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7.342 Pluripotent Stem Cells and Genome Engineering for Modeling Human Diseases (MIT) 7.342 Pluripotent Stem Cells and Genome Engineering for Modeling Human Diseases (MIT)

Description

One of the major priorities in biomedical research is understanding the molecular events that establish the complex processes involved in human development and the relationships of these processes to human disease and disease progression. In this class, we will explore stem cell biology and the way in which it has developed and shaped our ability to study complex human disease. We will introduce the field of stem cell biology and genome engineering through critical reading of both the classical and newest primary research literature. In addition, this course will discuss specific disease model systems and their benefits / limitations for understanding the disease and treating human patients. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT One of the major priorities in biomedical research is understanding the molecular events that establish the complex processes involved in human development and the relationships of these processes to human disease and disease progression. In this class, we will explore stem cell biology and the way in which it has developed and shaped our ability to study complex human disease. We will introduce the field of stem cell biology and genome engineering through critical reading of both the classical and newest primary research literature. In addition, this course will discuss specific disease model systems and their benefits / limitations for understanding the disease and treating human patients. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT

Subjects

stem cells | stem cells | genome engineering | genome engineering | pluripotency | pluripotency | disease progression | disease progression | embryonic stem cells | embryonic stem cells | induced pluripotent stem cells | induced pluripotent stem cells | transgenic animals | transgenic animals | regenerative medicine | regenerative medicine | CRISPR/cas9 | CRISPR/cas9 | Nuclear Transfer | Nuclear Transfer | Cellular Reprogramming | Cellular Reprogramming

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7.344 The Fountain of Life: From Dolly to Customized Embryonic Stem Cells (MIT) 7.344 The Fountain of Life: From Dolly to Customized Embryonic Stem Cells (MIT)

Description

During development, the genetic content of each cell remains, with a few exceptions, identical to that of the zygote. Most differentiated cells therefore retain all of the genetic information necessary to generate an entire organism. It was through pioneering technology of somatic cell nuclear transfer (SCNT) that this concept was experimentally proven. Only 10 years ago the sheep Dolly was the first mammal to be cloned from an adult organism, demonstrating that the differentiated state of a mammalian cell can be fully reversible to a pluripotent embryonic state. A key conclusion from these experiments was that the difference between pluripotent cells such as embryonic stem (ES) cells and unipotent differentiated cells is solely a consequence of reversible changes. These changes, which hav During development, the genetic content of each cell remains, with a few exceptions, identical to that of the zygote. Most differentiated cells therefore retain all of the genetic information necessary to generate an entire organism. It was through pioneering technology of somatic cell nuclear transfer (SCNT) that this concept was experimentally proven. Only 10 years ago the sheep Dolly was the first mammal to be cloned from an adult organism, demonstrating that the differentiated state of a mammalian cell can be fully reversible to a pluripotent embryonic state. A key conclusion from these experiments was that the difference between pluripotent cells such as embryonic stem (ES) cells and unipotent differentiated cells is solely a consequence of reversible changes. These changes, which hav

Subjects

embryonic stem cells | embryonic stem cells | stem cells | stem cells | cells | cells | genetics | genetics | genome | genome | Dolly | Dolly | clone | clone | regenerative therapy | regenerative therapy | somatic | somatic | SCNT | SCNT | pluripotent | pluripotent | scientific literature | scientific literature | nuclear | nuclear | embryonic | embryonic | adult | adult | epigenetics | epigenetics | methylation | methylation | DNA | DNA | histone | histone | biomedical | biomedical | differentiation | differentiation | epigenome | epigenome | nuclear transfer | nuclear transfer | customized | customized | zygote | zygote | RNA | RNA | cancer | cancer | medicine | medicine

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7.342 Pluripotent Stem Cells and Genome Engineering for Modeling Human Diseases (MIT)

Description

One of the major priorities in biomedical research is understanding the molecular events that establish the complex processes involved in human development and the relationships of these processes to human disease and disease progression. In this class, we will explore stem cell biology and the way in which it has developed and shaped our ability to study complex human disease. We will introduce the field of stem cell biology and genome engineering through critical reading of both the classical and newest primary research literature. In addition, this course will discuss specific disease model systems and their benefits / limitations for understanding the disease and treating human patients. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT

Subjects

stem cells | genome engineering | pluripotency | disease progression | embryonic stem cells | induced pluripotent stem cells | transgenic animals | regenerative medicine | CRISPR/cas9 | Nuclear Transfer | Cellular Reprogramming

License

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7.013 Introductory Biology (MIT) 7.013 Introductory Biology (MIT)

Description

The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.7.013 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.7.013 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer),

Subjects

biology | biology | biochemistry | biochemistry | genetics | genetics | molecular biology | molecular biology | recombinant DNA | recombinant DNA | cell cycle | cell cycle | cell signaling | cell signaling | cloning | cloning | stem cells | stem cells | cancer | cancer | immunology | immunology | virology | virology | genomics | genomics | molecular medicine | molecular medicine | DNA | DNA | RNA | RNA | proteins | proteins | replication | replication | transcription | transcription | mRNA | mRNA | translation | translation | ribosome | ribosome | nervous system | nervous system | amino acids | amino acids | polypeptide chain | polypeptide chain | cell biology | cell biology | neurobiology | neurobiology | gene regulation | gene regulation | protein structure | protein structure | protein synthesis | protein synthesis | gene structure | gene structure | PCR | PCR | polymerase chain reaction | polymerase chain reaction | protein localization | protein localization | endoplasmic reticulum | endoplasmic reticulum | human biology | human biology | inherited diseases | inherited diseases | developmental biology | developmental biology | evolution | evolution | human genetics | human genetics | human diseases | human diseases | infectious agents | infectious agents | infectious diseases | infectious diseases

License

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7.012 Introduction to Biology (MIT) 7.012 Introduction to Biology (MIT)

Description

All three courses: 7.012, 7.013 and 7.014 cover the same core material which includes: the fundamental principles of biochemistry as they apply to introductory biology, genetics, molecular biology, basic recombinant DNA technology, and gene regulation.In addition, each version of the subject has its own distinctive material, described below. Note: All three versions require a familiarity with some basic chemistry. For details, see the Chemistry Self-evaluation.7.012 focuses on cell biology, immunology, neurobiology, and includes an exploration into current research in cancer, genomics, and molecular medicine. 7.013 focuses on the application of the fundamental principles toward an understanding of cells, human genetics and diseases, infectious agents, cancer, immunology, molecular All three courses: 7.012, 7.013 and 7.014 cover the same core material which includes: the fundamental principles of biochemistry as they apply to introductory biology, genetics, molecular biology, basic recombinant DNA technology, and gene regulation.In addition, each version of the subject has its own distinctive material, described below. Note: All three versions require a familiarity with some basic chemistry. For details, see the Chemistry Self-evaluation.7.012 focuses on cell biology, immunology, neurobiology, and includes an exploration into current research in cancer, genomics, and molecular medicine. 7.013 focuses on the application of the fundamental principles toward an understanding of cells, human genetics and diseases, infectious agents, cancer, immunology, molecular

Subjects

amino acids | amino acids | biochemistry | biochemistry | cancer | cancer | cell biology | cell biology | cell cycle | cell cycle | cell signaling | cell signaling | cloning | cloning | DNA | DNA | endoplasmic reticulum | endoplasmic reticulum | gene regulation | gene regulation | gene structure | gene structure | genetics | genetics | genomics | genomics | immunology | immunology | molecular biology | molecular biology | molecular medicine | molecular medicine | mRNA | mRNA | nervous system | nervous system | neurobiology | neurobiology | PCR | PCR | polymerase chain reaction | polymerase chain reaction | polypeptide chain | polypeptide chain | protein localization | protein localization | protein structure | protein structure | protein synthesis | protein synthesis | proteins | proteins | recombinant DNA | recombinant DNA | replication | replication | ribosome | ribosome | RNA | RNA | stem cells | stem cells | transcription | transcription | translation | translation | virology | virology | biology | biology

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New Cells for Old Members: The Science of Stem Cells

Description

Dr Francis Szele gives a talk for the Oxford Alumni Weekend on Stem Cell science and looks at how they could be used in repairing brain disease and injuries. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

science | biology | alumni | stem cells | neuroscience | science | biology | alumni | stem cells | neuroscience | 2011-09-17

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7.013 Introductory Biology (MIT) 7.013 Introductory Biology (MIT)

Description

The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material. 7.013 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material. 7.013 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer),

Subjects

biology | biology | biochemistry | biochemistry | genetics | genetics | molecular biology | molecular biology | recombinant DNA | recombinant DNA | cell cycle | cell cycle | cell signaling | cell signaling | cloning | cloning | stem cells | stem cells | cancer | cancer | immunology | immunology | virology | virology | genomics | genomics | molecular medicine | molecular medicine | DNA | DNA | RNA | RNA | proteins | proteins | replication | replication | transcription | transcription | mRNA | mRNA | translation | translation | ribosome | ribosome | nervous system | nervous system | amino acids | amino acids | polypeptide chain | polypeptide chain | cell biology | cell biology | neurobiology | neurobiology | gene regulation | gene regulation | protein structure | protein structure | protein synthesis | protein synthesis | gene structure | gene structure | PCR | PCR | polymerase chain reaction | polymerase chain reaction | protein localization | protein localization | endoplasmic reticulum | endoplasmic reticulum | human biology | human biology | inherited diseases | inherited diseases | developmental biology | developmental biology | evolution | evolution | human genetics | human genetics | human diseases | human diseases | infectious agents | infectious agents | infectious diseases | infectious diseases

License

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7.014 Introductory Biology (MIT) 7.014 Introductory Biology (MIT)

Description

The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.7.014 focuses on the application of these fundamental principles, toward an understanding of microorganisms as geochemical agents responsible for the evolution and renewal of the biosphere and of their role in human health The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.7.014 focuses on the application of these fundamental principles, toward an understanding of microorganisms as geochemical agents responsible for the evolution and renewal of the biosphere and of their role in human health

Subjects

microorganisms | microorganisms | geochemistry | geochemistry | geochemical agents | geochemical agents | biosphere | biosphere | bacterial genetics | bacterial genetics | carbon metabolism | carbon metabolism | energy metabolism | energy metabolism | productivity | productivity | biogeochemical cycles | biogeochemical cycles | molecular evolution | molecular evolution | population genetics | population genetics | evolution | evolution | population growth | population growth | biology | biology | biochemistry | biochemistry | genetics | genetics | molecular biology | molecular biology | recombinant DNA | recombinant DNA | cell cycle | cell cycle | cell signaling | cell signaling | cloning | cloning | stem cells | stem cells | cancer | cancer | immunology | immunology | virology | virology | genomics | genomics | molecular medicine | molecular medicine | DNA | DNA | RNA | RNA | proteins | proteins | replication | replication | transcription | transcription | mRNA | mRNA | translation | translation | ribosome | ribosome | nervous system | nervous system | amino acids | amino acids | polypeptide chain | polypeptide chain | cell biology | cell biology | neurobiology | neurobiology | gene regulation | gene regulation | protein structure | protein structure | protein synthesis | protein synthesis | gene structure | gene structure | PCR | PCR | polymerase chain reaction | polymerase chain reaction | protein localization | protein localization | endoplasmic reticulum | endoplasmic reticulum | ecology | ecology | communities | communities

License

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7.012 Introduction to Biology (MIT) 7.012 Introduction to Biology (MIT)

Description

The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.7.012 focuses on the exploration of current research in cell biology, immunology, neurobiology, genomics, and molecular medicine.AcknowledgmentsThe study materials, problem sets, and quiz materials used during Fall 2004 for The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. Biological function at the molecular level is particularly emphasized and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In addition, each version of the subject has its own distinctive material.7.012 focuses on the exploration of current research in cell biology, immunology, neurobiology, genomics, and molecular medicine.AcknowledgmentsThe study materials, problem sets, and quiz materials used during Fall 2004 for

Subjects

biology | biology | biochemistry | biochemistry | genetics | genetics | molecular biology | molecular biology | recombinant DNA | recombinant DNA | cell cycle | cell cycle | cell signaling | cell signaling | cloning | cloning | stem cells | stem cells | cancer | cancer | immunology | immunology | virology | virology | genomics | genomics | molecular medicine | molecular medicine | DNA | DNA | RNA | RNA | proteins | proteins | replication | replication | transcription | transcription | mRNA | mRNA | translation | translation | ribosome | ribosome | nervous system | nervous system | amino acids | amino acids | polypeptide chain | polypeptide chain | cell biology | cell biology | neurobiology | neurobiology | gene regulation | gene regulation | protein structure | protein structure | protein synthesis | protein synthesis | gene structure | gene structure | PCR | PCR | polymerase chain reaction | polymerase chain reaction | protein localization | protein localization | endoplasmic reticulum | endoplasmic reticulum

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.013 Introductory Biology (MIT) 7.013 Introductory Biology (MIT)

Description

The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. 7.013 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), developmental biology, neurobiology and evolution.Biological function at the molecular level is particularly emphasized in all courses and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In add The MIT Biology Department core courses, 7.012, 7.013, and 7.014, all cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. 7.013 focuses on the application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), developmental biology, neurobiology and evolution.Biological function at the molecular level is particularly emphasized in all courses and covers the structure and regulation of genes, as well as, the structure and synthesis of proteins, how these molecules are integrated into cells, and how these cells are integrated into multicellular systems and organisms. In add

Subjects

biology | biology | biochemistry | biochemistry | genetics | genetics | molecular biology | molecular biology | recombinant DNA | recombinant DNA | cell cycle | cell cycle | cell signaling | cell signaling | cloning | cloning | stem cells | stem cells | cancer | cancer | immunology | immunology | virology | virology | genomics | genomics | molecular medicine | molecular medicine | DNA | DNA | RNA | RNA | proteins | proteins | replication | replication | transcription | transcription | mRNA | mRNA | translation | translation | ribosome | ribosome | nervous system | nervous system | amino acids | amino acids | polypeptide chain | polypeptide chain | cell biology | cell biology | neurobiology | neurobiology | gene regulation | gene regulation | protein structure | protein structure | protein synthesis | protein synthesis | gene structure | gene structure | PCR | PCR | polymerase chain reaction | polymerase chain reaction | protein localization | protein localization | endoplasmic reticulum | endoplasmic reticulum | human biology | human biology | inherited diseases | inherited diseases | developmental biology | developmental biology | evolution | evolution | human genetics | human genetics | human diseases | human diseases | infectious agents | infectious agents | infectious diseases | infectious diseases

License

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7.349 Stem Cells: A Cure or Disease? (MIT) 7.349 Stem Cells: A Cure or Disease? (MIT)

Description

Have you ever considered going to a pharmacy to order some new cardiomyocytes (heart muscle cells) for your ailing heart? It might sound crazy, but recent developments in stem cell science have made this concept not so futuristic. In this course, we will explore the underlying biology behind the idea of using stem cells to treat disease, specifically analyzing the mechanisms that enable a single genome to encode multiple cell states ranging from neurons to fibroblasts to T cells. Overall, we hope to provide a comprehensive overview of this exciting new field of research and its clinical relevance. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literat Have you ever considered going to a pharmacy to order some new cardiomyocytes (heart muscle cells) for your ailing heart? It might sound crazy, but recent developments in stem cell science have made this concept not so futuristic. In this course, we will explore the underlying biology behind the idea of using stem cells to treat disease, specifically analyzing the mechanisms that enable a single genome to encode multiple cell states ranging from neurons to fibroblasts to T cells. Overall, we hope to provide a comprehensive overview of this exciting new field of research and its clinical relevance. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literat

Subjects

stem cells | stem cells | stem cell therapy | stem cell therapy | cellular reprogramming | cellular reprogramming | transdifferentiation | transdifferentiation | pluripotency | pluripotency | epigenetics | epigenetics | genome-wide sequencing | genome-wide sequencing | transcription-mediated reprogramming | transcription-mediated reprogramming | embryonic stem cell technology | embryonic stem cell technology | transcription factors | transcription factors | chromatin structure | chromatin structure | H3K4me3 | H3K4me3 | H3K27me3 | H3K27me3 | histone deacetylase 1 | histone deacetylase 1 | RNAi screens | RNAi screens | Oct4 | Oct4 | cloning | cloning | Dolly | Dolly | in vitro differentiation | in vitro differentiation | regenerative medicine | regenerative medicine

License

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7.340 Regenerative Medicine: from Bench to Bedside (MIT) 7.340 Regenerative Medicine: from Bench to Bedside (MIT)

Description

Regenerative medicine involves the repair and regeneration of tissues for therapeutic purposes, such as replacing bone marrow in leukemia, cartilage in osteoarthritis or cells of the heart after a heart attack. In this course, we will explore basic mechanisms of how cells differentiate into specific tissues in response to a variety of biologic signaling molecules. We will discuss the use of such factors for in vitro tissue production. We will also study the cellular mechanisms involved in the cloning of animals and how Scottish researchers produced the sheep Dolly using the nucleus of a mammary gland cell from an adult sheep. We will read papers describing organ production, such as the in vitro formation of beating heart cells. We will also consider the molecular bases of cellular tissue r Regenerative medicine involves the repair and regeneration of tissues for therapeutic purposes, such as replacing bone marrow in leukemia, cartilage in osteoarthritis or cells of the heart after a heart attack. In this course, we will explore basic mechanisms of how cells differentiate into specific tissues in response to a variety of biologic signaling molecules. We will discuss the use of such factors for in vitro tissue production. We will also study the cellular mechanisms involved in the cloning of animals and how Scottish researchers produced the sheep Dolly using the nucleus of a mammary gland cell from an adult sheep. We will read papers describing organ production, such as the in vitro formation of beating heart cells. We will also consider the molecular bases of cellular tissue r

Subjects

regenerative medicine | regenerative medicine | tissue repair | tissue repair | cell differentiation | cell differentiation | stem cells | stem cells

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7.341 Bench to Bedside: Molecularly Targeted Therapies in Blood Disorders and Malignancy (MIT) 7.341 Bench to Bedside: Molecularly Targeted Therapies in Blood Disorders and Malignancy (MIT)

Description

Where do new drugs and treatments come from? This class will take you from the test tubes and mice of the laboratory to the treatment of patients with deadly blood disorders. Students will learn how to think as a scientist through discussion of primary research papers describing the discoveries of several novel treatments. Topics such as gene therapy, the potential of drugs based on RNA interference and the reprogramming of somatic cells into stem cells for regenerative medicine will be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instruct Where do new drugs and treatments come from? This class will take you from the test tubes and mice of the laboratory to the treatment of patients with deadly blood disorders. Students will learn how to think as a scientist through discussion of primary research papers describing the discoveries of several novel treatments. Topics such as gene therapy, the potential of drugs based on RNA interference and the reprogramming of somatic cells into stem cells for regenerative medicine will be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instruct

Subjects

molecularly targeted therapy | molecularly targeted therapy | blood disorders | blood disorders | chronic myelogenous leukemia | chronic myelogenous leukemia | CML | CML | Gleevec | Gleevec | chromosomal translocation | chromosomal translocation | stem cells | stem cells | blood cells | blood cells | hematopoiesis | hematopoiesis | hematopoieteic stem cell | hematopoieteic stem cell | genetic disorder | genetic disorder | Leukemia | Leukemia

License

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7.342 Developmental and Molecular Biology of Regeneration (MIT) 7.342 Developmental and Molecular Biology of Regeneration (MIT)

Description

How does a regenerating animal "know" what's missing? How are stem cells or differentiated cells used to create new tissues during regeneration? In this class we will take a comparative approach to explore this fascinating problem by critically examining classic and modern scientific literature about the developmental and molecular biology of regeneration. We will learn about conserved developmental pathways that are necessary for regeneration, and we will discuss the relevance of these findings for regenerative medicine. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highl How does a regenerating animal "know" what's missing? How are stem cells or differentiated cells used to create new tissues during regeneration? In this class we will take a comparative approach to explore this fascinating problem by critically examining classic and modern scientific literature about the developmental and molecular biology of regeneration. We will learn about conserved developmental pathways that are necessary for regeneration, and we will discuss the relevance of these findings for regenerative medicine. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highl

Subjects

Regeneration | Regeneration | blastema | blastema | embryo | embryo | progenitor | progenitor | stem cells | stem cells | differentiation | differentiation | dedifferentiation | dedifferentiation | hydra | hydra | morphallaxis | morphallaxis | limb | limb | organ | organ | zebrafish | zebrafish | homeostasis | homeostasis | self-renewal | self-renewal | regenerative medicine | regenerative medicine | differentitate | differentitate | regulate | regulate | salamander | salamander | catenin | catenin | newt | newt | liver | liver | pluriptent | pluriptent | fibroblast | fibroblast

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7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT) 7.342 Reading the Blueprint of Life: Transcription, Stem Cells and Differentiation (MIT)

Description

In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at In this course, we will address how transcriptional regulators both prohibit and drive differentiation during the course of development. How does a stem cell know when to remain a stem cell and when to become a specific cell type? Are there global differences in the way the genome is read in multipotent and terminally differentiated cells? We will explore how stem cell pluripotency is preserved, how master regulators of cell-fate decisions execute developmental programs, and how chromatin regulators control undifferentiated versus differentiated states. Additionally, we will discuss how aberrant regulation of transcriptional regulators produces disorders such as developmental defects and cancer.This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at

Subjects

blueprint of life | blueprint of life | transcription | transcription | stem cells | stem cells | differentiation | differentiation | human tissues | human tissues | tissue regeneration | tissue regeneration | human disease | human disease | RNA and protein expression patterns | RNA and protein expression patterns | transcriptional regulation | transcriptional regulation | specialized gene expression programs | specialized gene expression programs | genome | genome | multipotent | multipotent | terminally differentiated | terminally differentiated | pluripotency | pluripotency | master regulators | master regulators | chromatin regulators | chromatin regulators | developmental defects | developmental defects | cancer | cancer

License

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7.22 Developmental Biology (MIT) 7.22 Developmental Biology (MIT)

Description

This graduate and advanced undergraduate level lecture and literature discussion course covers the current understanding of the molecular mechanisms that regulate animal development. Evolutionary mechanisms are emphasized as well as the discussion of relevant diseases. Vertebrate (mouse, chick, frog, fish) and invertebrate (fly, worm) models are covered. Specific topics include formation of early body plan, cell type determination, organogenesis, morphogenesis, stem cells, cloning, and issues in human development. This graduate and advanced undergraduate level lecture and literature discussion course covers the current understanding of the molecular mechanisms that regulate animal development. Evolutionary mechanisms are emphasized as well as the discussion of relevant diseases. Vertebrate (mouse, chick, frog, fish) and invertebrate (fly, worm) models are covered. Specific topics include formation of early body plan, cell type determination, organogenesis, morphogenesis, stem cells, cloning, and issues in human development.

Subjects

animal development | animal development | developmental biology | developmental biology | evolution | evolution | formation of early body plan | formation of early body plan | cell type determination | cell type determination | organogenesis | organogenesis | morphogenesis | morphogenesis | stem cells | stem cells | cloning | cloning | human development | human development

License

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7.342 Cancer Biology: From Basic Research to the Clinic (MIT) 7.342 Cancer Biology: From Basic Research to the Clinic (MIT)

Description

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. In 1971, President Nixon declared the "War on Cancer," but after three decades the war is still raging. How much progress have we made toward winning the war and what are we doing to improve the fight? Understanding the molecular and cellular events involved in tumor formation, progression, and metastasis is crucial to the development of innovative therapy for cancer patients. Insights into these processes have been gleaned through basic research using biochemical, molecular, and genetic ana This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. In 1971, President Nixon declared the "War on Cancer," but after three decades the war is still raging. How much progress have we made toward winning the war and what are we doing to improve the fight? Understanding the molecular and cellular events involved in tumor formation, progression, and metastasis is crucial to the development of innovative therapy for cancer patients. Insights into these processes have been gleaned through basic research using biochemical, molecular, and genetic ana

Subjects

cancer | cancer | tumor | tumor | metastasis | metastasis | genetic analysis | genetic analysis | cancer biology | cancer biology | model organisms | model organisms | genetic pathways | genetic pathways | uncontrolled growth | uncontrolled growth | tumor suppressor genes | tumor suppressor genes | oncogenes | oncogenes | tumor initiation | tumor initiation | cell cycle | cell cycle | chromosomal aberration | chromosomal aberration | apoptosis | apoptosis | cell death | cell death | signal transduction pathways | signal transduction pathways | proto-oncogene | proto-oncogene | mutation | mutation | DNA mismatch repair | DNA mismatch repair | telomeres | telomeres | mouse models | mouse models | tissue specificity | tissue specificity | malignancy | malignancy | stem cells | stem cells | therapeutic resistance | therapeutic resistance | differentiation | differentiation | caner research | caner research | cancer therapeutics | cancer therapeutics | chemotherapy | chemotherapy

License

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HST.525J Tumor Pathophysiology and Transport Phenomena (MIT) HST.525J Tumor Pathophysiology and Transport Phenomena (MIT)

Description

Tumor pathophysiology plays a central role in the growth, invasion, metastasis and treatment of solid tumors. This class applies principles of transport phenomena to develop a systems-level, quantitative understanding of angiogenesis, blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, and treatment response. Additional Faculty Dr. Pat D'Amore Dr. Dan Duda Dr. Robert Langer Prof. Robert Weinberg Dr. Marsha Moses Dr. Raghu Kalluri Dr. Lance Munn Tumor pathophysiology plays a central role in the growth, invasion, metastasis and treatment of solid tumors. This class applies principles of transport phenomena to develop a systems-level, quantitative understanding of angiogenesis, blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, and treatment response. Additional Faculty Dr. Pat D'Amore Dr. Dan Duda Dr. Robert Langer Prof. Robert Weinberg Dr. Marsha Moses Dr. Raghu Kalluri Dr. Lance Munn

Subjects

HST.525 | HST.525 | 10.548 | 10.548 | tumor | tumor | cancer | cancer | tumor vasculature | tumor vasculature | antiangiogenesis | antiangiogenesis | bone marrow-derived stem cells | bone marrow-derived stem cells | BMDC | BMDC | stem cell research | stem cell research | experimental cancer therapy | experimental cancer therapy | cancer research | cancer research | tumor-host interactions | tumor-host interactions | vascular normalization | vascular normalization | vascular transport | vascular transport | interstitial transport | interstitial transport | lymphatic transport | lymphatic transport | microcirculation | microcirculation | molecular therapeutics | molecular therapeutics | blood vessels | blood vessels | angiogenesis | angiogenesis | drug delivery | drug delivery | intravital microscopy | intravital microscopy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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HST.510 Genomics, Computing, Economics, and Society (MIT) HST.510 Genomics, Computing, Economics, and Society (MIT)

Description

This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports. This course will focus on understanding aspects of modern technology displaying exponential growth curves and the impact on global quality of life through a weekly updated class project integrating knowledge and providing practical tools for political and business decision-making concerning new aspects of bioengineering, personalized medicine, genetically modified organisms, and stem cells. Interplays of economic, ethical, ecological, and biophysical modeling will be explored through multi-disciplinary teams of students, and individual brief reports.

Subjects

genomics | genomics | bioengineering | bioengineering | biological engineering | biological engineering | personalized medicine | personalized medicine | informatics | informatics | bioinformatics | bioinformatics | human genome | human genome | stem cells | stem cells | genetically modified organisms | genetically modified organisms | biophysics | biophysics | bioethics | bioethics | society | society | bioeconomics | bioeconomics | statistics | statistics | modeling | modeling | datamining | datamining | systems biology | systems biology | technology development | technology development | biotechnology | biotechnology | public policy | public policy | health policy | health policy | business | business | economics | economics

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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New Cells for Old Members: The Science of Stem Cells

Description

Dr Francis Szele gives a talk for the Oxford Alumni Weekend on Stem Cell science and looks at how they could be used in repairing brain disease and injuries. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

science | biology | alumni | stem cells | neuroscience | science | biology | alumni | stem cells | neuroscience | 2011-09-17

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Stem cells and cancer

Description

Adult gastrointestinal stem cells The gastrointestinal tract is lined with a single sheet of epithelium that is replaced every 4-5 days. The base of a flask-shaped structured called the crypt is where the gastrointestinal stem cells are found. These divide to form daughter cells that travel up the crypt to replace these cells. Dr Simon Leedham's current research focuses on the cell-signaling pathways that control intestinal stem cells and the dysregulation of these pathways in cancer. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

simon leedham | cancer | stem cells | gastrointestinal | simon leedham | cancer | stem cells | gastrointestinal | 2014-07-02

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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7.344 Treating Infertility-- From Bench to Bedside and Bedside to Bench (MIT) 7.344 Treating Infertility-- From Bench to Bedside and Bedside to Bench (MIT)

Description

In the western world, approximately 10–15% of couples suffer from subfertility. Consequently, over 5 million babies have been born thanks to assisted reproductive technologies, and more than half of those have been born in the past six years alone. This class will cover the basic biology behind fertility and explore the etiology of infertility. We will highlight open questions in reproductive biology, familiarize students with both tried-and-true and emerging reproductive technologies, and explore the advantages and pitfalls of each. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in In the western world, approximately 10–15% of couples suffer from subfertility. Consequently, over 5 million babies have been born thanks to assisted reproductive technologies, and more than half of those have been born in the past six years alone. This class will cover the basic biology behind fertility and explore the etiology of infertility. We will highlight open questions in reproductive biology, familiarize students with both tried-and-true and emerging reproductive technologies, and explore the advantages and pitfalls of each. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in

Subjects

fertility | fertility | infertility | infertility | assisted reproductive technology | assisted reproductive technology | gonadal stem cells | gonadal stem cells | reproductive biology | reproductive biology | embryo cryopreservation | embryo cryopreservation | oocyte cryopreservation | oocyte cryopreservation | antral follicle counts | antral follicle counts | microdeletions | microdeletions | aneuploidy | aneuploidy | reproductive phenotypes | reproductive phenotypes

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Melanoma

Description

Melanoma or skin cancer is one of the fastest rising cancer types. When identified early, melanoma is relatively easy to cure, but once it starts to metastasise, it becomes very difficult to treat. DEREGULATION OF TRANSCRIPTION The interface between signal transduction and transcription regulation coordinates gene expression. Deregulation of transcription is a key factor in cancer. Professor Colin Goding studies how a precise programme of transcription regulation is achieved, particularly in the transition between normal and cancer stem cells, and the parallels with normal stem cell populations. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

transcription regulation | melanoma | cancer | stem cells | transcription regulation | melanoma | cancer | stem cells

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Melanoma

Description

Melanoma or skin cancer is one of the fastest rising cancer types. When identified early, melanoma is relatively easy to cure, but once it starts to metastasise, it becomes very difficult to treat. DEREGULATION OF TRANSCRIPTION The interface between signal transduction and transcription regulation coordinates gene expression. Deregulation of transcription is a key factor in cancer. Professor Colin Goding studies how a precise programme of transcription regulation is achieved, particularly in the transition between normal and cancer stem cells, and the parallels with normal stem cell populations. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

transcription regulation | melanoma | cancer | stem cells | transcription regulation | melanoma | cancer | stem cells

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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7.344 The Fountain of Life: From Dolly to Customized Embryonic Stem Cells (MIT)

Description

During development, the genetic content of each cell remains, with a few exceptions, identical to that of the zygote. Most differentiated cells therefore retain all of the genetic information necessary to generate an entire organism. It was through pioneering technology of somatic cell nuclear transfer (SCNT) that this concept was experimentally proven. Only 10 years ago the sheep Dolly was the first mammal to be cloned from an adult organism, demonstrating that the differentiated state of a mammalian cell can be fully reversible to a pluripotent embryonic state. A key conclusion from these experiments was that the difference between pluripotent cells such as embryonic stem (ES) cells and unipotent differentiated cells is solely a consequence of reversible changes. These changes, which hav

Subjects

embryonic stem cells | stem cells | cells | genetics | genome | Dolly | clone | regenerative therapy | somatic | SCNT | pluripotent | scientific literature | nuclear | embryonic | adult | epigenetics | methylation | DNA | histone | biomedical | differentiation | epigenome | nuclear transfer | customized | zygote | RNA | cancer | medicine

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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