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During development a single totipotent cell gives rise to the vast array of cell types present in the adult human body, yet each cell has essentially the same DNA sequence. As cells differentiate, distinct sets of genes must be coordinately activated and repressed, ultimately leading to a cell-type specific pattern of gene expression and a particular cell fate. In eukaryotic organisms, DNA is packaged in a complex protein super structure known as chromatin. Modification and reorganization of chromatin play a critical role in coordinating the cell-type specific gene expression programs that are required as a cell transitions from a pluripotent stem cell to a fully differentiated cell type. Epigenetics refers to such heritable changes that occur in chromatin without altering the primary DNA During development a single totipotent cell gives rise to the vast array of cell types present in the adult human body, yet each cell has essentially the same DNA sequence. As cells differentiate, distinct sets of genes must be coordinately activated and repressed, ultimately leading to a cell-type specific pattern of gene expression and a particular cell fate. In eukaryotic organisms, DNA is packaged in a complex protein super structure known as chromatin. Modification and reorganization of chromatin play a critical role in coordinating the cell-type specific gene expression programs that are required as a cell transitions from a pluripotent stem cell to a fully differentiated cell type. Epigenetics refers to such heritable changes that occur in chromatin without altering the primary DNA

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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The First Redstone Rocket Firing

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Progress at Roker Pier, 1889 Progress at Roker Pier, 1889

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The 43rd length in place on Roker Pier, 1891 The 43rd length in place on Roker Pier, 1891

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Calendario Azteca, Museo de Mexico Calendario Azteca, Museo de Mexico

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A meeting of waters... is Belleek, Co. Fermanagh A meeting of waters... is Belleek, Co. Fermanagh

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Grand Canyon between the Falls, Yellowstone National Park. Grand Canyon between the Falls, Yellowstone National Park.

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Aztec Sacrificial Stone, Mexico. Aztec Sacrificial Stone, Mexico.

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Classes at Silkstone State School, 1919 Classes at Silkstone State School, 1919

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Warren Stone (LOC)

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s alternatives in 18th Century debate about Women, Virtue and the progress of Civilisation

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Madeline Cronin, graduate student at University of Notre Dame, delivers a talk for the Inaugural Oxford Graduate Conference in Political Theory. The conference theme was Political Theory and the Liberal Tradition. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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21G.044 Traditional Chinese Literature: Poetry, Fiction, and Drama (MIT) 21G.044 Traditional Chinese Literature: Poetry, Fiction, and Drama (MIT)

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This course is an introduction to some of the major genres of traditional Chinese poetry, fiction, and drama. Intended to give students a basic understanding of the central features of traditional Chinese literary genres, as well as to introduce students to the classic works of the Chinese literary tradition. Works read include Journey to the West, Outlaws of the Marsh, Dream of the Red Chamber, and the poetry of the major Tang dynasty poets. Literature read in translation. Taught in English. This course is an introduction to some of the major genres of traditional Chinese poetry, fiction, and drama. Intended to give students a basic understanding of the central features of traditional Chinese literary genres, as well as to introduce students to the classic works of the Chinese literary tradition. Works read include Journey to the West, Outlaws of the Marsh, Dream of the Red Chamber, and the poetry of the major Tang dynasty poets. Literature read in translation. Taught in English.

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SP.406 Sexual and Gender Identities (MIT) SP.406 Sexual and Gender Identities (MIT)

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This course introduces scholarly debates about sexual identities, gender identities and expressions, and sexual orientation and its representation in various media. We begin with an investigation of the theoretical underpinnings of the emerging field of queer studies, from the nineteenth century to the present day, and consider how subsequent work in transgender studies continues to challenge traditional understandings of sex, gender, and sexuality. This course introduces scholarly debates about sexual identities, gender identities and expressions, and sexual orientation and its representation in various media. We begin with an investigation of the theoretical underpinnings of the emerging field of queer studies, from the nineteenth century to the present day, and consider how subsequent work in transgender studies continues to challenge traditional understandings of sex, gender, and sexuality.

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Oxford Literary Festival 2010 Pieces of Places Discussion The Weirdstone of Brisingamen

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Alan Garner, Mark Edmonds and Robert Powell take part in a discussion on the subject of pieces of places, objects and artefacts found and what they mean for writing fiction and for archeology in general. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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s Work

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The 50th anniversary of the publication of Alan Garner's first novel, The Weirdstone of Brisingamen. A talk examining the importance of place in Alan Garner's work. Robert Powell gives a reading of The Stone Book, from The Stone Book Quartet. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Oxford Literary Festival 2010 By Seven Firs and Goldenstone - An account of the Legend of Alderley

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Alan Garner gives an illustrated lecture on the Legend of Alderley. This version of the myth of the Sleeping Hero is rooted to places on Alderley Edge in Cheshire, where Alan Garner grew up. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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