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7.345 Vascular Development in Life, Disease and Cancer Medicine (MIT) 7.345 Vascular Development in Life, Disease and Cancer Medicine (MIT)

Description

The growth of blood vessels, a process known as angiogenesis, is one of the earliest events in mammalian development and is regulated by a sensitive interplay of growth factors and other molecules. In this course, we will discuss the key molecular regulators of blood vessel development as well as the techniques and experimental systems that have been utilized by vascular biologists. We will also examine the success of several anti-angiogenic treatments that have been approved by the Food and Drug Administration (FDA), that inhibit the pro-angiogenic vascular endothelial growth factor, VEGF, and that are now being used to treat age-related macular degeneration. Finally, we will explore how during the course of cancer progression, establishment of a blood supply into a tumor can lead to the The growth of blood vessels, a process known as angiogenesis, is one of the earliest events in mammalian development and is regulated by a sensitive interplay of growth factors and other molecules. In this course, we will discuss the key molecular regulators of blood vessel development as well as the techniques and experimental systems that have been utilized by vascular biologists. We will also examine the success of several anti-angiogenic treatments that have been approved by the Food and Drug Administration (FDA), that inhibit the pro-angiogenic vascular endothelial growth factor, VEGF, and that are now being used to treat age-related macular degeneration. Finally, we will explore how during the course of cancer progression, establishment of a blood supply into a tumor can lead to the

Subjects

angiogenesis | angiogenesis | growth factors | growth factors | VEGF | VEGF | microscopic visualization | microscopic visualization | intravital imaging | intravital imaging | anti-angiogenic treatments | anti-angiogenic treatments | macular degeneration | macular degeneration | cancer progression | cancer progression | tumor blood vessels | tumor blood vessels

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Ageing eye

Description

This resource starts with a diagrammatic comparison between the structures of a normal and an ageing eye. The topic contains an image which is simulated to compare normal vision against blurred and discoloured vision. The same image is again simulated to show the effects of glaucoma and macular degeneration vision. Each image is accompanied by respective text to explain key differences. (UKEC: Higher Education, HE2, Medicine)

Subjects

eyes | vision | ageing | blurred vision | discoloured vision | glaucoma | macular degeneration | ukoer | ooer | medev | Medicine and Dentistry | Subjects allied to Medicine | Biological Sciences | SAFETY | Learning | Design and delivery of programmes | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | UK EL07 = SCQF 7 | Higher Certificate | NICAT 4 | CQFW 4 | NVQ 4 | Advanced Higher | SVQ 4 | HN Certificate | UK EL08 = SCQF 8 | Higher Diploma | NICAT 5 | CQFW 5 | HN Diploma | Diploma in HE | UK EL09 = SCQF 9 | Ordinary degree | NICAT 6 | CQFW 6 | NVQ 5 | SVQ 5 | Ordinary degree | Graduate certific | dentistry | A000

License

Attribution-Share Alike 2.0 UK: England & Wales Attribution-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-sa/2.0/uk/ http://creativecommons.org/licenses/by-sa/2.0/uk/

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7.345 Vascular Development in Life, Disease and Cancer Medicine (MIT)

Description

The growth of blood vessels, a process known as angiogenesis, is one of the earliest events in mammalian development and is regulated by a sensitive interplay of growth factors and other molecules. In this course, we will discuss the key molecular regulators of blood vessel development as well as the techniques and experimental systems that have been utilized by vascular biologists. We will also examine the success of several anti-angiogenic treatments that have been approved by the Food and Drug Administration (FDA), that inhibit the pro-angiogenic vascular endothelial growth factor, VEGF, and that are now being used to treat age-related macular degeneration. Finally, we will explore how during the course of cancer progression, establishment of a blood supply into a tumor can lead to the

Subjects

angiogenesis | growth factors | VEGF | microscopic visualization | intravital imaging | anti-angiogenic treatments | macular degeneration | cancer progression | tumor blood vessels

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

Site sourced from

https://ocw.mit.edu/rss/all/mit-alllifesciencescourses.xml

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