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The growth of blood vessels, a process known as angiogenesis, is one of the earliest events in mammalian development and is regulated by a sensitive interplay of growth factors and other molecules. In this course, we will discuss the key molecular regulators of blood vessel development as well as the techniques and experimental systems that have been utilized by vascular biologists. We will also examine the success of several anti-angiogenic treatments that have been approved by the Food and Drug Administration (FDA), that inhibit the pro-angiogenic vascular endothelial growth factor, VEGF, and that are now being used to treat age-related macular degeneration. Finally, we will explore how during the course of cancer progression, establishment of a blood supply into a tumor can lead to the The growth of blood vessels, a process known as angiogenesis, is one of the earliest events in mammalian development and is regulated by a sensitive interplay of growth factors and other molecules. In this course, we will discuss the key molecular regulators of blood vessel development as well as the techniques and experimental systems that have been utilized by vascular biologists. We will also examine the success of several anti-angiogenic treatments that have been approved by the Food and Drug Administration (FDA), that inhibit the pro-angiogenic vascular endothelial growth factor, VEGF, and that are now being used to treat age-related macular degeneration. Finally, we will explore how during the course of cancer progression, establishment of a blood supply into a tumor can lead to the

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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Tumor pathophysiology plays a central role in the growth, invasion, metastasis and treatment of solid tumors. This class applies principles of transport phenomena to develop a systems-level, quantitative understanding of angiogenesis, blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, and treatment response. Additional Faculty Dr. Pat D'Amore Dr. Dan Duda Dr. Robert Langer Prof. Robert Weinberg Dr. Marsha Moses Dr. Raghu Kalluri Dr. Lance Munn Tumor pathophysiology plays a central role in the growth, invasion, metastasis and treatment of solid tumors. This class applies principles of transport phenomena to develop a systems-level, quantitative understanding of angiogenesis, blood flow and microcirculation, metabolism and microenvironment, transport and binding of small and large molecules, movement of cancer and immune cells, metastatic process, and treatment response. Additional Faculty Dr. Pat D'Amore Dr. Dan Duda Dr. Robert Langer Prof. Robert Weinberg Dr. Marsha Moses Dr. Raghu Kalluri Dr. Lance Munn

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Content within individual OCW courses is (c) by the individual authors unless otherwise noted. MIT OpenCourseWare materials are licensed by the Massachusetts Institute of Technology under a Creative Commons License (Attribution-NonCommercial-ShareAlike). For further information see http://ocw.mit.edu/terms/index.htm

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This topic begins with a brief introduction to the vascular system and its components (arteries, veins and capillaries). An overall schematic diagram illustrates the position of the components in relation to the heart. Layers of the components are described in more detail (e.g. collagen fibres; smooth muscles) and are accompanied by diagrams. The control of blood flow is described; emphasis is on spincters and shunt vessels.

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View of the Japanese battleship 'Yashima' at Jarrow, c1897 (TWAM ref. GU.HO/19). She was launched at the Elswick Shipyard on 26 February 1896. ?Workshop of the World? is a phrase often used to describe Britain?s manufacturing dominance during the Nineteenth Century. It?s also a very apt description for the Elswick Works and Scotswood Works of Vickers Armstrong and its predecessor companies. These great factories, situated in Newcastle along the banks of the River Tyne, employed hundreds of thousands of men and women and built a huge variety of products for customers around the globe. The Elswick Works was established by William George Armstrong (later Lord Armstrong) in 1847 to manufacture hydraulic cranes. From these relatively humble beginnings the company diversified into many fields including shipbuilding, armaments and locomotives. By 1953 the Elswick Works covered 70 acres and extended over a mile along the River Tyne. This set of images, mostly taken from our Vickers Armstrong collection, includes fascinating views of the factories at Elswick and Scotswood, the products they produced and the people that worked there. By preserving these archives we can ensure that their legacy lives on. (Copyright) We're happy for you to share this digital image within the spirit of The Commons. Please cite 'Tyne & Wear Archives & Museums' when reusing. Certain restrictions on high quality reproductions and commercial use of the original physical version apply though; if you're unsure please email info@twarchives.org.uk.

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