired Experimental Chemistry Alternatives (URIECA) introduces students to cutting edge research topics in a modular format. Acknowledgments Development of this course was funded through an HHMI Professors grant to Professor Catherine L. Drennan.

Subjects

URIECA | URIECA | laboratory | laboratory | kinase | kinase | cancer cells | cancer cells | laboratory techniques | laboratory techniques | DNA | DNA | cultures | cultures | UV-Vis | UV-Vis | agarose gel | agarose gel | Abl-gleevec | Abl-gleevec | affinity tags | affinity tags | lyse | lyse | digest | digest | mutants | mutants | resistance | resistance | gel electrophoresis | gel electrophoresis | recombinant | recombinant | nickel affinity | nickel affinity | inhibitors | inhibitors | biochemistry | biochemistry | kinetics | kinetics | enzyme | enzyme | inhibition | inhibition | purification | purification | expression | expression

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Essentials of Medical Microbiology III - Part 2 of 2

Description

This presentation explains how to treat bacterial infections and covers the mode of action and use of antibiotics, inhibitors of nucleic acid metabolism, RNA metabolism and protein synthesis inhibitors, and concludes with information on antifungal and antiviral drugs. Included is a help file which should be read first.

Subjects

microbiology | medical microbiology | antimicrobial chemotherapy | cidal | static | drug interactions | cell wall inhibitors | nucleic acid metabolism | rna metabolism | protein synthesis inhibitors | antifungal | antiviral | bioukoer | ukoer | Biological sciences | C000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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7.342 Personal Genomics and Medicine: What's in Your Genome? (MIT)

Description

Human genome sequencing has revolutionized our understanding of disease susceptibility, drug metabolism and human ancestry. This course will explore how these advances have been made possible by revolutionary new sequencing methodologies that have decreased costs and increased throughput of genome analysis, making it possible to examine genetic correlates for a variety of biological processes and disorders. The course will combine discussions of primary scientific research papers with hands-on data analysis and small group presentations. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a

Subjects

genome sequencing | genome analysis | disease susceptibility | drug metabolism | human ancestry | mitochondrial DNA | tyrosine kinase inhibitors | BCR-ABL gene fusion | PCSK9 inhibitors | hypercholesterolemia | genetic testing | next generation sequencing | Single-nucleotide polymorphisms (SNPs) | copy number variations (CNVs) | genome-wide association studies (GWAS) | Chronic myelogenous leukemia (CML) | mosaics | chimeras | bioinformatics

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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TALAT Lecture 5103: Corrosion Control of Aluminium - Forms of Corrosion and Prevention

Description

This lecture helps to understand the corrosion principles and to select protection methods; it explains how to use aluminium optimally even in aggressive environments. Some knowledge in aluminium metallurgy and general electrochemistry is assumed.

Subjects

aluminium | aluminum | european aluminium association | EAA | Training in Aluminium Application Technologies | training | metallurgy | technology | lecture | surface treatment | corrosion | acid solutions | neutral solutions | passivation | localized corrosion | environmentally influenced corrosion | pitting corrosion | crevice corrosion | filiform corrosion | biological corrosion | metallurgically influenced corrosion | galvanic corrosion | intergranular corrosion | mechanically assisted degradation | erosion | fretting corrosion | corrosion fatigue | environmentally induced cracking | stress corrosion cracking | SCC | hydrogen embrittlement | corrosion prevention | temper selection | alloy selection | organic coating | inhibitors | anorganic surface treatments | cathodic protection | corematerials | ukoer

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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TALAT Lecture 5104: Basic Approaches to Prevent Corrosion of Aluminium

Description

This lecture describes important measures for the prevention of corrosion of unprotected, bare aluminium. Basic knowledge of corrosion behaviour of aluminium and some knowledge of the electrochemical nature of corrosion is assumed

Subjects

aluminium | aluminum | european aluminium association | EAA | Training in Aluminium Application Technologies | training | metallurgy | technology | lecture | surface treatment | corrosion resistant alloys | wrought alloys | cast alloys | equipment design | galvanic corrosion | prevention | deposition corrosion | crevice corrosion | stress corrosion | stress corrosion resistant tempers | corrosion inhibitors | environment alteration | cathodic protection | sacrificial anodes | impressed current | Alclad alloys | corematerials | ukoer

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Virtual laboratories in Molecular and Cell Biology - Intracellular signalling

Description

A virtual laboratory which allows users to analyse intracellular signalling pathways. The programme allows the student to stimulate cells for different periods of time and analyse phosphorylation/activation of kinases in the signalling pathways, using SDS-PAGE and immunoblotting. Use of different cell types (dominant-negative mutants) and pull-down assays allows them to derive the hierarchy in the signalling pathways. The programme first introduces the theory behind the techniques. It then takes the student through a series of guided questions, which they answer by going to the virtual laboratory to devise and interpret their own experiments. Results from the experiments (gels and blots) can be saved to produce laboratory reports. The programme is an installer which places all the files re

Subjects

bioukoer | kinases | phosphorylation | sds-page | immunoblotting | map kinase pathway | pdgf receptor | enzyme inhibitors | writing a laboratory report | Biological sciences | C000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Renal function diuretics

Description

This topic describes the various drugs that affect renal function and introduces diuretics. Diuretics are explored in more detail, specifically the mechanism of action and the different types, including examples.

Subjects

renal function | diuretics | osmotic | electrolytes | thiazides | inhibitors | potassium | loop | ukoer | ooer | medev | Medicine and Dentistry | Subjects allied to Medicine | Biological Sciences | SAFETY | Learning | Teaching | Institutions | Students | UK EL10 = SCQF 10 | Honours degree | Graduate diploma | dentistry | A000

License

Attribution-Share Alike 2.0 UK: England & Wales Attribution-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-sa/2.0/uk/ http://creativecommons.org/licenses/by-sa/2.0/uk/

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TALAT Lecture 5103: Corrosion Control of Aluminium - Forms of Corrosion and Prevention

Description

This lecture helps to understand the corrosion principles and to select protection methods; it explains how to use aluminium optimally even in aggressive environments. Some knowledge in aluminium metallurgy and general electrochemistry is assumed.

Subjects

aluminium | aluminum | european aluminium association | eaa | talat | training in aluminium application technologies | training | metallurgy | technology | lecture | surface treatment | corrosion | acid solutions | neutral solutions | passivation | localized corrosion | environmentally influenced corrosion | pitting corrosion | crevice corrosion | filiform corrosion | biological corrosion | metallurgically influenced corrosion | galvanic corrosion | intergranular corrosion | mechanically assisted degradation | erosion | fretting corrosion | corrosion fatigue | environmentally induced cracking | stress corrosion cracking | scc | hydrogen embrittlement | corrosion prevention | temper selection | alloy selection | organic coating | inhibitors | anorganic surface treatments | cathodic protection | corematerials | ukoer | Engineering | H000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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TALAT Lecture 5104: Basic Approaches to Prevent Corrosion of Aluminium

Description

This lecture describes important measures for the prevention of corrosion of unprotected, bare aluminium. Basic knowledge of corrosion behaviour of aluminium and some knowledge of the electrochemical nature of corrosion is assumed

Subjects

aluminium | aluminum | european aluminium association | eaa | talat | training in aluminium application technologies | training | metallurgy | technology | lecture | surface treatment | corrosion resistant alloys | wrought alloys | cast alloys | equipment design | galvanic corrosion | prevention | deposition corrosion | crevice corrosion | stress corrosion | stress corrosion resistant tempers | corrosion inhibitors | environment alteration | cathodic protection | sacrificial anodes | impressed current | alclad alloys | corematerials | ukoer | Engineering | H000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Corrosion inhibitors

Description

An introduction to corrosion inhibitors, comprising a learning context and associated assessment.

Subjects

engineering | corrosion inhibitors | electroplating | galvanising | dip coating | OIL / MINING / PLASTICS / CHEMICALS | Engineering | Assessment | Students | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | H000 | ENGINEERING | X | Y

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Enzymes

Description

This is a revision resource for A-Level Biology about enzyme function. covering the lock and key theory, induced fit, inhibitors and activation energy.

Subjects

enzymes | lock and key | induced fit | carbonic anhydrase | inhibitors | activation energy | SCIENCES and MATHEMATICS | R

License

Attribution-Noncommercial-No Derivative Works 2.0 UK: England & Wales Attribution-Noncommercial-No Derivative Works 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-nd/2.0/uk/ http://creativecommons.org/licenses/by-nc-nd/2.0/uk/

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Cancer Biology

Description

This course will cover the origins of cancer and the genetic and cellular basis for cancer. It will examine the factors that have been implicated in triggering cancers, the intercellular interactions involved in cancer proliferation, current treatments for cancer and how these are designed, and future research and treatment directions for cancer therapy. This free course may be completed online at any time. See course site for detailed overview and learning outcomes. (Biology 404)

Subjects

biology | cancer | genes | death | carcinogens | expression | regulation | inhibitors | apoptosis | immortality | therapy | prevention | Biological sciences | C000

License

Attribution 2.0 UK: England & Wales Attribution 2.0 UK: England & Wales http://creativecommons.org/licenses/by/2.0/uk/ http://creativecommons.org/licenses/by/2.0/uk/

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17.462 Innovation in Military Organizations (MIT)

Description

This seminar has three purposes. One, it inquires into the causes of military innovation by examining a number of the most outstanding historical cases. Two, it views military innovations through the lens of organization theory to develop generalizations about the innovation process within militaries. Three, it uses the empirical study of military innovations as a way to examine the strength and credibility of hypotheses that organization theorists have generated about innovation in non-military organizations.

Subjects

URIECA | laboratory | kinase | cancer cells | laboratory techniques | DNA | cultures | UV-Vis | agarose gel | Abl-gleevec | affinity tags | lyse | digest | mutants | resistance | gel electrophoresis | recombinant | nickel affinity | inhibitors | biochemistry | kinetics | enzyme | inhibition | purification | expression | Political science | security studies | innovation | military organizations | war | history | organization theory | empirical study | land warfare | battleships | airpower | submarines | cruise | ballistic | missiles | armor | military affairs | strategic | tactical | counterinsurgency | Vietnam | Revolution in Military Affairs | RMA

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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5.36 Biochemistry Laboratory (MIT)

Description

The course, which spans two thirds of a semester, provides students with a research-inspired laboratory experience that introduces standard biochemical techniques in the context of investigating a current and exciting research topic, acquired resistance to the cancer drug Gleevec. Techniques include protein expression, purification, and gel analysis, PCR, site-directed mutagenesis, kinase activity assays, and protein structure viewing. This class is part of the new laboratory curriculum in the MIT Department of Chemistry. Undergraduate Research-Inspired Experimental Chemistry Alternatives (URIECA) introduces students to cutting edge research topics in a modular format. Acknowledgments Development of this course was funded through an HHMI Professors grant to Professor Catherine L. Drennan.

Subjects

URIECA | laboratory | kinase | cancer cells | laboratory techniques | DNA | cultures | UV-Vis | agarose gel | Abl-gleevec | affinity tags | lyse | digest | mutants | resistance | gel electrophoresis | recombinant | nickel affinity | inhibitors | biochemistry | kinetics | enzyme | inhibition | purification | expression

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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