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PPIVMs of the cervical spine PPIVMs of the cervical spine

Description

A short introduction to the concept of manual therapy for the cervical spine for Physiotherapy undergraduate students. A short introduction to the concept of manual therapy for the cervical spine for Physiotherapy undergraduate students.

Subjects

ukoer | ukoer | Physiotherapy | Physiotherapy | Physiotherapy Manual therapy skills | Physiotherapy Manual therapy skills

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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7.341 Of Mice and Men: Humanized Mice in Cancer Research (MIT) 7.341 Of Mice and Men: Humanized Mice in Cancer Research (MIT)

Description

This course will act as an introduction to the latest developments in the fields of cancer biology and immunotherapy. Almost everyone knows someone whose life has been affected by cancer. Why is cancer such a difficult disease to treat? What is the best system to model the development of a human tumor? How can new treatment modalities, especially immune-based therapies that harness the natural ability of immune cells to kill target cells, be developed to treat cancer? These and other questions will be addressed in this course. We will explore the concepts of mouse models for human cancer, humanized cancer mice and cancer immunotherapy by reading recent and classic research articles. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These This course will act as an introduction to the latest developments in the fields of cancer biology and immunotherapy. Almost everyone knows someone whose life has been affected by cancer. Why is cancer such a difficult disease to treat? What is the best system to model the development of a human tumor? How can new treatment modalities, especially immune-based therapies that harness the natural ability of immune cells to kill target cells, be developed to treat cancer? These and other questions will be addressed in this course. We will explore the concepts of mouse models for human cancer, humanized cancer mice and cancer immunotherapy by reading recent and classic research articles. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These

Subjects

cancer | cancer | immunotherapy | immunotherapy | mouse models | mouse models | humanized cancer mice | humanized cancer mice | humice | humice | cancer biology | cancer biology | cancer therapy | cancer therapy | oncogenes | oncogenes | humanization | humanization | personalized mice | personalized mice

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Understanding cancer of the breast resource stub

Description

A resource stub for the Understanding cancer of the breast webpage, produced by the Irish Cancer Society.

Subjects

breast neoplasms | disease prevention and control | diagnosis | surgery | radiotherapy | drug therapy | therapy | breast cancer | Diseases | Medicine and Dentistry | SAFETY | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | UK EL07 = SCQF 7 | Higher Certificate | NICAT 4 | CQFW 4 | NVQ 4 | Advanced Higher | SVQ 4 | HN Certificate | Students | Learning | Teaching | dentistry | A000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | G | P

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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MedlinePLUS : prostate cancer resource stub

Description

A resource stub for the MedlinePLUS: prostate cancer webpage. It provides access to a basic overview, tutorials and videos, research and further references.

Subjects

prostatic neoplasms | prevention and control | diagnosis | surgery | radiotherapy | drug therapy | genetics | therapy | prostatectomy | prostate cancer | prostate neoplasms | prostatic cancer | Technology | Diseases | Analytical | Diagnostic and Therapeutic Techniques and Equipment | SAFETY | Subjects allied to Medicine | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | UK EL07 = SCQF 7 | Higher Certificate | NICAT 4 | CQFW 4 | NVQ 4 | Advanced Higher | SVQ 4 | HN Certificate | Learning | Teaching | Students | Subjects allied to medicine | B000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | INFORMATION TECHNOLOGY and INFORMATION | G | P | C

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Bandolier: cancer resource stub

Description

A resource stub for the Bandolier: cancer webpage

Subjects

breast cancer | prevention and control | diagnosis | surgery | radiotherapy | drug therapy | diet therapy | breast cancers | Technology | Diseases | Medicine and Dentistry | SAFETY | UK EL04 = SCQF 4 | Foundational Level | NICAT 1 | CQFW 1 | Foundation | GCSE D-G | NVQ 1 | Intermediate 1 | | UK EL05 = SCQF 5 | Intermediate level | Intermediate | NICAT 2 | CQFW 2 | Intermediate | GSCE A-C | NVQ 2 | | UK EL06 = SCQF 6 | Advanced courses | | NICAT 3 | CQFW 3 | Advanced | A/AS Level | NVQ 3 | Higher | SVQ 3 | UK EL07 = SCQF 7 | Higher Certificate | NICAT 4 | CQFW 4 | NVQ 4 | Advanced Higher | SVQ 4 | HN Certificate | Design and delivery of programmes | Educational research | Learning | Teaching | dentistry | A000 | EDUCATION / TRAINING / TEACHING | HEALTH CARE / MEDICINE / HEALTH and SAFETY | INFORMATION TECHNOLOGY and INFORMATION | G | P | C

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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HST.725 Music Perception and Cognition (MIT) HST.725 Music Perception and Cognition (MIT)

Description

Survey of perceptual and cognitive aspects of the psychology of music, with special emphasis on underlying neuronal and neurocomputational representations and mechanisms. Basic perceptual dimensions of hearing (pitch, timbre, consonance/roughness, loudness, auditory grouping) form salient qualities, contrasts, patterns and streams that are used in music to convey melody, harmony, rhythm and separate voices. Perceptual, cognitive, and neurophysiological aspects of the temporal dimension of music (rhythm, timing, duration, temporal expectation) are explored. Special topics include comparative, evolutionary, and developmental psychology of music perception, biological vs. cultural influences, Gestaltist vs. associationist vs. schema-based theories, comparison of music and speech perception, p Survey of perceptual and cognitive aspects of the psychology of music, with special emphasis on underlying neuronal and neurocomputational representations and mechanisms. Basic perceptual dimensions of hearing (pitch, timbre, consonance/roughness, loudness, auditory grouping) form salient qualities, contrasts, patterns and streams that are used in music to convey melody, harmony, rhythm and separate voices. Perceptual, cognitive, and neurophysiological aspects of the temporal dimension of music (rhythm, timing, duration, temporal expectation) are explored. Special topics include comparative, evolutionary, and developmental psychology of music perception, biological vs. cultural influences, Gestaltist vs. associationist vs. schema-based theories, comparison of music and speech perception, p

Subjects

music perception | music perception | music cognition | music cognition | music memory | music memory | pitch | pitch | timbre | timbre | consonance | consonance | harmony | harmony | tonality | tonality | melody | melody | expressive timing | expressive timing | rhythmic hierarchies | rhythmic hierarchies | auditory perception | auditory perception | auditory pathway | auditory pathway | musical acoustics | musical acoustics | power spectra | power spectra | psychophysics | psychophysics | neurocomputational models | neurocomputational models | neural correlates | neural correlates | music therapy | music therapy | synesthesia | synesthesia | absolute pitch | absolute pitch

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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22.01 Introduction to Ionizing Radiation (MIT) 22.01 Introduction to Ionizing Radiation (MIT)

Description

This course is an introduction to basic properties of ionizing radiations and their uses in medicine, industry, science, and environmental studies. Discusses natural and man-made radiation sources, energy deposition and dose calculations, various physical, chemical, and biological processes and effects of radiation with examples of their uses, and principles of radiation protection. Term paper and oral presentation of paper required.This course was originally developed by Dr. Jacquelyn Yanch.  As such, significant portions of the materials presented here were derived from her work. This course is an introduction to basic properties of ionizing radiations and their uses in medicine, industry, science, and environmental studies. Discusses natural and man-made radiation sources, energy deposition and dose calculations, various physical, chemical, and biological processes and effects of radiation with examples of their uses, and principles of radiation protection. Term paper and oral presentation of paper required.This course was originally developed by Dr. Jacquelyn Yanch.  As such, significant portions of the materials presented here were derived from her work.

Subjects

ionizing radiations | ionizing radiations | radiation sources | radiation sources | energy deposition | energy deposition | dose calculations | dose calculations | principles of radiation protection | principles of radiation protection | ionizing | ionizing | radiation | radiation | medicine | medicine | industry | industry | science | science | environmental studies | environmental studies | natural radiation sources | natural radiation sources | man-made radiation | man-made radiation | radiation protection | radiation protection | material interaction | material interaction | biological material | biological material | radiation therapy | radiation therapy | medical imaging | medical imaging | non-destructive evaluation | non-destructive evaluation | food irradiation | food irradiation | radionuclide dating | radionuclide dating | well-logging | well-logging

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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HST.725 Music Perception and Cognition (MIT) HST.725 Music Perception and Cognition (MIT)

Description

Includes audio/video content: AV faculty introductions. This course is a survey of perceptual and cognitive aspects of the psychology of music, with special emphasis on underlying neuronal and neurocomputational representations and mechanisms. Basic perceptual dimensions of hearing (pitch, timbre, consonance/roughness, loudness, auditory grouping) form salient qualities, contrasts, patterns and streams that are used in music to convey melody, harmony, rhythm and separate voices. Perceptual, cognitive, and neurophysiological aspects of the temporal dimension of music (rhythm, timing, duration, temporal expectation) are explored. Special topics include comparative, evolutionary, and developmental psychology of music perception, biological vs. cultural influences, Gestaltist vs. associationis Includes audio/video content: AV faculty introductions. This course is a survey of perceptual and cognitive aspects of the psychology of music, with special emphasis on underlying neuronal and neurocomputational representations and mechanisms. Basic perceptual dimensions of hearing (pitch, timbre, consonance/roughness, loudness, auditory grouping) form salient qualities, contrasts, patterns and streams that are used in music to convey melody, harmony, rhythm and separate voices. Perceptual, cognitive, and neurophysiological aspects of the temporal dimension of music (rhythm, timing, duration, temporal expectation) are explored. Special topics include comparative, evolutionary, and developmental psychology of music perception, biological vs. cultural influences, Gestaltist vs. associationis

Subjects

music perception | music perception | music cognition | music cognition | music memory | music memory | pitch | pitch | timbre | timbre | consonance | consonance | harmony | harmony | tonality | tonality | melody | melody | expressive timing | expressive timing | rhythmic hierarchies | rhythmic hierarchies | auditory perception | auditory perception | auditory pathway | auditory pathway | musical acoustics | musical acoustics | power spectra | power spectra | psychophysics | psychophysics | neurocomputational models | neurocomputational models | neural correlates | neural correlates | music therapy | music therapy | synesthesia | synesthesia | absolute pitch | absolute pitch

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.349 Stem Cells: A Cure or Disease? (MIT) 7.349 Stem Cells: A Cure or Disease? (MIT)

Description

Have you ever considered going to a pharmacy to order some new cardiomyocytes (heart muscle cells) for your ailing heart? It might sound crazy, but recent developments in stem cell science have made this concept not so futuristic. In this course, we will explore the underlying biology behind the idea of using stem cells to treat disease, specifically analyzing the mechanisms that enable a single genome to encode multiple cell states ranging from neurons to fibroblasts to T cells. Overall, we hope to provide a comprehensive overview of this exciting new field of research and its clinical relevance. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literat Have you ever considered going to a pharmacy to order some new cardiomyocytes (heart muscle cells) for your ailing heart? It might sound crazy, but recent developments in stem cell science have made this concept not so futuristic. In this course, we will explore the underlying biology behind the idea of using stem cells to treat disease, specifically analyzing the mechanisms that enable a single genome to encode multiple cell states ranging from neurons to fibroblasts to T cells. Overall, we hope to provide a comprehensive overview of this exciting new field of research and its clinical relevance. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literat

Subjects

stem cells | stem cells | stem cell therapy | stem cell therapy | cellular reprogramming | cellular reprogramming | transdifferentiation | transdifferentiation | pluripotency | pluripotency | epigenetics | epigenetics | genome-wide sequencing | genome-wide sequencing | transcription-mediated reprogramming | transcription-mediated reprogramming | embryonic stem cell technology | embryonic stem cell technology | transcription factors | transcription factors | chromatin structure | chromatin structure | H3K4me3 | H3K4me3 | H3K27me3 | H3K27me3 | histone deacetylase 1 | histone deacetylase 1 | RNAi screens | RNAi screens | Oct4 | Oct4 | cloning | cloning | Dolly | Dolly | in vitro differentiation | in vitro differentiation | regenerative medicine | regenerative medicine

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.341 Bench to Bedside: Molecularly Targeted Therapies in Blood Disorders and Malignancy (MIT) 7.341 Bench to Bedside: Molecularly Targeted Therapies in Blood Disorders and Malignancy (MIT)

Description

Where do new drugs and treatments come from? This class will take you from the test tubes and mice of the laboratory to the treatment of patients with deadly blood disorders. Students will learn how to think as a scientist through discussion of primary research papers describing the discoveries of several novel treatments. Topics such as gene therapy, the potential of drugs based on RNA interference and the reprogramming of somatic cells into stem cells for regenerative medicine will be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instruct Where do new drugs and treatments come from? This class will take you from the test tubes and mice of the laboratory to the treatment of patients with deadly blood disorders. Students will learn how to think as a scientist through discussion of primary research papers describing the discoveries of several novel treatments. Topics such as gene therapy, the potential of drugs based on RNA interference and the reprogramming of somatic cells into stem cells for regenerative medicine will be discussed. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. Many instruct

Subjects

molecularly targeted therapy | molecularly targeted therapy | blood disorders | blood disorders | chronic myelogenous leukemia | chronic myelogenous leukemia | CML | CML | Gleevec | Gleevec | chromosomal translocation | chromosomal translocation | stem cells | stem cells | blood cells | blood cells | hematopoiesis | hematopoiesis | hematopoieteic stem cell | hematopoieteic stem cell | genetic disorder | genetic disorder | Leukemia | Leukemia

License

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7.344 The Fountain of Life: From Dolly to Customized Embryonic Stem Cells (MIT) 7.344 The Fountain of Life: From Dolly to Customized Embryonic Stem Cells (MIT)

Description

During development, the genetic content of each cell remains, with a few exceptions, identical to that of the zygote. Most differentiated cells therefore retain all of the genetic information necessary to generate an entire organism. It was through pioneering technology of somatic cell nuclear transfer (SCNT) that this concept was experimentally proven. Only 10 years ago the sheep Dolly was the first mammal to be cloned from an adult organism, demonstrating that the differentiated state of a mammalian cell can be fully reversible to a pluripotent embryonic state. A key conclusion from these experiments was that the difference between pluripotent cells such as embryonic stem (ES) cells and unipotent differentiated cells is solely a consequence of reversible changes. These changes, which hav During development, the genetic content of each cell remains, with a few exceptions, identical to that of the zygote. Most differentiated cells therefore retain all of the genetic information necessary to generate an entire organism. It was through pioneering technology of somatic cell nuclear transfer (SCNT) that this concept was experimentally proven. Only 10 years ago the sheep Dolly was the first mammal to be cloned from an adult organism, demonstrating that the differentiated state of a mammalian cell can be fully reversible to a pluripotent embryonic state. A key conclusion from these experiments was that the difference between pluripotent cells such as embryonic stem (ES) cells and unipotent differentiated cells is solely a consequence of reversible changes. These changes, which hav

Subjects

embryonic stem cells | embryonic stem cells | stem cells | stem cells | cells | cells | genetics | genetics | genome | genome | Dolly | Dolly | clone | clone | regenerative therapy | regenerative therapy | somatic | somatic | SCNT | SCNT | pluripotent | pluripotent | scientific literature | scientific literature | nuclear | nuclear | embryonic | embryonic | adult | adult | epigenetics | epigenetics | methylation | methylation | DNA | DNA | histone | histone | biomedical | biomedical | differentiation | differentiation | epigenome | epigenome | nuclear transfer | nuclear transfer | customized | customized | zygote | zygote | RNA | RNA | cancer | cancer | medicine | medicine

License

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7.27 Principles of Human Disease (MIT) 7.27 Principles of Human Disease (MIT)

Description

This course covers current understanding of, and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Topics include: The Genetics of Simple and Complex Traits; Karyotypic Analysis and Positional Cloning; Genetic Diagnosis; The Roles of Oncogenes and Tumor Suppressors in Tumor Initiation, Progression, and Treatment; The Interaction between Genetics and Environment; Animal Models of Human Disease; Cancer; and Conventional and Gene Therapy Treatment Strategies. This course covers current understanding of, and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Topics include: The Genetics of Simple and Complex Traits; Karyotypic Analysis and Positional Cloning; Genetic Diagnosis; The Roles of Oncogenes and Tumor Suppressors in Tumor Initiation, Progression, and Treatment; The Interaction between Genetics and Environment; Animal Models of Human Disease; Cancer; and Conventional and Gene Therapy Treatment Strategies.

Subjects

human disease | human disease | molecular basis of genetic disease | molecular basis of genetic disease | molecular basis of cancer | molecular basis of cancer | cellular basis of genetic disease | cellular basis of genetic disease | cellular basis of cancer | cellular basis of cancer | genetics of simple and complex traits | genetics of simple and complex traits | karyotypic analysis | karyotypic analysis | positional cloning | positional cloning | genetic diagnosis | genetic diagnosis | roles of oncogenes | roles of oncogenes | tumor suppressors | tumor suppressors | tumor initiation | tumor initiation | tumor progression | tumor progression | tumor treatment | tumor treatment | interaction between genetics and environment | interaction between genetics and environment | animal models of human disease | animal models of human disease | cancer | cancer | conventional treatment strategies | conventional treatment strategies | gene therapy treatment strategies | gene therapy treatment strategies

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.342 Cancer Biology: From Basic Research to the Clinic (MIT) 7.342 Cancer Biology: From Basic Research to the Clinic (MIT)

Description

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. In 1971, President Nixon declared the "War on Cancer," but after three decades the war is still raging. How much progress have we made toward winning the war and what are we doing to improve the fight? Understanding the molecular and cellular events involved in tumor formation, progression, and metastasis is crucial to the development of innovative therapy for cancer patients. Insights into these processes have been gleaned through basic research using biochemical, molecular, and genetic ana This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. In 1971, President Nixon declared the "War on Cancer," but after three decades the war is still raging. How much progress have we made toward winning the war and what are we doing to improve the fight? Understanding the molecular and cellular events involved in tumor formation, progression, and metastasis is crucial to the development of innovative therapy for cancer patients. Insights into these processes have been gleaned through basic research using biochemical, molecular, and genetic ana

Subjects

cancer | cancer | tumor | tumor | metastasis | metastasis | genetic analysis | genetic analysis | cancer biology | cancer biology | model organisms | model organisms | genetic pathways | genetic pathways | uncontrolled growth | uncontrolled growth | tumor suppressor genes | tumor suppressor genes | oncogenes | oncogenes | tumor initiation | tumor initiation | cell cycle | cell cycle | chromosomal aberration | chromosomal aberration | apoptosis | apoptosis | cell death | cell death | signal transduction pathways | signal transduction pathways | proto-oncogene | proto-oncogene | mutation | mutation | DNA mismatch repair | DNA mismatch repair | telomeres | telomeres | mouse models | mouse models | tissue specificity | tissue specificity | malignancy | malignancy | stem cells | stem cells | therapeutic resistance | therapeutic resistance | differentiation | differentiation | caner research | caner research | cancer therapeutics | cancer therapeutics | chemotherapy | chemotherapy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.344 RNA Interference: A New Tool for Genetic Analysis and Therapeutics (MIT) 7.344 RNA Interference: A New Tool for Genetic Analysis and Therapeutics (MIT)

Description

This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. To understand and treat any disease with a genetic basis or predisposition, scientists and clinicians need effective ways of manipulating the levels of genes and gene products. Conventional methods for the genetic modification of many experimental organisms are technically demanding and time consuming. Just over 5 years ago, a new mechanism of gene-silencing, termed RNA interference (RNAi), was discovered. In addition to being a fascinating biological process, RNAi provides a revolutionary technology that has a This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an interest in using primary research literature to discuss and learn about current biological research in a highly interactive setting. To understand and treat any disease with a genetic basis or predisposition, scientists and clinicians need effective ways of manipulating the levels of genes and gene products. Conventional methods for the genetic modification of many experimental organisms are technically demanding and time consuming. Just over 5 years ago, a new mechanism of gene-silencing, termed RNA interference (RNAi), was discovered. In addition to being a fascinating biological process, RNAi provides a revolutionary technology that has a

Subjects

RNA interference | RNA interference | RNAi | RNAi | RNA | RNA | genetic analysis | genetic analysis | gene therapy | gene therapy | gene products | gene products | gene silencing | gene silencing | gene expression | gene expression | human disease models | human disease models | mRNA | mRNA | genetic interference | genetic interference | short interfering RNA | short interfering RNA | siRNAs | siRNAs | expression vectors | expression vectors | RNA sequences | RNA sequences | nucleotide fragments | nucleotide fragments | microRNA | microRNA | mRNA degradation | mRNA degradation | transgenic mice | transgenic mice | lentivirus | lentivirus | knock-down animals | knock-down animals | tissue specificity | tissue specificity

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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22.55J Principles of Radiation Interactions (MIT) 22.55J Principles of Radiation Interactions (MIT)

Description

The central theme of this course is the interaction of radiation with biological material. The course is intended to provide a broad understanding of how different types of radiation deposit energy, including the creation and behavior of secondary radiations; of how radiation affects cells and why the different types of radiation have very different biological effects. Topics will include: the effects of radiation on biological systems including DNA damage; in vitro cell survival models; and in vivo mammalian systems. The course covers radiation therapy, radiation syndromes in humans and carcinogenesis. Environmental radiation sources on earth and in space, and aspects of radiation protection are also discussed. Examples from the current literature will be used to supplement lecture materi The central theme of this course is the interaction of radiation with biological material. The course is intended to provide a broad understanding of how different types of radiation deposit energy, including the creation and behavior of secondary radiations; of how radiation affects cells and why the different types of radiation have very different biological effects. Topics will include: the effects of radiation on biological systems including DNA damage; in vitro cell survival models; and in vivo mammalian systems. The course covers radiation therapy, radiation syndromes in humans and carcinogenesis. Environmental radiation sources on earth and in space, and aspects of radiation protection are also discussed. Examples from the current literature will be used to supplement lecture materi

Subjects

Interaction of radiation with biological material | Interaction of radiation with biological material | how different types of radiation deposit energy | how different types of radiation deposit energy | secondary radiations | secondary radiations | how radiation affects cells | how radiation affects cells | biological effects | biological effects | effects of radiation on biological systems | effects of radiation on biological systems | DNA damage | DNA damage | in vitro cell survival models | in vitro cell survival models | in vivo mammalian systems | in vivo mammalian systems | radiation therapy | radiation therapy | radiation syndromes in humans | radiation syndromes in humans | carcinogenesis | carcinogenesis | Environmental radiation sources | Environmental radiation sources | radiation protection | radiation protection | cells | cells | tissues | tissues | radiation interactions | radiation interactions | radiation chemistry | radiation chemistry | LET | LET | tracks | tracks | chromosome damags | chromosome damags | in vivo | in vivo | in vitro | in vitro | cell survival curves | cell survival curves | dose response | dose response | RBE | RBE | clustered damage | clustered damage | radiation response | radiation response | tumor kinetics | tumor kinetics | tumor radiobiology | tumor radiobiology | fractionation | fractionation | protons | protons | alpha particles | alpha particles | whole body exposure | whole body exposure | chronic exposure | chronic exposure | space | space | microbeams | microbeams | radon | radon | background radiation | background radiation | 22.55 | 22.55 | HST.560 | HST.560

License

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HST.161 Molecular Biology and Genetics in Modern Medicine (MIT) HST.161 Molecular Biology and Genetics in Modern Medicine (MIT)

Description

This course provides a foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. It develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics are reviewed. We translate clinical understanding into analysis at the level of the gene, chromosome and molecule; we cover the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. Material in the course extends beyond basic principles to current research activity in human genetics. This course provides a foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. It develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics are reviewed. We translate clinical understanding into analysis at the level of the gene, chromosome and molecule; we cover the concepts and techniques of molecular biology and genomics, and the strategies and methods of genetic analysis, including an introduction to bioinformatics. Material in the course extends beyond basic principles to current research activity in human genetics.

Subjects

Genetics | Genetics | genes | genes | genetic disorders | genetic disorders | inborn error | inborn error | muscular dystrophy | muscular dystrophy | PKU | PKU | phenylketoneuria | phenylketoneuria | cancer | cancer | tumors | tumors | gene therapy | gene therapy | disease | disease | birth defects | birth defects | chromosomes | chromosomes | leukemia | leukemia | RNAi | RNAi | hemophilia | hemophilia | thalassemia | thalassemia | deafness | deafness | mutations | mutations | hypertrophic cardiomyopathy | hypertrophic cardiomyopathy | epigenetics | epigenetics | rett syndrome | rett syndrome | prenatal diagnosis | prenatal diagnosis | LOD scores | LOD scores | gene linkage | gene linkage | mitochondrial disorders | mitochondrial disorders | degenerative disorders | degenerative disorders | complex traits | complex traits | Mendelian inheritance | Mendelian inheritance

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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HST.525J Tumor Pathophysiology and Transport Phenomena (MIT) HST.525J Tumor Pathophysiology and Transport Phenomena (MIT)

Description

Tumor pathophysiology plays a central role in the growth, invasion, metastasis and treatment of solid tumors. This class applies principles of transport phenomena to develop a systems-level, quantitative understanding of angiogenesis, blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, and treatment response. Additional Faculty Dr. Pat D'Amore Dr. Dan Duda Dr. Robert Langer Prof. Robert Weinberg Dr. Marsha Moses Dr. Raghu Kalluri Dr. Lance Munn Tumor pathophysiology plays a central role in the growth, invasion, metastasis and treatment of solid tumors. This class applies principles of transport phenomena to develop a systems-level, quantitative understanding of angiogenesis, blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, and treatment response. Additional Faculty Dr. Pat D'Amore Dr. Dan Duda Dr. Robert Langer Prof. Robert Weinberg Dr. Marsha Moses Dr. Raghu Kalluri Dr. Lance Munn

Subjects

HST.525 | HST.525 | 10.548 | 10.548 | tumor | tumor | cancer | cancer | tumor vasculature | tumor vasculature | antiangiogenesis | antiangiogenesis | bone marrow-derived stem cells | bone marrow-derived stem cells | BMDC | BMDC | stem cell research | stem cell research | experimental cancer therapy | experimental cancer therapy | cancer research | cancer research | tumor-host interactions | tumor-host interactions | vascular normalization | vascular normalization | vascular transport | vascular transport | interstitial transport | interstitial transport | lymphatic transport | lymphatic transport | microcirculation | microcirculation | molecular therapeutics | molecular therapeutics | blood vessels | blood vessels | angiogenesis | angiogenesis | drug delivery | drug delivery | intravital microscopy | intravital microscopy

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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MAS.965 Relational Machines (MIT) MAS.965 Relational Machines (MIT)

Description

This course examines the issues, principles, and challenges toward building relational machines through a combination of studio-style design and critique along with lecture, lively discussion of course readings, and assignments. Insights from social psychology, human-computer interaction, and design will be examined, as well as how these ideas are manifest in a broad range of applications for software agents and robots. This course examines the issues, principles, and challenges toward building relational machines through a combination of studio-style design and critique along with lecture, lively discussion of course readings, and assignments. Insights from social psychology, human-computer interaction, and design will be examined, as well as how these ideas are manifest in a broad range of applications for software agents and robots.

Subjects

relational machines | relational machines | emotional design | emotional design | technology | technology | human relationships | human relationships | emotional expression | emotional expression | representation and manipulation | representation and manipulation | measuring relationships and interactions | measuring relationships and interactions | assitive robotics for elderly | assitive robotics for elderly | robotic pets | robotic pets | robotic therapy | robotic therapy | language processing | language processing | machine teammates | machine teammates | collaboration | collaboration | interactive learning | interactive learning | tutorials | tutorials | wearable agent interaction | wearable agent interaction | ambient agent interaction | ambient agent interaction

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Cancer Immunlogy

Description

Professor Vincenzo Cerundolo tells us how research in immunology leads to the development of new cancer treatments. Immunotherapy stimulates the bodys immune system and can be a powerful treatment for cancer. With the aim of developing better treatment strategies for cancer patients, Professor Vincenzo Cerundolo is working to gain a better understanding of the cell-to-cell interplay required for optimal expansion and activation of tumour-specific T cell populations. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

cancer | immunotherapy | T cell | vaccines | adjuvants | tumour immunology | cancer | immunotherapy | T cell | vaccines | adjuvants | tumour immunology

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Hepatitis C vaccine

Description

Dr Ellie Barnes talks about her research on Hepatitis C and her work on a T cell vaccine. Dr Ellie Barnes aims to develop a prophylactic and a therapeutic hepatitis C virus vaccine to combat a global epidemic currently infecting 170 million people worldwide. Many chronically infected patients silently develop complications of liver disease that can include hepatocellular cancer, liver cirrhosis and liver failure. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

therapy | Hepatitis C virus | T cells | vaccine | genotype-3 | therapy | Hepatitis C virus | T cells | vaccine | genotype-3

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Cancer Immunlogy

Description

Professor Vincenzo Cerundolo tells us how research in immunology leads to the development of new cancer treatments. Immunotherapy stimulates the bodys immune system and can be a powerful treatment for cancer. With the aim of developing better treatment strategies for cancer patients, Professor Vincenzo Cerundolo is working to gain a better understanding of the cell-to-cell interplay required for optimal expansion and activation of tumour-specific T cell populations. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

cancer | immunotherapy | T cell | vaccines | adjuvants | tumour immunology | cancer | immunotherapy | T cell | vaccines | adjuvants | tumour immunology

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Hepatitis C vaccine

Description

Dr Ellie Barnes talks about her research on Hepatitis C and her work on a T cell vaccine. Dr Ellie Barnes aims to develop a prophylactic and a therapeutic hepatitis C virus vaccine to combat a global epidemic currently infecting 170 million people worldwide. Many chronically infected patients silently develop complications of liver disease that can include hepatocellular cancer, liver cirrhosis and liver failure. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

therapy | Hepatitis C virus | T cells | vaccine | genotype-3 | therapy | Hepatitis C virus | T cells | vaccine | genotype-3

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Occupation-based Community Development Framework

Description

Authors:  Roshan Galvaan and Liesl Peters This resource provides an introductory framework for occupation-based community development for occupational therapy students and practitioners. Clicked 494 times. Last clicked 11/11/2014 - 11:18. Teaching & Learning Context:  This is a free guide to practice for occupational therapists intending to apply critical occupational therapy. It provides an outline for occupational therapists to practice in community development from an occupational and development perspective.

Subjects

Health and Rehabilitation Sciences | Health Sciences | Text/HTML Webpages | Lecture Notes | English | Post-secondary | community development | critical occupational therapy | health promotion | Human Occupation | marginalisation | occupation | occupational science | occupational therapy | social inclusion

License

http://creativecommons.org/licenses/by-nc-nd/2.5/za/

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The Upper Limb Anatomy Wiki

Description

Authors:  Roisin Kelly-Laubscher & students The Upper Limb Wiki was created in 2010 as part of an Anatomy & Physiology class project for 1st year Physiotherapy and Occupational Therapy students at the University of Cape Town. Clicked 139 times. Last clicked 09/24/2014 - 23:36. Teaching & Learning Context:  The Upper Limb Wiki was created in 2010 as part of an Anatomy & Physiology class project for 1st year Physiotherapy and Occupational Therapy students at the University of Cape Town. Each student wrote a wiki page and two Physiotherapy students worked over their vacations to improve the W

Subjects

Human Biology | Health Sciences | Text/HTML Webpages | Textbooks | English | Post-secondary | anatomy | muscles | nerves | occupational therapy | physiotherapy | student generated content

License

http://creativecommons.org/licenses/by-nc-sa/2.5/za/

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Introduction to the use of the International Classification of Functioning (ICF) in clinical management in undergraduate physiotherapy programme

Description

Authors:  Jennifer Jelsma and Lunelle Pienaar One of the most difficult skills that a physiotherapy student has to learn is clinical reasoning. Clicked 148 times. Last clicked 11/07/2014 - 10:32. Teaching & Learning Context:  Module notes and presentations designed for undergraduate students in the physiotherapy programme. Case studies presented of the use of ICF in the assessment of respiratory, cerebral palsy and orthopaedics patients.

Subjects

Health Sciences | Physiotherapy | Downloadable Documents | Lecture Notes | English | Post-secondary | cerebral palsy | ICF | International Classification of Functioning | orthopaedics | physiotherapy | respiratory

License

http://creativecommons.org/licenses/by-nc-sa/2.5/za/

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