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7.341 Designer Immunity: Lessons in Engineering the Immune System (MIT) 7.341 Designer Immunity: Lessons in Engineering the Immune System (MIT)

Description

The immune system is one of the most complex and powerful of human body systems. It is highly dynamic and flexible, yet strictly regulates homeostasis and protects our bodies from both foreign and self-derived challenges. As basic understanding of immune function is growing, researchers are rapidly designing clever and diverse strategies to manipulate immunology to improve human health. In this course, we will explore important advances rooted in engineering principles to harness the power of the immune system, focusing on how engineering has fueled or inspired research concerning (1) vaccines, (2) immunotherapies, and (3) systems immunology. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an The immune system is one of the most complex and powerful of human body systems. It is highly dynamic and flexible, yet strictly regulates homeostasis and protects our bodies from both foreign and self-derived challenges. As basic understanding of immune function is growing, researchers are rapidly designing clever and diverse strategies to manipulate immunology to improve human health. In this course, we will explore important advances rooted in engineering principles to harness the power of the immune system, focusing on how engineering has fueled or inspired research concerning (1) vaccines, (2) immunotherapies, and (3) systems immunology. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an

Subjects

immune system | immune system | immunoengineering | immunoengineering | vaccines | vaccines | immunotherapies | immunotherapies | systems immunology | systems immunology | multivariate profiling | multivariate profiling | regulatory network analyses | regulatory network analyses | vaccine design | vaccine design | immunomodulation | immunomodulation | autoimmunity | autoimmunity | vaccine carriers | vaccine carriers | tolerogenic particle vaccines | tolerogenic particle vaccines | pathogen-mimicking | pathogen-mimicking | lipid nanoparticle vaccines | lipid nanoparticle vaccines

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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7.341 Designer Immunity: Lessons in Engineering the Immune System (MIT)

Description

The immune system is one of the most complex and powerful of human body systems. It is highly dynamic and flexible, yet strictly regulates homeostasis and protects our bodies from both foreign and self-derived challenges. As basic understanding of immune function is growing, researchers are rapidly designing clever and diverse strategies to manipulate immunology to improve human health. In this course, we will explore important advances rooted in engineering principles to harness the power of the immune system, focusing on how engineering has fueled or inspired research concerning (1) vaccines, (2) immunotherapies, and (3) systems immunology. This course is one of many Advanced Undergraduate Seminars offered by the Biology Department at MIT. These seminars are tailored for students with an

Subjects

immune system | immunoengineering | vaccines | immunotherapies | systems immunology | multivariate profiling | regulatory network analyses | vaccine design | immunomodulation | autoimmunity | vaccine carriers | tolerogenic particle vaccines | pathogen-mimicking | lipid nanoparticle vaccines

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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20.462J Molecular Principles of Biomaterials (MIT) 20.462J Molecular Principles of Biomaterials (MIT)

Description

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces. This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Subjects

biomaterials | biomaterials | biomaterial engineering | biomaterial engineering | biotechnology | biotechnology | cell-guiding surface | cell-guiding surface | molecular biomaterials | molecular biomaterials | drug release | drug release | polymers | polymers | pulsatile release | pulsatile release | polymerization | polymerization | polyer erosion | polyer erosion | tissue engineering | tissue engineering | hydrogels | hydrogels | adhesion | adhesion | migration | migration | drug diffusion | drug diffusion | molecular switches | molecular switches | molecular motors | molecular motors | nanoparticles | nanoparticles | microparticles | microparticles | vaccines | vaccines | drug targeting | drug targeting | micro carriers | micro carriers | nano carriers | nano carriers | intracellular drug delivery | intracellular drug delivery | 20.462 | 20.462 | 3.962 | 3.962

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Can we block malaria transmission by Sumi Biswas

Description

Dr Sumi Biswas talks about the development of a vaccine aimed at the mosquito stage of the malaria parasite cycle Malaria transmission-blocking vaccines aim to induce immunity against the parasites that infect mosquitoes. Such vaccines will prevent malaria transmission on a wider scale, focusing on the community rather than the individual. Dr Sumi Biswas is working on the development of transmission-blocking vaccines to prevent the spread of malaria.

Subjects

vaccines | malaria | Jenner Institute | clinical trials | ukoer | vaccines | malaria | Jenner Institute | clinical trials

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Cancer Immunlogy

Description

Professor Vincenzo Cerundolo tells us how research in immunology leads to the development of new cancer treatments. Immunotherapy stimulates the bodys immune system and can be a powerful treatment for cancer. With the aim of developing better treatment strategies for cancer patients, Professor Vincenzo Cerundolo is working to gain a better understanding of the cell-to-cell interplay required for optimal expansion and activation of tumour-specific T cell populations. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

cancer | immunotherapy | T cell | vaccines | adjuvants | tumour immunology | cancer | immunotherapy | T cell | vaccines | adjuvants | tumour immunology

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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Malaria vaccine for P. vivax

Description

Dr Arturo Reyes-Sandoval tells us about his research on a vaccine against Plasmodium vivax. Dr Reyes Sandoval aims to develop a novel malaria vaccine against Plasmodium vivax, one of the four malaria parasites that affect humans. P. vivax is found in Africa, Asia, Latin America and the Western Pacific. 40 percent of the world's population is exposed to the disease that is responsible for around 130 to 350 million clinical cases every year. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

recombinant viral vectors | Plasmodium vivax | malaria vaccines | recombinant viral vectors | Plasmodium vivax | malaria vaccines

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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http://mediapub.it.ox.ac.uk/feeds/129165/audio.xml

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Aiming for a HIV vaccine

Description

Professor Sir Andrew McMichael tells us about recent developments in the search for a vaccine against HIV. Prof. Sir Andrew McMichael is working on human immunology and vaccines, first looking at flu virus and now HIV. His current lines of research include analysing early molecular events in HIV infection, T cell immune response to HIV and the use of vaccination to control HIV infection. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

vaccines | T cell immunity | hiv | vaccines | T cell immunity | hiv

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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http://mediapub.it.ox.ac.uk/feeds/129165/audio.xml

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Malaria Vaccines

Description

Professor Adrian Hill has been studying the immune system and malaria susceptibility in African children for years. We asked him about his latest findings in the development of vaccines against malaria. Professor Hill develops vaccines against malaria based on inducing cellular immune responses (T lymphocytes) instead of the more commonly used stimulation of antibodies. Prophylactic vaccines developed in Oxford are now showing great promise in clinical trials. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

jenner | malaria | Africa | vaccines | developing world | tropical diseases | jenner | malaria | Africa | vaccines | developing world | tropical diseases

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/audio.xml

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Cancer Immunlogy

Description

Professor Vincenzo Cerundolo tells us how research in immunology leads to the development of new cancer treatments. Immunotherapy stimulates the bodys immune system and can be a powerful treatment for cancer. With the aim of developing better treatment strategies for cancer patients, Professor Vincenzo Cerundolo is working to gain a better understanding of the cell-to-cell interplay required for optimal expansion and activation of tumour-specific T cell populations. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

cancer | immunotherapy | T cell | vaccines | adjuvants | tumour immunology | cancer | immunotherapy | T cell | vaccines | adjuvants | tumour immunology

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/video.xml

Attribution

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Malaria vaccine for P. vivax

Description

Dr Arturo Reyes-Sandoval tells us about his research on a vaccine against Plasmodium vivax. Dr Reyes Sandoval aims to develop a novel malaria vaccine against Plasmodium vivax, one of the four malaria parasites that affect humans. P. vivax is found in Africa, Asia, Latin America and the Western Pacific. 40 percent of the world's population is exposed to the disease that is responsible for around 130 to 350 million clinical cases every year. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

recombinant viral vectors | Plasmodium vivax | malaria vaccines | recombinant viral vectors | Plasmodium vivax | malaria vaccines

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/video.xml

Attribution

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Aiming for a HIV vaccine

Description

Professor Sir Andrew McMichael tells us about recent developments in the search for a vaccine against HIV. Prof. Sir Andrew McMichael is working on human immunology and vaccines, first looking at flu virus and now HIV. His current lines of research include analysing early molecular events in HIV infection, T cell immune response to HIV and the use of vaccination to control HIV infection. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

vaccines | T cell immunity | hiv | vaccines | T cell immunity | hiv

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/video.xml

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Malaria Vaccines

Description

Professor Adrian Hill has been studying the immune system and malaria susceptibility in African children for years. We asked him about his latest findings in the development of vaccines against malaria. Professor Hill develops vaccines against malaria based on inducing cellular immune responses (T lymphocytes) instead of the more commonly used stimulation of antibodies. Prophylactic vaccines developed in Oxford are now showing great promise in clinical trials. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

jenner | malaria | Africa | vaccines | developing world | tropical diseases | jenner | malaria | Africa | vaccines | developing world | tropical diseases

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Site sourced from

http://mediapub.it.ox.ac.uk/feeds/129165/video.xml

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Malaria in Kenya

Description

There is a great need for better treatments for malaria and for a preventative malaria vaccine. SPACIAL EPIDEMIOLOGY & VACCINES Understanding the variation of malaria risk between houses, villages or region, and how malaria is transmitted in and around that variability helps develop better malaria control programmes and use their resources more wisely. Since malaria control tools are becoming less effective with time, progress in vaccine design is essential. Wales; http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

Subjects

malaria | malaria vaccines | Epidemiology | malaria | malaria vaccines | Epidemiology

License

http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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C0000P0123

Description

flu-ent choices

Subjects

svmsvet | drugs | cat | vaccination | drug | vaccine | catvaccines

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

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Nottingham Vet School | FlickR

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Vaccination

Description

Vaccinations are now considered a part of everyday life, but how do they work? This unit will help those with a background in biology understand the historical development of vaccination, assess the various types of vaccines used today, examine their production and explore the limitations that are placed on vaccination programmes.

Subjects

science and nature | antibodies | antigen | biology | disease | immunisation | immunogen | infectious_disease | mutation | polio | safety | smallpox | vaccination | vaccines | Education | X000

License

Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales Attribution-Noncommercial-Share Alike 2.0 UK: England & Wales http://creativecommons.org/licenses/by-nc-sa/2.0/uk/ http://creativecommons.org/licenses/by-nc-sa/2.0/uk/

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C0000P0123

Description

flu-ent choices

Subjects

svmsvet | drugs | cat | vaccination | drug | vaccine | catvaccines

License

http://creativecommons.org/licenses/by-nc-sa/2.0/

Site sourced from

Nottingham Vet School | FlickR

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20.462J Molecular Principles of Biomaterials (MIT)

Description

This course covers the analysis and design at a molecular scale of materials used in contact with biological systems, including biotechnology and biomedical engineering. Topics include molecular interactions between bio- and synthetic molecules and surfaces; design, synthesis, and processing approaches for materials that control cell functions; and application of state-of-the-art materials science to problems in tissue engineering, drug delivery, vaccines, and cell-guiding surfaces.

Subjects

biomaterials | biomaterial engineering | biotechnology | cell-guiding surface | molecular biomaterials | drug release | polymers | pulsatile release | polymerization | polyer erosion | tissue engineering | hydrogels | adhesion | migration | drug diffusion | molecular switches | molecular motors | nanoparticles | microparticles | vaccines | drug targeting | micro carriers | nano carriers | intracellular drug delivery | 20.462 | 3.962

License

Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see https://ocw.mit.edu/terms/index.htm

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