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7.27 Principles of Human Disease (MIT) 7.27 Principles of Human Disease (MIT)

Description

This course covers current understanding of, and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Topics include: The Genetics of Simple and Complex Traits; Karyotypic Analysis and Positional Cloning; Genetic Diagnosis; The Roles of Oncogenes and Tumor Suppressors in Tumor Initiation, Progression, and Treatment; The Interaction between Genetics and Environment; Animal Models of Human Disease; Cancer; and Conventional and Gene Therapy Treatment Strategies. This course covers current understanding of, and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Topics include: The Genetics of Simple and Complex Traits; Karyotypic Analysis and Positional Cloning; Genetic Diagnosis; The Roles of Oncogenes and Tumor Suppressors in Tumor Initiation, Progression, and Treatment; The Interaction between Genetics and Environment; Animal Models of Human Disease; Cancer; and Conventional and Gene Therapy Treatment Strategies.

Subjects

human disease | human disease | molecular basis of genetic disease | molecular basis of genetic disease | molecular basis of cancer | molecular basis of cancer | cellular basis of genetic disease | cellular basis of genetic disease | cellular basis of cancer | cellular basis of cancer | genetics of simple and complex traits | genetics of simple and complex traits | karyotypic analysis | karyotypic analysis | positional cloning | positional cloning | genetic diagnosis | genetic diagnosis | roles of oncogenes | roles of oncogenes | tumor suppressors | tumor suppressors | tumor initiation | tumor initiation | tumor progression | tumor progression | tumor treatment | tumor treatment | interaction between genetics and environment | interaction between genetics and environment | animal models of human disease | animal models of human disease | cancer | cancer | conventional treatment strategies | conventional treatment strategies | gene therapy treatment strategies | gene therapy treatment strategies

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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1.85 Water and Wastewater Treatment Engineering (MIT) 1.85 Water and Wastewater Treatment Engineering (MIT)

Description

This course is an overview of engineering approaches to protecting water quality with an emphasis on fundamental principals. Theory and conceptual design of systems for treating municipal wastewater and drinking water are discussed, as well as reactor theory, process kinetics, and models. Physical, chemical, and biological processes are presented, including sedimentation, filtration, biological treatment, disinfection, and sludge processing. Finally, there is discussion of engineered and natural processes for wastewater treatment.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files. This course is an overview of engineering approaches to protecting water quality with an emphasis on fundamental principals. Theory and conceptual design of systems for treating municipal wastewater and drinking water are discussed, as well as reactor theory, process kinetics, and models. Physical, chemical, and biological processes are presented, including sedimentation, filtration, biological treatment, disinfection, and sludge processing. Finally, there is discussion of engineered and natural processes for wastewater treatment.Technical RequirementsMicrosoft® Excel software is recommended for viewing the .xls files found on this course site. Free Microsoft® Excel viewer software can also be used to view the .xls files.

Subjects

water pollution | water pollution | wastewater treatment | wastewater treatment | chemical treatment | chemical treatment | gas transfer | gas transfer | reactor tanks | reactor tanks | water quality | water quality | trickling filters | trickling filters | sludge handling | sludge handling | wastewater screening | wastewater screening

License

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1.85 Water and Wastewater Treatment Engineering (MIT) 1.85 Water and Wastewater Treatment Engineering (MIT)

Description

This course is an overview of engineering approaches to protecting water quality with an emphasis on fundamental principals. Theory and conceptual design of systems for treating municipal wastewater and drinking water are discussed, as well as reactor theory, process kinetics, and models. Physical, chemical, and biological processes are presented, including sedimentation, filtration, biological treatment, disinfection, and sludge processing. Finally, there is discussion of engineered and natural processes for wastewater treatment. This course is an overview of engineering approaches to protecting water quality with an emphasis on fundamental principals. Theory and conceptual design of systems for treating municipal wastewater and drinking water are discussed, as well as reactor theory, process kinetics, and models. Physical, chemical, and biological processes are presented, including sedimentation, filtration, biological treatment, disinfection, and sludge processing. Finally, there is discussion of engineered and natural processes for wastewater treatment.

Subjects

water pollution | water pollution | wastewater treatment | wastewater treatment | chemical treatment | chemical treatment | gas transfer | gas transfer | reactor tanks | reactor tanks | water quality | water quality | trickling filters | trickling filters | sludge handling | sludge handling | wastewater screening | wastewater screening

License

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1.782 Environmental Engineering Masters of Engineering Project (MIT) 1.782 Environmental Engineering Masters of Engineering Project (MIT)

Description

This class is one of the core requirements for the Environmental Masters of Engineering program. It is designed to teach about environmental engineering through the use of case studies, computer software tools, and seminars from industrial experts. Case studies provide the basis for group projects as well as individual theses. Past case studies have included the MMR Superfund site on Cape Cod; restoration of the Florida Everglades; dredging of Boston Harbor; local watershed trading programs; appropriate wastewater treatment technology for Brazil; point-of-use water treatment for Nepal, Brownfields Development in Providence, RI, and water resource planning for the island of Cyprus. This class spans the entire academic year: students must register for the Fall term, IAP, and the Spring term. This class is one of the core requirements for the Environmental Masters of Engineering program. It is designed to teach about environmental engineering through the use of case studies, computer software tools, and seminars from industrial experts. Case studies provide the basis for group projects as well as individual theses. Past case studies have included the MMR Superfund site on Cape Cod; restoration of the Florida Everglades; dredging of Boston Harbor; local watershed trading programs; appropriate wastewater treatment technology for Brazil; point-of-use water treatment for Nepal, Brownfields Development in Providence, RI, and water resource planning for the island of Cyprus. This class spans the entire academic year: students must register for the Fall term, IAP, and the Spring term.

Subjects

civil engineering; environmental engineering; professional practice; methodology; thesis; proposal; yonder; geotechnical data; water treatment; aquifer; groundwater; hydrology; Chattahoochee; Tennessee; US Virgin Islands; pollution; contaminants; drinking water | civil engineering; environmental engineering; professional practice; methodology; thesis; proposal; yonder; geotechnical data; water treatment; aquifer; groundwater; hydrology; Chattahoochee; Tennessee; US Virgin Islands; pollution; contaminants; drinking water | civil engineering | civil engineering | environmental engineering | environmental engineering | professional practice | professional practice | methodology | methodology | thesis | thesis | proposal | proposal | yonder | yonder | geotechnical data | geotechnical data | water treatment | water treatment | aquifer | aquifer | groundwater | groundwater | hydrology | hydrology | Chattahoochee | Chattahoochee | Tennessee | Tennessee | US Virgin Islands | US Virgin Islands | pollution | pollution | contaminants | contaminants | drinking water | drinking water

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.27 Principles of Human Disease (MIT)

Description

This course covers current understanding of, and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Topics include: The Genetics of Simple and Complex Traits; Karyotypic Analysis and Positional Cloning; Genetic Diagnosis; The Roles of Oncogenes and Tumor Suppressors in Tumor Initiation, Progression, and Treatment; The Interaction between Genetics and Environment; Animal Models of Human Disease; Cancer; and Conventional and Gene Therapy Treatment Strategies.

Subjects

human disease | molecular basis of genetic disease | molecular basis of cancer | cellular basis of genetic disease | cellular basis of cancer | genetics of simple and complex traits | karyotypic analysis | positional cloning | genetic diagnosis | roles of oncogenes | tumor suppressors | tumor initiation | tumor progression | tumor treatment | interaction between genetics and environment | animal models of human disease | cancer | conventional treatment strategies | gene therapy treatment strategies

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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SP.722 D-Lab: Development, Design and Dissemination (MIT) SP.722 D-Lab: Development, Design and Dissemination (MIT)

Description

D-Lab: Development, Design and Dissemination is a design studio course in which students work on international development projects for underserved communities. The class is focused on a participatory, iterative prototyping design process, with particular attention on the constraints faced when designing for developing communities. Students work in multidisciplinary teams on term-long projects in collaboration with community partners, field practitioners, and experts in relevant fields. Students will learn about their partner communities through the collaborative design process and be exposed to many hands-on fabrication and prototyping skills relevant to development at MIT and manufacturing in their partner community. The course will consist of hands-on labs, guest speakers, and a gu D-Lab: Development, Design and Dissemination is a design studio course in which students work on international development projects for underserved communities. The class is focused on a participatory, iterative prototyping design process, with particular attention on the constraints faced when designing for developing communities. Students work in multidisciplinary teams on term-long projects in collaboration with community partners, field practitioners, and experts in relevant fields. Students will learn about their partner communities through the collaborative design process and be exposed to many hands-on fabrication and prototyping skills relevant to development at MIT and manufacturing in their partner community. The course will consist of hands-on labs, guest speakers, and a gu

Subjects

development project | development project | appropriate technology | appropriate technology | sustainable development | sustainable development | intermediate technology | intermediate technology | stakeholder analysis | stakeholder analysis | India | India | Brazil | Brazil | Honduras | Honduras | Zambia | Zambia | Lesotho | Lesotho | Nicaragua | Nicaragua | developing country | developing country | international development | international development | third world | third world | energy | energy | charcoal | charcoal | wheelchair | wheelchair | poverty | poverty | water | water | water quality | water quality | safe water | safe water | water treatment | water treatment | health | health | sanitation | sanitation | AIDS | AIDS | solar water disinfection | solar water disinfection

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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SP.721 D-Lab: Development, Dialogue and Delivery (MIT) SP.721 D-Lab: Development, Dialogue and Delivery (MIT)

Description

D-Lab is a year-long series of courses and field trips. The fall class provides a basic background in international development and appropriate technology through guest speakers, case studies and hands-on exercises. Students will also have the opportunity to participate in an IAP field trip to Haiti, India, Brazil, Honduras, Zambia, Samoa, or Lesotho and continue their work in a spring term design class. As part of the fall class, students will partner with community organizations in these countries and develop plans for the IAP site visit. In addition, students will learn about the culture, language, economics, politics and history of their host country. D-Lab is a year-long series of courses and field trips. The fall class provides a basic background in international development and appropriate technology through guest speakers, case studies and hands-on exercises. Students will also have the opportunity to participate in an IAP field trip to Haiti, India, Brazil, Honduras, Zambia, Samoa, or Lesotho and continue their work in a spring term design class. As part of the fall class, students will partner with community organizations in these countries and develop plans for the IAP site visit. In addition, students will learn about the culture, language, economics, politics and history of their host country.

Subjects

development project | development project | appropriate technology | appropriate technology | sustainable development | sustainable development | intermediate technology | intermediate technology | stakeholder analysis | stakeholder analysis | Haiti | Haiti | India | India | Brazil | Brazil | Honduras | Honduras | Zambia | Zambia | Samoa | Samoa | Lesotho | Lesotho | developing country | developing country | international development | international development | third world | third world | cooking | cooking | latrine | latrine | grain mill | grain mill | solar energy | solar energy | energy | energy | charcoal | charcoal | wheelchair | wheelchair | poverty | poverty | water | water | water quality | water quality | safe water | safe water | water treatment | water treatment | health | health | sanitation | sanitation

License

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18.014 Calculus with Theory I (MIT) 18.014 Calculus with Theory I (MIT)

Description

18.014, Calculus with Theory, covers the same material as 18.01 (Calculus), but at a deeper and more rigorous level. It emphasizes careful reasoning and understanding of proofs. The course assumes knowledge of elementary calculus. Topics: Axioms for the real numbers; the Riemann integral; limits, theorems on continuous functions; derivatives of functions of one variable; the fundamental theorems of calculus; Taylor's theorem; infinite series, power series, rigorous treatment of the elementary functions. Dr. Lachowska wishes to acknowledge Andrew Brooke-Taylor, Natasha Bershadsky, and Alex Retakh for their help with this course web site. 18.014, Calculus with Theory, covers the same material as 18.01 (Calculus), but at a deeper and more rigorous level. It emphasizes careful reasoning and understanding of proofs. The course assumes knowledge of elementary calculus. Topics: Axioms for the real numbers; the Riemann integral; limits, theorems on continuous functions; derivatives of functions of one variable; the fundamental theorems of calculus; Taylor's theorem; infinite series, power series, rigorous treatment of the elementary functions. Dr. Lachowska wishes to acknowledge Andrew Brooke-Taylor, Natasha Bershadsky, and Alex Retakh for their help with this course web site.

Subjects

axioms for the real numbers | axioms for the real numbers | the Riemann integral | the Riemann integral | limits | limits | theorems on continuous functions | theorems on continuous functions | derivatives of functions of one variablethe fundamental theorems of calculus | derivatives of functions of one variablethe fundamental theorems of calculus | Taylor's theorem | Taylor's theorem | infinite series | infinite series | power series | power series | rigorous treatment of the elementary functions | rigorous treatment of the elementary functions

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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21A.348 Photography and Truth (MIT) 21A.348 Photography and Truth (MIT)

Description

Photographs in anthropology serve many purposes: as primary data, illustrations of words in a book, documentation for disappearing cultures, evidence of fieldwork, material objects for museum exhibitions, and even works of art. This course explores photography as art, research tool, and communication. Photographs in anthropology serve many purposes: as primary data, illustrations of words in a book, documentation for disappearing cultures, evidence of fieldwork, material objects for museum exhibitions, and even works of art. This course explores photography as art, research tool, and communication.

Subjects

Photography | Photography | anthropology | anthropology | culture | culture | subject and treatment of image | subject and treatment of image | art | art | ethnographic documentation | ethnographic documentation | ethnography | ethnography | documentary | documentary | museum photography | museum photography | taking pictures | taking pictures | Middle East | Middle East | North Africa | North Africa | Abu Ghraib | Abu Ghraib

License

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Trying to do more good than harm in health care

Description

The 2012 Wolfson College Haldane Lecture was given by leading health services researcher Sir Iain Chalmers, currently Coordinator of the James Lind Initiative, Oxford, UK. Sir Iain Chalmers is a leading health services researcher who has spent the past 30 years trying to ensure that health professionals and patients have free access to unbiased evidence of the effects of medical and other treatments. Sir Iain qualified in medicine in the mid-1960s. He practised as a clinician for seven years in the UK and the Gaza Strip, and then became a full time health services researcher with a particular interest in assessing the effects of health care. Between 1978 and 1992 he was founding director of the National Perinatal Epidemiology Unit in Oxford. Between 1992 and 2002 he was founding director o Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

Epidemiology | public health | treatment | evidence-based healthcare | Epidemiology | public health | treatment | evidence-based healthcare | 2012-02-16

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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1.103 Civil Engineering Materials Laboratory (MIT) 1.103 Civil Engineering Materials Laboratory (MIT)

Description

Includes audio/video content: AV special element video. This course introduces the concepts, techniques, and devices used to measure engineering properties of materials. There is an emphasis on measurement of load-deformation characteristics and failure modes of both natural and fabricated materials. Weekly experiments include data collection, data analysis, and interpretation and presentation of results. Includes audio/video content: AV special element video. This course introduces the concepts, techniques, and devices used to measure engineering properties of materials. There is an emphasis on measurement of load-deformation characteristics and failure modes of both natural and fabricated materials. Weekly experiments include data collection, data analysis, and interpretation and presentation of results.

Subjects

materials laboratory | materials laboratory | load-deformation characteristics | load-deformation characteristics | failure modes | failure modes | experiments | experiments | data collection | data collection | data analysis | data analysis | tension | tension | elastic behavior | elastic behavior | direct shear | direct shear | friction | friction | concrete | concrete | early age properties | early age properties | compression | compression | directionality | directionality | soil classification | soil classification | consolidation test | consolidation test | heat treatment | heat treatment

License

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1.782 Environmental Engineering Masters of Engineering Project (MIT) 1.782 Environmental Engineering Masters of Engineering Project (MIT)

Description

This class is one of the core requirements for the Environmental Masters of Engineering program, in conjunction with 1.133 Masters of Engineering Concepts of Engineering Practice. It is designed to teach about environmental engineering through the use of case studies, computer software tools, and seminars from industrial experts. Case studies provide the basis for group projects as well as individual theses. Recent 1.782 projects include the MMR Superfund site on Cape Cod, appropriate wastewater treatment technology for Brazil and Honduras, point-of-use water treatment and safe storage procedures for Nepal and Ghana, Brownfields Development in Providence, RI, and water resource planning for the island of Cyprus and refugee settlements in Thailand. This class spans the entire academic year; This class is one of the core requirements for the Environmental Masters of Engineering program, in conjunction with 1.133 Masters of Engineering Concepts of Engineering Practice. It is designed to teach about environmental engineering through the use of case studies, computer software tools, and seminars from industrial experts. Case studies provide the basis for group projects as well as individual theses. Recent 1.782 projects include the MMR Superfund site on Cape Cod, appropriate wastewater treatment technology for Brazil and Honduras, point-of-use water treatment and safe storage procedures for Nepal and Ghana, Brownfields Development in Providence, RI, and water resource planning for the island of Cyprus and refugee settlements in Thailand. This class spans the entire academic year;

Subjects

civil engineering | civil engineering | environmental engineering | environmental engineering | professional practice | professional practice | methodology | methodology | thesis | thesis | proposal | proposal | request for proposal | request for proposal | water treatment | water treatment | aquifer | aquifer | groundwater | groundwater | hydrology | hydrology | Ghana | Ghana | Thailand | Thailand | Honduras | Honduras | pollution | pollution | contaminants | contaminants | drinking water | drinking water | refugee camp | refugee camp | sanitation | sanitation | water filtration | water filtration | guinea worm | guinea worm | biosand filter | biosand filter | horizontal roughing filter | horizontal roughing filter

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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1.101 Introduction to Civil and Environmental Engineering Design I (MIT) 1.101 Introduction to Civil and Environmental Engineering Design I (MIT)

Description

In this sophomore design course, you will be challenged with three design tasks: a first concerning water resources/treatment, a second concerning structural design, and a third focusing on the conceptual (re)design of a large system, Boston's Back Bay. The first two tasks require the design, fabrication and testing of hardware. Several laboratory experiments will be carried out and lectures will be presented to introduce students to the conceptual and experimental basis for design in both domains. This course was based in large part on the Fall 2005 offering of 1.101, developed by Prof. Harold Hemond. In this sophomore design course, you will be challenged with three design tasks: a first concerning water resources/treatment, a second concerning structural design, and a third focusing on the conceptual (re)design of a large system, Boston's Back Bay. The first two tasks require the design, fabrication and testing of hardware. Several laboratory experiments will be carried out and lectures will be presented to introduce students to the conceptual and experimental basis for design in both domains. This course was based in large part on the Fall 2005 offering of 1.101, developed by Prof. Harold Hemond.

Subjects

design tasks | design tasks | water resources | water resources | water treatment | water treatment | structural design | structural design | conceptual design | conceptual design | Boston | Boston | Back Bay | Back Bay | redesign | redesign | measuring pH | measuring pH | acidity | acidity | water filter testing | water filter testing | tension tests | tension tests

License

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1.101 Introduction to Civil and Environmental Engineering Design I (MIT) 1.101 Introduction to Civil and Environmental Engineering Design I (MIT)

Description

This sophomore-level course is a project-oriented introduction to the principles and practice of engineering design. Design projects and exercises are chosen that relate to the built and natural environments. Emphasis is placed on achieving function and sustainability through choice of materials and processes, compatibility with natural cycles, and the use of active or adaptive systems. The course also encourages development of hands-on skills, teamwork, and communication; exercises and projects engage students in the building, implementation, and testing of their designs. This sophomore-level course is a project-oriented introduction to the principles and practice of engineering design. Design projects and exercises are chosen that relate to the built and natural environments. Emphasis is placed on achieving function and sustainability through choice of materials and processes, compatibility with natural cycles, and the use of active or adaptive systems. The course also encourages development of hands-on skills, teamwork, and communication; exercises and projects engage students in the building, implementation, and testing of their designs.

Subjects

Design | Design | water resources | water resources | water treatment | water treatment | structures | structures | structural design | structural design | fabrication | fabrication | testing | testing | hardware | hardware | laboratory experiments | laboratory experiments | pH | pH | neutralization | neutralization | hydraulic conductivity | hydraulic conductivity | porosity | porosity | truss | truss | tension | tension | beam bending | beam bending | beam buckling | beam buckling | thermal design | thermal design | heating | heating | cooling | cooling | thermal infrared camera | thermal infrared camera | thermal IR imaging | thermal IR imaging | heat loss | heat loss

License

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2.500 Desalination and Water Purification (MIT) 2.500 Desalination and Water Purification (MIT)

Description

Water supply is a problem of worldwide concern: more than 1 billion people do not have reliable access to clean drinking water. Water is a particular problem for the developing world, but scarcity also impacts industrial societies. Water purification and desalination technology can be used to convert brackish ground water or seawater into drinking water. The challenge is to do so sustainably, with minimum cost and energy consumption, and with appropriately accessible technologies. This subject will survey the state-of-the-art in water purification by desalination and filtration. Fundamental thermodynamic and transport processes which govern the creation of fresh water from seawater and brackish ground water will be developed. The technologies of existing desalination systems will be discus Water supply is a problem of worldwide concern: more than 1 billion people do not have reliable access to clean drinking water. Water is a particular problem for the developing world, but scarcity also impacts industrial societies. Water purification and desalination technology can be used to convert brackish ground water or seawater into drinking water. The challenge is to do so sustainably, with minimum cost and energy consumption, and with appropriately accessible technologies. This subject will survey the state-of-the-art in water purification by desalination and filtration. Fundamental thermodynamic and transport processes which govern the creation of fresh water from seawater and brackish ground water will be developed. The technologies of existing desalination systems will be discus

Subjects

reverse osmosis | reverse osmosis | seawater | seawater | electrodialysis | electrodialysis | student work | student work | distillation | distillation | flash evaporation | flash evaporation | power generation | power generation | wastewater treatment | wastewater treatment | particulate removal | particulate removal | system engineering | system engineering | cogeneration | cogeneration | solar still | solar still | chlorination | chlorination | Haiti | Haiti

License

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2.002 Mechanics and Materials II (MIT) 2.002 Mechanics and Materials II (MIT)

Description

This course provides Mechanical Engineering students with an awareness of various responses exhibited by solid engineering materials when subjected to mechanical and thermal loadings; an introduction to the physical mechanisms associated with design-limiting behavior of engineering materials, especially stiffness, strength, toughness, and durability; an understanding of basic mechanical properties of engineering materials, testing procedures used to quantify these properties, and ways in which these properties characterize material response; quantitative skills to deal with materials-limiting problems in engineering design; and a basis for materials selection in mechanical design. This course provides Mechanical Engineering students with an awareness of various responses exhibited by solid engineering materials when subjected to mechanical and thermal loadings; an introduction to the physical mechanisms associated with design-limiting behavior of engineering materials, especially stiffness, strength, toughness, and durability; an understanding of basic mechanical properties of engineering materials, testing procedures used to quantify these properties, and ways in which these properties characterize material response; quantitative skills to deal with materials-limiting problems in engineering design; and a basis for materials selection in mechanical design.

Subjects

beam bending | beam bending | buckling | buckling | vibration | vibration | polymers | polymers | viscoelasticity | viscoelasticity | strength | strength | ductility | ductility | stress | stress | stress concentration | stress concentration | sheet bending | sheet bending | heat treatment | heat treatment | fracture | fracture | plasticity | plasticity | creep | creep | fatigue | fatigue | solid materials | solid materials | mechanical loading | mechanical loading | thermal loading | thermal loading | design-limiting behavior | design-limiting behavior | stiffness | stiffness | toughness | toughness | durability | durability | engineering materials | engineering materials | materials-limiting problem | materials-limiting problem | materials selection | materials selection

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.345 Vascular Development in Life, Disease and Cancer Medicine (MIT) 7.345 Vascular Development in Life, Disease and Cancer Medicine (MIT)

Description

The growth of blood vessels, a process known as angiogenesis, is one of the earliest events in mammalian development and is regulated by a sensitive interplay of growth factors and other molecules. In this course, we will discuss the key molecular regulators of blood vessel development as well as the techniques and experimental systems that have been utilized by vascular biologists. We will also examine the success of several anti-angiogenic treatments that have been approved by the Food and Drug Administration (FDA), that inhibit the pro-angiogenic vascular endothelial growth factor, VEGF, and that are now being used to treat age-related macular degeneration. Finally, we will explore how during the course of cancer progression, establishment of a blood supply into a tumor can lead to the The growth of blood vessels, a process known as angiogenesis, is one of the earliest events in mammalian development and is regulated by a sensitive interplay of growth factors and other molecules. In this course, we will discuss the key molecular regulators of blood vessel development as well as the techniques and experimental systems that have been utilized by vascular biologists. We will also examine the success of several anti-angiogenic treatments that have been approved by the Food and Drug Administration (FDA), that inhibit the pro-angiogenic vascular endothelial growth factor, VEGF, and that are now being used to treat age-related macular degeneration. Finally, we will explore how during the course of cancer progression, establishment of a blood supply into a tumor can lead to the

Subjects

angiogenesis | angiogenesis | growth factors | growth factors | VEGF | VEGF | microscopic visualization | microscopic visualization | intravital imaging | intravital imaging | anti-angiogenic treatments | anti-angiogenic treatments | macular degeneration | macular degeneration | cancer progression | cancer progression | tumor blood vessels | tumor blood vessels

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7.342 Chronic Infection and Inflammation: What are the Consequences on Your Health? (MIT) 7.342 Chronic Infection and Inflammation: What are the Consequences on Your Health? (MIT)

Description

In this course we will explore the new emerging field of pathogen-induced chronic diseases. Work in this field has redefined the causes of some major disorders, such as ulcers. By reading the primary research literature we will learn about the molecular mechanisms through which pathogens cause disease. The diseases that we cover will be introduced with a short patient case study. We will discuss the bacterium Helicobacter pylori and gastric disease, HPV and cervical cancer, hepatitis C virus and liver disease, Epstein-Barr virus and lymphoma, Cytomegalovirus and atherosclerosis, as well as diabetes and multiple sclerosis. We will study technical advances in the fight against microbes and explore future directions for new treatment strategies of chronic infections and inflammation. This cou In this course we will explore the new emerging field of pathogen-induced chronic diseases. Work in this field has redefined the causes of some major disorders, such as ulcers. By reading the primary research literature we will learn about the molecular mechanisms through which pathogens cause disease. The diseases that we cover will be introduced with a short patient case study. We will discuss the bacterium Helicobacter pylori and gastric disease, HPV and cervical cancer, hepatitis C virus and liver disease, Epstein-Barr virus and lymphoma, Cytomegalovirus and atherosclerosis, as well as diabetes and multiple sclerosis. We will study technical advances in the fight against microbes and explore future directions for new treatment strategies of chronic infections and inflammation. This cou

Subjects

Seminar | Seminar | literature review | literature review | cancer | cancer | vaccine | vaccine | antibiotic | antibiotic | chronic | chronic | atherosclerosis | atherosclerosis | diabetes | diabetes | human papilloma virus | human papilloma virus | HPV | HPV | helicobacter pylori | helicobacter pylori | epstein-barr | epstein-barr | treatment strategies | treatment strategies | laboratory techniques | laboratory techniques | lab | lab | herpes | herpes | microbes | microbes | infection | infection | health | health | Epstein-Barr | Epstein-Barr | cervical cancer | cervical cancer | cirrhosis | cirrhosis | multiple sclerosis | multiple sclerosis | hepatitis | hepatitis | hepatocellular carcinoma | hepatocellular carcinoma | gastric | gastric

License

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14.385 Nonlinear Econometric Analysis (MIT) 14.385 Nonlinear Econometric Analysis (MIT)

Description

This course presents micro-econometric models, including large sample theory for estimation and hypothesis testing, generalized method of moments (GMM), estimation of censored and truncated specifications, quantile regression, structural estimation, nonparametric and semiparametric estimation, treatment effects, panel data, bootstrapping, simulation methods, and Bayesian methods. The methods are illustrated with economic applications. This course presents micro-econometric models, including large sample theory for estimation and hypothesis testing, generalized method of moments (GMM), estimation of censored and truncated specifications, quantile regression, structural estimation, nonparametric and semiparametric estimation, treatment effects, panel data, bootstrapping, simulation methods, and Bayesian methods. The methods are illustrated with economic applications.

Subjects

nonlinear | nonlinear | econometric | econometric | analysis | analysis | generalized method of moments | generalized method of moments | GMM | GMM | maximum likelihood estimation | maximum likelihood estimation | MLE | MLE | minimum distance | minimum distance | extremum | extremum | large sample theory | large sample theory | asymptotic theory | asymptotic theory | discrete choice | discrete choice | censoring | censoring | sample selection | sample selection | bootstrap | bootstrap | subsampling | subsampling | finite-sample methods | finite-sample methods | quantile regression | quantile regression | QR | QR | distributional methods | distributional methods | Bayesian methods | Bayesian methods | quasi-Bayesian methods | quasi-Bayesian methods | bounds | bounds | partial identification | partial identification | weak instruments | weak instruments | many instruments | many instruments | instrumental variables | instrumental variables | nonparametric estimation | nonparametric estimation | semiparametric estimation | semiparametric estimation | treatment effects | treatment effects | nonlinear models | nonlinear models | panel data | panel data | economic modeling | economic modeling

License

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15.616 Innovative Businesses and Breakthrough Technologies - The Legal Issues (MIT) 15.616 Innovative Businesses and Breakthrough Technologies - The Legal Issues (MIT)

Description

15.616 is an introduction to business law which covers the fundamentals, including contracts, liability, regulation, employment, and corporations, with an in-depth treatment of the legal issues relating to breakthrough technologies, including the legal framework of R&D, the commercialization of new high-technology products in start-ups and mature companies, and the liability and regulatory implications of new products and innovative business models. There is extensive attention to national and international intellectual property protection and strategies. Examples are drawn from many industries, including information technology, communications, and life sciences. Note: This course used to be numbered 15.648. 15.616 is an introduction to business law which covers the fundamentals, including contracts, liability, regulation, employment, and corporations, with an in-depth treatment of the legal issues relating to breakthrough technologies, including the legal framework of R&D, the commercialization of new high-technology products in start-ups and mature companies, and the liability and regulatory implications of new products and innovative business models. There is extensive attention to national and international intellectual property protection and strategies. Examples are drawn from many industries, including information technology, communications, and life sciences. Note: This course used to be numbered 15.648.

Subjects

geomorphic processes | geomorphic processes | climate | climate | tectonics | tectonics | surface processes | surface processes | fluvial processes | fluvial processes | hillslope processes | hillslope processes | glacial processes | glacial processes | weathering | weathering | soil formation | soil formation | runoff | runoff | erosion | erosion | slope stability | slope stability | sediment transport | sediment transport | river morphology | river morphology | glacial erosion | glacial erosion | climatic forcings | climatic forcings | tectonic forcings | tectonic forcings | glaciation | glaciation | sea level change | sea level change | uplift | subsidence | uplift | subsidence | post-glacial isostatic rebound | post-glacial isostatic rebound | contracts | contracts | liability | liability | regulation | regulation | business law | business law | employment | employment | corporations | corporations | in-depth treatment of the legal issues relating to breakthrough technologies | in-depth treatment of the legal issues relating to breakthrough technologies | D | D | commercialization of new high-technology products | commercialization of new high-technology products | start-ups | start-ups | liability and regulatory implications of new products and innovative business models | liability and regulatory implications of new products and innovative business models | national and international intellectual property | national and international intellectual property | intellectual property | intellectual property | industries | industries | information technology | information technology | communications | communications | life sciences | life sciences

License

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16.892J Space System Architecture and Design (MIT) 16.892J Space System Architecture and Design (MIT)

Description

Space System Architecture and Design incorporates lectures, readings and discussion on topics in the architecting of space systems. The class reviews existing space system architectures and the classical methods of designing them. Sessions focus on multi-attribute utility theory as a new design paradigm for space systems, when combined with integrated concurrent engineering and efficient searches of large architectural tradespaces. Designing for flexibility and uncertainty is considered, as are policy and product development issues. Space System Architecture and Design incorporates lectures, readings and discussion on topics in the architecting of space systems. The class reviews existing space system architectures and the classical methods of designing them. Sessions focus on multi-attribute utility theory as a new design paradigm for space systems, when combined with integrated concurrent engineering and efficient searches of large architectural tradespaces. Designing for flexibility and uncertainty is considered, as are policy and product development issues.

Subjects

space system | space system | space system architecture | space system architecture | space architecting | space architecting | uncertainties | uncertainties | space policy | space policy | robustness | robustness | flexibility | flexibility | optimality | optimality | tradespace analysis | tradespace analysis | quality function deployment | quality function deployment | multi-attribute utility theory | multi-attribute utility theory | n-squared | n-squared | design structure matrix | design structure matrix | multi-attribution tradespace exploration | multi-attribution tradespace exploration | MATE | MATE | MATE-CON | MATE-CON | satellite | satellite | classes of space system | classes of space system | XTOS | XTOS | spacetug | spacetug | GINA | GINA | pareto fronts | pareto fronts | engineering design process | engineering design process | optimization methods | optimization methods | genetic algorithms | genetic algorithms | simulated annealing | simulated annealing | MMDOSA | MMDOSA | distributed space systems design optimization | distributed space systems design optimization | clarity test | clarity test | taxonomy of uncertainty | taxonomy of uncertainty | treatment of uncertainty | treatment of uncertainty | irreducible uncertainty | irreducible uncertainty | portfolio theory | portfolio theory | portfolio applications | portfolio applications | taxonomy of flexibility | taxonomy of flexibility | on-orbit servicing | on-orbit servicing | US national space policy | US national space policy | space policy heuristics | space policy heuristics | policy architectures | policy architectures | 16.892 | 16.892 | ESD.353 | ESD.353

License

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18.014 Calculus with Theory (MIT) 18.014 Calculus with Theory (MIT)

Description

18.014, Calculus with Theory, covers the same material as 18.01 (Single Variable Calculus), but at a deeper and more rigorous level. It emphasizes careful reasoning and understanding of proofs. The course assumes knowledge of elementary calculus. 18.014, Calculus with Theory, covers the same material as 18.01 (Single Variable Calculus), but at a deeper and more rigorous level. It emphasizes careful reasoning and understanding of proofs. The course assumes knowledge of elementary calculus.

Subjects

axioms for the real numbers | axioms for the real numbers | the Riemann integral | the Riemann integral | limits | limits | theorems on continuous functions | theorems on continuous functions | derivatives of functions of one variable | derivatives of functions of one variable | the fundamental theorems of calculus | the fundamental theorems of calculus | Taylor's theorem | Taylor's theorem | infinite series | infinite series | power series | power series | rigorous treatment of the elementary functions | rigorous treatment of the elementary functions

License

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21A.215 Disease and Health: Culture, Society, and Ethics (MIT) 21A.215 Disease and Health: Culture, Society, and Ethics (MIT)

Description

This course examines how medicine is practiced cross-culturally, with particular emphasis on Western biomedicine. Students analyze medical practice as a cultural system, focusing on the human, as opposed to the biological, side of things. Also considered is how people in different cultures think of disease, health, body, and mind. This course examines how medicine is practiced cross-culturally, with particular emphasis on Western biomedicine. Students analyze medical practice as a cultural system, focusing on the human, as opposed to the biological, side of things. Also considered is how people in different cultures think of disease, health, body, and mind.

Subjects

history of medicine | history of medicine | sickness | sickness | healing | healing | disease causation | disease causation | beliefs | beliefs | disease treatment | disease treatment | institutions of medicine | institutions of medicine

License

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21A.348 Photography and Truth (MIT) 21A.348 Photography and Truth (MIT)

Description

Still photography, a practice and form of expression that has worked its way into every facet of social life and every culture in the world, is considered here from the perspectives of history and social science. We will discuss the uses and functions of pictures; how they are to be understood and interpreted; whether they have clear-cut content and meanings; how they shape and are shaped by politics, economics, and social life. Still photography, a practice and form of expression that has worked its way into every facet of social life and every culture in the world, is considered here from the perspectives of history and social science. We will discuss the uses and functions of pictures; how they are to be understood and interpreted; whether they have clear-cut content and meanings; how they shape and are shaped by politics, economics, and social life.

Subjects

Photography | Photography | anthropology | anthropology | culture | culture | subject and treatment of image | subject and treatment of image | art | art | ethnographic documentation | ethnographic documentation | ethnography | ethnography | documentary | documentary | taking pictures | taking pictures

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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TALAT Lecture 2102.03: The Transmission Housing of an Inboard-Outboard Engine, Special Study: Casting

Description

This lecture offers an example of product development. It imparts knowledge about different ways of casting aluminium and criteria for selecting casting methods; the heat treatment of aluminium; corrosion-proofing and surface treatment of cast alloys used in a saline environment and choice of alloy. It provides insight into how to develop a product using the general specificiations and the interaction between form, material and processing chain and ?the importance of being thoroughly familiar with the different design materials, their processing possibilities and properties. The lecture is recommended for those situations, where a brief, general background information about aluminium is needed as an introduction of other subject areas of aluminium application technologies. This lecture is

Subjects

aluminium | aluminum | european aluminium association | EAA | Training in Aluminium Application Technologies | training | metallurgy | technology | lecture | design | product | properties | stainless steel | magnesium | plastic | conclusion | casting | pressure die-casting | gravity die-casting | sand-casting | choice of alloy | heat treatment | surface treatment | corrosion-proofing | cathodic protection | evaluation | corematerials | ukoer

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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