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7.343 A Love-Hate Relationship: Cholesterol in Health and Disease (MIT) 7.343 A Love-Hate Relationship: Cholesterol in Health and Disease (MIT)

Description

In this class, we will examine cholesterol's role in the cell and in the body as a whole, from its function as a structural component of the membrane to its function in signaling. We will discuss mechanisms of cholesterol sensing, mechanisms of feedback regulation in cells, cholesterol in the brain, cholesterol in the circulation, 'good cholesterol' and 'bad cholesterol,' cholesterol-related human disorders, and the drugs that deal with some of these disorders. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanc In this class, we will examine cholesterol's role in the cell and in the body as a whole, from its function as a structural component of the membrane to its function in signaling. We will discuss mechanisms of cholesterol sensing, mechanisms of feedback regulation in cells, cholesterol in the brain, cholesterol in the circulation, 'good cholesterol' and 'bad cholesterol,' cholesterol-related human disorders, and the drugs that deal with some of these disorders. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instructors of the Advanc

Subjects

cholesterol | cholesterol | biosynthesis | biosynthesis | LDL | LDL | HDL | HDL | Smith-Lemli-Opitz Syndrome | Smith-Lemli-Opitz Syndrome | uptake | uptake | endocytosis | endocytosis | hypercholesterolemia | hypercholesterolemia | atherosclerosis | atherosclerosis | plaque | plaque | statins | statins | HMG-CoA | HMG-CoA | ezetimibe | ezetimibe | heart attack | heart attack | lipoprotein | lipoprotein | Fibrates | Fibrates | receptor | receptor | alzheimer's | alzheimer's

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Memorial Plaque for Yuri Gagarin Memorial Plaque for Yuri Gagarin

Description

Subjects

plaque | plaque | johnglenn | johnglenn | starcity | starcity | yurigagarin | yurigagarin | neilarmstrong | neilarmstrong | georgelow | georgelow | jamesmcdivitt | jamesmcdivitt | generalkuznetsov | generalkuznetsov

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Cromaboo bridge, first stone laid in 1796, Athy, Co. Kildare. Cromaboo bridge, first stone laid in 1796, Athy, Co. Kildare.

Description

Subjects

bridge | bridge | plaque | plaque | coatofarms | coatofarms | athy | athy | countykildare | countykildare | johnroberts | johnroberts | mastermason | mastermason | nationallibraryofireland | nationallibraryofireland | williamfitzgerald | williamfitzgerald | jamesdelahunty | jamesdelahunty | dukeofleinster | dukeofleinster | cromaboo | cromaboo | jamespo’dea | jamespo’dea | o’deaphotographiccollection | o’deaphotographiccollection | knightofthetrowel | knightofthetrowel | cromabú | cromabú | yousaycontracterisay | yousaycontracterisay | jamesdelehunty | jamesdelehunty

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Replica of Plaque Left on Moon by Apollo 17 Astronauts Replica of Plaque Left on Moon by Apollo 17 Astronauts

Description

Subjects

plaque | plaque | lunarmodule | lunarmodule | apollo17 | apollo17 | tauruslittrow | tauruslittrow

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" "

Description

Subjects

dublin | dublin | plaque | plaque | war | war | poem | poem | general | general | earl | earl | roberts | roberts | newtown | newtown | sleigh | sleigh | vc | vc | waterford | waterford | frederick | frederick | battles | battles | glassnegative | glassnegative | rudyardkipling | rudyardkipling | viscount | viscount | victoriacross | victoriacross | fieldmarshal | fieldmarshal | nationallibraryofireland | nationallibraryofireland | orderofstpatrick | orderofstpatrick | ahpoole | ahpoole | poolecollection | poolecollection | limerickbybeachcomber | limerickbybeachcomber | arthurhenripoole | arthurhenripoole | skiingenthusiast | skiingenthusiast | lordfrederickrobertsvc | lordfrederickrobertsvc | curraghmutiny | curraghmutiny

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116 St James's Street - Probably Guinness owned 116 St James's Street - Probably Guinness owned

Description

Subjects

dublin | dublin | rolleiflex | rolleiflex | gate | gate | 1966 | 1966 | guinness | guinness | matchbox | matchbox | 1865 | 1865 | guinnessbrewery | guinnessbrewery | leinster | leinster | stjamessstreet | stjamessstreet | codublin | codublin | nationallibraryofireland | nationallibraryofireland | rolleiflexcamera | rolleiflexcamera | militarysymbols | militarysymbols | parnellsquarenorth | parnellsquarenorth | locationidentified | locationidentified | fordthames400e | fordthames400e | charlemonthouse | charlemonthouse | elinorwiltshire | elinorwiltshire | wiltshirephotographiccollection | wiltshirephotographiccollection | droppedkeystone | droppedkeystone | elinoro’brienwiltshire | elinoro’brienwiltshire | reginaldwiltshire | reginaldwiltshire | vehicleidentified | vehicleidentified | 116stjames’sstreet | 116stjames’sstreet | ornatearchandgateway | ornatearchandgateway | wwwbuildingsofirelandie | wwwbuildingsofirelandie | freestandingpedimentedgateway | freestandingpedimentedgateway | erectedc1865 | erectedc1865 | carvedvoussoirs | carvedvoussoirs | rusticatedcutgranitepiers | rusticatedcutgranitepiers | carvedgranitecornice | carvedgranitecornice | carvedinlaidplaque | carvedinlaidplaque

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a Preventiva y Comunitaria I (2015) a Preventiva y Comunitaria I (2015)

Description

La Odontologa Preventiva y Comunitaria pretende que el alumno sea capaz de conseguir y mantener la salud bucodental del individuo y de la comunidad a travs del desarrollo de conocimientos, actitudes y habilidadaes bsicos y aplicados para la promocin, prevencin, diagnstico y tratamiento integrado de las alteraciones ms prevalentes del sistema estomatogntico, independientemente que estos mtodos preventivos sean aplicados a nivel individual o colectivo. La materia aporta una considerable contribucin para adquirir competencias de la titulacin, teniendo su estudio continuacin con todas las disciplinas que integran el cirrculum del grado en Odontologa. La Odontologa Preventiva y Comunitaria pretende que el alumno sea capaz de conseguir y mantener la salud bucodental del individuo y de la comunidad a travs del desarrollo de conocimientos, actitudes y habilidadaes bsicos y aplicados para la promocin, prevencin, diagnstico y tratamiento integrado de las alteraciones ms prevalentes del sistema estomatogntico, independientemente que estos mtodos preventivos sean aplicados a nivel individual o colectivo. La materia aporta una considerable contribucin para adquirir competencias de la titulacin, teniendo su estudio continuacin con todas las disciplinas que integran el cirrculum del grado en Odontologa.

Subjects

a preventiva | a preventiva | a | a | ph salivar | ph salivar | control de placa | control de placa | test de saliva | test de saliva | triplaque | triplaque

License

http://creativecommons.org/licenses/by-nc-sa/3.0/

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is actually Switzerland is actually Switzerland

Description

Subjects

theclonbrockphotographiccollection | theclonbrockphotographiccollection | lukegeralddillon | lukegeralddillon | baronclonbrock | baronclonbrock | augustacarolinedillon | augustacarolinedillon | baronessclonbrock | baronessclonbrock | dillonfamily | dillonfamily | nationallibraryofireland | nationallibraryofireland | chapel | chapel | banim | banim | crestplaque | crestplaque | sundial | sundial | tempesfugit | tempesfugit | timeflies | timeflies | saint | saint | idda | idda | church | church | kirche | kirche | bauen | bauen | onion | onion | dome | dome | turner | turner | locationidentified | locationidentified | switzerland | switzerland | ch | ch | uri | uri | pfarrkirchestidda | pfarrkirchestidda | stidda | stidda | stida | stida | possiblecataloguecorrection | possiblecataloguecorrection

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X0002P0538

Description

Nasal plaques in a cow

Subjects

svmsvet | cow | bovine | nasal | nose | plaques

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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Virology

Description

An articulate presentation that includes several engage produced units that provide scripted photographic illustrations of techniques used in virology. The techniques covered are: Plaque assay of Herpes Simplex virus; Neutralisation of virus infectivity as a means of virus identification; Assay of T4 Bacteriophage by the Agar Layer technique; Haemagglutination/Haemagglutination Inhibition test. Each of the engage interactions can be accessed individually if required once unzipped. A help file is included.

Subjects

virus infectivity | virus identification | ukoer | haemagglutination | bacteriophage | agar layer technique | herpes simplex virus | haemagglutination inhibition | plaque assay | bioukoer | microbiology | Biological sciences | C000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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[Men Standing by Historical Marker, Pecos River High Bridge, Southern Pacific Railroad Company]

Description

Subjects

signs | men | bridges | sp | rivers | railroads | plaques | pecoshighbridge

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X0002P0538

Description

Nasal plaques in a cow

Subjects

svmsvet | cow | bovine | nasal | nose | plaques

License

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"General U.S. Grant" Framed Medallion

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: "General U.S. Grant" Framed Medallion Political Party: Republican Election Year: 1868 Date Made: ca. 1868 Measurement: Frame: 3 x 2 1/2 in.; 7.62 x 6.35 cm Classification: Sculpture Persistent URI: hdl.handle.net/1813.001/5zc2 There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | portraits | plaquesflatobjects | grantulyssess18221885 | politics | promotionalmaterials | generals | americancivilwar | busts | uniforms | culidentifier:value=2214bb0054 | culidentifier:lunafield=idnumber

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"General U.S. Grant" Framed Medallion

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: "General U.S. Grant" Framed Medallion Political Party: Republican Election Year: 1868 Date Made: ca. 1868 Measurement: Frame: 3 x 2 1/2 in.; 7.62 x 6.35 cm Classification: Sculpture Persistent URI: hdl.handle.net/1813.001/5zc3 There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | portraits | plaquesflatobjects | grantulyssess18221885 | politics | promotionalmaterials | generals | americancivilwar | busts | uniforms | culidentifier:value=2214bb0054 | culidentifier:lunafield=idnumber

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McKinley "1843-1901" Bronze Memorial Plaque

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: McKinley "1843-1901" Bronze Memorial Plaque Political Party: Republican Date Made: 1901 Measurement: Plaque (diameter): x 6 1/4 in.; x 15.875 cm Classification: Sculpture Persistent URI: hdl.handle.net/1813.001/5zm4 There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | plaquesflatobjects | portraits | wallhangings | basreliefs | mckinleywilliam | commemoratives | politics | mourning | deaths | busts | profileportraits | culidentifier:value=2214bb0167 | culidentifier:lunafield=idnumber

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McKinley "Protection" Tin Portrait Plaque, ca. 1896

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: McKinley "Protection" Tin Portrait Plaque, ca. 1896 Political Party: Republican Election Year: 1896 Date Made: ca. 1896 Measurement: Plaque: 6 1/2 x 4 1/2 in.; 16.51 x 11.43 cm Classification: Metalwork Persistent URI: hdl.handle.net/1813.001/5zkh There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | plaquesflatobjects | portraits | wallhangings | mckinleywilliam | politics | promotionalmaterials | busts | profileportraits | protectionism | trade | industry | economicpolicy | tin | culidentifier:value=2214bb0153 | culidentifier:lunafield=idnumber

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Hendricks Metal Portrait Plaque, ca. 1884

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: Hendricks Metal Portrait Plaque, ca. 1884 Political Party: Democratic Election Year: 1884 Date Made: ca. 1884 Measurement: Plaque: 5 3/4 x 4 1/2 in.; 14.605 x 11.43 cm Classification: Sculpture Persistent URI: hdl.handle.net/1813.001/5zfh There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | plaquesflatobjects | portraits | wallhangings | basreliefs | hendricksthomasa | politics | promotionalmaterials | busts | profileportraits | culidentifier:value=2214bb0103 | culidentifier:lunafield=idnumber

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McKinley Cast Iron Portrait Plaque, ca. 1896

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: McKinley Cast Iron Portrait Plaque, ca. 1896 Political Party: Republican Election Year: 1896 Date Made: ca. 1896 Measurement: Plaque: 10 x 8.75 in.; 25.4 x 22.225 cm Classification: Sculpture Persistent URI: hdl.handle.net/1813.001/5zgm There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | portraits | plaquesflatobjects | wallhangings | mckinleywilliam | politics | busts | promotionalmaterials | profileportraits | oakbranches | culidentifier:value=2214bb0130 | culidentifier:lunafield=idnumber

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Winfield Scott Campaign and Commemorative Items

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: Winfield Scott Campaign and Commemorative Items Political Party: Whig Election Year: 1852 Date Made: ca. 1852-1861 Measurement: Mount: 8 x 12 in.; 20.32 x 30.48 cm Classification: Ephemera Persistent URI: hdl.handle.net/1813.001/60qg There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | medals | medallionsmedals | pendantsjewelry | plaquesflatobjects | portraits | scottwinfield | grahamwilliama | politics | promotionalmaterials | busts | profileportraits | warof1812 | mexicanwar | generals | uniforms | battles | americanflags | caps | freedom | unity | constitutionoftheunitedstates | soldiers | symbols | animals | eagles | roses | mexicocitymexico | cannons | wreaths | shields | commemoratives | americancivilwar | birds | culidentifier:value=2214tk0013 | culidentifier:lunafield=idnumber

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Winfield Scott Campaign and Commemorative Items

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: Winfield Scott Campaign and Commemorative Items Political Party: Whig Election Year: 1852 Date Made: ca. 1852-1861 Measurement: Mount: 8 x 12 in.; 20.32 x 30.48 cm Classification: Ephemera Persistent URI: hdl.handle.net/1813.001/60qh There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | medals | medallionsmedals | pendantsjewelry | plaquesflatobjects | portraits | scottwinfield | grahamwilliama | politics | promotionalmaterials | busts | profileportraits | warof1812 | mexicanwar | generals | uniforms | battles | americanflags | caps | freedom | unity | constitutionoftheunitedstates | soldiers | symbols | animals | eagles | roses | mexicocitymexico | cannons | wreaths | shields | commemoratives | americancivilwar | birds | culidentifier:value=2214tk0013 | culidentifier:lunafield=idnumber

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Theodore Roosevelt "Aggressive Fighting For the Right..." Bronze Portrait Plaque, 1920

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: Theodore Roosevelt "Aggressive Fighting For the Right..." Bronze Portrait Plaque, 1920 Political Party: Progressive Date Made: 1920 Measurement: Plaque: 12 3/4 x 9 3/4 in.; 32.385 x 24.765 cm Classification: Sculpture Persistent URI: hdl.handle.net/1813.001/5zrt There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | plaquesflatobjects | portraits | wallhangings | basreliefs | roosevelttheodore18581919 | busts | profileportraits | quotationstexts | fighting | sport | commemoratives | politics | culidentifier:value=2214bb0217 | culidentifier:lunafield=idnumber

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Butler Metal Portrait Plaque, ca. 1884

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: Butler Metal Portrait Plaque, ca. 1884 Political Party: Greenback Election Year: 1884 Date Made: ca. 1884 Measurement: Plaque: 5 3/4 x 4 1/2 in.; 14.605 x 11.43 cm Classification: Sculpture Persistent URI: hdl.handle.net/1813.001/5zfj There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | plaquesflatobjects | portraits | wallhangings | basreliefs | butlerbenjaminf | politics | promotionalmaterials | busts | profileportraits | culidentifier:value=2214bb0104 | culidentifier:lunafield=idnumber

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McKinley "It is God's Way / Lead, Kindly Light" Portrait Plaque, ca. 1901

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: McKinley "It is God's Way / Lead, Kindly Light" Portrait Plaque, ca. 1901 Political Party: Republican Date Made: ca. 1901 Measurement: Plaque: 12 x 9 in.; 30.48 x 22.86 cm Classification: Metalwork Persistent URI: hdl.handle.net/1813.001/5zmz There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | plaquesflatobjects | portraits | wallhangings | hymns | mckinleywilliam | busts | quotationstexts | songs | deaths | mourning | politics | commemoratives | religion | profileportraits | culidentifier:value=2214bb0176 | culidentifier:lunafield=idnumber

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Cleveland-Hendricks Wooden Portrait Plaque, 1884

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: Cleveland-Hendricks Wooden Portrait Plaque, 1884 Political Party: Democratic Election Year: 1884 Date Made: 1884 Measurement: Plaque (diameter): x 3 in.; x 7.62 cm Classification: Artifacts Persistent URI: hdl.handle.net/1813.001/5zff There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | plaquesflatobjects | wallhangings | portraits | clevelandgrover | hendricksthomasa | politics | promotionalmaterials | symbols | animals | eagles | shields | stars | wreaths | busts | birds | culidentifier:value=2214bb0101 | culidentifier:lunafield=idnumber

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Cleveland Metal Portrait Plaque, ca. 1884

Description

Collection: Cornell University Collection of Political Americana, Cornell University Library Repository: Susan H. Douglas Political Americana Collection, #2214 Rare & Manuscript Collections, Cornell University Library, Cornell University Title: Cleveland Metal Portrait Plaque, ca. 1884 Political Party: Democratic Election Year: 1884 Date Made: ca. 1884 Measurement: Plaque: 5 2/4 x 4 1/4 in.; 13.97 x 10.795 cm Classification: Sculpture Persistent URI: hdl.handle.net/1813.001/5zfg There are no known U.S. copyright restrictions on this image. The digital file is owned by the Cornell University Library which is making it freely available with the request that, when possible, the Library be credited as its source.

Subjects

cornelluniversitylibrary | plaquesflatobjects | portraits | wallhangings | basreliefs | clevelandgrover | politics | promotionalmaterials | busts | profileportraits | culidentifier:value=2214bb0102 | culidentifier:lunafield=idnumber

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